CELG.RT / Bristol-Myers Squibb Company - Equity Right - Depositi SEC, Relazione annuale, dichiarazione di delega

Bristol-Myers Squibb Company - Equity Right
US ˙ NYSE ˙ US1101221406

Statistiche di base
LEI HLYYNH7UQUORYSJQCN42
CIK 14272
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Bristol-Myers Squibb Company - Equity Right
SEC Filings (Chronological Order)
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July 31, 2025 EX-32.B

Section 906 Certification Letter (furnished herewith).

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2025 (the "Report"), as filed with the

July 31, 2025 EX-99.1

Bristol Myers Squibb Reports Second Quarter Financial Results for 2025 Performance Underscores Continued Execution Against Long-Term Growth Strategy

Exhibit 99.1 Bristol Myers Squibb Reports Second Quarter Financial Results for 2025 Performance Underscores Continued Execution Against Long-Term Growth Strategy •Second quarter revenues were $12.3 billion ◦Growth Portfolio revenues were $6.6 billion, +18% (+17% Ex-FX) •GAAP EPS was $0.64 and non-GAAP EPS was $1.46; Both figures include net impact of $(0.57) due to the Acquired IPRD charge associa

July 31, 2025 EX-32.A

Section 906 Certification Letter (furnished herewith).

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2025 (the "Report"), as filed with

July 31, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 ☐ TRANSITION REPORT PURSUANT TO S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB C

July 31, 2025 EX-31.B

Section 302 Certification Letter (filed herewith).

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

July 31, 2025 EX-31.A

Section 302 Certification Letter (filed herewith).

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

July 31, 2025 EX-99.2

Not for Product Promotional Use Q2 2025 Results July 31, 2025 Not for Product Promotional UseQ2 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (t

q22025earningspresentati Not for Product Promotional Use Q2 2025 Results July 31, 2025 Not for Product Promotional UseQ2 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

July 31, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2025 BRISTOL-MYERS SQUIB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organi

July 25, 2025 EX-99.1

Cristian Massacesi, M.D., Joins Bristol Myers Squibb as Executive Vice President, Chief Medical Officer and Head of Development

Exhibit 99.1 Cristian Massacesi, M.D., Joins Bristol Myers Squibb as Executive Vice President, Chief Medical Officer and Head of Development Dr. Massacesi will join BMS August 1 and serve on the Executive Leadership Team Samit Hirawat, M.D., Executive Vice President, to step down from his role on August 1 and will depart BMS on November 1 PRINCETON, N.J., [BUSINESS WIRE] – Bristol Myers Squibb (NY

July 25, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 21, 2025 BRISTOL-MYERS SQUIB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 21, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organi

June 6, 2025 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 6, 2025 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 6, 2025 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 6, 2025 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 6, 2025 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 6, 2025 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

May 15, 2025 EX-99.25

EX-99.25

NOTIFICATION OF THE REMOVAL FROM LISTING AND REGISTRATION OF THE STATED SECURITIES The New York Stock Exchange hereby notifies the SEC of its intention to remove the entire class of the stated securities from listing and registration on the Exchange at the opening of business on May 27, 2025, pursuant to the provisions of Rule 12d2-2 (a).

May 13, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 5) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 5) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

May 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 6, 2025 BRISTOL-MYERS SQUIBB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 6, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 1-1136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commission F

May 6, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 4) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 4) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

May 5, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

April 24, 2025 EX-32.B

Section 906 Certification Letter

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2025 (the "Report"), as filed with th

April 24, 2025 EX-99.2

Not for Product Promotional Use Q1 2025 Results April 24, 2025 Not for Product Promotional UseQ1 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (

Not for Product Promotional Use Q1 2025 Results April 24, 2025 Not for Product Promotional UseQ1 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

April 24, 2025 EX-10.B

Form of 2025 Market Share Units Award Agreement under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10b NOTICE OF GRANT OF MARKET SHARE UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Market Share Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Market Share Units (such units, “MSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as described in this No

April 24, 2025 EX-10.C

Form of 2025 Restricted Stock Units Award Agreement with three-year, four-year, or five-year prorated vesting under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10c NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 24, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB

April 24, 2025 EX-31.B

Section 302 Certification Letter

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

April 24, 2025 EX-10.D

Form of 2025 Restricted Stock Units Award Agreement with three-year cliff vesting under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10d NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 24, 2025 EX-10.F

Form of 2025 Restricted Stock Units Award Agreement with one-year cliff vesting with a two-year post-vest holding period under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10f NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 24, 2025 EX-10.A

Form of 2025 Performance Share Units Award Agreement under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10a NOTICE OF GRANT OF PERFORMANCE SHARE UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Performance Share Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Performance Share Units (such units, “PSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as descr

April 24, 2025 EX-99.1

Bristol Myers Squibb Reports First Quarter Financial Results for 2025 Results Reflect Continued Growth Portfolio Momentum and Disciplined Execution

Exhibit 99.1 Bristol Myers Squibb Reports First Quarter Financial Results for 2025 Results Reflect Continued Growth Portfolio Momentum and Disciplined Execution •First quarter revenues were $11.2 billion, -6% (-4% Ex-FX) ◦Growth Portfolio revenues were $5.6 billion, +16% (+18% Ex-FX) •GAAP EPS was $1.20 and non-GAAP EPS was $1.80 •Raising 2025 revenue guidance to a range of ~$45.8 billion to $46.8

April 24, 2025 EX-31.A

Section 302 Certification Letter

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

April 24, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organ

April 24, 2025 EX-10.E

Form of 2025 Restricted Stock Units Award Agreement with two-year cliff vesting with a one-year post-vest holding period under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10e NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 24, 2025 EX-10.G

Bristol-Myers Squibb Company Severance Benefits Plan (filed herewith).

EXHIBIT 10g BRISTOL-MYERS SQUIBB COMPANY SEVERANCE BENEFITS PLAN AND SUMMARY PLAN DESCRIPTION 1.

April 24, 2025 EX-32.A

Section 906 Certification Letter

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2025 (the "Report"), as filed wit

April 23, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

April 17, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

April 15, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

April 14, 2025 EX-FILING FEES

Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Names of Filing Persons (Offerors))

Exhibit 107 Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) 2SEVENTY BIO, INC.

April 14, 2025 EX-99.(A)(1)(IV)

Offer to Purchase for Cash All Outstanding Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share Pursuant to the Offer to Purchase Dated April 14, 2025 DAYBREAK MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company

Exhibit (a)(1)(iv) Offer to Purchase for Cash All Outstanding Shares of Common Stock of 2SEVENTY BIO, INC.

