ISEE Insider Trading - IVERIC bio Inc

Azioni degli insider

3.333.207 shares

Indice del sentiment degli insider

L'indice del sentiment degli insider identifica le società le cui azioni vengono acquistate dagli insider aziendali.

È il risultato di un sofisticato modello quantitativo multi-fattore che identifica le società con i più alti livelli di accumulo di insider. Il modello di punteggio utilizza una combinazione del numero netto di acquisti degli insider negli ultimi 90 giorni, delle azioni totali acquistate in percentuale del flottante e delle azioni totali possedute dagli insider. Il punteggio varia da 0 a 100: i numeri più alti indicano un livello di accumulo superiore ad altre società, mentre 50 rappresenta la media.

Frequenza di aggiornamento: giornaliera

Vedi I preferiti degli insider, per accedere all'elenco delle società con il più alto accumulo di insider.

Vedi i titoli più quotati

Indice del sentiment dei dirigenti

L'indice del sentiment dei dirigenti identifica le società le cui azioni vengono acquistate dai dirigenti aziendali.

Per definizione, i dirigenti aziendali sono insider della società, ma a differenza di altri insider (azionisti al 10% e membri del consiglio di amministrazione), i dirigenti lavorano quotidianamente per la società e utilizzano il proprio denaro quando fanno trading (gli azionisti al 10% e i membri del consiglio di amministrazione sono spesso gestori di fondi che gestiscono il denaro di altre persone). Pertanto, le operazioni di insider trading effettuate dai dirigenti sono molto più significative e devono essere trattate in modo appropriato.

Come l'indice del sentiment degli insider, l'indice del sentiment dei dirigenti è il risultato di un sofisticato modello quantitativo multi-fattore che identifica le società con i più alti livelli di accumulo di dirigenti.

Frequenza di aggiornamento: giornaliera

Vedi I preferiti degli insider, per accedere all'elenco delle società con il più alto sentiment degli insider.

Vedi i titoli più quotati

Principali indicatori per gli insider

Questa scheda mostra il posizionamento della società in base a diversi indicatori di insider. Il grado percentile mostra come la società si colloca rispetto alle altre società dei mercati statunitensi. Posizioni più alte indicano situazioni migliori.

Ad esempio, è generalmente accettato che gli acquisti di insider siano un indicatore positivo, per cui le società con un maggior numero di acquisti di insider si classificherebbero più in alto rispetto a quelle con un minor numero di acquisti di insider (o addirittura di vendite di insider).

Numero netto di acquisti di insider (classifica)

N/A

Il numero netto di acquisti di insider è il numero totale di acquisti di insider meno il numero totale di vendite di insider negli ultimi 90 giorni. Il grado percentile è mostrato qui (intervallo da 0 a 100%).

Percentuale del flottante acquistato dagli insider (classifica)

N/A

La percentuale del flottante acquistato dagli insider è data dal numero totale di azioni acquistate dagli insider meno il numero totale di azioni vendute dagli insider negli ultimi 90 giorni, divisa per il flottante totale e moltiplicata per 100.

Grafico sull'insider trading

Il grafico seguente mostra le operazioni di insider trading di IVERIC bio Inc. Gli insider sono funzionari, direttori o investitori importanti di una società. In generale, è illegale per gli insider effettuare operazioni di compravendita nelle loro aziende sulla base di informazioni materiali non pubbliche. Ciò non significa che sia illegale per loro effettuare qualsiasi operazioni di trading nelle proprie aziende. Tuttavia, devono segnalare tutte le operazioni alla SEC tramite un modulo 4.

Lista degli insider e indicatori di redditività

Questa tabella mostra la lista degli insider noti ed è generata automaticamente a partire dai depositi effettuati presso la SEC. Oltre ai nomi, al titolo più recente e alla designazione di amministratore, funzionario o proprietario al 10%, forniamo le ultime partecipazioni divulgate. Inoltre, quando possibile, forniamo la performance storica delle transazioni dell'insider. La performance storica delle transazioni è una media ponderata della performance delle operazioni di acquisto sul mercato aperto effettuate dall'insider. Per maggiori informazioni su come viene calcolata, guarda questo webinar su YouTube.

See our leaderboard of most profitable insider traders.

Insider	Utile medio (%)	Azioni possedute	Rettificato per il frazionamento azionario

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Storico degli acquisti di insider - Analisi degli utili a breve termine

In questa sezione analizziamo la redditività di ogni acquisto non pianificato di insider effettuato sul mercato aperto in ISEE / IVERIC bio Inc. Questa analisi aiuta a capire se l'insider genera costantemente rendimenti anomali e se vale la pena seguirlo. L'analisi riguarda l'anno successivo a ciascuna operazione, e i risultati sono teorici .

La tabella seguente mostra gli acquisti più recenti sul mercato aperto che non facevano parte di un piano di trading automatico.

Data dell'operazione	Insider	Azioni dichiarate	Prezzo dichiarato	Azioni rettificate	Prezzo rettificato	Base di costo	Giorni fino al massimo	Prezzo al massimo	Profitto massimo ($)	Rendimento massimo (%)
2022-06-13	Roberts Calvin W.	25.000	9,6200	25.000	9,6200	240.500	358	38.9000	732.000	304,37
2021-11-18	Simms Christopher Paul	3.069	16,3000	3.069	16,3000	50.025
2019-12-10	SBLENDORIO GLENN	62.500	4,0000	62.500	4,0000	250.000
2019-11-15	SBLENDORIO GLENN	15.000	3,1234	15.000	3,1234	46.851
2019-05-10	SBLENDORIO GLENN	25.000	1,4800	25.000	1,4800	37.000
2016-06-03	Bolte Axel	3.500	56,9700	3.500	56,9700	199.395
2015-03-30	Bolte Axel	500	48,2700	500	48,2700	24.135
2013-09-30	SBLENDORIO GLENN	1.000	22,0000	1.000	22,0000	22.000
2013-09-30	Novo A/S	455.000	22,0000	455.000	22,0000	10.010.000

Il prezzo rettificato è il prezzo rettificato per il frazionamento azionario. Le azioni rettificate sono le azioni rettificate per il frazionamento azionario.

Storico delle vendite di insider - Analisi delle perdite a breve termine

In questa sezione, analizziamo l'evitamento delle perdite a breve termine di ogni vendita di insider non pianificata ed effettuata sul mercato aperto in ISEE / IVERIC bio Inc. Un modello coerente di evitamento delle perdite può suggerire che future transazioni di vendita potrebbero predire cali di prezzo. L'analisi riguarda l'anno successivo a ciascuna operazione, e i risultati sono teorici .

La tabella seguente mostra le vendite più recenti sul mercato aperto che non facevano parte di un piano di trading automatico.

Data dell'operazione	Insider	Azioni dichiarate	Prezzo dichiarato	Azioni rettificate	Prezzo rettificato	Base di costo	Giorni fino al minimo	Prezzo al minimo	Perdita massima evitata ($)	Perdita massima evitata (%)
2023-01-03	SBLENDORIO GLENN	17.447	20,0600	17.447	20,0600	349.987	7	18.6700	-24.251	-6,93
2023-01-03	Carroll David Francis	3.602	20,0600	3.602	20,0600	72.256
2023-01-03	Westby Keith	3.480	20,0600	3.480	20,0600	69.809
2023-01-03	Simms Christopher Paul	2.368	20,0600	2.368	20,0600	47.502
2022-12-19	SBLENDORIO GLENN	19.457	21,5100	19.457	21,5100	418.520
2022-12-19	Carroll David Francis	5.671	21,5100	5.671	21,5100	121.983
2022-12-19	Westby Keith	6.740	21,5100	6.740	21,5100	144.977
2022-12-13	Westby Keith	6.741	21,7300	6.741	21,7300	146.482
2022-12-13	Carroll David Francis	4.932	21,7300	4.932	21,7300	107.172

Il prezzo rettificato è il prezzo rettificato per il frazionamento azionario. Le azioni rettificate sono le azioni rettificate per il frazionamento azionario.

Storico delle transazioni

Clicca sull'icona del link per visualizzare la cronologia completa delle transazioni. Le transazioni segnalate come parte di un piano di trading automatico 10b5-1 saranno contrassegnate con una X nella colonna contrassegnata con 10b-5.

