MTP / Midatech Pharma Plc - ADR - Depositi SEC, Relazione annuale, dichiarazione di delega

Midatech Pharma Plc - ADR
US ˙ NASDAQ ˙ US59564R3021
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Statistiche di base
LEI 549300GKR2G40H3QFY57
CIK 1643918
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Midatech Pharma Plc - ADR
SEC Filings (Chronological Order)
Questa pagina fornisce un elenco completo e cronologico dei depositi SEC, esclusi i documenti di proprietà che forniamo altrove.
May 14, 2026 EX-99.3

NOTICE OF ANNUAL GENERAL MEETINGBIODEXA PHARMACEUTICALS PLC(Incorporated and registered in England and Wales with registered no. 09216368)Notice is hereby given that an Annual General Meeting ("AGM") of the members of Biodexa Pharmaceuticals PLC (the

Exhibit 99.3 NOTICE OF ANNUAL GENERAL MEETINGBIODEXA PHARMACEUTICALS PLC(Incorporated and registered in England and Wales with registered no. 09216368)Notice is hereby given that an Annual General Meeting ("AGM") of the members of Biodexa Pharmaceuticals PLC (the "Company") will be held at 1 Caspian Point, Caspian Way, Cardiff, Wales, CF10 4DQ on 17 June 2026 at 11:00 a.m. to consider and, if thou

May 14, 2026 EX-99.2

EXHIBIT 99.2

Biodexa Pharmaceuticals PLC Annual Report 2025 Exhibit 99.2Biodexa is a clinical-stage biopharmaceutical company developing innovative products focused on the treatment or prevention of gastrointestinal cancers Contents Page Strategic Report Strategy 01 Business Model 02 Clinical Stage Assets 02 Chief Executive’s Review 04 Financial Review 06 Stakeholder Engagement/s.172 statement 10 Risk Manageme

May 14, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2026 Commission File Number 001-37652 Biod

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2026 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of pri

May 14, 2026 EX-99.5

If you are planning to attend the Annual General Meeting, please tick the following box:>123-0Resolutions (*Special Resolutions)FORM OF PROXYBiodexa Pharmaceuticals PLC(a company incorporated in England and Wales under the Companies Act 2006 with com

Exhibit 99.5 If you are planning to attend the Annual General Meeting, please tick the following box:>123-0Resolutions (*Special Resolutions)FORM OF PROXYBiodexa Pharmaceuticals PLC(a company incorporated in England and Wales under the Companies Act 2006 with company number 09216368)I?We being (a) member(s) of the Company and entitled to vote at the AnnualGeneral Meeting, hereby appoint(Please onl

May 14, 2026 EX-99.6

ORDINARY RESOLUTIONS SPECIAL RESOLUTIONS FOR AGAINST WITHHELD FOR AGAINST WITHHELD FOR AGAINST WITHHELD Res 1. Res 7. Res 10. Res 2. Res 8. Res 11. Res 3. Res 9. Res 4. Res 5. Res 6. BIODEXA PHARMACEUTICALS PLC TO THE REGISTERED HOLDERS OF AMERICAN D

Exhibit 99.6 ORDINARY RESOLUTIONS SPECIAL RESOLUTIONS FOR AGAINST WITHHELD FOR AGAINST WITHHELD FOR AGAINST WITHHELD Res 1. Res 7. Res 10. Res 2. Res 8. Res 11. Res 3. Res 9. Res 4. Res 5. Res 6. BIODEXA PHARMACEUTICALS PLC TO THE REGISTERED HOLDERS OF AMERICAN DEPOSITARY RECEIPTS ("ADRs") REPRESENTING ORDINARY SHARES OF BIODEXA PHARMACEUTICALS PLC Sign below Date: Please sign this Voting Instruct

May 14, 2026 EX-99.4

t: +44 (0)29 20480180 | www.biodexapharma.com | Registered in England & Wales, No. 09216368 Biodexa Pharmaceuticals PLC 1 Caspian Point Caspian Way Cardiff CF10 4DQ Biodexa Pharmaceuticals PLC (Biodexa or the Company) May 14, 2026 Dear Shareholder, A

Exhibit 99.4 t: +44 (0)29 20480180 | www.biodexapharma.com | Registered in England & Wales, No. 09216368 Biodexa Pharmaceuticals PLC 1 Caspian Point Caspian Way Cardiff CF10 4DQ Biodexa Pharmaceuticals PLC (Biodexa or the Company) May 14, 2026 Dear Shareholder, Annual General Meeting Proposals to Reorganize Share Capital Without Affecting Shareholder's Rights or Number of ADSs Outstanding With thi

May 14, 2026 EX-99.1

Biodexa issues letter to Shareholders

Exhibit 99.1 May 14, 2026 Biodexa issues letter to Shareholders Biodexa Pharmaceuticals PLC (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing innovative products focused on the treatment or prevention of gastrointestinal cancers has today issued the following letter to shareholders explaining the proposals to reorganize the company’s share capital at the forthcoming Annual Gene

April 2, 2026 424B3

Up to 489,000 American Depositary Shares Representing 48,900,000,000 Ordinary Shares Underlying the Pre-Funded Warrants Up to 6,097,562 American Depositary Shares Representing 609,756,200,000 Ordinary Shares Underlying the Series L Warrants Up to 152

Filed Pursuant to Rule 424(b)(3) Registration No. 333-291598 PROSPECTUS Up to 489,000 American Depositary Shares Representing 48,900,000,000 Ordinary Shares Underlying the Pre-Funded Warrants Up to 6,097,562 American Depositary Shares Representing 609,756,200,000 Ordinary Shares Underlying the Series L Warrants Up to 152,439 American Depositary Shares Representing 15,243,900,000 Ordinary Shares Un

April 2, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares

Filed Pursuant to Rule 424(b)(3) File No. 333-278040 PROSPECTUS BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares This prospectus relates to the resale, by the selling shareholders identified in this prospectus, of an aggregate of 171,700,000 ordinary shares, nominal value £0.000001 per share, or Ordinary Shares, of Biodexa Pharmaceuticals PLC, o

April 2, 2026 424B3

1,701,800,000 Ordinary Shares Representing 17,018 American Depositary Shares

Filed Pursuant to Rule 424(b)(3) File No. 333-281489 PROSPECTUS 1,701,800,000 Ordinary Shares Representing 17,018 American Depositary Shares This prospectus relates to the resale from time to time, by the selling shareholders identified in this prospectus, of up to an aggregate of 1,701,800,000 ordinary shares, nominal value £0.000001 per share, or Ordinary Shares, of Biodexa Pharmaceuticals PLC,

April 2, 2026 424B3

299,261,540,000 Ordinary Shares Representing 2,992,615 American Depositary Shares

Filed Pursuant to Rule 424(b)(3) File No. 333-284350 PROSPECTUS 299,261,540,000 Ordinary Shares Representing 2,992,615 American Depositary Shares This prospectus relates to the potential offer and sale from time to time by C/M Capital Master Fund, LP, or the Selling Shareholder, of up to 299,261,540,000 of our ordinary shares, nominal value £0.000001 per share, or Ordinary Shares, represented by 2

April 2, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares

Filed Pursuant to Rule 424(b)(3) File No. 333-272693 PROSPECTUS BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares This prospectus relates to the resale, by the selling shareholders identified in this prospectus, of an aggregate of 109,800,000 ordinary shares, nominal value £0.000001 per share, or Ordinary Shares, of Biodexa Pharmaceuticals PLC, o

April 2, 2026 424B3

943,400,000 Ordinary Shares Representing 9,434 American Depositary Shares

Filed Pursuant to Rule 424(b)(3) File No. 333-279994 PROSPECTUS 943,400,000 Ordinary Shares Representing 9,434 American Depositary Shares This prospectus relates to the resale from time to time, by the selling shareholders identified in this prospectus, of up to an aggregate of 943,400,000 ordinary shares, nominal value £0.000001 per share, or Ordinary Shares, of Biodexa Pharmaceuticals PLC, or th

March 30, 2026 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026 Registration No.

March 30, 2026 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026 Registration No.

March 30, 2026 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026 Registration No.

March 30, 2026 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026 Registration No.

March 30, 2026 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 27, 2026 Registration No.

March 30, 2026 POS AM

As filed with the U.S. Securities and Exchange Commission on March 27, 2026.