April 14, 2025 EX-99.(A)(1)(II)

Letter of Transmittal to Tender Shares of Common Stock 2SEVENTY BIO, INC. At $5.00 Net per Share Pursuant to the Offer to Purchase Dated April 14, 2025 by Daybreak Merger Sub Inc. a wholly owned subsidiary of Bristol-Myers Squibb Company

Exhibit (a)(1)(ii) Letter of Transmittal to Tender Shares of Common Stock of 2SEVENTY BIO, INC.

April 14, 2025 EX-99.(A)(1)(III)

Offer to Purchase for Cash All Outstanding Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share Pursuant to the Offer to Purchase Dated April 14, 2025 DAYBREAK MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company

Exhibit (a)(1)(iii) Offer to Purchase for Cash All Outstanding Shares of Common Stock of 2SEVENTY BIO, INC.

April 14, 2025 SC TO-T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying status as offe

April 14, 2025 EX-99.(D)(2)

TENDER AND SUPPORT AGREEMENT

Exhibit (d)(2) TENDER AND SUPPORT AGREEMENT This Tender and Support Agreement (this “Agreement”), dated as of March 10, 2025, is entered into by and between Bristol-Myers Squibb Company, a Delaware corporation (“Parent”), and the undersigned stockholder of 2seventy bio, Inc.

April 14, 2025 EX-99.(A)(1)(VI)

Notice of Offer to Purchase for Cash All Outstanding Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share DAYBREAK MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY

Exhibit (a)(1)(vi) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below).

April 14, 2025 EX-99.(A)(1)(I)

Offer to Purchase for Cash All Outstanding Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share DAYBREAK MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY THE OFFER AND WITHDRAWAL RIGHTS EXPIRE ONE MINUTE FOLLOWING 11

TABLE OF CONTENTS Exhibit (a)(1)(i) Offer to Purchase for Cash All Outstanding Shares of Common Stock of 2SEVENTY BIO, INC.

April 14, 2025 EX-99.(A)(1)(V)

NOTICE OF GUARANTEED DELIVERY to Tender Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share Pursuant to the Offer to Purchase Dated April 14, 2025 DAYBREAK MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company

Exhibit (a)(1)(v) NOTICE OF GUARANTEED DELIVERY to Tender Shares of Common Stock of 2SEVENTY BIO, INC.

March 26, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

March 26, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

March 13, 2025 SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Offeror) (Name of Filing Persons (identifying status as offeror, issuer

March 13, 2025 EX-99.1

-BMS CONFIDENTIAL-

Exhibit 99.1 -BMS CONFIDENTIAL- From: Lynelle Hoch To: 2seventy bio employees Date: Thursday, 3/13 Subject: Continuing our work together to bring Abecma to patients Dear 2seventy bio colleagues, Monday was an important day with the announcement that Bristol Myers Squibb (BMS) has entered into an agreement to acquire 2seventy bio. As the president of BMS’ Cell Therapy Organization, I have had a fro

February 18, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 18, 2025 (February 14, 2025) BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of

February 12, 2025 EX-32.A

Section 906 Certification Letter (filed herewith).

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2024 (the Report), as filed with t

February 12, 2025 EX-31.B

Section 302 Certification Letter (filed herewith).

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

February 12, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB COMPA

February 12, 2025 EX-21

Subsidiaries of the Registrant (filed herewith).

EXHIBIT 21 Subsidiaries of Bristol-Myers Squibb Company The following are subsidiaries of the Bristol-Myers Squibb Company at December 31, 2024.

February 12, 2025 EX-32.B

Section 906 Certification Letter (filed herewith).

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2024 (the Report), as filed with the S

February 12, 2025 EX-31.A

Section 302 Certification Letter (filed herewith).

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

February 6, 2025 EX-99.1

Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2024 Performance Reflects Progress Toward Delivering Sustained, Top-Tier Growth

Exhibit 99.1 Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2024 Performance Reflects Progress Toward Delivering Sustained, Top-Tier Growth •Fourth Quarter Revenues were $12.3 Billion, Increasing 8% (+9% Adjusting for Foreign Exchange); GAAP Earnings Per Share (EPS) was $0.04 and Non-GAAP EPS was $1.67 ◦Growth Portfolio Revenues were $6.4 Billion, Increasing 21% (+

February 6, 2025 EX-99.2

Not for Product Promotional Use Q4 2024 Results February 6, 2025 Not for Product Promotional UseQ4 2024 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s

Not for Product Promotional Use Q4 2024 Results February 6, 2025 Not for Product Promotional UseQ4 2024 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

February 6, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 6, 2025 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 6, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

January 13, 2025 EX-99.1

43rd Annual J.P. Morgan Healthcare Conference January 13th, 2025 Christopher Boerner, Ph.D., Board Chair and Chief Executive Officer Forward Looking Statements and Non-GAAP Financial Information 2 This presentation (as well as the oral statements mad

Exhibit 99.1 43rd Annual J.P. Morgan Healthcare Conference January 13th, 2025 Christopher Boerner, Ph.D., Board Chair and Chief Executive Officer Forward Looking Statements and Non-GAAP Financial Information 2 This presentation (as well as the oral statements made with respect to the information contained in this presentation) contains statements about Bristol-Myers Squibb Company’s (the “Company”

January 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

December 13, 2024 EX-25.1

= = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION D

Exhibit 25.1 = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO SECTION 305(b)(2) || THE BANK OF NE

December 13, 2024 EX-FILING FEES

Calculation of Filing Fee Tables Form S-3 (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registratio

December 13, 2024 EX-23.A

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 23a CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Registration Statement on Form S-3 of our reports dated February 12, 2024 relating to the financial statements of Bristol-Myers Squibb Company, and the effectiveness of Bristol-Myers Squibb Company’s internal control over financial reporting, appearing in the Annual Report on Form 10-K of Bristol-Myers Squibb Company for the year ended December 31, 2023.

December 13, 2024 S-3ASR

As filed with the Securities and Exchange Commission on December 13, 2024

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on December 13, 2024 No.