Data di deposito	Data dell' operazione	Modulo	Insider	Ticker	Titolo	Codice	Diretto	Prezzo di esercizio	Prezzo unitario	Unità modificate	Valore modificato (1K)	Opzioni rimanenti	Azioni rimanenti
2023-07-13	2023-07-11	4	Carroll David Francis	ISEE	Common Stock	D - Sale to Issuer	D			-44.152			0
2023-07-13	2023-07-11	4	Blumenkranz Mark S.	ISEE	Common Stock	D - Sale to Issuer	D			-32.088			0
2023-07-13	2023-07-11	4	Miller Christine Ann	ISEE	Common Stock	D - Sale to Issuer	D			-13.075			0
2023-07-13	2023-07-11	4	Graves Adrienne L	ISEE	Common Stock	D - Sale to Issuer	D			-22.088			0
2023-07-13	2023-07-11	4	Roberts Calvin W.	ISEE	Common Stock	D - Sale to Issuer	D			-47.088			0
2023-07-13	2023-07-11	4	Simms Christopher Paul	ISEE	Common Stock	D - Sale to Issuer	D			-32.429			0
2023-07-13	2023-07-11	4	SBLENDORIO GLENN	ISEE	Common Stock	D - Sale to Issuer	D			-239.275			0
2023-07-13	2023-07-11	4	Dugel Pravin	ISEE	Common Stock	D - Sale to Issuer	D			-203.035			0
2023-07-13	2023-07-11	4	Henderson Jane	ISEE	Common Stock	D - Sale to Issuer	D			-22.088			0
2023-07-13	2023-07-11	4	Westby Keith	ISEE	Common Stock	D - Sale to Issuer	D			-39.652			0
2023-07-13	2023-07-11	4	Gibney Anthony S	ISEE	Common Stock	D - Sale to Issuer	D			-40.291			0
2023-07-13	2023-07-11	4	Bolte Axel	ISEE	Common Stock	D - Sale to Issuer	D			-22.088			0
2023-07-06	2023-07-03	4	Westby Keith	ISEE	Common Stock	S - Sale	D		39,4500	-20.000	-789		39.652
2023-07-06	2023-07-03	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		2,9400	20.000	59		59.652
2023-06-30	2023-06-28	4	Gibney Anthony S	ISEE	Common Stock	G - Gift	D			-2.500			40.291
2023-06-28	2023-06-26	4	Carroll David Francis	ISEE	Common Stock	G - Gift	D			-24.320			44.152
2023-06-26	2023-06-22	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		13,2160	11.084	146		239.275
2023-06-06	2023-06-02	4	Westby Keith	ISEE	Common Stock	S - Sale	D		37,8700	-20.000	-757		39.652
2023-06-06	2023-06-02	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		2,9400	20.000	59		59.652
2023-05-15	2023-05-11	4	Bolte Axel	ISEE	Common Stock	M - Exercise	D			14.588			22.088
2023-05-15	2023-05-11	4	Blumenkranz Mark S.	ISEE	Common Stock	M - Exercise	D			14.588			32.088
2023-05-15	2023-05-11	4	Roberts Calvin W.	ISEE	Common Stock	M - Exercise	D			14.588			47.088
2023-05-15	2023-05-11	4	Graves Adrienne L	ISEE	Common Stock	M - Exercise	D			14.588			22.088
2023-05-15	2023-05-11	4	Miller Christine Ann	ISEE	Common Stock	M - Exercise	D			8.075			13.075
2023-05-15	2023-05-11	4	Henderson Jane	ISEE	Common Stock	M - Exercise	D			14.588			22.088
2023-05-11	2023-05-03	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D			4.312			203.035
2023-05-03	2023-05-01	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		37,0400	-63.500	-2.352		68.472
2023-05-03	2023-05-01	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D		2,8100	63.500	178		131.972
2023-05-03	2023-05-02	4	Westby Keith	ISEE	Common Stock	S - Sale	D		37,8100	-20.000	-756		39.652
2023-05-03	2023-05-02	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		2,9400	20.000	59		59.652
2023-05-03	2023-05-01	4	Westby Keith	ISEE	Common Stock	S - Sale	D		37,1200	-11.214	-416		39.652
2023-05-03	2023-05-01	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		5,2200	11.214	59		50.866
2023-05-03	2023-05-01	4	Westby Keith	ISEE	Common Stock	S - Sale	D		37,1200	-8.786	-326		39.652
2023-05-03	2023-05-01	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		4,5200	8.786	40		48.438
2023-04-25	2023-04-24	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		30,2100	-48.171	-1.455		68.472
2023-04-25	2023-04-24	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D		1,4500	48.171	70		116.643
2023-04-25	2023-04-21	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		30,0000	-1.829	-55		68.472
2023-04-25	2023-04-21	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D		1,4500	1.829	3		70.301
2023-04-25	2023-04-24	4	Westby Keith	ISEE	Common Stock	S - Sale	D		30,0700	-18.782	-565		39.652
2023-04-25	2023-04-24	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		4,5200	18.782	85		58.434
2023-04-25	2023-04-21	4	Westby Keith	ISEE	Common Stock	S - Sale	D		30,0000	-1.218	-37		39.652
2023-04-25	2023-04-21	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		4,5200	1.218	6		40.870
2023-04-05	2023-04-03	4	Westby Keith	ISEE	Common Stock	S - Sale	D		26,9800	-22.530	-608		39.652
2023-04-05	2023-04-03	4	Westby Keith	ISEE	Common Stock	S - Sale	D		26,3500	-17.470	-460		62.182
2023-04-05	2023-04-03	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		4,5200	20.000	90		79.652
2023-04-05	2023-04-03	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		2,9400	6.214	18		59.652
2023-04-05	2023-04-03	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		1,4500	13.786	20		53.438
2023-04-04	2023-04-01	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D			50.000			198.723
2023-03-06	2023-03-02	4	Westby Keith	ISEE	Common Stock	S - Sale	D		24,6000	-600	-15		39.652
2023-03-06	2023-03-02	4	Westby Keith	ISEE	Common Stock	S - Sale	D		23,9100	-19.400	-464		40.252
2023-03-06	2023-03-02	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		1,4500	13.298	19		59.652
2023-02-27	2023-01-05	4	Miller Christine Ann	ISEE	Common Stock	M - Exercise	D			5.000			5.000
2023-02-22	2023-02-17	4	Westby Keith	ISEE	Common Stock	S - Sale	D		25,0500	-11.214	-281		46.354
2023-02-22	2023-02-17	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		4,5200	11.214	51		57.568
2023-02-22	2023-02-17	4	Westby Keith	ISEE	Common Stock	S - Sale	D		25,0500	-3.786	-95		46.354
2023-02-22	2023-02-17	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		2,9400	3.786	11		50.140
2023-02-03	2023-02-02	4	Westby Keith	ISEE	Common Stock	S - Sale	D		23,8200	-20.000	-476		46.354
2023-02-03	2023-02-01	4	Westby Keith	ISEE	Common Stock	S - Sale	D		23,0300	-20.000	-461		66.354
2023-01-04	2023-01-03	4	Simms Christopher Paul	ISEE	Common Stock	S - Sale	D		20,0600	-2.368	-48		32.429
2023-01-04	2023-01-02	4	Simms Christopher Paul	ISEE	Common Stock	M - Exercise	D			6.250			34.797
2023-01-04	2023-01-03	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		20,0600	-3.602	-72		68.472
2023-01-04	2023-01-02	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			8.750			72.074
2023-01-04	2023-01-03	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		20,0600	-17.447	-350		228.191
2023-01-04	2023-01-02	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			31.500			245.638
2023-01-04	2023-01-03	4	Westby Keith	ISEE	Common Stock	S - Sale	D		20,0600	-3.480	-70		86.354
2023-01-04	2023-01-02	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			8.750			89.834
2023-01-04	2023-01-02	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D			12.500			148.723
2022-12-29	2022-12-27	4	SBLENDORIO GLENN	ISEE	Common Stock	G - Gift	D			-30.000			214.138
2022-12-20	2022-12-19	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		21,5100	-19.457	-419		244.138
2022-12-20	2022-12-18	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			36.658			263.595
2022-12-20	2022-12-19	4	Westby Keith	ISEE	Common Stock	S - Sale	D		21,5100	-6.740	-145		81.084
2022-12-20	2022-12-18	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			12.500			87.824
2022-12-20	2022-12-18	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D			13.750			136.223
2022-12-20	2022-12-19	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		21,5100	-5.671	-122		63.324
2022-12-20	2022-12-18	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			14.375			68.995
2022-12-14	2022-12-13	4	Gibney Anthony S	ISEE	Common Stock	M - Exercise	D			25.000			42.791
2022-12-14	2022-12-13	4	Gibney Anthony S	ISEE	Common Stock	M - Exercise	D			6.000			17.791
2022-12-13	2022-12-13	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		21,7300	-4.932	-107		54.620
2022-12-13	2022-12-12	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			12.500			59.552
2022-12-13	2022-12-12	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		21,2500	-1.541	-33		47.052
2022-12-13	2022-12-12	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		20,6600	-2.405	-50		48.593