As filed with the U.S. Securities and Exchange Commission on March 27, 2026. Registration No. 333-291598 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-1 POST-EFFECTIVE AMENDMENT NO. 1 TO REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Biodexa Pharmaceuticals PLC (Exact name of registrant as specified in its charter) England and Wales 2834 Not Applicable (St

March 27, 2026 EX-4.21

License and Collaboration Agreement

Exhibit 4.21 License and Collaboration Agreement This License and Collaboration Agreement is made and entered into as of February 3, 2026 (the “Effective Date”), between Otsuka Pharmaceutical Co., Ltd. (“Otsuka”), a company incorporated under the laws of Japan with offices at Shinagawa Grand Central Tower, 2-16-4 Konan, Minato-ku, Tokyo 108-8241, Japan, and Biodexa Pharmaceuticals PLC (“Biodexa”),

March 27, 2026 EX-15.1

The Directors

Exhibit 15.1 The Directors Biodexa Pharmaceuticals plc 1 Caspian Point Caspian Way Cardiff Wales CF10 4DQ DDI: +44 (0)20 7516 2200 Email: [email protected] Date: 26 March 2026 Consent of Independent Registered Public Accounting Firm – Exhibit 15.1 Dear Sir / Madam We consent to the inclusion of our audit report dated March 26, 2026 in the Annual Report on Form 20-F on the consolidated financial

March 27, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2026 Commission File Number: 001-3765

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2026 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address

March 27, 2026 EX-13.2

Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report on Form 20-F of Biodexa Pharmaceuticals PLC (the “Company”) for the year ended December 31, 2025, as filed with the United States Securities and Exchange Commission on the date hereof (the “Report”), the undersigned Fiona (Powell)

March 27, 2026 EX-12.2

Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Fiona (Powell) Sharp, certify that: 1. I have reviewed this annual report on Form 20-F of Biodexa Pharmaceuticals PLC (the “Company”); 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light o

March 27, 2026 EX-13.1

Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report on Form 20-F of Biodexa Pharmaceuticals PLC (the “Company”) for the year ended December 31, 2025, as filed with the United States Securities and Exchange Commission on the date hereof (the “Report”), the undersigned Stephen Stamp,

March 27, 2026 EX-15.2

30 Old Bailey

Exhibit 15.2 30 Old Bailey London EC4M 7AU Tel: +44 (0)20 7063 4000 forvismazars.com/uk Consent of Independent Registered Public Accounting Firm RE: The Board of Directors of Biodexa Pharmaceuticals PLC, We hereby consent to the incorporation by reference in this Form 20-F (to be filed on or about March 26, 2026) of our audit report dated April 18, 2024 with respect to the consolidated balance she

March 27, 2026 EX-2.1

DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT

Exhibit 2.1 DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT The following description of the securities registered under Section 12 of the Securities Exchange Act of 1934, as amended of Biodexa Pharmaceutucals PLC (“Biodexa,” “we,” “us,” “our” or the “Company”) is a summary of the rights of our issued share capital and certain provisions of our articles of association. Th

March 27, 2026 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F (Mark One) ¨ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXC

March 27, 2026 EX-12.1

Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Stephen Stamp, certify that: 1. I have reviewed this annual report on Form 20-F of Biodexa Pharmaceuticals PLC (the “Company”); 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the c

March 27, 2026 EX-99.1

Preliminary Results for the Year Ended 31 December 2025

EXHIBIT 99.1 Preliminary Results for the Year Ended 31 December 2025 March 27, 2026 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company” or, together with its subsidiaries, the “Group”) Preliminary Results for the Year Ended 31 December 2025 Biodexa Pharmaceuticals PLC (Nasdaq: BDRX), a clinical-stage biopharmaceutical company developing innovative products focused on the treatment or preventio

March 18, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2026 Commission File Number 001-37652 Bi

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2026 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of p

March 18, 2026 EX-99.1

Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) ADR Ratio Change

Exhibit 99.1 March 18, 2026 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) ADR Ratio Change Biodexa Pharmaceuticals PLC (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of rare diseases with unmet medical needs, today announces a ratio change on its American Depositary Receipts (“ADR”) from one (1) ADR representing

February 4, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 157,000 Units, Each Unit Consisting of One American Depositary Share and Two Series L Warrants, Each to Purchase One American Depositary Share, and 2,891,781 Pre-Funded Units, Each Pre-Funded Unit Consisting of One Pre-Fun

Filed pursuant to Rule 424(b)(3) Registration No.: 333-291598 PROSPECTUS SUPPLEMENT No. 2 (To the Prospectus dated December 17, 2025) BIODEXA PHARMACEUTICALS PLC 157,000 Units, Each Unit Consisting of One American Depositary Share and Two Series L Warrants, Each to Purchase One American Depositary Share, and 2,891,781 Pre-Funded Units, Each Pre-Funded Unit Consisting of One Pre-Funded Warrant to P

February 4, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-278040 PROSPECTUS SUPPLEMENT No. 3 (To the Prospectus dated November 21, 2025) BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares This prospectus supplement No. 3 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended

February 4, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-272693 PROSPECTUS SUPPLEMENT No. 3 (To the Prospectus dated November 21, 2025) BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares This prospectus supplement No. 3 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended

February 4, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 13 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares This prospectus supplement No. 13 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

February 4, 2026 EX-99.1

Biodexa Announces Exclusive License of Otsuka’s OPB-171775, a potent Phase 1 ready Molecular Glue for GIST Novel Mechanism of Action Shown to be Effective in TKI Resistant PDX Models

Exhibit 99.1 February 4, 2026 Biodexa Announces Exclusive License of Otsuka’s OPB-171775, a potent Phase 1 ready Molecular Glue for GIST Novel Mechanism of Action Shown to be Effective in TKI Resistant PDX Models Cardiff, UK – February 4, 2025 – Biodexa Pharmaceuticals PLC (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of r

February 4, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 13 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares This prospectus supplement No. 13 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as ame

February 4, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2026 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2026 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address o

February 4, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 13 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares This prospectus supplement No. 13 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

January 6, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-278040 PROSPECTUS SUPPLEMENT No. 2 (To the Prospectus dated November 21, 2025) BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares This prospectus supplement No. 2 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended

January 6, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2026 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2026 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of

January 6, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 157,000 Units, Each Unit Consisting of One American Depositary Share and Two Series L Warrants, Each to Purchase One American Depositary Share, and 2,891,781 Pre-Funded Units, Each Pre-Funded Unit Consisting of One Pre-Fun

Filed pursuant to Rule 424(b)(3) Registration No.: 333-291598 PROSPECTUS SUPPLEMENT No. 1 (To the Prospectus dated December 17, 2025) BIODEXA PHARMACEUTICALS PLC 157,000 Units, Each Unit Consisting of One American Depositary Share and Two Series L Warrants, Each to Purchase One American Depositary Share, and 2,891,781 Pre-Funded Units, Each Pre-Funded Unit Consisting of One Pre-Funded Warrant to P

January 6, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-272693 PROSPECTUS SUPPLEMENT No. 2 (To the Prospectus dated November 21, 2025) BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares This prospectus supplement No. 2 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended

January 6, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 12 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares This prospectus supplement No. 12 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

January 6, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 12 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares This prospectus supplement No. 9 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

January 6, 2026 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 12 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares This prospectus supplement No. 12 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as ame

January 5, 2026 EX-99.1

Appointment of Fiona Sharp to the Board as Chief Financial Officer and Company Secretary

EXHIBIT 99.1 Appointment of Fiona Sharp to the Board as Chief Financial Officer and Company Secretary January 05, 2026 Biodexa Pharmaceuticals PLC Appointment of Fiona Sharp to the Board as Chief Financial Officer and Company Secretary Biodexa Pharmaceuticals PLC (“Biodexa” or “the Company”), (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products fo

January 5, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2026 Commission File Number: 001-37

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2026 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Addre

December 19, 2025 424B4

157,000 Units, Each Unit Consisting of One American Depositary Share and Two Series L Warrants, Each to Purchase One American Depositary Share 2,891,781 Pre-Funded Units, Each Pre-Funded Unit Consisting of One Pre-Funded Warrant to Purchase One Ameri

Filed Pursuant to Rule 424(b)(4) Registration Statement No. 333-291598 PROSPECTUS 157,000 Units, Each Unit Consisting of One American Depositary Share and Two Series L Warrants, Each to Purchase One American Depositary Share and 2,891,781 Pre-Funded Units, Each Pre-Funded Unit Consisting of One Pre-Funded Warrant to Purchase One American Depositary Share and Two Series L Warrants, Each to Purchase

December 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-272693 PROSPECTUS SUPPLEMENT No. 1 (To the Prospectus dated November 21, 2025) BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares This prospectus supplement No. 1 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended

December 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-278040 PROSPECTUS SUPPLEMENT No. 1 (To the Prospectus dated November 21, 2025) BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares This prospectus supplement No. 1 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended

December 18, 2025 EX-4.1

FORM OF SERIES L WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC

Exhibit 4.1 FORM OF SERIES L WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC Warrant Depositary Shares: Issue Date: Initial Exercise Date: THIS SERIES L WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms a

December 18, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2025 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address

December 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 11 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares This prospectus supplement No. 8 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

December 18, 2025 EX-99.1

Biodexa Announces Pricing of $10 Million Public Offering

Exhibit 99.1 Biodexa Announces Pricing of $10 Million Public Offering December 18, 2025 Biodexa Pharmaceuticals PLC, (Nasdaq: BDRX) (“Biodexa” or the “Company”), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs, today announced the pricing of a best efforts public offering of an aggregate of (i) 157,000 u

December 18, 2025 EX-10.2

PLACEMENT AGENCY AGREEMENT

Exhibit 10.2 PLACEMENT AGENCY AGREEMENT December 17, 2025 Maxim Group LLC 300 Park Avenue, 16th Floor New York, NY 10022 Ladies and Gentlemen: Subject to the terms and conditions herein (this “Agreement”), Biodexa Pharmaceuticals PLC, a public limited company organized under the laws of England and Wales (including any successor thereto, the “Company”), hereby agrees to sell up to an aggregate of

December 18, 2025 EX-4.2

FORM OF PRE-FUNDED WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC

Exhibit 4.2 FORM OF PRE-FUNDED WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC Warrant Depositary Shares: Issue Date: Initial Exercise Date: THIS PRE-FUNDED WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the ter

December 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 11 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares This prospectus supplement No. 8 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amen

December 18, 2025 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of December 17, 2025, between Biodexa Pharmaceuticals PLC, a public limited company incorporated under the laws of England and Wales (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “

December 18, 2025 EX-4.3

PLACEMENT AGENT WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC

Exhibit 4.3 PLACEMENT AGENT WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC Warrant Depositary Shares: Issue Date: Initial Exercise Date: THIS PLACEMENT AGENT WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the t

December 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 11 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares This prospectus supplement No. 9 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

December 11, 2025 EX-10.19

PLACEMENT AGENCY AGREEMENT

Exhibit 10.19 PLACEMENT AGENCY AGREEMENT December [·], 2025 Maxim Group LLC 300 Park Avenue, 16th Floor New York, NY 10022 Ladies and Gentlemen: Subject to the terms and conditions herein (this “Agreement”), Biodexa Pharmaceuticals PLC, a public limited company organized under the laws of England and Wales (including any successor thereto, the “Company”), hereby agrees to sell up to an aggregate o

December 11, 2025 EX-4.5

FORM OF SERIES L WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC

Exhibit 4.5 FORM OF SERIES L WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC Warrant Depositary Shares: Issue Date: Initial Exercise Date: THIS SERIES L WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms a

December 11, 2025 EX-10.20

SECURITIES PURCHASE AGREEMENT

Exhibit 10.20 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of , 2025, between Biodexa Pharmaceuticals PLC, a public limited company incorporated under the laws of England and Wales (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers

December 11, 2025 F-1/A

As filed with the U.S. Securities and Exchange Commission on December 11, 2025.

As filed with the U.S. Securities and Exchange Commission on December 11, 2025. Registration No. 333-291598 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 2 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Biodexa Pharmaceuticals PLC (Exact name of registrant as specified in its charter) England and Wales 2834 Not Applicable (State or Other

December 8, 2025 F-1/A

As filed with the U.S. Securities and Exchange Commission on December 8, 2025.

As filed with the U.S. Securities and Exchange Commission on December 8, 2025. Registration No. 333-291598 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Biodexa Pharmaceuticals PLC (Exact name of registrant as specified in its charter) England and Wales 2834 Not Applicable (State or Other

November 24, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares

PROSPECTUS Filed Pursuant to Rule 424(b)(3) Registration No. 333-272693 BIODEXA PHARMACEUTICALS PLC 109,800,000 Ordinary Shares Representing 1,098 American Depositary Shares This prospectus relates to the resale, by the selling shareholders identified in this prospectus, of an aggregate of 109,800,000 ordinary shares, nominal value £0.000001 per share, or Ordinary Shares, of Biodexa Pharmaceutical

November 24, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares

PROSPECTUS Filed Pursuant to Rule 424(b)(3) Registration No. 333-278040 BIODEXA PHARMACEUTICALS PLC 171,700,000 Ordinary Shares Representing 1,717 American Depositary Shares This prospectus relates to the resale, by the selling shareholders identified in this prospectus, of an aggregate of 171,700,000 ordinary shares, nominal value £0.000001 per share, or Ordinary Shares, of Biodexa Pharmaceutical

November 17, 2025 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON NOVEMBER 17, 2025

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON NOVEMBER 17, 2025 Registration No.

November 17, 2025 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON NOVEMBER 17, 2025

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON NOVEMBER 17, 2025 Registration No.

November 17, 2025 F-1

As filed with the U.S. Securities and Exchange Commission on November 17, 2025.

As filed with the U.S. Securities and Exchange Commission on November 17, 2025. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Biodexa Pharmaceuticals PLC (Exact name of registrant as specified in its charter) England and Wales 2834 Not Applicable (State or Other Jurisdiction of Incorpor

November 17, 2025 EX-4.6

FORM OF PRE-FUNDED WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC

Exhibit 4.6 FORM OF PRE-FUNDED WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC Warrant Depositary Shares: Issue Date: Initial Exercise Date: THIS PRE-FUNDED WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the ter

November 17, 2025 EX-10.19

PLACEMENT AGENCY AGREEMENT

Exhibit 10.19 PLACEMENT AGENCY AGREEMENT [·], 2025 Maxim Group LLC 300 Park Avenue, 16th Floor New York, NY 10022 Ladies and Gentlemen: Subject to the terms and conditions herein (this “Agreement”), Biodexa Pharmaceuticals PLC, a public limited company organized under the laws of England and Wales (including any successor thereto, the “Company”), hereby agrees to sell up to an aggregate of $[●]of

November 17, 2025 EX-FILING FEES

CALCULATION OF FILING FEE TABLES Biodexa Pharmaceuticals PLC Table 1: Newly Registered and Carry Forward Securities

Ex-Filing Fees CALCULATION OF FILING FEE TABLES F-1 Biodexa Pharmaceuticals PLC Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Registered Securities Fees to be Paid Equity Units, each consisting of one American Depositary Share ("ADS") and one Series L Warrant to purchase one ADS (1) Other $ $ 18,000,000.

November 17, 2025 EX-10.20

SECURITIES PURCHASE AGREEMENT

Exhibit 10.20 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of , 2025, between Biodexa Pharmaceuticals PLC, a public limited company incorporated under the laws of England and Wales (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers

November 17, 2025 EX-4.5

FORM OF SERIES L WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC

Exhibit 4.5 FORM OF SERIES L WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES BIODEXA PHARMACEUTICALS PLC Warrant Depositary Shares: Issue Date: Initial Exercise Date: THIS SERIES L WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms a

November 3, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 10 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares This prospectus supplement No. 10 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as ame

November 3, 2025 EX-99.1

Biodexa Announces Approval of CTA in Europe for Phase 3 Serenta Trial in FAP First European patient expected to be enrolled in 4Q 2025 Addressable US - European Market Put at $7 Billion

Exhibit 99.1 November 3, 2025 Biodexa Announces Approval of CTA in Europe for Phase 3 Serenta Trial in FAP First European patient expected to be enrolled in 4Q 2025 Addressable US - European Market Put at $7 Billion Biodexa Pharmaceuticals PLC (“Biodexa” or “the Company”), (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of d

November 3, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2025 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address o

November 3, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 10 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares This prospectus supplement No.10 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

November 3, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 10 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares This prospectus supplement No. 10 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

September 30, 2025 EFFECT

EFFECT

X0101 EFFECT 33 LIVE 2025-09-30 16:00:00 F-3 0001643918 Biodexa Pharmaceuticals Plc 333-290554

September 29, 2025 CORRESP

Biodexa Pharmaceuticals PLC 1 Caspian Point Caspian Way Cardiff, CF10 4DQ United Kingdom

Biodexa Pharmaceuticals PLC 1 Caspian Point Caspian Way Cardiff, CF10 4DQ United Kingdom September 29, 2025 VIA EDGAR U.