November 13, 2024 SC 13G/A

RNA / Avidity Biosciences, Inc. / BRISTOL MYERS SQUIBB CO - SC 13G/A Passive Investment

SC 13G/A 1 ef20038544sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Avidity Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 05370A108 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statemen

November 13, 2024 SC 13G/A

QURE / uniQure N.V. / BRISTOL MYERS SQUIBB CO - SC 13G/A Passive Investment

SC 13G/A 1 ef20038542sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* uniQure N.V. (Name of Issuer) Ordinary Shares (Title of Class of Securities) N90064101 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designa

November 13, 2024 SC 13G/A

IKNA / Ikena Oncology, Inc. / BRISTOL MYERS SQUIBB CO - SC 13G/A Passive Investment

SC 13G/A 1 ef20038543sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Ikena Oncology, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 45175G108 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the app

November 13, 2024 SC 13G

QTTB / Q32 Bio Inc. / BRISTOL MYERS SQUIBB CO - SC 13G Passive Investment

SC 13G 1 ef20038540sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Q32 Bio Inc. (Name of Issuer) Common stock, par value $0.0001 per share (Title of Class of Securities) 746964105 (CUSIP Number) March 25, 2024 (Date of Event Which Requires Filing of this Statement) Check the Appropriat

October 31, 2024 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

October 31, 2024 EX-99.2

Not for Product Promotional Use Q3 2024 Results October 31, 2024 Not for Product Promotional UseQ3 2024 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s

q32024earningspresentati Not for Product Promotional Use Q3 2024 Results October 31, 2024 Not for Product Promotional UseQ3 2024 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

October 31, 2024 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2024 (the "Report"), as filed wit

October 31, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 ☐ TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQU

October 31, 2024 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2024 (the "Report"), as filed

October 31, 2024 EX-99.1

Bristol Myers Squibb Reports Third Quarter Financial Results for 2024 Performance Reflects Continued Focus on Near-Term Execution and Building a Foundation for Long-Term Sustainable Growth

Exhibit 99.1 Bristol Myers Squibb Reports Third Quarter Financial Results for 2024 Performance Reflects Continued Focus on Near-Term Execution and Building a Foundation for Long-Term Sustainable Growth •Third Quarter Revenues were $11.9 Billion, increasing 8% (+10% Adjusting for Foreign Exchange) •Growth Portfolio Revenues were $5.8 Billion, increasing 18% (+20% Adjusting for Foreign Exchange) •GA

October 31, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2024 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

October 31, 2024 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

October 4, 2024 SC 13G

PRME / Prime Medicine, Inc. / BRISTOL MYERS SQUIBB CO - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Prime Medicine, Inc. (Name of Issuer) Common Stock, par value $0.00001 per share (Title of Class of Securities) 74168J101 (CUSIP Number) September 30, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

July 26, 2024 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2024 (the "Report"), as filed with

July 26, 2024 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

July 26, 2024 EX-99.2

Q2 2024 Results July 26, 2024 Q2 2024 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial

q22024earningspresentati Q2 2024 Results July 26, 2024 Q2 2024 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

July 26, 2024 EX-3.A

Amended and Restated Certificate of Incorporation of Bristol-Myers Squibb Company, as

Exhibit 3a AMENDED AND RESTATED CERTIFICATE OF INCORPORATION of BRISTOL-MYERS SQUIBB COMPANY This Amended and Restated Certificate of Incorporation of Bristol-Myers Squibb Company, originally incorporated as Bristol-Myers Company, was duly proposed by the board of directors of the corporation and adopted by the stockholders in accordance with the provisions of Sections 242 and 245 of the General Corporation Law of the State of Delaware.

July 26, 2024 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2024 (the "Report"), as filed with the

July 26, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 26, 2024 BRISTOL-MYERS SQUIB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 26, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organi

July 26, 2024 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

July 26, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 ☐ TRANSITION REPORT PURSUANT TO S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB C

July 26, 2024 EX-99.1

Bristol Myers Squibb Reports Second Quarter Financial Results for 2024 Results Underscore Continued Progress on Commercial Execution, Driving the Growth Portfolio and Pipeline Advancement

Exhibit 99.1 Bristol Myers Squibb Reports Second Quarter Financial Results for 2024 Results Underscore Continued Progress on Commercial Execution, Driving the Growth Portfolio and Pipeline Advancement •Second Quarter Revenues were $12.2 Billion, increasing 9% (+11% Adjusting for Foreign Exchange) •Growth Portfolio Revenues were $5.6 Billion, increasing 18% (+21% Adjusting for Foreign Exchange) •GA

June 25, 2024 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 25, 2024 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 25, 2024 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 25, 2024 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 25, 2024 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 25, 2024 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2024 BRISTOL-MYERS SQUIB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organi

June 18, 2024 EX-99.1

Bristol Myers Squibb Elects Michael R. McMullen to Board of Directors

Exhibit 99.1 Bristol Myers Squibb Elects Michael R. McMullen to Board of Directors (Princeton, N.J., June 18, 2024) – Bristol Myers Squibb (NYSE: BMY) today announced that its Board of Directors has elected independent director Michael R. McMullen to the Board, effective July 1, 2024. Mr. McMullen will serve as a member of the Audit Committee of the Board of Directors. “We are pleased to welcome M

May 9, 2024 EX-3.A

CERTIFICATE OF AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION BRISTOL-MYERS SQUIBB COMPANY Pursuant to Section 242 of the General Corporation Law of the State of Delaware

Exhibit 3a CERTIFICATE OF AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF BRISTOL-MYERS SQUIBB COMPANY Pursuant to Section 242 of the General Corporation Law of the State of Delaware Bristol-Myers Squibb Company, a corporation duly organized and existing under the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify that: 1.

May 9, 2024 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 1-1136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commission F

April 25, 2024 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2024 (the "Report"), as filed with th

April 25, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 25, 2024 BRISTOL-MYERS SQUI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 25, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organ

April 25, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB

April 25, 2024 EX-99.2

Q1 2024 Results April 25, 2024 Q1 2024 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial

q12024earningspresentati Q1 2024 Results April 25, 2024 Q1 2024 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

April 25, 2024 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2024 (the "Report"), as filed wit

April 25, 2024 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

April 25, 2024 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

April 25, 2024 EX-99.1

Bristol Myers Squibb Reports First Quarter Financial Results for 2024 Performance Reflects Execution and Actions to Strengthen the Company's Long-Term Growth Profile

Exhibit 99.1 Bristol Myers Squibb Reports First Quarter Financial Results for 2024 Performance Reflects Execution and Actions to Strengthen the Company's Long-Term Growth Profile •First Quarter Revenues were $11.9 Billion, increasing 5% (+6% Adjusting for Foreign Exchange) ◦Growth Portfolio Revenues were $4.8 Billion, increasing 8% (+11% Adjusting for Foreign Exchange) •Strengthened Long-Term Grow