2022-12-13	2022-12-09	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			10.000			50.998
2022-12-13	2022-12-13	4	Westby Keith	ISEE	Common Stock	S - Sale	D		21,7300	-6.741	-146		75.324
2022-12-13	2022-12-12	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			12.500			82.065
2022-12-13	2022-12-12	4	Westby Keith	ISEE	Common Stock	S - Sale	D		21,2500	-2.106	-45		69.565
2022-12-13	2022-12-12	4	Westby Keith	ISEE	Common Stock	S - Sale	D		20,6600	-3.287	-68		71.671
2022-12-13	2022-12-09	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			10.000			74.958
2022-12-13	2022-12-12	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			22.950			226.937
2022-12-13	2022-12-09	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			23.750			203.987
2022-12-05	2022-12-02	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		10,0300	5.199	52		64.958
2022-12-05	2022-12-01	4	Westby Keith	ISEE	Common Stock	S - Sale	D		22,9600	-10.030	-230		59.759
2022-11-21	2022-11-17	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D		10,0300	8.474	85		122.473
2022-11-04	2022-11-02	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		23,0100	-50.000	-1.150		179.689
2022-11-03	2022-11-01	4	Westby Keith	ISEE	Common Stock	S - Sale	D		23,9200	-72.916	-1.744		69.128
2022-11-03	2022-11-01	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		1,4500	42.916	62		142.044
2022-08-04	2022-08-03	4	Simms Christopher Paul	ISEE	Common Stock	S - Sale	D		11,2500	-6.818	-77		28.547
2022-08-04	2022-08-03	4	Simms Christopher Paul	ISEE	Common Stock	S - Sale	D		11,2500	-5.454	-61		35.365
2022-08-04	2022-08-02	4	Simms Christopher Paul	ISEE	Common Stock	M - Exercise	D			18.750			40.819
2022-08-04	2022-08-02	4	Simms Christopher Paul	ISEE	Common Stock	M - Exercise	D			15.000			22.069
2022-07-19	2022-07-15	4	Blumenkranz Mark S.	ISEE	Common Stock	M - Exercise	D			5.000			17.500
2022-07-05	2022-07-05	4	Gibney Anthony S	ISEE	Common Stock	S - Sale	D		9,4100	-7.791	-73		10.959
2022-07-05	2022-06-30	4	Gibney Anthony S	ISEE	Common Stock	M - Exercise	D			18.750			18.750
2022-06-14	2022-06-13	4	Roberts Calvin W.	ISEE	Common Stock	P - Purchase	D		9,6200	25.000	240		32.500
2022-05-16	2022-05-12	4	Miller Christine Ann	ISEE	Stock Option (right to buy)	A - Award	D	9,94		12.835		12.835
2022-05-16	2022-05-12	4	Miller Christine Ann	ISEE	Restricted Stock Units	A - Award	D			8.075		8.075
2022-05-13	2022-05-12	4	Graves Adrienne L	ISEE	Stock Option (right to buy)	A - Award	D	9,94		23.186		23.186
2022-05-13	2022-05-12	4	Graves Adrienne L	ISEE	Restricted Stock Units	A - Award	D			14.588		14.588
2022-05-13	2022-05-11	4	Graves Adrienne L	ISEE	Restricted Stock Units	M - Exercise	D			-7.500		0
2022-05-13	2022-05-11	4	Graves Adrienne L	ISEE	Common Stock	M - Exercise	D			7.500			7.500
2022-05-13	2022-05-12	4	Henderson Jane	ISEE	Stock Option (right to buy)	A - Award	D	9,94		23.186		23.186
2022-05-13	2022-05-12	4	Henderson Jane	ISEE	Restricted Stock Units	A - Award	D			14.588		14.588
2022-05-13	2022-05-11	4	Henderson Jane	ISEE	Restricted Stock Units	M - Exercise	D			-7.500		0
2022-05-13	2022-05-11	4	Henderson Jane	ISEE	Common Stock	M - Exercise	D			7.500			7.500
2022-05-13	2022-05-12	4	Bolte Axel	ISEE	Stock Option (right to buy)	A - Award	D	9,94		23.186		23.186
2022-05-13	2022-05-12	4	Bolte Axel	ISEE	Restricted Stock Units	A - Award	D			14.588		14.588
2022-05-13	2022-05-11	4	Bolte Axel	ISEE	Restricted Stock Units	M - Exercise	D			-7.500		0
2022-05-13	2022-05-11	4	Bolte Axel	ISEE	Common Stock	M - Exercise	D			7.500			7.500
2022-05-13	2022-05-12	4	Roberts Calvin W.	ISEE	Stock Option (right to buy)	A - Award	D	9,94		23.186		23.186
2022-05-13	2022-05-12	4	Roberts Calvin W.	ISEE	Restricted Stock Units	A - Award	D			14.588		14.588
2022-05-13	2022-05-11	4	Roberts Calvin W.	ISEE	Restricted Stock Units	M - Exercise	D			-7.500		0
2022-05-13	2022-05-11	4	Roberts Calvin W.	ISEE	Common Stock	M - Exercise	D			7.500			7.500
2022-05-13	2022-05-12	4	Blumenkranz Mark S.	ISEE	Stock Option (right to buy)	A - Award	D	9,94		23.186		23.186
2022-05-13	2022-05-12	4	Blumenkranz Mark S.	ISEE	Restricted Stock Units	A - Award	D			14.588		14.588
2022-05-13	2022-05-11	4	Blumenkranz Mark S.	ISEE	Restricted Stock Units	M - Exercise	D			-7.500		0
2022-05-13	2022-05-11	4	Blumenkranz Mark S.	ISEE	Common Stock	M - Exercise	D			7.500			12.500
2022-05-05	2022-05-03	4	Dugel Pravin	ISEE	Restricted Stock Units	M - Exercise	D			-4.313		12.937
2022-05-05	2022-05-03	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D			4.313			113.999
2022-04-20	2022-04-18	4	Westby Keith	ISEE	Common Stock	S - Sale	D		16,6300	-10.000	-166		99.128
2022-04-06	2022-04-05	4	Westby Keith	ISEE	Stock Option (right to buy)	M - Exercise	D	1,45	1,4500	-9.298	-13	70.000
2022-04-06	2022-04-05	4	Westby Keith	ISEE	Common Stock	S - Sale	D		19,0157	-9.298	-177		109.128
2022-04-06	2022-04-05	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		1,4500	9.298	13		118.426
2022-04-06	2022-04-04	4	Westby Keith	ISEE	Stock Option (right to buy)	M - Exercise	D	1,45	1,4500	-20.702	-30	79.298
2022-04-06	2022-04-04	4	Westby Keith	ISEE	Common Stock	S - Sale	D		19,0004	-20.702	-393		109.128
2022-04-06	2022-04-04	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		1,4500	20.702	30		129.830
2022-04-06	2022-04-04	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		18,7561	-50.000	-938		229.689
2022-04-05	2022-04-05	4	Carroll David Francis	ISEE	Stock Option (right to buy)	M - Exercise	D	1,45		-4.684		50.000
2022-04-05	2022-04-05	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		19,0100	-4.684	-89		40.166
2022-04-05	2022-04-05	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D		1,4500	4.684	7		44.850
2022-04-05	2022-04-04	4	Carroll David Francis	ISEE	Stock Option (right to buy)	M - Exercise	D	1,45		-20.316		54.684
2022-04-05	2022-04-04	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		19,0100	-600	-11		40.166
2022-04-05	2022-04-04	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		18,4900	-40.341	-746		40.766
2022-04-05	2022-04-04	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D		1,4500	20.316	29		81.107
2022-04-05	2022-04-01	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		17,0000	-2.144	-36		60.791
2022-04-05	2022-04-01	4	Dugel Pravin	ISEE	Restricted Stock Units	M - Exercise	D			-50.000		100.000
2022-04-05	2022-04-01	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D			50.000			109.686
2022-04-01	2022-04-01	4	SBLENDORIO GLENN	ISEE	Stock Option (right to buy)	M - Exercise	D	2,94		-40.756		325.000
2022-04-01	2022-04-01	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		17,5000	-40.756	-713		279.689
2022-04-01	2022-04-01	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		2,9400	40.756	120		320.445
2022-04-01	2022-03-31	4	SBLENDORIO GLENN	ISEE	Stock Option (right to buy)	M - Exercise	D	2,94		-1.400		365.756
2022-04-01	2022-03-31	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		17,0200	-1.400	-24		279.689
2022-04-01	2022-03-31	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		2,9400	1.400	4		281.089
2022-04-01	2022-03-30	4	SBLENDORIO GLENN	ISEE	Stock Option (right to buy)	M - Exercise	D	2,94		-1.213		367.156
2022-04-01	2022-03-30	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		17,0040	-1.213	-21		279.689
2022-04-01	2022-03-30	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		2,9400	1.213	4		280.902
2022-03-29	2022-03-25	4	Carroll David Francis	ISEE	Stock Option (right to buy)	M - Exercise	D	1,45		-16.763		75.000
2022-03-29	2022-03-25	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		17,0157	-16.772	-285		62.935
2022-03-29	2022-03-25	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D		1,4500	16.763	24		79.707
2022-03-29	2022-03-25	4	SBLENDORIO GLENN	ISEE	Stock Option (right to buy)	M - Exercise	D	2,94		-18.775		368.369
2022-03-29	2022-03-25	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		17,0600	-18.775	-320		279.689
2022-03-29	2022-03-25	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		2,9400	18.775	55		298.464
2022-03-22	2022-03-18	4	Carroll David Francis	ISEE	Stock Option (right to buy)	M - Exercise	D	1,45		-8.237		91.763