September 29, 2025 LETTER

LETTER

September 29, 2025 Stephen Stamp Chief Executive Officer Biodexa Pharmaceuticals PLC 1 Caspian Point Caspian Way Cardiff, CF10 4DQ United Kingdom Re: Biodexa Pharmaceuticals PLC Registration Statement on Form F-3 Filed September 26, 2025 File No.

September 26, 2025 EX-FILING FEES

CALCULATION OF FILING FEE TABLES Biodexa Pharmaceuticals Plc Table 1: Newly Registered and Carry Forward Securities

Ex-Filing Fees CALCULATION OF FILING FEE TABLES F-3 Biodexa Pharmaceuticals Plc Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to be Paid Equity Ordinary Shares, nominal value GBP0.

September 26, 2025 F-3

As filed with the Securities and Exchange Commission on September 26, 2025

As filed with the Securities and Exchange Commission on September 26, 2025 Registration No.

September 26, 2025 EX-4.5

BIODEXA PHARMACEUTICALS PLC [ ] Dated as of [ ] Senior Debt Securities CROSS-REFERENCE TABLE (1)

Exhibit 4.5 BIODEXA PHARMACEUTICALS PLC Issuer AND [ ] Trustee INDENTURE Dated as of [ ] Senior Debt Securities CROSS-REFERENCE TABLE (1) Section of Trust Indenture Act Section of of 1939, as Amended Indenture 310(a). 7.09 310(b). 7.08 7.10 310(c). Inapplicable 311(a). 7.13(a) 311(b). 7.13(b) 311(c). Inapplicable 312(a) 5.02(a) 312(b). 5.02(b) 312(c). 5.02(c) 313(a). 5.04(a) 313(b). 5.04(a) 313(c)

September 26, 2025 EX-4.6

BIODEXA PHARMACEUTICALS PLC [ ] Trustee Dated as of [ ] Subordinated Debt Securities CROSS-REFERENCE TABLE (1)

Exhibit 4.6 BIODEXA PHARMACEUTICALS PLC Issuer AND [ ] Trustee INDENTURE Dated as of [ ] Subordinated Debt Securities CROSS-REFERENCE TABLE (1) Section of Trust Indenture Act of 1939, as Amended Section of Indenture 310(a). 7.09 310(b). 7.08 7.10 310(c). Inapplicable 311(a). 7.13(a) 311(b). 7.13(b) 311(c). Inapplicable 312(a). 5.02(a) 312(b). 5.02(b) 312(c). 5.02(c) 313(a). 5.04(a) 313(b). 5.04(a)

September 12, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 9 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares This prospectus supplement No. 9 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended, e

September 12, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2025 Commission File Number 001-3765

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address

September 12, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 9 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares This prospectus supplement No. 9 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amend

September 12, 2025 EX-99.1

Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Interim results for the six months ended June 30, 2025

Exhibit 99.1 September 12, 2025 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Interim results for the six months ended June 30, 2025 Biodexa Pharmaceuticals PLC (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs, today announces its unaudited interim results for the six months end

September 12, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 9 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares This prospectus supplement No. 9 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended, e

August 20, 2025 LETTER

LETTER

August 20, 2025 Stephen Stamp Chief Executive Officer Biodexa Pharmaceuticals plc 1 Caspian Point Caspian Way Cardiff, CF10 4DQ, United Kingdom Re: Biodexa Pharmaceuticals plc Form 20-F for Fiscal Year Ended December 31, 2024 File No.

August 19, 2025 CORRESP

Boston Los Angeles MIAMI New York San Diego San Francisco TORONTO Washington MINTZ, LEVIN, COHN, FERRIS, GLOVSKY AND POPEO, P.C.

One Financial Center Boston, MA 02111 617 542 6000 mintz.com August 19, 2025 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attention: Tracie Mariner and Kevin Vaughn Re: Biodexa Pharmaceuticals plc Form 20-F for Fiscal Year Ended December 31, 2024 File No. 001-37652 Ladies and Gentlemen: We are submitt

August 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 8 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares This prospectus supplement No. 8 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended, e

August 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 8 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares This prospectus supplement No. 8 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended, e

August 18, 2025 LETTER

LETTER

August 18, 2025 Stephen Stamp Chief Executive Officer Biodexa Pharmaceuticals plc 1 Caspian Point Caspian Way Cardiff, CF10 4DQ, United Kingdom Re: Biodexa Pharmaceuticals plc Form 20-F for Fiscal Year Ended December 31, 2024 File No.

August 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 8 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares This prospectus supplement No. 8 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amend

August 18, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2025 Commission File Number: 001-376

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Addres

August 18, 2025 EX-99.1

Biodexa Announces Enrolment of First Patients into Pivotal Phase 3 Serenta Trial in Familial Adenomatous Polyposis (FAP)

EXHIBIT 99.1 Biodexa Announces Enrolment of First Patients into Pivotal Phase 3 Serenta Trial in Familial Adenomatous Polyposis (FAP) August 18, 2025 Biodexa Announces Enrolment of First Patients into Pivotal Phase 3 Serenta Trial in Familial Adenomatous Polyposis (FAP) Opportunity to be First Mover in $7.3Bn Addressable Market Biodexa Pharmaceuticals PLC (“Biodexa” or “the Company”), (Nasdaq: BDR

August 6, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 7 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 3,413,520 American Depositary Shares This prospectus supplement No. 7 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amend

August 6, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 7 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,100,000 Ordinary Shares Representing 24,861 American Depositary Shares This prospectus supplement No. 7 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended, e

August 6, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 7 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,000,000 Ordinary Shares Representing 43,490 American Depositary Shares This prospectus supplement No. 7 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended, e

July 31, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2025 Commission File Number: 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address

July 31, 2025 EX-99.1

ADR Ratio Change Effective

EXHIBIT 99.1 ADR Ratio Change Effective July 31, 2025 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) ADR Ratio Change Effective ADSs Outstanding Post Ratio Change Biodexa Pharmaceuticals PLC (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs, today announces the previously announce

July 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 6 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares This prospectus supplement No. 6 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

July 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 6 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares This prospectus supplement No. 6 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

July 18, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 6 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares This prospectus supplement No. 6 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amen

July 15, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2025 Commission File Number 001-37652 Bio

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of pr

July 15, 2025 EX-99.1

Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) ADR Ratio Change

Exhibit 99.1 July 15, 2025 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) ADR Ratio Change Biodexa Pharmaceuticals PLC (Nasdaq: BDRX), an acquisition-focused clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs, today announces a ratio change on its American Depositary Receipts (“ADR”) from one (1) AD

June 27, 2025 EX-99.1

Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Results of Annual General Meeting

Exhibit 99.1 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Results of Annual General Meeting Biodexa Pharmaceuticals PLC (NASDAQ: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs, announces that at its Annual General Meeting held yesterday, all resolutions put to the Company’s shareholde

June 27, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 5 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares This prospectus supplement No. 4 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

June 27, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 5 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares This prospectus supplement No. 4 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amen

June 27, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 5 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares This prospectus supplement No. 3 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

June 27, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission File Number 001-37652 Bio

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of pr

June 13, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 4 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares This prospectus supplement No. 4 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

June 13, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission File Number 001-37652 Bio

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of pr

June 13, 2025 EX-1.1

BIODEXA PHARMACEUTICALS PLC (registered number 09216368) ARTICLES OF ASSOCIATION Table of Contents

Exhibit 1.1 BIODEXA PHARMACEUTICALS PLC (registered number 09216368) ARTICLES OF ASSOCIATION Table of Contents PRELIMINARY 1 1 DEFINITIONS 1 2 LIABILITY OF MEMBERS 6 3 FORM OF RESOLUTION 6 4 EXCLUSION OF MODEL ARTICLES (AND ANY OTHER PRESCRIBED REGULATIONS) 6 5 REGISTERED OFFICE 6 SHARE CAPITAL 6 6 ALLOTMENT, REDUCTION AND ALTERATION 6 7 SHARE WARRANTS TO BEARER 7 8 COMMISSIONS AND BROKERAGE 8 9 T

June 13, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 4 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares This prospectus supplement No. 4 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amen

June 13, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 4 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares This prospectus supplement No. 4 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

June 11, 2025 EX-99.1

Result of General Meeting

EXHIBIT 99.1 Result of General Meeting June 11, 2025 Biodexa Pharmaceuticals PLC Result of General Meeting Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) (NASDAQ: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs announces, announces that at its General Meeting held earlier today, all four

June 11, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission File Number: 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address

June 4, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission File Number: 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address