April 22, 2024 DEFA14A

Bristol-Myers Squibb Company

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

March 28, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))  ☐

March 28, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Ru

March 18, 2024 EX-99.1

Bristol Myers Squibb Completes Acquisition of Karuna Therapeutics, Strengthening Neuroscience Portfolio KarXT, Karuna’s Lead Asset, Is a Potential First-in-Class Treatment for Schizophrenia with Multi-Billion Dollar Sales Potential Across Multiple In

Exhibit 99.1 Bristol Myers Squibb Completes Acquisition of Karuna Therapeutics, Strengthening Neuroscience Portfolio KarXT, Karuna’s Lead Asset, Is a Potential First-in-Class Treatment for Schizophrenia with Multi-Billion Dollar Sales Potential Across Multiple Indications PRINCETON, N.J. – March 18, 2024 – Bristol Myers Squibb (NYSE: BMY) today announced that it has successfully completed its acqu

March 18, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rul

March 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2024 BRISTOL-MYERS SQUI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organ

March 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2024 BRISTOL-MYERS SQUI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commis

February 23, 2024 EX-99.(A)(5)(XII)

Exhibit (a)(5)(xii)

Exhibit (a)(5)(xii) Bristol Myers Squibb Announces Expiration of RayzeBio Tender Offer PRINCETON, N.

February 23, 2024 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) RAYZEBIO, INC. (Name of Subject Company (Issuer)) R

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying s

February 22, 2024 EX-1.1

UNDERWRITING AGREEMENT, dated as of February 14, 2024 Bristol-Myers Squibb Company $500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000

Exhibit 1.1 Execution Version UNDERWRITING AGREEMENT, dated as of February 14, 2024 Bristol-Myers Squibb Company $500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000 5.100% Notes due 2031 $2,500,000,000 5.200% Notes due 2034 $500,000,000 5.500% Notes due 2044 $2,750,000,000 5.550% Not

February 22, 2024 EX-4.1

Fifteenth Supplemental Indenture, dated as of February 22, 2024, by and between Bristol-Myers Squibb Company and The Bank of New York Mellon, as Trustee, to the Indenture dated as of June 1, 1993

Exhibit 4.1 Execution Version BRISTOL-MYERS SQUIBB COMPANY and THE BANK OF NEW YORK MELLON, as Trustee FIFTEENTH SUPPLEMENTAL INDENTURE Dated as of February 22, 2024 to INDENTURE Dated as of June 1, 1993 $500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000 5.100% Notes due 2031 $2,500

February 22, 2024 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 22, 2024 (February 14, 2024) BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of

February 16, 2024 CORRESP

February 16, 2024

February 16, 2024 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, DC 20549 Attention: Laura McKenzie and Christina Chalk, Division of Corporation Finance, Office of Mergers & Acquisitions Re: Bristol-Myers Squibb Company RayzeBio, Inc. Schedule TO-T filed January 25, 2024 File No. 005-94159 Dear Ms. McKenzie and Ms. Chalk: This letter

February 16, 2024 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) RAYZEBIO, INC. (Name of Subject Company (Issuer)) R

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) RAYZEBIO, INC. (Name of Subject Company (Issuer))   RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying

February 16, 2024 424B5

$500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000 5.100% Notes due 2031 $2,500,000,000 5.200% Notes due 2034 $500,000,000 5.500% Not

TABLE OF CONTENTS Filed Pursuant to Rule 424(b)(5) Registration No. 333-261623 PROSPECTUS SUPPLEMENT (to Prospectus dated December 13, 2021) $13,000,000,000   $500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000 5.100% Notes due 2031 $2,500,000,000 5.200% Notes due 2034 $500,000,000 5

February 16, 2024 EX-FILING FEES

Calculation of Filing Fee Tables

Exhibit 107 Calculation of Filing Fee Tables 424(b)(5) (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule(1) Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to Be Paid Debt Floating Rate Notes due 2026 Rule 457(r) $500,000,000 100.

February 15, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or or

February 15, 2024 FWP

Bristol-Myers Squibb Company Pricing Term Sheet February 14, 2024 $500,000,000 Floating Rate Notes due 2026 (the “Floating Rate Notes”) $1,000,000,000 4.950% Notes due 2026 (the “2026 Notes”) $1,000,000,000 4.900% Notes due 2027 (the “2027 Notes”) $1

Issuer Free Writing Prospectus, dated February 14, 2024 Filed Pursuant to Rule 433 of the Securities Act of 1933 Registration Statement No.

February 14, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 14, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or or

February 14, 2024 EX-99.1

Bristol Myers Squibb Recommends Stockholders Reject “Mini-Tender” Offer by Tutanota LLC

Exhibit 99.1 Bristol Myers Squibb Recommends Stockholders Reject “Mini-Tender” Offer by Tutanota LLC (Princeton, N.J., February 14, 2024) – Bristol Myers Squibb (NYSE: BMY) today announced that it recently became aware of an unsolicited “mini-tender” offer by Tutanota LLC (“Tutanota”) to purchase up to five hundred thousand shares of Bristol Myers Squibb’s common stock, representing significantly

February 13, 2024 EX-31.B

Section 302 Certification Letter (filed herewith).

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

February 13, 2024 EX-10.BB

Form of Restricted Stock Units Agreement with five year vesting under the 2021 Stock Award and Incentive Plan

EXHIBIT 10bb RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-10.DD

Form of Restricted Stock Units Agreement with three year vesting under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10dd RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-10.EE

Form of Restricted Stock Units Agreement with two-year cliff vesting with a one-year post-vest holding period under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10ee RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-10.I

incorporated herein by reference to Exhibit 10i to the Form 10-K for the fiscal year ended December 31, 2023

EXHIBIT 10i PERFORMANCE SHARE UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2024-2026 Performance Share Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Performance Share Units (“PSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Performance Share Units Agreement (including, Exhibit A, Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-97

Policies and Procedures for the Recoupment of

EXHIBIT 97 Policies and Procedures for the Recoupment of Compensation for Accounting Restatement Introduction/Purpose Bristol-Myers Squibb Company (the “Company”) believes that it is in the best interests of the Company and its shareholders to create and maintain a culture that emphasizes integrity and accountability and that reinforces the Company’s pay-for-performance compensation philosophy.

February 13, 2024 EX-21

Subsidiaries of the Registrant (filed herewith).

EXHIBIT 21 Subsidiaries of Bristol-Myers Squibb Company The following are subsidiaries of the Bristol-Myers Squibb Company at December 31, 2023.

February 13, 2024 EX-10.FF

Form of Restricted Stock Units Agreement with one-year cliff vesting with a two-year post-vest holding period under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10ff RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-32.A

Section 906 Certification Letter (filed herewith).