2022-03-22	2022-03-18	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		17,0022	-11.561	-197		62.944
2022-03-22	2022-03-18	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D		1,4500	8.237	12		74.505
2022-03-22	2022-03-18	4	SBLENDORIO GLENN	ISEE	Stock Option (right to buy)	M - Exercise	D	2,94		-3.479		387.144
2022-03-22	2022-03-18	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		17,0006	-3.479	-59		279.689
2022-03-22	2022-03-18	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		2,9400	3.479	10		283.168
2022-03-18	2022-03-17	4	Westby Keith	ISEE	Common Stock	S - Sale	D		15,0628	-2.143	-32		109.128
2022-03-18	2022-03-16	4	Westby Keith	ISEE	Common Stock	S - Sale	D		15,0071	-7.857	-118		111.271
2022-03-02	2022-03-01	4	Westby Keith	ISEE	Stock Option (right to buy)	M - Exercise	D	1,65		-10.169		0
2022-03-02	2022-03-01	4	Westby Keith	ISEE	Common Stock	M - Exercise	D		1,6520	10.169	17		118.449
2022-02-17	2022-02-15	4	Westby Keith	ISEE	Common Stock	S - Sale	D		15,1634	-10.000	-152		108.280
2022-02-08	2022-02-07	4	Westby Keith	ISEE	Common Stock	S - Sale	D		15,0033	-10.000	-150		118.280
2022-01-07	2022-01-05	4	Miller Christine Ann	ISEE	Restricted Stock Units	A - Award	D			15.000		15.000
2022-01-07	2022-01-05	4	Miller Christine Ann	ISEE	Stock Option (Right to Buy)	A - Award	D	14,31		31.000		31.000
2022-01-04	2022-01-03	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		16,3923	-15.819	-259		65.504
2022-01-04	2021-12-31	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-32.500		0
2022-01-04	2021-12-31	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			32.500			81.323
2022-01-04	2022-01-03	4	Westby Keith	ISEE	Common Stock	S - Sale	D		16,3923	-12.278	-201		128.280
2022-01-04	2021-12-31	4	Westby Keith	ISEE	Restricted Stock Units	M - Exercise	D			-32.500		0
2022-01-04	2021-12-31	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			32.500			140.558
2022-01-03	2021-12-31	4	SBLENDORIO GLENN	ISEE	Stock Option (Right to Buy)	M - Exercise	D	2,94		-801		390.623
2022-01-03	2021-12-31	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		17,0050	-801	-14		279.133
2022-01-03	2021-12-31	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		2,9400	801	2		279.934
2022-01-03	2021-12-30	4	SBLENDORIO GLENN	ISEE	Stock Option (Right to Buy)	M - Exercise	D	2,94		-100		391.424
2022-01-03	2021-12-30	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		17,0100	-100	-2		279.133
2022-01-03	2021-12-30	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		2,9400	100	0		279.233
2021-12-27	2021-12-27	4	SBLENDORIO GLENN	ISEE	Stock Option (Right to Buy)	M - Exercise	D	1,45		-5.229		133.500
2021-12-27	2021-12-27	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		16,6360	-5.229	-87		279.133
2021-12-27	2021-12-27	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		1,4500	5.229	8		284.362
2021-12-27	2021-12-23	4	SBLENDORIO GLENN	ISEE	Stock Option (Right to Buy)	M - Exercise	D	2,94		-8.476		391.524
2021-12-27	2021-12-23	4	SBLENDORIO GLENN	ISEE	Stock Option (Right to Buy)	M - Exercise	D	1,45		-22.608		138.729
2021-12-27	2021-12-23	4	SBLENDORIO GLENN	ISEE	Common Stock	G - Gift	D			-20.000			279.133
2021-12-27	2021-12-23	4	SBLENDORIO GLENN	ISEE	Common Stock	G - Gift	D			-20.000			279.133
2021-12-27	2021-12-23	4	SBLENDORIO GLENN	ISEE	Common Stock	G - Gift	D			-20.000			299.133
2021-12-27	2021-12-23	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		16,9584	-31.084	-527		339.133
2021-12-27	2021-12-23	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		2,9400	8.476	25		370.217
2021-12-27	2021-12-23	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		1,4500	22.608	33		361.741
2021-12-27	2021-12-22	4	SBLENDORIO GLENN	ISEE	Stock Option (Right to Buy)	M - Exercise	D	1,45		-22.163		161.337
2021-12-27	2021-12-22	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		16,5042	-22.163	-366		339.133
2021-12-27	2021-12-22	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D		1,4500	22.163	32		361.296
2021-12-23	2021-12-21	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		15,9826	-56.207	-898		48.823
2021-12-23	2021-12-21	4	Westby Keith	ISEE	Common Stock	S - Sale	D		15,8872	-20.000	-318		108.058
2021-12-21	2021-12-20	4	Westby Keith	ISEE	Common Stock	S - Sale	D		15,4435	-4.516	-70		128.058
2021-12-21	2021-12-18	4	Westby Keith	ISEE	Restricted Stock Units	M - Exercise	D			-12.500		37.500
2021-12-21	2021-12-18	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			12.500			132.574
2021-12-21	2021-12-18	4	Dugel Pravin	ISEE	Restricted Stock Units	M - Exercise	D			-13.750		41.250
2021-12-21	2021-12-18	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D			13.750			59.686
2021-12-21	2021-12-20	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		15,4435	-18.524	-286		339.133
2021-12-21	2021-12-18	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	M - Exercise	D			-36.658		109.972
2021-12-21	2021-12-18	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			36.658			357.657
2021-12-21	2021-12-20	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		15,4435	-6.710	-104		105.030
2021-12-21	2021-12-18	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-14.375		43.125
2021-12-21	2021-12-18	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			14.375			111.740
2021-12-20	2021-12-16	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	A - Award	D			126.000		126.000
2021-12-20	2021-12-16	4	SBLENDORIO GLENN	ISEE	Stock Option (Right to Buy)	A - Award	D	14,83		252.000		252.000
2021-12-20	2021-12-16	4	Dugel Pravin	ISEE	Restricted Stock Units	A - Award	D			50.000		50.000
2021-12-20	2021-12-16	4	Dugel Pravin	ISEE	Stock Option (Right to Buy)	A - Award	D	14,83		100.000		100.000
2021-12-20	2021-12-16	4	Westby Keith	ISEE	Restricted Stock Units	A - Award	D			35.000		35.000
2021-12-20	2021-12-16	4	Westby Keith	ISEE	Stock Option (Right to Buy)	A - Award	D	14,83		70.000		70.000
2021-12-20	2021-12-16	4	Carroll David Francis	ISEE	Restricted Stock Units	A - Award	D			35.000		35.000
2021-12-20	2021-12-16	4	Carroll David Francis	ISEE	Stock Option (Right to Buy)	A - Award	D	14,83		70.000		70.000
2021-12-20	2021-12-16	4	Simms Christopher Paul	ISEE	Restricted Stock Units	A - Award	D			25.000		25.000
2021-12-20	2021-12-16	4	Simms Christopher Paul	ISEE	Stock Option (Right to Buy)	A - Award	D	14,83		50.000		50.000
2021-12-15	2021-12-13	4	Gibney Anthony S	ISEE	Restricted Stock Units	A - Award	D			6.000		6.000
2021-12-15	2021-12-13	4	Gibney Anthony S	ISEE	Restricted Stock Units	A - Award	D			75.000		75.000
2021-12-15	2021-12-13	4	Gibney Anthony S	ISEE	Restricted Stock Units	A - Award	D			100.000		100.000
2021-12-15	2021-12-13	4	Gibney Anthony S	ISEE	Stock Option (Right to Buy)	A - Award	D	15,16		200.000		200.000
2021-12-14	2021-12-13	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		14,7449	-5.836	-86		97.365
2021-12-14	2021-12-12	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-12.500		12.500
2021-12-14	2021-12-12	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			12.500			103.201
2021-12-14	2021-12-13	4	Westby Keith	ISEE	Common Stock	S - Sale	D		14,7449	-4.517	-67		120.074
2021-12-14	2021-12-12	4	Westby Keith	ISEE	Restricted Stock Units	M - Exercise	D			-12.500		12.500
2021-12-14	2021-12-12	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			12.500			124.591
2021-12-14	2021-12-13	4	SBLENDORIO GLENN	ISEE	Common Stock	S - Sale	D		14,7449	-8.293	-122		320.999
2021-12-14	2021-12-12	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	M - Exercise	D			-22.950		22.950
2021-12-14	2021-12-12	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			22.950			329.292
2021-12-13	2021-12-10	4	Westby Keith	ISEE	Common Stock	S - Sale	D		14,5315	-3.614	-53		112.091
2021-12-13	2021-12-09	4	Westby Keith	ISEE	Restricted Stock Units	M - Exercise	D			-10.000		20.000
2021-12-13	2021-12-09	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			10.000			115.705
2021-12-13	2021-12-09	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	M - Exercise	D			-23.750		47.500