June 4, 2025 EX-99.1

Biodexa Announces Recruitment of First Patient in Phase 2 Study of Tolimidone in Type 1 Diabetes

EXHIBIT 99.1 Biodexa Announces Recruitment of First Patient in Phase 2 Study of Tolimidone in Type 1 Diabetes June 4, 2025 Biodexa Announces Recruitment of First Patient in Phase 2 Study of Tolimidone in Type 1 Diabetes Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment o

June 2, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 3 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares This prospectus supplement No. 3 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

June 2, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 3 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares This prospectus supplement No. 3 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

May 30, 2025 EX-99.1

Shareholder Update

EXHIBIT 99.1 Shareholder Update May 30, 2025 Biodexa Pharmaceuticals PLC Shareholder Update Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs, today announced a brief update for shareholders. Financial position As of May 29, 2025, the

May 30, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 3 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares This prospectus supplement No. 3 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amen

May 30, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number: 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address o

May 23, 2025 EX-99.4

Proof 6 20-May-25 FOR AGAINST WITHHELD FOR AGAINST WITHHELD Res 1. Res 5. Res 2. Res 6. Res 3. Res 7. Res 4. BIODEXA PHARMACEUTICALS PLC TO THE REGISTERED HOLDERS OF AMERICAN DEPOSITARY RECEIPTS ("ADRs") REPRESENTING ORDINARY SHARES OF BIODEXA PHARMA

Exhibit 99.4 Proof 6 20-May-25 FOR AGAINST WITHHELD FOR AGAINST WITHHELD Res 1. Res 5. Res 2. Res 6. Res 3. Res 7. Res 4. BIODEXA PHARMACEUTICALS PLC TO THE REGISTERED HOLDERS OF AMERICAN DEPOSITARY RECEIPTS ("ADRs") REPRESENTING ORDINARY SHARES OF BIODEXA PHARMACEUTICALS PLC Sign below Date: Please sign this Voting Instruction Card exactly as your name(s) appear(s) on the face of this card and on

May 23, 2025 EX-99.3

If you are planning to attend the Annual General Meeting, please tick the following box:Ñ>123|Ó>123-0Ordinary ResolutionsFORM OF PROXYBiodexa Pharmaceuticals PLC(a company incorporated in England and Wales under the Companies Act 2006 with company nu

Exhibit 99.3 If you are planning to attend the Annual General Meeting, please tick the following box:Ñ>123|Ó>123-0Ordinary ResolutionsFORM OF PROXYBiodexa Pharmaceuticals PLC(a company incorporated in England and Wales under the Companies Act 2006 with company number 09216368)I?We being (a) member(s) of the Company and entitled to vote at the AnnualGeneral Meeting, hereby appoint(Please only compl

May 23, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 2 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares This prospectus supplement No. 2 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

May 23, 2025 EX-99.2

NOTICE OF ANNUAL GENERAL MEETING BIODEXA PHARMACEUTICALS PLC (Incorporated and registered in England and Wales with registered no. 09216368)

Exhibit 99.2 NOTICE OF ANNUAL GENERAL MEETING BIODEXA PHARMACEUTICALS PLC (Incorporated and registered in England and Wales with registered no. 09216368) Notice is hereby given that an Annual General Meeting (“AGM”) of the members of Biodexa Pharmaceuticals PLC (the “Company”) will be held at 1 Caspian Point, Caspian Way, Cardiff, Wales, CF10 4DQ on 26 June 2025 at 1:00 p.m. to consider and, if th

May 23, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 2 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares This prospectus supplement No. 2 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

May 23, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 2 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares This prospectus supplement No. 2 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amen

May 23, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number 001-37652 Biod

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of pri

May 22, 2025 EX-99.2

Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Notice of General Meeting

Exhibit 99.2 May 22, 2025 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Notice of General Meeting Biodexa Pharmaceuticals PLC, (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs announces a Notice of a General Meeting to be held at the Company’s offices, 1 Caspian Point, Caspian W

May 22, 2025 EX-99.1

NOTICE OF GENERAL MEETING BIODEXA PHARMACEUTICALS PLC (Incorporated and registered in England and Wales with registered no. 09216368)

Exhibit 99.1 NOTICE OF GENERAL MEETING BIODEXA PHARMACEUTICALS PLC (Incorporated and registered in England and Wales with registered no. 09216368) Notice is hereby given that a general meeting (“GM”) of the members of Biodexa Pharmaceuticals PLC (the “Company”) will be held at 1 Caspian Point, Caspian Way, Cardiff, Wales, CF10 4DQ on 11 June 2025 at 1:00 p.m. to consider and, if thought fit, pass

May 22, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number 001-37652 Biod

6-K 1 z5212516k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kin

May 22, 2025 EX-99.1

Biodexa Announces Award of Additional $3.0M Grant from CPRIT to Support Registrational eRapa Phase 3 Program in FAP Brings Total CPRIT Grant Funding for eRapa Phase 3 Program to $20.0M

EXHIBIT 99.1 Biodexa Announces Award of Additional $3.0M Grant from CPRIT to Support Registrational eRapa Phase 3 Program in FAP Brings Total CPRIT Grant Funding for eRapa Phase 3 Program to $20.0M May 22, 2025 Biodexa Announces Award of Additional $3.0M Grant from CPRIT to Support Registrational eRapa Phase 3 Program in FAP Brings Total CPRIT Grant Funding for eRapa Phase 3 Program to $20.0M Biod

May 22, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number: 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address o

May 15, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number 001-37652 Biod

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of pri

May 15, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 1 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares This prospectus supplement No. 1 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

May 15, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 1 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 434,901 American Depositary Shares This prospectus supplement No. 1 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amended,

May 15, 2025 EX-10.1

Annex A – Representations and Warranties

Exhibit 10.1 May 15, 2025 [Name and address of warrant holder] Re: Reprice of Warrants To Whom It May Concern: Biodexa Pharmaceuticals PLC, a public limited company organized under the laws of England and Wales (the “Company”), is pleased to offer to you the opportunity to exercise the warrants set forth on your signature page attached hereto (the “Warrants”) and held by you (the “Holder”). The or

May 15, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-284350 PROSPECTUS SUPPLEMENT No. 1 (To the Prospectus dated May 9, 2025) BIODEXA PHARMACEUTICALS PLC 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares This prospectus supplement No. 1 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, as amen

May 12, 2025 424B3

341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares

Filed Pursuant to Rule 424(b)(3) Registration No. 333-284350 PROSPECTUS 341,352,000,000 Ordinary Shares Representing 34,135,200 American Depositary Shares This prospectus relates to the potential offer and sale from time to time by C/M Capital Master Fund, LP, or the Selling Shareholder, of up to 341,352,000,000 of our ordinary shares, nominal value £0.00005 per share, or Ordinary Shares, represen

May 12, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number: 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address o

May 12, 2025 424B3

2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares

Filed Pursuant to Rule 424(b)(3) Registration No. 333-279994 PROSPECTUS 2,486,190,000 Ordinary Shares Representing 248,619 American Depositary Shares This prospectus relates to the resale from time to time, by the selling shareholders identified in this prospectus, of up to an aggregate of 2,486,190,000 ordinary shares, nominal value £0.00005 per share, or Ordinary Shares, of Biodexa Pharmaceutica

May 12, 2025 EX-99.1

Biodexa Receives Orphan Drug Designation in Europe for eRapa in FAP

EXHIBIT 99.1 Biodexa Receives Orphan Drug Designation in Europe for eRapa in FAP May 12, 2025 Biodexa Receives Orphan Drug Designation in Europe for eRapa in FAP New designation follows the U.S. Food and Drug Administration (FDA) Orphan Drug Designation for eRapa in FAP granted in 2019 Company nears start of Registrational Phase 3 study targeted at an addressable market of $7.3Bn Biodexa Pharmaceu

May 12, 2025 424B3

4,349,010,000 Ordinary Shares Representing 434,901 American Depositary Shares

Filed Pursuant to Rule 424(b)(3) Registration No. 333-281489 PROSPECTUS 4,349,010,000 Ordinary Shares Representing 434,901 American Depositary Shares This prospectus relates to the resale from time to time, by the selling shareholders identified in this prospectus, of up to an aggregate of 4,349,010,000 ordinary shares, nominal value £0.00005 per share, or Ordinary Shares, of Biodexa Pharmaceutica

May 8, 2025 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 8, 2025

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 8, 2025 Registration No.

May 8, 2025 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 8, 2025

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 8, 2025 Registration No.