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2023 (the Report), as filed with t

February 13, 2024 424B2

Subject to Completion, dated February 13, 2024

TABLE OF CONTENTS Filed Pursuant to Rule 424(b)(2) Registration No. 333-261623 Subject to Completion, dated February 13, 2024 The information in this preliminary prospectus supplement and the accompanying prospectus is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus do not constitute an offer to sell or the solicitation of an offer to buy, no

February 13, 2024 EX-31.A

Section 302 Certification Letter (filed herewith).

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

February 13, 2024 SC 13G/A

BMY / Bristol-Myers Squibb Company / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv0481-bristolmyerssquibbco.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 9)* Name of issuer: Bristol-Myers Squibb Co Title of Class of Securities: Common Stock CUSIP Number: 110122108 Date of Event Which Requires Filing of this Statement: December 29, 2023 Check the appropriate box to

February 13, 2024 EX-19

Standard Operating Procedure BMS-SOP-5k: Securities Trading (

EXHIBIT 19 Standard Operating Procedure BMS-SOP-5k: Securities Trading PURPOSE To provide the Bristol-Myers Squibb Company (BMS) principles and expectations to prevent the illegal trading of Securities based on Material Non-Public Information (or “Insider Trading”) and other restrictions on trading of Securities.

February 13, 2024 EX-32.B

Section 906 Certification Letter (filed herewith).

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2023 (the Report), as filed with the S

February 13, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB COMPA

February 13, 2024 EX-10.GG

Form of Market Share Units Agreement under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10gg MARKET SHARE UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Market Share Units (“MSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Market Share Units Agreement (including, Exhibit A, Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-10.CC

Form of Restricted Stock Units Agreement with four year vesting under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10cc RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 12, 2024 EX-99.(A)(5)(XI)

Bristol Myers Squibb and RayzeBio Announce Expiration of HSR Act Waiting Period

Exhibit (a)(5)(xi) Bristol Myers Squibb and RayzeBio Announce Expiration of HSR Act Waiting Period PRINCETON, NJ & SAN DIEGO, CA – February 12, 2024 – Bristol Myers Squibb (NYSE: BMY) and RayzeBio, Inc.

February 12, 2024 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) RAYZEBIO, INC. (Name of Subject Company (Issuer)) R

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) RAYZEBIO, INC. (Name of Subject Company (Issuer))   RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying

February 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 2, 2024 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 2, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

February 2, 2024 EX-99.2

Q4 2023 Results February 2, 2024 Q4 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financi

q42023earningspresentati Q4 2023 Results February 2, 2024 Q4 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

February 2, 2024 EX-99.1

Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2023 Results Reflect Continued Strength of In-Line and New Products, Pipeline Execution and Business Development Activity, Supporting Growth Momentum into 2024

Exhibit 99.1 Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2023 Results Reflect Continued Strength of In-Line and New Products, Pipeline Execution and Business Development Activity, Supporting Growth Momentum into 2024 •Reports Fourth Quarter Revenues of $11.5 Billion; GAAP EPS of $0.87 and Non-GAAP EPS of $1.70 ◦In-Line and New Product Portfolio Revenues Increase

January 25, 2024 EX-FILING FEES

Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Names of Filing Persons (Offerors))

Exhibit 107 Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) RAYZEBIO, INC.

January 25, 2024 EX-99.(A)(1)(IV)

Offer to Purchase for Cash All Outstanding Shares of Common Stock RAYZEBIO, INC. $62.50 Net Per Share Pursuant to the Offer to Purchase Dated January 25, 2024 RUDOLPH MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company THE OFFER

Exhibit (a)(1)(iv) Offer to Purchase for Cash All Outstanding Shares of Common Stock   of   RAYZEBIO, INC.

January 25, 2024 EX-99.(A)(1)(II)

LETTER OF TRANSMITTAL to Tender Shares of Common Stock RAYZEBIO, INC. $62.50 Net per Share Pursuant to the Offer to Purchase Dated January 25, 2024 RUDOLPH MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY THE OFFER AND WITHDR

Exhibit (a)(1)(ii) LETTER OF TRANSMITTAL   to Tender Shares of Common Stock   of RAYZEBIO, INC.

January 25, 2024 EX-99.(D)(3)

CONFIDENTIALITY AGREEMENT

Exhibit (d)(3) CONFIDENTIALITY AGREEMENT THIS CONFIDENTIALITY AGREEMENT (“Agreement”) is being entered into as of December 16, 2023, between RayzeBio, Inc.

January 25, 2024 EX-99.(A)(1)(III)

Offer to Purchase for Cash All Outstanding Shares of Common Stock RAYZEBIO, INC. $62.50 Net Per Share Pursuant to the Offer to Purchase Dated January 25, 2024 RUDOLPH MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company THE OFFER

Exhibit (a)(1)(iii) Offer to Purchase for Cash All Outstanding Shares of Common Stock   of   RAYZEBIO, INC.

January 25, 2024 EX-99.(D)(2)

[Remainder of page intentionally left blank; signature page follows]

Exhibit (d)(2) JOINDER This Joinder to the Agreement and Plan of Merger (this “Joinder”), is made and entered into as of December 26, 2023, by Rudolph Merger Sub Inc.

January 25, 2024 SC TO-T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RAYZEBIO, INC. (Name of Subject Company (Issuer))   RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying status as offeror

January 25, 2024 EX-99.(A)(1)(I)

Offer to Purchase for Cash All Outstanding Shares of Common Stock RAYZEBIO, INC. $62.50 Net Per Share RUDOLPH MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY THE OFFER AND WITHDRAWAL RIGHTS EXPIRE ONE MINUTE FOLLOWING 11:59

TABLE OF CONTENTS Exhibit (a)(1)(i) Offer to Purchase for Cash   All Outstanding Shares of Common Stock   of   RAYZEBIO, INC.

January 25, 2024 EX-99.(A)(1)(V)

Notice of Offer to Purchase for Cash All Outstanding Shares of Common Stock RAYZEBIO, INC. at $62.50 Net Per Share by RUDOLPH MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY

Exhibit (a)(1)(v) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below).