2021-12-13	2021-12-09	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			23.750			306.342
2021-12-13	2021-12-10	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		14,5315	-3.614	-53		90.701
2021-12-13	2021-12-09	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-10.000		20.000
2021-12-13	2021-12-09	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			10.000			94.315
2021-11-22	2021-11-18	4	Simms Christopher Paul	ISEE	Common Stock	P - Purchase	D		16,3000	3.069	50		7.069
2021-11-15	2021-11-11	4	Dugel Pravin	ISEE	Stock Option (Right to Buy)	M - Exercise	D	1,65		-4.237		0
2021-11-15	2021-11-11	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D		1,6520	4.237	7		45.936
2021-08-04	2021-08-02	4	Simms Christopher Paul	(ISEE)	Restricted Stock Units	A - Award	D			15.000		15.000
2021-08-04	2021-08-02	4	Simms Christopher Paul	(ISEE)	Restricted Stock Units	A - Award	D			75.000		75.000
2021-08-04	2021-08-02	4	Simms Christopher Paul	(ISEE)	Stock Option (Right to Buy)	A - Award	D	8,64		160.000		160.000
2021-08-04		3	Simms Christopher Paul	ISEE	Common stock		D						4.000
2021-07-19	2021-07-15	4	Blumenkranz Mark S.	ISEE	Restricted Stock Units	M - Exercise	D			-5.000		10.000
2021-07-19	2021-07-15	4	Blumenkranz Mark S.	ISEE	Common Stock	M - Exercise	D			5.000			5.000
2021-05-20	2021-05-19	4	Henderson Jane	ISEE	Restricted Stock Units	A - Award	D			7.500		7.500
2021-05-20	2021-05-19	4	Henderson Jane	ISEE	Stock Option (Right to Buy)	A - Award	D	6,82		15.500		15.500
2021-05-20	2021-05-19	4	Blumenkranz Mark S.	ISEE	Restricted Stock Units	A - Award	D			7.500		7.500
2021-05-20	2021-05-19	4	Blumenkranz Mark S.	ISEE	Stock Option (Right to Buy)	A - Award	D	6,82		15.500		15.500
2021-05-20	2021-05-19	4	Roberts Calvin W.	ISEE	Restricted Stock Units	A - Award	D			7.500		7.500
2021-05-20	2021-05-19	4	Roberts Calvin W.	ISEE	Stock Option (Right to Buy)	A - Award	D	6,82		15.500		15.500
2021-05-20	2021-05-19	4	Graves Adrienne L	ISEE	Restricted Stock Units	A - Award	D			7.500		7.500
2021-05-20	2021-05-19	4	Graves Adrienne L	ISEE	Stock Option (Right to Buy)	A - Award	D	6,82		15.500		15.500
2021-05-20	2021-05-19	4	Bolte Axel	ISEE	Restricted Stock Units	A - Award	D			7.500		7.500
2021-05-20	2021-05-19	4	Bolte Axel	ISEE	Stock Option (Right to Buy)	A - Award	D	6,82		15.500		15.500
2021-05-04	2021-05-03	4	Dugel Pravin	ISEE	Restricted Stock Units	A - Award	D			17.250		17.250
2021-05-04	2021-05-03	4	Dugel Pravin	ISEE	Stock Option (Right to Buy)	A - Award	D	7,17		35.000		35.000
2021-04-05	2021-04-05	4	Dugel Pravin	ISEE	Common Stock	S - Sale	D		6,3400	-28.301	-179		41.699
2021-04-05	2021-04-01	4	Dugel Pravin	ISEE	Restricted Stock Units	M - Exercise	D			-20.000		0
2021-04-05	2021-04-01	4	Dugel Pravin	ISEE	Restricted Stock Units	M - Exercise	D			-50.000		150.000
2021-04-05	2021-04-01	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D			20.000			70.000
2021-04-05	2021-04-01	4	Dugel Pravin	ISEE	Common Stock	M - Exercise	D			50.000			50.000
2021-01-05	2021-01-04	4	Westby Keith	ISEE	Common Stock	S - Sale	D		6,8500	-11.875	-81		86.466
2021-01-05	2020-12-31	4	Westby Keith	ISEE	Restricted Stock Units	M - Exercise	D			-32.500		32.500
2021-01-05	2020-12-31	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			32.500			98.341
2021-01-05	2021-01-04	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		6,8500	-11.875	-81		80.165
2021-01-05	2020-12-31	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-32.500		32.500
2021-01-05	2020-12-31	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			32.500			92.040
2020-12-22	2020-12-18	4	Carroll David Francis	ISEE	Restricted Stock Units	A - Award	D			57.500		57.500
2020-12-22	2020-12-18	4	Carroll David Francis	ISEE	Stock Option (Right to Buy)	A - Award	D	7,50		115.000		115.000
2020-12-22	2020-12-18	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	A - Award	D			146.630		146.630
2020-12-22	2020-12-18	4	SBLENDORIO GLENN	ISEE	Stock Option (Right to Buy)	A - Award	D	7,50		293.130		293.130
2020-12-22	2020-12-18	4	Westby Keith	ISEE	Restricted Stock Units	A - Award	D			50.000		50.000
2020-12-22	2020-12-18	4	Westby Keith	ISEE	Stock Option (Right to Buy)	A - Award	D	7,50		100.000		100.000
2020-12-22	2020-12-18	4	Dugel Pravin	ISEE	Restricted Stock Units	A - Award	D			55.000		55.000
2020-12-22	2020-12-18	4	Dugel Pravin	ISEE	Stock Option (Right to Buy)	A - Award	D	7,50		110.000		110.000
2020-12-22	2020-12-18	4	GUYER DAVID R	ISEE	Restricted Stock Units	A - Award	D			102.630		102.630
2020-12-22	2020-12-18	4	GUYER DAVID R	ISEE	Stock Option (Right to Buy)	A - Award	D	7,50		205.150		205.150
2020-12-15	2020-12-14	4	GUYER DAVID R	ISEE	Common Stock	S - Sale	D		7,1600	-9.270	-66		70.113
2020-12-15	2020-12-12	4	GUYER DAVID R	ISEE	Restricted Stock Units	M - Exercise	D			-17.200		34.400
2020-12-15	2020-12-12	4	GUYER DAVID R	ISEE	Common Stock	M - Exercise	D			17.200			79.383
2020-12-15	2020-12-14	4	Westby Keith	ISEE	Common Stock	S - Sale	D		7,1600	-4.527	-32		65.841
2020-12-15	2020-12-12	4	Westby Keith	ISEE	Restricted Stock Units	M - Exercise	D			-12.500		25.000
2020-12-15	2020-12-12	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			12.500			70.368
2020-12-15	2020-12-12	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-12.500		25.000
2020-12-15	2020-12-12	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			12.500			59.540
2020-12-15	2020-12-12	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	M - Exercise	D			-22.950		45.900
2020-12-15	2020-12-12	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			22.950			273.773
2020-12-11	2020-12-10	4	GUYER DAVID R	ISEE	Common Stock	S - Sale	D		6,9600	-9.602	-67		62.183
2020-12-11	2020-12-09	4	GUYER DAVID R	ISEE	Restricted Stock Units	A - Award	D			-17.813		53.437
2020-12-11	2020-12-09	4	GUYER DAVID R	ISEE	Common Stock	M - Exercise	D			17.813			71.785
2020-12-11	2020-12-09	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	M - Exercise	D			-23.750		71.250
2020-12-11	2020-12-09	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			23.750			250.823
2020-12-11	2020-12-09	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-10.000		30.000
2020-12-11	2020-12-09	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			10.000			47.040
2020-12-11	2020-12-10	4	Westby Keith	ISEE	Common Stock	S - Sale	D		6,9600	-3.676	-26		57.868
2020-12-11	2020-12-09	4	Westby Keith	ISEE	Restricted Stock Units	M - Exercise	D			-10.000		30.000
2020-12-11	2020-12-09	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			10.000			61.544
2020-07-17	2020-07-15	4	Blumenkranz Mark S.	ISEE	Restricted Stock Units	A - Award	D			15.000		15.000
2020-07-17	2020-07-15	4	Blumenkranz Mark S.	ISEE	Stock Option (Right to Buy)	A - Award	D	4,48		31.000		31.000
2020-07-06	2020-07-01	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-7.500		0
2020-07-06	2020-07-01	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			7.500			33.707
2020-06-23	2020-06-19	4	Versant Venture Capital IV, L.P. footnote	ISEE	Common Stock	J - Other	I			-34.282			0
2020-06-23	2020-06-19	4	Versant Venture Capital IV, L.P. footnote	ISEE	Common Stock	J - Other	I			34.282			34.282
2020-06-23	2020-06-19	4	Versant Venture Capital IV, L.P. footnote	ISEE	Common Stock	J - Other	I			-21.597			10.798
2020-06-23	2020-06-19	4	Versant Venture Capital IV, L.P. footnote	ISEE	Common Stock	J - Other	I			-3.428.221			1.714.111
2020-06-11	2020-06-09	4	Henderson Jane	ISEE	Stock Option (Right to Buy)	A - Award	D	4,14		16.000		16.000
2020-06-11	2020-06-09	4	Graves Adrienne L	ISEE	Stock Option (Right to Buy)	A - Award	D	4,14		16.000		16.000
2020-06-11	2020-06-09	4	Roberts Calvin W.	ISEE	Stock Option (Right to Buy)	A - Award	D	4,14		16.000		16.000
2020-06-11	2020-06-09	4	Bolte Axel	ISEE	Stock Option (Right to Buy)	A - Award	D	4,14		16.000		16.000
2020-04-03	2020-04-01	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	M - Exercise	D			-18.750		0
2020-04-03	2020-04-01	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			18.750			225.061
2020-01-07	2020-01-06	4	GUYER DAVID R	ISEE	Common Stock	S - Sale	D		8,0700	-3.367	-27		53.972
2020-01-07	2020-01-04	4	GUYER DAVID R	ISEE	Restricted Stock Units	M - Exercise	D			-6.250		0