May 2, 2025 EX-99.1

Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Result of General Meeting

Exhibit 99.1 May 2, 2025 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Result of General Meeting Biodexa Pharmaceuticals PLC, (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs announces that at its General Meeting held at 1.00pm BST today, ordinary resolutions 1 and 2 were passed

May 2, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number 001-37652 Biod

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of pri

May 1, 2025 DRS

Confidential Treatment Requested by Biodexa Pharmaceuticals PLC Pursuant to 17 C.F.R. Section 200.83 As confidentially submitted to the U.S. Securities and Exchange Commission on May 1, 2025. This draft registration statement has not been publicly fi

Confidential Treatment Requested by Biodexa Pharmaceuticals PLC Pursuant to 17 C.F.R. Section 200.83 As confidentially submitted to the U.S. Securities and Exchange Commission on May 1, 2025. This draft registration statement has not been publicly filed with the U.S. Securities and Exchange Commission and all information herein remains strictly confidential. Registration No. 333- UNITED STATES SEC

April 29, 2025 POS AM

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON APRIL 29, 2025

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON APRIL 29, 2025 Registration No.

April 17, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of April 2025 Commission File Number: 001-3765

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of April 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address

April 17, 2025 EX-99.2

NOTICE OF GENERAL MEETING BIODEXA PHARMACEUTICALS PLC (Incorporated and registered in England and Wales with registered no. 09216368)

Exhibit 99.2 NOTICE OF GENERAL MEETING BIODEXA PHARMACEUTICALS PLC (Incorporated and registered in England and Wales with registered no. 09216368) Notice is hereby given that a general meeting (“GM”) of the members of Biodexa Pharmaceuticals PLC (the “Company”) will be held at 1 Caspian Point, Caspian Way, Cardiff, Wales, CF10 4DQ on 2 May 2025 at 1:00 p.m. to consider and, if thought fit, pass th

April 17, 2025 EX-99.1

Notice of General Meeting

EXHIBIT 99.1 Notice of General Meeting April 17, 2025 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Notice of General Meeting Biodexa Pharmaceuticals PLC, (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs announces a Notice of a General Meeting to be held at the Company’s offices

April 11, 2025 EX-99.1

Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company” or, together with its subsidiaries, the “Group”) Preliminary Results for the Year Ended 31 December 2024

Exhibit 99.1 April 11, 2025 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company” or, together with its subsidiaries, the “Group”) Preliminary Results for the Year Ended 31 December 2024 Biodexa Pharmaceuticals PLC (Nasdaq: BDRX), an acquisition-focused clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs, an

April 11, 2025 EX-15.1

The Directors

Exhibit 15.1 The Directors Biodexa Pharmaceuticals plc 1 Caspian Point Caspian Way Cardiff Wales CF10 4DQ DDI: +44 (0)20 7516 2200 Email: [email protected] Date: 10 April 2025 Consent of Independent Registered Public Accounting Firm – Exhibit 15.1 Dear Sir / Madam We consent to the inclusion of our audit report dated April 10, 2025 in the Annual Report on Form 20-F on the consolidated financial

April 11, 2025 EX-2.1

DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT

Exhibit 2.1 DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT The following description of the securities registered under Section 12 of the Securities Exchange Act of 1934, as amended of Biodexa Pharmaceutucals PLC (“Biodexa,” “we,” “us,” “our” or the “Company”) is a summary of the rights of our issued share capital and certain provisions of our articles of association. Th

April 11, 2025 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F (Mark One) ¨ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXC

April 11, 2025 EX-11.1

DATED 14 March 2025 BIODEXA PHARMACEUTICALS PLC INSIDER TRADING/SHARE DEALING CODE

Exhibit 11.1 DATED 14 March 2025 BIODEXA PHARMACEUTICALS PLC INSIDER TRADING/SHARE DEALING CODE BIODEXA PHARMACEUTICALS PLC COMPANY INSIDER TRADING SHARE DEALING CODE (the Code) 1. INTRODUCTION 1.1 Laws of the United Kingdom, the United States and other territories in which the Company operates prohibit dealing in Securities and certain other actions based on inside information. 1.2 If you have an

April 11, 2025 EX-13.1

Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report on Form 20-F of Biodexa Pharmaceuticals PLC (the “Company”) for the year ended December 31, 2024, as filed with the United States Securities and Exchange Commission on the date hereof (the “Report”), the undersigned Stephen Stamp,

April 11, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of April 2025 Commission File Number 001-37652 Bi

6-K 1 z4102506k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of April 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United K

April 11, 2025 EX-15.2

30 Old Bailey

Exhibit 15.2 30 Old Bailey London EC4M 7AU Tel: +44 (0)20 7063 4000 forvismazars.com/uk Consent of Independent Registered Public Accounting Firm The Board of Directors of Biodexa Pharmaceuticals PLC, We hereby consent to the incorporation by reference in this Form 20-F (to be filed on or about April 11, 2025) of our audit report dated April 18, 2024 with respect to the consolidated balance sheets

April 11, 2025 EX-4.15

Biodexa Pharmaceuticals PLC Promissory Note

Exhibit 4.15 THIS HAS NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE. THIS NOTE HAS BEEN SOLD IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PU

April 11, 2025 EX-12.1

Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Stephen Stamp, certify that: 1. I have reviewed this annual report on Form 20-F of Biodexa Pharmaceuticals PLC (the “Company”); 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the c

March 10, 2025 EX-99.1

Biodexa Announces Successful Outcome of a Type C Meeting with FDA Regarding the Phase 3 Program for eRapa in FAP

EXHIBIT 99.1 Biodexa Announces Successful Outcome of a Type C Meeting with FDA Regarding the Phase 3 Program for eRapa in FAP March 10, 2025 Biodexa Announces Successful Outcome of a Type C Meeting with FDA Regarding the Phase 3 Program for eRapa in FAP Clears the way to finalize Phase 3 protocol and recruit sites for U.S. Phase 3 substantially funded by $17.0 million CPRIT grant and $8.5 million

March 10, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2025 Commission File Number: 001-3765

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address

March 6, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2025 Commission File Number: 001-3765

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Address

March 6, 2025 EX-99.1

Biodexa Announces Appointment of Precision for Medicine LLC as CRO for European Component of Phase 3 Study of eRapa in FAP

EXHIBIT 99.1 Biodexa Announces Appointment of Precision for Medicine LLC as CRO for European Component of Phase 3 Study of eRapa in FAP March 6, 2025 Biodexa Announces Appointment of Precision for Medicine LLC as CRO for European Component of Phase 3 Study of eRapa in FAP Biodexa is finalizing plans to initiate an international Phase 3 registrational study of eRapa in Familial Adenomatous Polyposi

February 24, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2025 Commission File Number: 001-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Addr

February 24, 2025 EX-99.1

Biodexa Announces Allowance of U.S. Patent Covering Oral Rapamycin Nanoparticle Preparations (“eRapa”) and Use

EXHIBIT 99.1 Biodexa Announces Allowance of U.S. Patent Covering Oral Rapamycin Nanoparticle Preparations (“eRapa”) and Use February 24, 2025 Biodexa Announces Allowance of U.S. Patent Covering Oral Rapamycin Nanoparticle Preparations (“eRapa”) and Use Biodexa plans to initiate a Phase 3 registrational study of eRapa in Familial Adenomatous Polyposis (FAP) next quarter Biodexa Pharmaceuticals PLC

February 18, 2025 EX-99.1

BDRX / Biodexa Pharmaceuticals Plc - Depositary Receipt (Common Stock) / C/M CAPITAL PARTNERS, LP - JOINT FILING AGREEMENT JOINT ACQUISITION STATEMENT PURSUANT TO RULE 13d-1(k)

EXHIBIT 99.1 JOINT ACQUISITION STATEMENT PURSUANT TO RULE 13d-1(k) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements. The unders

February 13, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2025 Commission File Number: 001-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Addr

February 13, 2025 EX-99.1

Biodexa Pharmaceuticals PLC to Present at the Emerging Growth Conference on February 19, 2025

EXHIBIT 99.1 Biodexa Pharmaceuticals PLC to Present at the Emerging Growth Conference on February 19, 2025 February 13, 2025 Biodexa Pharmaceuticals PLC to Present at the Emerging Growth Conference on February 19, 2025 Biodexa Pharmaceuticals PLC invites individual and institutional investors as well as advisors and analysts, to attend its real-time, interactive presentation at the Emerging Growth

February 10, 2025 EX-99.1

Biodexa Receives US FDA Fast Track Designation for eRapa in Familial Adenomatous Polyposis

EXHIBIT 99.1 Biodexa Receives US FDA Fast Track Designation for eRapa in Familial Adenomatous Polyposis February 10, 2025 Biodexa Receives US FDA Fast Track Designation for eRapa in Familial Adenomatous Polyposis Underscores unmet need for a therapeutic alternative with the potential to delay or prevent surgical removal of the colon and/or rectum Biodexa Pharmaceuticals PLC (“Biodexa” or “the Comp

February 10, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2025 Commission File Number: 001-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Addr

January 28, 2025 424B3

358,750,000,000 Ordinary Shares Representing 35,875,000 American Depositary Shares

Filed Pursuant to Rule 424(b)(3) Registration No. 333-284350 PROSPECTUS 358,750,000,000 Ordinary Shares Representing 35,875,000 American Depositary Shares This prospectus relates to the potential offer and sale from time to time by C/M Capital Master Fund, LP, or the Selling Shareholder, of up to 358,750,000,000 of our ordinary shares, nominal value £0.00005 per share, or Ordinary Shares, represen

January 23, 2025 LETTER

LETTER

January 23, 2025 Stephen Stamp Chief Executive Officer Biodexa Pharmaceuticals PLC 1 Caspian Point Caspian Way Cardiff, CF10 4DQ, United Kingdom Re: Biodexa Pharmaceuticals PLC Registration Statement on Form F-1 Filed January 17, 2025 File No.