January 8, 2024 EX-99.1

January 8, 2024 J.P. Morgan Presentation Forward looking statements and non-GAAP financial information 2 This presentation (as well as the oral statements made with respect to information contained in this presentation) contains statements about Bris

Exhibit 99.1 January 8, 2024 J.P. Morgan Presentation Forward looking statements and non-GAAP financial information 2 This presentation (as well as the oral statements made with respect to information contained in this presentation) contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, r

January 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2024 BRISTOL-MYERS SQU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 1-1136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commissi

December 26, 2023 EX-99.2

Transaction Infographic dated December 26, 2023

Exhibit 99.2 Bristol Myers Squibb Adds Premier Radiopharmaceutical Platform with Acquisition of RayzeBio Transaction Brings RayzeBio’s Differentiated Actinium-Based Radiopharmaceutical Platform » Lead program, RYZ101, in Phase 3 development for treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and early-stage development for treatment of small cell lung cancer and potentially ot

December 26, 2023 EX-99.5

Letter to RayzeBio Employees dated December 26, 2023

Exhibit 99.5 BMS-RYZB Letter to RYZB Employees Subject: Welcome to the Bristol Myers Squibb Team! To: RayzeBio Employees Date: December 26, 2023 Dear RayzeBio Team, On behalf of everyone at Bristol Myers Squibb, I am writing to share how excited we are about the proposed transaction. We deeply admire what RayzeBio has accomplished, and all of us at BMS are impressed by your technology, differentia

December 26, 2023 EX-99.4

Enterprise Letter dated December 26, 2023

Exhibit 99.4 BMS-RYZB BMS Employee Letter Subject: Broadening our Oncology Capabilities with Acquisition of RayzeBio To: Bristol Myers Squibb Employees Date: December 26, 2023 Dear Colleagues, We hope that you are reading this following a quiet and restful Shutdown Week. We are excited to share that today, December 26, 2023, we announced an agreement to acquire RayzeBio, a radiopharmaceutical ther

December 26, 2023 EX-99.1

Joint Press Release dated December 26, 2023

Exhibit 99.1 Bristol Myers Squibb Adds Premier Radiopharmaceutical Platform with Acquisition of RayzeBio Transaction Brings RayzeBio’s Differentiated Actinium-Based Radiopharmaceutical Platform, Including Rich Pipeline of Multiple Drug Development Programs, to Bristol Myers Squibb’s Leading Oncology Franchise Lead Program, RYZ101, in Phase 3 Development for Treatment of Gastroenteropancreatic Neur

December 26, 2023 SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Offeror) (Name of Filing Persons (identifying status as offeror, issuer or o

December 26, 2023 EX-99.3

Bristol Myers Squibb Social Media Content dated December 26, 2023

Exhibit 99.3 Social Media Content Twitter/X LinkedIn Additional Information about the Tender Offer and Where to Find It The tender offer described in this communication has not yet commenced. This communication is for informational purposes only and is neither an offer to purchase nor a solicitation of an offer to sell any shares of the common stock of RayzeBio or any other securities, nor is it a

December 22, 2023 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. ) Filed by the Registrant ☐ Filed by a Party other than the Registrant ☒ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule14a-6(

December 22, 2023 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 BRISTOL-MYERS S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of Incorporation) (Com

December 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 BRISTOL-MYERS S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of Incorporation) (Com

December 22, 2023 EX-99.1

Bristol Myers Squibb Strengthens Neuroscience Portfolio with Acquisition of Karuna Therapeutics Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Cl

Exhibit 99.1 Bristol Myers Squibb Strengthens Neuroscience Portfolio with Acquisition of Karuna Therapeutics Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Class Treatment for Schizophrenia and as an Adjunctive Therapy, and First-in-Disease Treatment for Alzheimer’s Disease Psychosis, with Prom

December 22, 2023 EX-99.1

Bristol Myers Squibb Strengthens Neuroscience Portfolio with Acquisition of Karuna Therapeutics Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Cl

Exhibit 99.1 Bristol Myers Squibb Strengthens Neuroscience Portfolio with Acquisition of Karuna Therapeutics Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Class Treatment for Schizophrenia and as an Adjunctive Therapy, and First-in-Disease Treatment for Alzheimer’s Disease Psychosis, with Prom

December 4, 2023 SC 13G

RNA / Avidity Biosciences Inc / BRISTOL MYERS SQUIBB CO - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.)* Avidity Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 05370A108 (CUSIP Number) November 27, 2023 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate th

November 13, 2023 EX-4.1

Fourteenth Supplemental Indenture, dated as of November 13, 2023, by and between Bristol-Myers Squibb Company and The Bank of New York Mellon, as Trustee, to the Indenture dated as of June 1, 1993 (incorporated herein by reference to Exhibit 4.1 to the Form 8-K

Exhibit 4.1 Bristol-Myers Squibb Company and THE BANK OF NEW YORK MELLON, as Trustee FOURTEENTH SUPPLEMENTAL INDENTURE Dated as of November 13, 2023 to INDENTURE Dated as of June 1, 1993 $1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063 TABLE OF CONTENTS Page ARTICLE I DEFINITIONS 2 Section 1.01 Defin

November 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2023 (October 30, 20

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2023 (October 30, 2023) BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of

November 13, 2023 EX-1.1

UNDERWRITING AGREEMENT, dated as of October 30, 2023 Bristol-Myers Squibb Company $1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063

Exhibit 1.1 Execution Version UNDERWRITING AGREEMENT, dated as of October 30, 2023 Bristol-Myers Squibb Company $1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063 New York, New York October 30, 2023 To the Representatives named in Schedule I hereto of the Underwriters named in Schedule II hereto Ladies

November 1, 2023 EX-FILING FEES

Calculation of Filing Fee Tables

Exhibit 107 Calculation of Filing Fee Tables 424(b)(5) (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule(1) Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to Be Paid Debt 5.

November 1, 2023 424B5

$1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063

TABLE OF CONTENTS Filed Pursuant to Rule 424(b)(5) Registration Statement No. 333-261623 PROSPECTUS SUPPLEMENT (to Prospectus dated December 13, 2021) $4,500,000,000   $1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063 We are offering $1,000,000,000 aggregate principal amount of 5.750% Notes due 2031 (

October 31, 2023 8-K/A

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 21, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of in

October 30, 2023 FWP

Bristol-Myers Squibb Company Pricing Term Sheet October 30, 2023 $1,000,000,000 5.750% Notes due 2031 (the “2031 Notes”) $1,000,000,000 5.900% Notes due 2033 (the “2033 Notes”) $1,250,000,000 6.250% Notes due 2053 (the “2053 Notes”) $1,250,000,000 6.

Issuer Free Writing Prospectus, dated October 30, 2023 Filed Pursuant to Rule 433 of the Securities Act of 1933 Registration Statement No.

October 30, 2023 424B3

Subject to Completion, dated October 30, 2023

TABLE OF CONTENTS The information in this preliminary prospectus supplement and the accompanying prospectus is not complete and may be changed.