2020-01-07	2020-01-04	4	GUYER DAVID R	ISEE	Common Stock	M - Exercise	D			6.250			57.339
2020-01-07	2020-01-06	4	Westby Keith	ISEE	Common Stock	S - Sale	D		8,0700	-293	-2		40.983
2020-01-07	2020-01-04	4	Westby Keith	ISEE	Restricted Stock Units	M - Exercise	D			-700		0
2020-01-07	2020-01-04	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			700			41.276
2019-12-16	2019-12-13	4	Westby Keith	ISEE	Common Stock	S - Sale	D		6,6000	-4.530	-30		40.576
2019-12-16	2019-12-12	4	Westby Keith	ISEE	Restricted Stock Units	M - Exercise	D			-12.500		37.500
2019-12-16	2019-12-12	4	Westby Keith	ISEE	Common Stock	M - Exercise	D			12.500			45.106
2019-12-16	2019-12-13	4	GUYER DAVID R	ISEE	Common Stock	S - Sale	D		6,6000	-9.275	-61		51.089
2019-12-16	2019-12-12	4	GUYER DAVID R	ISEE	Restricted Stock Units	M - Exercise	D			-17.200		51.600
2019-12-16	2019-12-12	4	GUYER DAVID R	ISEE	Common Stock	M - Exercise	D			17.200			60.364
2019-12-16	2019-12-12	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	M - Exercise	D			-22.950		68.850
2019-12-16	2019-12-12	4	SBLENDORIO GLENN	ISEE	Common Stock	M - Exercise	D			22.950			199.804
2019-12-16	2019-12-12	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-12.500		37.500
2019-12-16	2019-12-12	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			12.500			26.207
2019-12-11	2019-12-09	4	GUYER DAVID R	ISEE	Restricted Stock Units	A - Award	D			71.250		71.250
2019-12-11	2019-12-09	4	GUYER DAVID R	ISEE	Stock Option (Right to Buy)	A - Award	D	5,22		142.500		142.500
2019-12-11	2019-12-10	4	SBLENDORIO GLENN	ISEE	Common Stock	P - Purchase	D		4,0000	62.500	250		176.854
2019-12-11	2019-12-09	4	SBLENDORIO GLENN	ISEE	Restricted Stock Units	A - Award	D			95.000		95.000
2019-12-11	2019-12-09	4	SBLENDORIO GLENN	ISEE	Stock Option (Right to Buy)	A - Award	D	5,22		190.000		190.000
2019-12-11	2019-12-09	4	Westby Keith	ISEE	Restricted Stock Units	A - Award	D			65.000		65.000
2019-12-11	2019-12-09	4	Westby Keith	ISEE	Restricted Stock Units	A - Award	D			40.000		40.000
2019-12-11	2019-12-09	4	Westby Keith	ISEE	Stock Option (Right to Buy)	A - Award	D	5,22		75.000		75.000
2019-12-11	2019-12-09	4	Carroll David Francis	ISEE	Restricted Stock Units	A - Award	D			65.000		65.000
2019-12-11	2019-12-09	4	Carroll David Francis	ISEE	Restricted Stock Units	A - Award	D			40.000		40.000
2019-12-11	2019-12-09	4	Carroll David Francis	ISEE	Stock Option (Right to Buy)	A - Award	D	5,22		75.000		75.000
2019-11-18	2019-11-15	4	SBLENDORIO GLENN	ISEE	Common Stock	P - Purchase	D		3,1234	15.000	47		114.354
2019-07-03	2019-07-02	4	Carroll David Francis	ISEE	Common Stock	S - Sale	D		1,2500	-2.773	-3		13.707
2019-07-03	2019-07-01	4	Carroll David Francis	ISEE	Restricted Stock Units	M - Exercise	D			-7.500		7.500
2019-07-03	2019-07-01	4	Carroll David Francis	ISEE	Common Stock	M - Exercise	D			7.500			16.480
2019-05-16	2019-05-15	4	Bolte Axel	ISEE	Stock Option (Right to Buy)	A - Award	D	1,39		16.000		16.000
2019-05-16	2019-05-15	4	Redlick David E	ISEE	Stock Option (Right to Buy)	A - Award	D	1,39		16.000		16.000
2019-05-16	2019-05-15	4	Graves Adrienne L	ISEE	Stock Option (Right to Buy)	A - Award	D	1,39		16.000		16.000
2019-05-16	2019-05-15	4	Henderson Jane	ISEE	Stock Option (Right to Buy)	A - Award	D	1,39		16.000		16.000
2019-05-16	2019-05-15	4	Roberts Calvin W.	ISEE	Stock Option (Right to Buy)	A - Award	D	1,39		16.000		16.000
2019-05-13	2019-05-10	4	SBLENDORIO GLENN	ISEE	Common Stock	P - Purchase	D		1,4800	25.000	37		93.105
2019-04-03	2019-04-02	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		1,4300	-6.914	-10		68.105
2019-04-03	2019-04-01	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	M - Exercise	D			-18.750		18.750
2019-04-03	2019-04-01	4	SBLENDORIO GLENN	OPHT	Common Stock	M - Exercise	D			18.750			75.019
2019-01-16	2019-01-14	4	Versant Venture Capital IV, L.P.	OPHT	Common Stock	J - Other	I		2,2984	817	2		32.394
2019-01-16	2019-01-14	4	Versant Venture Capital IV, L.P.	OPHT	Common Stock	J - Other	I		2,2984	129.709	298		5.142.333
2019-01-07	2019-01-07	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		1,3000	-3.859	-5		43.164
2019-01-07	2019-01-04	4	GUYER DAVID R	OPHT	Restricted Stock Units	M - Exercise	D			-6.250		6.250
2019-01-07	2019-01-04	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D			6.250			47.023
2019-01-07	2019-01-07	4	Westby Keith	OPHT	Common Stock	S - Sale	D		1,3000	-299	-0		32.606
2019-01-07	2019-01-04	4	Westby Keith	OPHT	Restricted Stock Units	M - Exercise	D			-700		700
2019-01-07	2019-01-04	4	Westby Keith	OPHT	Common Stock	M - Exercise	D			700			32.905
2019-01-04	2019-01-03	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		1,2400	-3.637	-5		40.773
2019-01-04	2019-01-02	4	GUYER DAVID R	OPHT	Restricted Stock Units	M - Exercise	D			-5.750		0
2019-01-04	2019-01-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D			5.750			44.410
2019-01-04	2019-01-03	4	Westby Keith	OPHT	Common Stock	S - Sale	D		1,2400	-342	-0		32.205
2019-01-04	2019-01-02	4	Westby Keith	OPHT	Restricted Stock Units	M - Exercise	D			-781		0
2019-01-04	2019-01-02	4	Westby Keith	OPHT	Common Stock	M - Exercise	D			781			32.547
2019-01-03	2019-01-01	4	Roberts Calvin W.	OPHT	Stock Option (Right to Buy)	A - Award	D	1,20		32.000		32.000
2018-12-14	2018-12-12	4	Graves Adrienne L	OPHT	Stock Option (Right to Buy)	A - Award	D	1,45		32.000		32.000
2018-12-14	2018-12-12	4	Carroll David Francis	OPHT	Restricted Stock Units	A - Award	D			50.000		50.000
2018-12-14	2018-12-12	4	Carroll David Francis	OPHT	Stock Option (Right to Buy)	A - Award	D	1,45		100.000		100.000
2018-12-14	2018-12-12	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	A - Award	D			91.800		91.800
2018-12-14	2018-12-12	4	SBLENDORIO GLENN	OPHT	Stock Option (Right to Buy)	A - Award	D	1,45		183.500		183.500
2018-12-14	2018-12-12	4	Westby Keith	OPHT	Restricted Stock Units	A - Award	D			50.000		50.000
2018-12-14	2018-12-12	4	Westby Keith	OPHT	Stock Option (Right to Buy)	A - Award	D	1,45		100.000		100.000
2018-12-14	2018-12-12	4	GUYER DAVID R	OPHT	Restricted Stock Units	A - Award	D			68.800		68.800
2018-12-14	2018-12-12	4	GUYER DAVID R	OPHT	Stock Option (Right to Buy)	A - Award	D	1,45		137.500		137.500
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						10.056.825
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						10.056.825
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						10.056.825
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						5.075.778
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						10.056.825
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						5.075.778
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						5.075.778
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						10.056.825
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						5.075.778
2018-11-09		3	Versant Ventures IV, LLC	OPHT	Common Stock		I						5.075.778
2018-07-11	2018-05-23	4	ROSS MICHAEL JAY	OPHT	Stock Option (Right to Buy)	A - Award	D	2,78		16.000		16.000
2018-07-11	2018-05-23	4	Redlick David E	OPHT	Stock Option (Right to Buy)	A - Award	D	2,78		16.000		16.000
2018-07-11	2018-05-23	4	Henderson Jane	OPHT	Stock Option (Right to Buy)	A - Award	D	2,78		16.000		16.000
2018-07-11	2018-05-23	4	Bolte Axel	OPHT	Stock Option (Right to Buy)	A - Award	D	2,78		16.000		16.000
2018-07-03	2018-07-02	4	Carroll David Francis	OPHT	Common Stock	S - Sale	D		2,6800	-2.736	-7		8.980
2018-07-03	2018-07-01	4	Carroll David Francis	OPHT	Restricted Stock Units	M - Exercise	D			-7.500		15.000
2018-07-03	2018-07-01	4	Carroll David Francis	OPHT	Common Stock	M - Exercise	D			7.500			11.716
2018-04-03	2018-04-02	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		2,6900	-6.838	-18		48.407
2018-04-03	2018-04-01	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	M - Exercise	D			-18.750		37.500
2018-04-03	2018-04-01	4	SBLENDORIO GLENN	OPHT	Common Stock	M - Exercise	D			18.750			55.245
2018-01-17	2018-01-13	4	Henderson Jane	OPHT	Stock Option (Right to Buy)	A - Award	D	2,85		32.000		32.000
2018-01-05	2018-01-05	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		3,1700	-3.798	-12		38.660