January 23, 2025 CORRESP

Biodexa Pharmaceuticals PLC 1 Caspian Point Caspian Way Cardiff, CF10 4DQ United Kingdom

Biodexa Pharmaceuticals PLC 1 Caspian Point Caspian Way Cardiff, CF10 4DQ United Kingdom January 23, 2025 VIA EDGAR Securities and Exchange Commission Division of Corporate Finance 100 F Street, N.

January 22, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2025 Commission File Number: 001-37

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2025 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Addre

January 22, 2025 EX-99.1

Biodexa Strengthens Management Team - Appointment of Dr Gary A. Shangold as Chief Medical Officer

EXHIBIT 99.1 Biodexa Strengthens Management Team - Appointment of Dr Gary A. Shangold as Chief Medical Officer January 22, 2025 Biodexa Strengthens Management Team Appointment of Dr Gary A. Shangold as Chief Medical Officer Biodexa Pharmaceuticals PLC (“Biodexa” or “the Company”), (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatm

January 21, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-272693 PROSPECTUS SUPPLEMENT No. 19 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares This prospectus supplement No. 19 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registration State

January 21, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-270353 PROSPECTUS SUPPLEMENT No. 19 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares This prospectus supplement No. 19 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 3 to Registration Stat

January 21, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-240984 PROSPECTUS SUPPLEMENT No. 19 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares This prospectus supplement No. 19 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 4 to Registration Statement o

January 21, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 8 (To the Prospectus dated August 12, 2024) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares This prospectus supplement No. 8 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, effec

January 21, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-278040 PROSPECTUS SUPPLEMENT No. 12 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares This prospectus supplement No. 12 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registrati

January 21, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series

Filed pursuant to Rule 424(b)(3) Registration No.: 333-274895 PROSPECTUS SUPPLEMENT No. 13 (To the Prospectus dated December 18, 2023) BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series F Warrants to p

January 21, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares

424B3 1 b424b3ps10279994.htm PROSPECTUS SUPPLEMENT NO. 10 Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 10 (To the Prospectus dated June 14, 2024) BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares This prospectus supplement No. 10 (the “Prospectus Supplement”) amends and supplements our prospectus c

January 17, 2025 F-1

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JANUARY 17, 2025

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JANUARY 17, 2025 Registration No.

January 17, 2025 EX-21.1

EX-21.1

Exhibit 21.1 Subsidiaries Country of Incorporation Voting Interest Subsidiaries of Biodexa Pharmaceuticals PLC Biodexa Pharmaceuticals (Wales) Limited England and Wales 100% Biodexa Ltd England and Wales 100% Haaland UK Limited (2) England and Wales 100% Subsidiaries of Biodexa Ltd Pharmida AG (2) Switzerland 100% (1) Dormant entities.

January 17, 2025 EX-4.1

DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT

Exhibit 4.1 DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT The following describes our issued share capital, summarizes the material provisions of our articles of association and highlights certain differences in corporate law in the United Kingdom and the United States. Please note that this summary is not intended to be exhaustive. For further information please refer

January 17, 2025 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT THIS SECURITIES PURCHASE AGREEMENT (the “Agreement”), dated as of January 17, 2025 (the “Execution Date”), by and between BIODEXA PHARMACEUTICALS PLC, a company incorporated under the laws of England and Wales (the “Company”), and C/M CAPITAL MASTER FUND, LP, a Delaware limited partnership (the “Investor”). WHEREAS: Subject to the terms and conditions set

January 17, 2025 EX-FILING FEES

CALCULATION OF FILING FEE TABLES Biodexa Pharmaceuticals PLC Table 1: Newly Registered and Carry Forward Securities

Ex-Filing Fees CALCULATION OF FILING FEE TABLES F-1 Biodexa Pharmaceuticals PLC Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Registered Securities Fees to be Paid Equity Ordinary Shares, nominal value £0.

January 17, 2025 EX-10.2

REGISTRATION RIGHTS AGREEMENT

Exhibit 10.2 REGISTRATION RIGHTS AGREEMENT THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of January 17, 2025 (the “Execution Date”), is entered into by and between BIODEXA PHARMACEUTICALS PLC, a company incorporated under the laws of England and Wales (the “Company”), and C/M CAPITAL MASTER FUND, LP, a Delaware limited partnership (together with its permitted assigns, the “Buyer”

January 17, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2025 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2025 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of

January 8, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-240984 PROSPECTUS SUPPLEMENT No. 18 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares This prospectus supplement No. 18 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 4 to Registration Statement o

January 8, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series

Filed pursuant to Rule 424(b)(3) Registration No.: 333-274895 PROSPECTUS SUPPLEMENT No. 12 (To the Prospectus dated December 18, 2023) BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series F Warrants to p

January 8, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-272693 PROSPECTUS SUPPLEMENT No. 18 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares This prospectus supplement No. 18 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registration State

January 8, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 7 (To the Prospectus dated August 12, 2024) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares This prospectus supplement No. 7 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, effec

January 8, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-278040 PROSPECTUS SUPPLEMENT No. 11 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares This prospectus supplement No. 11 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registrati

January 8, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 9 (To the Prospectus dated June 14, 2024) BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares This prospectus supplement No. 9 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, effectiv

January 8, 2025 424B3

BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-270353 PROSPECTUS SUPPLEMENT No. 18 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares This prospectus supplement No. 18 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 3 to Registration Stat

December 27, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2024 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2024 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address o

December 27, 2024 EX-1.1

BIODEXA PHARMACEUTICALS PLC (registered number 09216368) ARTICLES OF ASSOCIATION 8 Clifford Street London W1S 2LQ T: 020 7851 6000 F: 020 7851 6100 Table of Contents

Exhibit 1.1 BIODEXA PHARMACEUTICALS PLC (registered number 09216368) ARTICLES OF ASSOCIATION TWM/031674.0002 8 Clifford Street London W1S 2LQ www.brownrudnick.com T: 020 7851 6000 F: 020 7851 6100 Table of Contents PRELIMINARY 1 1 DEFINITIONS 1 2 LIABILITY OF MEMBERS 5 3 FORM OF RESOLUTION 5 4 EXCLUSION OF MODEL ARTICLES (AND ANY OTHER PRESCRIBED REGULATIONS) 5 5 REGISTERED OFFICE 5 SHARE CAPITAL

December 27, 2024 EX-10.1

Biodexa Pharmaceuticals PLC Promissory Note

Exhibit 10.1 THIS HAS NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE. THIS NOTE HAS BEEN SOLD IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PU

December 4, 2024 EX-99.1

Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Result of General Meeting

Exhibit 99.1 November 22, 2024 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Result of General Meeting Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) (NASDAQ: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs announces, announces that at its General Meeting held earlier today, b

December 4, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2024 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2024 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address o

November 20, 2024 SC 13G/A

BDRX / Biodexa Pharmaceuticals Plc - Depositary Receipt (Common Stock) / Brio Capital Master Fund Ltd. - AMENDMENT NO. 1 TO SCHEDULE 13G Passive Investment

SC 13G/A 1 ea0221977-13ga1briobio.htm AMENDMENT NO. 1 TO SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (Amendment No. 1) UNDER THE SECURITIES EXCHANGE ACT OF 1934* BIODEXA PHARMACEUTICALS PLC (Name of Issuer) AMERICAN DEPOSITORY SHARES** (Title of Class of Securities) 59564R708*** (CUSIP Number) November 14, 2024 (Date of Event Which Requires Fil