October 26, 2023 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Giovanni Caforio, certify that: 1.

October 26, 2023 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Giovanni Caforio, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2023 (the "Report"), as filed wi

October 26, 2023 EX-99.2

Q3 2023 Results October 26, 2023 Exhibit 99.2 Q3 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) f

Q3 2023 Results October 26, 2023 Exhibit 99.2 Q3 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-l

October 26, 2023 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2023 (the "Report"), as filed wit

October 26, 2023 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

October 26, 2023 EX-99.1

Bristol Myers Squibb Reports Third Quarter Financial Results for 2023

Exhibit 99.1 Bristol Myers Squibb Reports Third Quarter Financial Results for 2023 •Reports Third Quarter Revenues of $11.0 Billion •Posts Third Quarter GAAP Earnings Per Share of $0.93 and Non-GAAP EPS of $2.00; Includes Net Impact of ($0.03) Per Share for GAAP and Non-GAAP EPS Due to Acquired IPRD Charges and Licensing Income •Reports Third Quarter Revenue Growth for In-Line Products and New Pro

October 26, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 ☐ TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQU

October 26, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 26, 2023 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 26, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

October 10, 2023 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. ) Filed by the Registrant ☐ Filed by a Party other than the Registrant ☒ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule14a-6(

August 10, 2023 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organ

July 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 27, 2023 BRISTOL-MYERS SQUIB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 27, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organi

July 27, 2023 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2023 (the "Report"), as filed with the

July 27, 2023 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Giovanni Caforio, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2023 (the "Report"), as filed with th

July 27, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 ☐ TRANSITION REPORT PURSUANT TO S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB C

July 27, 2023 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

July 27, 2023 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Giovanni Caforio, certify that: 1.

July 27, 2023 EX-99.2

Q2 2023 Results July 27, 2023 Q2 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial

q22023earningspresentati Q2 2023 Results July 27, 2023 Q2 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

July 27, 2023 EX-99.1

Bristol Myers Squibb Reports Second Quarter Financial Results for 2023

Exhibit 99.1 Bristol Myers Squibb Reports Second Quarter Financial Results for 2023 •Reports Second Quarter Revenues of $11.2 Billion •Posts Second Quarter GAAP Earnings Per Share of $0.99 and Non-GAAP EPS of $1.75; Includes Net Impact of ($0.05) Per Share for GAAP and Non-GAAP EPS Due to Acquired IPRD Charges and Licensing Income •Reports Second Quarter Revenue Growth for In-Line Products and New

June 8, 2023 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 8, 2023 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 8, 2023 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 8, 2023 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 8, 2023 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 8, 2023 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

May 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 2, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 1-1136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commission F

April 27, 2023 EX-99.2

Q1 2023 Results April 27, 2023 Q1 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial

q12023earningspresentati Q1 2023 Results April 27, 2023 Q1 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

April 27, 2023 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Giovanni Caforio, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2023 (the "Report"), as filed with t

April 27, 2023 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2023 (the "Report"), as filed with th

April 27, 2023 EX-99.1

Bristol Myers Squibb Reports First Quarter Financial Results for 2023

Exhibit 99.1 Bristol Myers Squibb Reports First Quarter Financial Results for 2023 •Reports First Quarter Revenues of $11.3 Billion •Posts First Quarter GAAP Earnings Per Share of $1.07 and Non-GAAP EPS of $2.05; Includes Net Impact of ($0.01) Per Share for GAAP and Non-GAAP EPS Due to Acquired IPRD Charges and Licensing Income •Delivers Strong Revenue Growth of 8% from In-Line Products and New Pr

April 27, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB

April 27, 2023 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

April 27, 2023 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Giovanni Caforio, certify that: 1.

April 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 27, 2023 BRISTOL-MYERS SQUI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 27, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organ

April 26, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 21, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commis

April 26, 2023 EX-99.1

Bristol Myers Squibb Announces Leadership Transition Plan Giovanni Caforio, MD, Bristol Myers Squibb Chairman and CEO, to Retire as CEO, Effective November 1, 2023; Will Continue as Executive Chairman of the Board Christopher Boerner, PhD, EVP, Chief

Exhibit 99.1 FOR IMMEDIATE RELEASE Bristol Myers Squibb Announces Leadership Transition Plan Giovanni Caforio, MD, Bristol Myers Squibb Chairman and CEO, to Retire as CEO, Effective November 1, 2023; Will Continue as Executive Chairman of the Board Christopher Boerner, PhD, EVP, Chief Commercialization Officer, Appointed EVP, Chief Operating Officer, Effective Immediately; to Succeed Giovanni Cafo

April 26, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 21, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commis

April 10, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 brhc10023253defa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission On

March 23, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

March 23, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Ru

February 28, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2023 (February 23, 2023) BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of

February 14, 2023 EX-10.AA

Form of Market Share Units Agreement under the 2021 Stock Award and Incentive Plan (incorporated herein by reference to Exhibit 10aa to the Form 10-K for the fiscal year ended December 31, 2022).

EXHIBIT 10aa MARKET SHARE UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you the Market Share Units (“MSUs”) specified in the Grant Summary located on the Stock Plan Administrator’s website, which is incorporated into this Market Share Units Agreement (the “Agreement”) and deemed to be a part hereof.

February 14, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ☐ TRANSITION REPORT PURSUANT TO SECTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB COMPA

February 14, 2023 EX-10.W

Form of Restricted Stock Units Agreement with four year vesting under the 2021 Stock Award and Incentive Plan

EXHIBIT 10w RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you the Restricted Stock Units (“RSUs”) specified in the Grant Summary located on the Stock Plan Administrator’s website, which is incorporated into this Restricted Stock Units Agreement (the “Agreement”) and deemed to be a part hereof.

February 14, 2023 EX-31.A

Section 302 Certification Letter (filed herewith).

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Giovanni Caforio, certify that: 1.

February 14, 2023 EX-10.Y

Form of Restricted Stock Units Agreement with two-year cliff vesting with a one-year post-vest holding period under the 2021 Stock Award and Incentive Plan

EXHIBIT 10y RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you the Restricted Stock Units (“RSUs”) specified in the Grant Summary located on the Stock Plan Administrator’s website, which is incorporated into this Restricted Stock Units Agreement (the “Agreement”) and deemed to be a part hereof.

February 14, 2023 EX-10.X

Form of Restricted Stock Units Agreement with three year vesting under the 2021 Stock Award and Incentive Plan

EXHIBIT 10x RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you the Restricted Stock Units (“RSUs”) specified in the Grant Summary located on the Stock Plan Administrator’s website, which is incorporated into this Restricted Stock Units Agreement (the “Agreement”) and deemed to be a part hereof.