2018-01-05	2018-01-04	4	GUYER DAVID R	OPHT	Restricted Stock Units	M - Exercise	D			-6.250		12.500
2018-01-05	2018-01-04	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D			6.250			42.458
2018-01-05	2018-01-05	4	Westby Keith	OPHT	Common Stock	S - Sale	D		3,1700	-317	-1		24.983
2018-01-05	2018-01-04	4	Westby Keith	OPHT	Restricted Stock Units	M - Exercise	D			-700		1.400
2018-01-05	2018-01-04	4	Westby Keith	OPHT	Common Stock	M - Exercise	D			700			25.300
2018-01-05	2018-01-05	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		3,1700	-602	-2		16.462
2018-01-05	2018-01-04	4	WOOD BARBARA A	OPHT	Restricted Stock Units	M - Exercise	D			-1.200		2.400
2018-01-05	2018-01-04	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D			1.200			17.064
2018-01-04	2018-01-03	4	Westby Keith	OPHT	Common Stock	S - Sale	D		3,2400	-356	-1		24.600
2018-01-04	2018-01-02	4	Westby Keith	OPHT	Restricted Stock Units	M - Exercise	D			-781		781
2018-01-04	2018-01-02	4	Westby Keith	OPHT	Common Stock	M - Exercise	D			781			24.956
2018-01-04	2018-01-03	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		3,2400	-694	-2		15.864
2018-01-04	2018-01-02	4	WOOD BARBARA A	OPHT	Restricted Stock Units	M - Exercise	D			-1.375		1.375
2018-01-04	2018-01-02	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D			1.375			16.558
2018-01-04	2018-01-03	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		3,2400	-3.516	-11		36.208
2018-01-04	2018-01-02	4	GUYER DAVID R	OPHT	Restricted Stock Units	M - Exercise	D			-5.750		5.750
2018-01-04	2018-01-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D			5.750			39.724
2018-01-03	2018-01-02	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		3,1900	-5.289	-17		15.183
2018-01-03	2017-12-29	4	WOOD BARBARA A	OPHT	Restricted Stock Units	M - Exercise	D			-12.140		0
2018-01-03	2017-12-29	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D			12.140			20.472
2018-01-03	2018-01-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		3,1900	-16.520	-53		33.974
2018-01-03	2017-12-29	4	GUYER DAVID R	OPHT	Restricted Stock Units	M - Exercise	D			-30.480		0
2018-01-03	2017-12-29	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D			30.480			50.494
2018-01-03	2018-01-02	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		3,1900	-8.089	-26		36.495
2018-01-03	2017-12-29	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	M - Exercise	D			-20.420		0
2018-01-03	2017-12-29	4	SBLENDORIO GLENN	OPHT	Common Stock	M - Exercise	D			20.420			44.584
2017-12-21	2017-12-19	4	Westby Keith	OPHT	Stock Option (Right to Buy)	A - Award	D	2,94		150.000		150.000
2017-12-21	2017-12-19	4	GUYER DAVID R	OPHT	Stock Option (Right to Buy)	A - Award	D	2,94		300.000		300.000
2017-12-21	2017-12-19	4	SBLENDORIO GLENN	OPHT	Stock Option (Right to Buy)	A - Award	D	2,94		400.000		400.000
2017-12-21	2017-12-19	4	Carroll David Francis	OPHT	Stock Option (Right to Buy)	A - Award	D	2,94		150.000		150.000
2017-07-05	2017-07-05	4	Carroll David Francis	OPHT	Common Stock	S - Sale	D		2,5800	-3.284	-8		4.216
2017-07-05	2017-07-01	4	Carroll David Francis	OPHT	Restricted Stock Units	M - Exercise	D			-7.500		22.500
2017-07-05	2017-07-01	4	Carroll David Francis	OPHT	Common Stock	M - Exercise	D			7.500			7.500
2017-07-05	2017-07-05	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		2,5800	-7.828	-20		24.164
2017-07-05	2017-06-30	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	M - Exercise	D			-20.420		20.420
2017-07-05	2017-06-30	4	SBLENDORIO GLENN	OPHT	Common Stock	M - Exercise	D			20.420			31.992
2017-07-05	2017-07-05	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		2,5800	-5.119	-13		8.332
2017-07-05	2017-06-30	4	WOOD BARBARA A	OPHT	Restricted Stock Units	M - Exercise	D			-12.140		12.140
2017-07-05	2017-06-30	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D			12.140			13.451
2017-07-05	2017-07-05	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		2,5800	-17.678	-46		20.014
2017-07-05	2017-06-30	4	GUYER DAVID R	OPHT	Restricted Stock Units	M - Exercise	D			-30.480		30.480
2017-07-05	2017-06-30	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D			30.480			37.692
2017-06-14	2017-06-13	4	Redlick David E	OPHT	Common Stock	S - Sale	D		2,5200	-700	-2		1.050
2017-05-22	2017-05-19	4	Redlick David E	OPHT	Stock Option (Right to Buy)	A - Award	D	2,46		16.000		16.000
2017-05-22	2017-05-18	4	Redlick David E	OPHT	Restricted Stock Units	M - Exercise	D			-1.750		0
2017-05-22	2017-05-18	4	Redlick David E	OPHT	Common Stock	M - Exercise	D			1.750			1.750
2017-05-22	2017-05-19	4	Bolte Axel	OPHT	Stock Option (Right to Buy)	A - Award	D	2,46		16.000		16.000
2017-05-22	2017-05-19	4	ROSS MICHAEL JAY	OPHT	Stock Option (right to buy)	A - Award	D	2,46		16.000		16.000
2017-05-22	2017-05-18	4	ROSS MICHAEL JAY	OPHT	Restricted Stock Units	M - Exercise	D			-1.750		0
2017-05-22	2017-05-18	4	ROSS MICHAEL JAY	OPHT	Common Stock	M - Exercise	D			1.750			3.500
2017-04-25	2017-04-24	4	Carroll David Francis	OPHT	Stock Option (Right To Buy)	A - Award	D	2,81		63.500		63.500
2017-04-04	2017-04-03	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		3,5600	-7.388	-26		11.572
2017-04-04	2017-04-01	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	M - Exercise	D			-18.750		56.250
2017-04-04	2017-04-01	4	SBLENDORIO GLENN	OPHT	Common Stock	M - Exercise	D			18.750			18.960
2017-02-14	2016-08-11	5	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	G - Gift	D			-90.000			11.531
2017-02-14	2016-08-10	5	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	G - Gift	D			-30.000			11.531
2017-02-01		3	Westby Keith	OPHT	Common Stock		D						48.350
2017-02-01		3	Westby Keith	OPHT	Common Stock		D						48.350
2017-02-01	2017-01-30	4	SBLENDORIO GLENN	OPHT	Stock Option (Right to Buy)	A - Award	D	4,52		260.000		260.000
2017-02-01	2017-01-30	4	WOOD BARBARA A	OPHT	Stock Option (Right to Buy)	A - Award	D	4,52		38.000		38.000
2017-02-01	2017-01-30	4	GUYER DAVID R	OPHT	Stock Option (Right to Buy)	A - Award	D	4,52		260.000		260.000
2017-02-01	2017-01-30	4	Westby Keith	OPHT	Stock Option (Right to Buy)	A - Award	D	4,52		60.000		60.000
2017-01-23	2016-12-30	4	Bolte Axel	OPHT	Common Stock	S - Sale	D		4,8300	-6.000	-29		0
2017-01-19	2017-01-17	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	A - Award	D			40.840		40.840
2017-01-19	2017-01-17	4	GUYER DAVID R	OPHT	Restricted Stock Units	A - Award	D			60.960		60.960
2017-01-19	2017-01-17	4	WOOD BARBARA A	OPHT	Restricted Stock Units	A - Award	D			24.280		24.280
2017-01-06	2017-01-05	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		4,9600	-815	-4		15.813
2017-01-06	2017-01-05	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		4,9600	-3.029	-15		16.628
2017-01-06	2017-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Restricted Stock Units	M - Exercise	D			1.325		3.975
2017-01-06	2017-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Restricted Stock Units	M - Exercise	D			4.925		14.775
2017-01-06	2017-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D			1.325			19.657
2017-01-06	2017-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D			4.925			18.332
2017-01-06	2017-01-05	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		4,9600	-3.785	-19		7.212
2017-01-06	2017-01-04	4	GUYER DAVID R	OPHT	Restricted Stock Units	M - Exercise	D			-6.250		18.750
2017-01-06	2017-01-04	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D			6.250			10.997
2017-01-06	2017-01-05	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		4,9600	-589	-3		1.311
2017-01-06	2017-01-04	4	WOOD BARBARA A	OPHT	Restricted Stock Units	M - Exercise	D			-1.200		3.600
2017-01-06	2017-01-04	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D			1.200			1.900
2017-01-06	2017-01-05	4	Bjarke Henric Bjorn	OPHT	Common Stock	S - Sale	D		4,9600	-316	-2		1.384
2017-01-06	2017-01-04	4	Bjarke Henric Bjorn	OPHT	Restricted Stock Units	M - Exercise	D			-700		2.100
2017-01-06	2017-01-04	4	Bjarke Henric Bjorn	OPHT	Common Stock	M - Exercise	D			700			1.700
2017-01-04	2017-01-03	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		4,9000	-675	-3		700
