BioCryst Pharmaceuticals, Inc.
MX ˙ BMV ˙ US09058V1035
SecurityMX:BCRX / BioCryst Pharmaceuticals, Inc.
InstitutionRenaissance Technologies Llc
ManagerJames Simons
Latest Disclosed Ownership776,990 shares
Latest Disclosed Value $ 7,396,945
Renaissance Technologies Llc reports 63.50% decrease in ownership of BCRX / BioCryst Pharmaceuticals, Inc.

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 776,990 shares of BioCryst Pharmaceuticals, Inc. (MX:BCRX) valued at $7,396,945 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 2,128,821 shares of BioCryst Pharmaceuticals, Inc.. This represents a change in shares of -63.50% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 776,990 -1,351,831 -63.50 7,397 -55.46 0.0116
2026-02-12 2025-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,128,821 -11,713 -0.55 16,605 2.20 0.0258
2025-11-13 2025-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,140,534 -386,200 -15.28 16,247 -28.24 0.0214
2025-08-13 2025-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,526,734 1,921,516 317.49 22,640 398.77 0.0301
2025-05-14 2025-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 605,218 60,197 11.04 4,539 10.76 0.0069
2025-02-13 2024-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 545,021 -44,059 -7.48 4,099 -8.47 0.0061
2024-11-13 2024-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 589,080 -371,100 -38.65 4,477 -24.54 0.0067
2024-08-09 2024-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 960,180 -630,200 -39.63 5,934 74,062.50 0.0101
2024-05-13 2024-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,590,380 -164,600 -9.38 8 -20.00 0.0127
2024-02-13 2023-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,754,980 1,553,135 769.47 11 900.00 0.0163
2023-11-14 2023-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 201,845 201,845 1 0.0024
2023-02-13 2022-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -565,380 -100.00 0 -100.00
2022-11-14 2022-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 565,380 438,900 347.01 7,124 432.44 0.0101
2022-08-12 2022-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 126,480 -125,000 -49.71 1,338 -67.28 0.0016
2022-05-13 2022-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 251,480 251,480 4,089 0.0048
2022-02-11 2021-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -408,180 -100.00 0 -100.00
2021-11-12 2021-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 408,180 -624,300 -60.47 5,866 -64.07 0.0076
2021-08-13 2021-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,032,480 965,010 1,430.28 16,324 2,279.59 0.0204
2021-05-13 2021-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 67,470 -1,212,910 -94.73 686 -92.81 0.0009
2021-02-10 2020-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,280,380 1,280,380 1,797.70 9,539 1,290.52 0.0104
2020-05-14 2020-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -840,734 -100.00 0 -100.00
2020-02-13 2019-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 840,734 629,919 298.80 2,901 380.30 0.0022
2019-11-13 2019-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 210,815 210,815 -74.92 604 -79.18 0.0005
2019-02-12 2018-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -217,203 -100.00 0 -100.00
2018-11-13 2018-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 217,203 -177,378 -44.95 1,657 -26.71 0.0017
2018-08-13 2018-06-30 13F/A-1 BIOCRYST PHARMACEUTICALS COM 09058V103 394,581 -373,222 -48.61 2,261 -38.26 0.0025
2018-08-13 2018-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 767,803 3,662
2018-05-14 2018-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 767,803 371,600 93.79 3,662 88.28 0.0040
2018-02-13 2017-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 396,203 169,700 74.92 1,945 63.86 0.0021
2017-11-13 2017-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 226,503 -178,000 -44.00 1,187 -47.22 0.0014
2017-08-11 2017-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 404,503 185,300 84.53 2,249 22.16 0.0029
2017-05-12 2017-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 219,203 169,300 339.26 1,841 482.59 0.0026
2017-02-13 2016-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 49,903 49,903 316 0.0005
2016-08-12 2016-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -292,221 -100.00 0 -100.00
2016-05-13 2016-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 292,221 149,318 104.49 827 -43.93 0.0016
2016-02-11 2015-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 142,903 142,903 -51.10 1,475 78.36 0.0032
2015-08-14 2015-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -32,403 -100.00 0 -100.00
2015-05-13 2015-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 32,403 -58,111 -64.20 293 -69.42 0.0006
2014-05-14 2014-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 90,514 90,514 958 0.0023
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.