February 14, 2023 EX-32.B

Section 906 Certification Letter (filed herewith).

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2022 (the Report), as filed with the S

February 14, 2023 EX-10.I

Form of 2023-2025 Performance Share Units Award Agreement under the 2021 Equity Incentive Plan (filed herewith).

EXHIBIT 10i PERFORMANCE SHARE UNITS AGREEMENT Under the Bristol-Myers Squibb Company 2021 Stock Award and Incentive Plan 2023-2025 Performance Share Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you the Performance Share Units (“Performance Share Units”) specified in the Grant Summary located on the Stock Plan Administrator’s website.

February 14, 2023 EX-10.Z

Form of Restricted Stock Units Agreement with one-year cliff vesting with a two-year post-vest holding period under the 2021 Stock Award and Incentive Plan

EXHIBIT 10z RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you the Restricted Stock Units (“RSUs”) specified in the Grant Summary located on the Stock Plan Administrator’s website, which is incorporated into this Restricted Stock Units Agreement (the “Agreement”) and deemed to be a part hereof.

February 14, 2023 EX-31.B

Section 302 Certification Letter (filed herewith).

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

February 14, 2023 EX-4.A

s securities registered pursuant to Section 12 of the Securities Exchange Act of 1934 (

EXHIBIT 4a DESCRIPTION OF THE REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of the date of the Annual Report on Form 10-K (“Annual Report”) of which this exhibit is a part, Bristol-Myers Squibb Company (“Bristol Myers Squibb,” or “we,” “us” and “our”) had the following classes of securities registered pursuant to Section 12(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”): (i) shares of common stock, $0.

February 14, 2023 EX-32.A

Section 906 Certification Letter (filed herewith).

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, Giovanni Caforio, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2022 (the Report), as filed with the

February 14, 2023 EX-10.V

Form of Restricted Stock Units Agreement with five year vesting under the 2021 Stock Award and Incentive Plan

EXHIBIT 10v RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you the Restricted Stock Units (“RSUs”) specified in the Grant Summary located on the Stock Plan Administrator’s website, which is incorporated into this Restricted Stock Units Agreement (the “Agreement”) and deemed to be a part hereof.

February 14, 2023 EX-21

Subsidiaries of the Registrant (filed herewith).

EXHIBIT 21 Subsidiaries of Bristol-Myers Squibb Company The following are subsidiaries of the Bristol-Myers Squibb Company at December 31, 2022.

February 9, 2023 SC 13G/A

BMY / Bristol-Myers Squibb Co / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 8)* Name of issuer: Bristol-Myers Squibb Co. Title of Class of Securities: Common Stock CUSIP Number: 110122108 Date of Event Which Requires Filing of this Statement: December 30, 2022 Check the appropriate box to designate the rule pursuant to which this Schedule is fil

February 2, 2023 EX-99.2

BRISTOL-MYERS SQUIBB COMPANY QUARTERLY TREND ANALYSIS OF REVENUES (Unaudited, dollars in millions) Revenues 2021 2022 % Change FX Impact(b) 1st Qtr 2nd Qtr 6 Months 3rd Qtr 9 Months 4th Qtr Year 1st Qtr 2nd Qtr 6 Months 3rd Qtr 9 Months 4th Qtr Year

Exhibit 99.2 BRISTOL-MYERS SQUIBB COMPANY QUARTERLY TREND ANALYSIS OF REVENUES (Unaudited, dollars in millions) Revenues 2021 2022 % Change FX Impact(b) 1st Qtr 2nd Qtr 6 Months 3rd Qtr 9 Months 4th Qtr Year 1st Qtr 2nd Qtr 6 Months 3rd Qtr 9 Months 4th Qtr Year Qtr vs. Qtr YTD vs. YTD Qtr vs. Qtr YTD vs. YTD United States $ 7,010 $ 7,388 $ 14,398 $ 7,296 $ 21,694 $ 7,520 $ 29,214 $ 7,694 $ 8,268

February 2, 2023 EX-99.3

Q4 2022 Results February 2, 2023 Q4 2022 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financi

Q4 2022 Results February 2, 2023 Q4 2022 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

February 2, 2023 EX-99.1

Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2022

Exhibit 99.1 Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2022 •Reports Fourth Quarter Revenues of $11.4 Billion; Full-Year Revenues of $46.2 Billion ◦Fourth Quarter Revenues from In-Line Products and New Product Portfolio were $9.0 Billion, an Increase of 7%, or 12% When Adjusted for Foreign Exchange ◦Full-Year Revenues from In-Line Products and New Product Port

February 2, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 2, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

January 31, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 29, 2023 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 29, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

January 9, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 9, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 1-1136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commissi

January 9, 2023 EX-99.1

January 2023 JP Morgan Presentation Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strat

Exhibit 99.1 January 2023 JP Morgan Presentation Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe ha

October 26, 2022 EX-99.2

BRISTOL-MYERS SQUIBB COMPANY QUARTERLY TREND ANALYSIS OF REVENUES (Unaudited, dollars in millions) Revenues 2021 2022 % Change FX Impact(b) 1st Qtr 2nd Qtr 6 Months 3rd Qtr 9 Months 4th Qtr Year 1st Qtr 2nd Qtr 6 Months 3rd Qtr 9 Months 4th Qtr Year

Exhibit 99.2 BRISTOL-MYERS SQUIBB COMPANY QUARTERLY TREND ANALYSIS OF REVENUES (Unaudited, dollars in millions) Revenues 2021 2022 % Change FX Impact(b) 1st Qtr 2nd Qtr 6 Months 3rd Qtr 9 Months 4th Qtr Year 1st Qtr 2nd Qtr 6 Months 3rd Qtr 9 Months 4th Qtr Year Qtr vs. Qtr YTD vs. YTD Qtr vs. Qtr YTD vs. YTD United States $ 7,010 $ 7,388 $ 14,398 $ 7,296 $ 21,694 $ 7,520 $ 29,214 $ 7,694 $ 8,268

October 26, 2022 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2022 (the "Report"), as filed wit

October 26, 2022 EX-99.3

Q3 2022 Results October 26, 2022 Q3 2022 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financi

q32022earningspresentati Q3 2022 Results October 26, 2022 Q3 2022 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

October 26, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 25, 2022 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 25, 2022 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

October 26, 2022 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Giovanni Caforio, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2022 (the "Report"), as filed wi

October 26, 2022 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

October 26, 2022 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Giovanni Caforio, certify that: 1.

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