November 14, 2024 SC 13G/A

BDRX / Biodexa Pharmaceuticals Plc - Depositary Receipt (Common Stock) / Iroquois Capital Management, LLC Passive Investment

SC 13G/A 1 c110565sc13ga.htm SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. 1)* Biodexa Pharmaceuticals PLC (Name of Issuer) American Depositary Shares, each representing 400 Ordinary Shares (Title of Clas

November 12, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 6 (To the Prospectus dated August 12, 2024) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares This prospectus supplement No. 6 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, effec

November 12, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-272693 PROSPECTUS SUPPLEMENT No. 17 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares This prospectus supplement No. 17 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registration State

November 12, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series

Filed pursuant to Rule 424(b)(3) Registration No.: 333-274895 PROSPECTUS SUPPLEMENT No. 11 (To the Prospectus dated December 18, 2023) BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series F Warrants to p

November 12, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address o

November 12, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-240984 PROSPECTUS SUPPLEMENT No. 17 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares This prospectus supplement No. 17 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 4 to Registration Statement o

November 12, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-278040 PROSPECTUS SUPPLEMENT No. 10 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares This prospectus supplement No. 10 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registrati

November 12, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 8 (To the Prospectus dated June 14, 2024) BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares This prospectus supplement No. 8 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, effectiv

November 12, 2024 SC 13G/A

BDRX / Biodexa Pharmaceuticals Plc - Depositary Receipt (Common Stock) / Bigger Capital, LLC Passive Investment

SC 13G/A 1 sc13ga110022bdrx11122024.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1)1 Biodexa Pharmaceuticals PLC (Name of Issuer) Ordinary Shares, Nominal Value $.001 per share (Title

November 12, 2024 EX-99.1

Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Regains Compliance For Continued Listing on Nasdaq

Exhibit 99.1 November 12, 2024 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Regains Compliance For Continued Listing on Nasdaq Biodexa Pharmaceuticals PLC, (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs announces that the Company has been formally notified that the Nasdaq Hea

November 12, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-270353 PROSPECTUS SUPPLEMENT No. 17 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares This prospectus supplement No. 17 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 3 to Registration Stat

November 7, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission File Number: 001-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Addr

November 7, 2024 SC 13G/A

BDRX / Biodexa Pharmaceuticals Plc - Depositary Receipt (Common Stock) / Cavalry Fund I LP Passive Investment

SC 13G/A 1 p24-3286sc13ga.htm SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Biodexa Pharmaceuticals PLC (Name of Issuer) Ordinary shares, nominal value £0.001 per share (Title of Class of Securities) 59564R708** (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the

November 7, 2024 EX-99.1

Notice of General Meeting

EXHIBIT 99.1 Notice of General Meeting November 7, 2024 Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) Notice of General Meeting Biodexa Pharmaceuticals PLC, (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs announces a Notice of a General Meeting to be held at the Company’s offic

November 5, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series

Filed pursuant to Rule 424(b)(3) Registration No.: 333-274895 PROSPECTUS SUPPLEMENT No. 10 (To the Prospectus dated December 18, 2023) BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series F Warrants to p

November 5, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 5 (To the Prospectus dated August 12, 2024) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares This prospectus supplement No. 5 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, effec

November 5, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-272693 PROSPECTUS SUPPLEMENT No. 16 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares This prospectus supplement No. 16 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registration State

November 5, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 7 (To the Prospectus dated June 14, 2024) BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares This prospectus supplement No. 7 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, effectiv

November 5, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-240984 PROSPECTUS SUPPLEMENT No. 16 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares This prospectus supplement No. 16 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 4 to Registration Statement o

November 5, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-270353 PROSPECTUS SUPPLEMENT No. 16 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares This prospectus supplement No. 16 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 3 to Registration Stat

November 5, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-278040 PROSPECTUS SUPPLEMENT No. 9 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares This prospectus supplement No. 9 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registration

November 1, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address o

November 1, 2024 EX-16.1

Securities and Exchange Commission

Exhibit 16.1 30 Old Bailey London EC4M 7AU Tel: +44 (0)20 7063 4000 forvismazars.com/uk Private & Confidential Securities and Exchange Commission 100 F Street NE Washington D.C. 20549 United States of America Date: 1 November 2024 Ladies and Gentlemen, We have been furnished with a copy of the form 6-K to be filed by our former client, Biodexa Pharmaceuticals plc, to satisfy its reporting obligati

October 16, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-240984 PROSPECTUS SUPPLEMENT No. 15 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 492,400 Ordinary Shares Representing 1,230 American Depositary Shares This prospectus supplement No. 15 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 4 to Registration Statement o

October 16, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-270353 PROSPECTUS SUPPLEMENT No. 15 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 8,203,200 Ordinary Shares Representing 20,508 American Depositary Shares This prospectus supplement No. 15 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 3 to Registration Stat

October 16, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-272693 PROSPECTUS SUPPLEMENT No. 15 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares This prospectus supplement No. 15 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registration State

October 16, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series

Filed pursuant to Rule 424(b)(3) Registration No.: 333-274895 PROSPECTUS SUPPLEMENT No. 9 (To the Prospectus dated December 18, 2023) BIODEXA PHARMACEUTICALS PLC 697,614 Class A Units consisting of 697,614 American Depositary Shares Representing Ordinary Shares, 697,614 Series E Warrants to purchase 697,614 American Depositary Shares Representing Ordinary shares and 697,614 Series F Warrants to pu

October 16, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-278040 PROSPECTUS SUPPLEMENT No. 8 (To the Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 1,192,023,200 Ordinary Shares Representing 2,980,058 American Depositary Shares This prospectus supplement No. 8 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registration

October 16, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-279994 PROSPECTUS SUPPLEMENT No. 6 (To the Prospectus dated June 14, 2024) BIODEXA PHARMACEUTICALS PLC 2,486,270,400 Ordinary Shares Representing 6,215,676 American Depositary Shares This prospectus supplement No. 6 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, effectiv

October 16, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-281489 PROSPECTUS SUPPLEMENT No. 4 (To the Prospectus dated August 12, 2024) BIODEXA PHARMACEUTICALS PLC 4,349,102,800 Ordinary Shares Representing 10,872,757 American Depositary Shares This prospectus supplement No. 4 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Registration Statement on Form F-1, effec

October 15, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of October 2024 Commission File Number 001-37652

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of October 2024 Commission File Number 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant’s name into English) 1 Caspian Point, Caspian Way Cardiff, CF10 4DQ, United Kingdom (Address of

October 15, 2024 EX-99.1

Biodexa Announces Successful Appeal of Nasdaq Delisting

Exhibit 99.1 October 15, 2024 Biodexa Announces Successful Appeal of Nasdaq Delisting Biodexa Pharmaceuticals PLC. (the “Company”) (Nasdaq: BDRX), an acquisition-focused clinical stage biopharmaceutical company developing a pipeline of innovative products for the treatment of diseases with unmet medical needs, announced today that a Nasdaq Hearings Panel (the “Panel”) has granted the Company’s req

October 4, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of October 2024 Commission File Number: 001-37

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of October 2024 Commission File Number: 001-37652 Biodexa Pharmaceuticals PLC (Translation of registrant's name into English) 1 Caspian Point, Caspian Way, Cardiff, CF10 4DQ, United Kingdom (Addre

October 4, 2024 EX-99.1

Biodexa Provides Update on Progression Free and Overall Survival in Phase 1 Study of MTX110 in Recurrent Glioblastoma

EXHIBIT 99.1 Biodexa Provides Update on Progression Free and Overall Survival in Phase 1 Study of MTX110 in Recurrent Glioblastoma October 4, 2024 Biodexa Provides Update on Progression Free and Overall Survival in Phase 1 Study of MTX110 in Recurrent Glioblastoma Cohort A Data on Overall Survival Compare Favorably with Published Survival Rates Results Build on MTX110’s Performance in Two Phase 1

September 27, 2024 424B3

BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares

Filed pursuant to Rule 424(b)(3) Registration No.: 333-272693 PROSPECTUS SUPPLEMENT No. 14 (to Prospectus dated May 2, 2024) BIODEXA PHARMACEUTICALS PLC 115,102,400 Ordinary Shares Representing 287,756 American Depositary Shares This prospectus supplement No. 14 (the “Prospectus Supplement”) amends and supplements our prospectus contained in our Post-Effective Amendment No. 1 to Registration State

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