2017-01-04	2017-01-02	4	WOOD BARBARA A	OPHT	Restricted Stock Units	M - Exercise	D			-1.375		2.750
2017-01-04	2017-01-02	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D			1.375			1.375
2017-01-04	2017-01-03	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		4,9000	-3.484	-17		4.747
2017-01-04	2017-01-02	4	GUYER DAVID R	OPHT	Restricted Stock Units	M - Exercise	D			-5.750		11.500
2017-01-04	2017-01-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D			5.750			8.231
2017-01-04	2017-01-03	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		4,9000	-2.999	-15		13.407
2017-01-04	2017-01-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Restricted Stock Units	M - Exercise	D			-4.875		9.750
2017-01-04	2017-01-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D			4.875			16.406
2016-12-27	2016-12-23	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		4,9200	-746	-4		0
2016-12-23	2016-12-22	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		4,8531	-1.079	-5		0
2016-12-16	2016-12-15	4	Novo A/S	OPHT	Common Stock	S - Sale	D		4,7215	-1.405.487	-6.636		0
2016-12-16	2016-12-14	4	Novo A/S	OPHT	Common Stock	S - Sale	D		4,9716	-2.205.000	-10.962		1.405.487
2016-11-03	2016-11-01	4	GUYER DAVID R	OPHT	Stock Options (Right to Buy)	M - Exercise	D	10,03		-22.060		105.636
2016-11-03	2016-11-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		36,8600	-3.820	-141		2.481
2016-11-03	2016-11-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		35,9300	-7.710	-277		6.301
2016-11-03	2016-11-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		34,9300	-10.530	-368		14.011
2016-11-03	2016-11-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	22.060	221		24.541
2016-10-05	2016-10-03	4	GUYER DAVID R	OPHT	Stock Options (Right to Buy)	M - Exercise	D	10,03		-16.210		8.334
2016-10-05	2016-10-03	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		45,9700	-1.600	-74		2.481
2016-10-05	2016-10-03	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		44,7700	-6.632	-297		4.081
2016-10-05	2016-10-03	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		44,0000	-13.828	-608		10.713
2016-10-05	2016-10-03	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	16.210	163		24.541
2016-10-03	2016-09-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		56,9000	-2.000	-114		11.531
2016-10-03	2016-09-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		55,7500	-8.096	-451		13.531
2016-10-03	2016-09-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		54,9300	-2.612	-143		21.627
2016-10-03	2016-09-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		54,1300	-7.292	-395		24.239
2016-09-06	2016-09-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		52,5800	-24.060	-1.265		8.331
2016-08-31	2016-08-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		52,8000	-20.000	-1.056		31.531
2016-08-04	2016-08-02	4	SMITH IAN F	OPHT	Stock Option (Right to Buy)	A - Award	D	62,63		20.000		20.000
2016-08-03	2016-08-01	4	GUYER DAVID R	OPHT	Stock Options (Right to Buy)	M - Exercise	D	10,03		-24.060		24.544
2016-08-03	2016-08-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		65,0600	-2.805	-182		32.391
2016-08-03	2016-08-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		64,3900	-21.255	-1.369		35.196
2016-08-03	2016-08-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	24.060	241		56.451
2016-08-02	2016-07-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		64,6200	-4.500	-291		171.531
2016-08-02	2016-07-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		64,0900	-15.500	-993		176.031
2016-07-06	2016-07-01	4	GUYER DAVID R	OPHT	Stock Options (Right to Buy)	M - Exercise	D	10,03		-24.060		48.604
2016-07-06	2016-07-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		52,7500	-800	-42		32.391
2016-07-06	2016-07-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		52,3800	-17.960	-941		33.191
2016-07-06	2016-07-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		51,1300	-5.300	-271		51.151
2016-07-06	2016-07-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	24.060	241		56.451
2016-07-01	2016-06-30	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		51,8600	-2.700	-140		191.531
2016-07-01	2016-06-30	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		50,9400	-19.146	-975		194.231
2016-07-01	2016-06-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D			40.000			213.377
2016-07-01	2016-06-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		51,9400	-1.615	-84		173.377
2016-07-01	2016-06-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		51,3700	-18.385	-944		174.992
2016-06-07	2016-06-03	4	Bolte Axel	OPHT	Common Stock	P - Purchase	D		56,9700	3.500	199		6.000
2016-06-03	2016-06-02	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		57,2000	-671	-38		1.079
2016-06-03	2016-06-01	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	M - Exercise	D			-1.750		0
2016-06-03	2016-06-01	4	SBLENDORIO GLENN	OPHT	Common Stock	M - Exercise	D			1.750			1.750
2016-06-03	2016-06-01	4	GUYER DAVID R	OPHT	Stock Options (Right to Buy)	M - Exercise	D	10,03		-30.060		72.664
2016-06-03	2016-06-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		53,4400	-4.294	-229		32.391
2016-06-03	2016-06-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		52,5900	-25.766	-1.355		36.685
2016-06-03	2016-06-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	30.060	302		62.451
2016-06-03	2016-06-02	4	ROSS MICHAEL JAY	OPHT	Restricted Stock Units	A - Award	D			1.750		1.750
2016-06-03	2016-06-02	4	ROSS MICHAEL JAY	OPHT	Stock Option (right to buy)	A - Award	D	58,29		7.000		7.000
2016-06-03	2016-06-01	4	ROSS MICHAEL JAY	OPHT	Common Stock	M - Exercise	D			1.750			1.750
2016-06-03	2016-06-02	4	Redlick David E	OPHT	Restricted Stock Units	A - Award	D			1.750		1.750
2016-06-03	2016-06-02	4	Redlick David E	OPHT	Stock Option (Right To Buy)	A - Award	D	58,29		7.000		7.000
2016-06-02	2016-05-31	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-1.185		14.214
2016-06-02	2016-05-31	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		54,0850	-300	-16		193.377
2016-06-02	2016-05-31	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		53,8100	-3.709	-200		193.677
2016-06-02	2016-05-31	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		53,3300	-14.317	-764		197.386
2016-06-02	2016-05-31	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		52,0300	-1.674	-87		211.703
2016-06-02	2016-05-31	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2160	1.185	16		213.377
2016-05-25	2016-05-24	4	Novo A/S	OPHT	COMMON STOCK	S - Sale	D		49,0000	-1.300.000	-63.700		3.610.489
2016-05-04	2016-05-02	4	GUYER DAVID R	OPHT	Stock Options (Right to Buy)	M - Exercise	D	10,03		-22.060		102.724
2016-05-04	2016-05-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		46,8200	-4.639	-217		32.391
2016-05-04	2016-05-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		46,0100	-17.421	-802		37.030
2016-05-04	2016-05-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	22.060	221		54.451
2016-05-03	2016-04-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-1.184		15.399
2016-05-03	2016-04-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-1.413		0
2016-05-03	2016-04-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		47,7800	-1.565	-75		212.192
2016-05-03	2016-04-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		46,7100	-18.435	-861		213.757
2016-05-03	2016-04-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2160	1.184	16		232.192
2016-05-03	2016-04-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	1.413	2		231.008
2016-04-05	2016-04-01	4	GUYER DAVID R	OPHT	Stock Options (Right to Buy)	M - Exercise	D	10,03				124.784
2016-04-05	2016-04-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		45,0900	-3.481	-157		32.391
2016-04-05	2016-04-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		44,4300	-12.969	-576		35.872
2016-04-05	2016-04-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		43,2100	-3.500	-151		48.841
2016-04-05	2016-04-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		41,9800	-2.110	-89		52.341
2016-04-05	2016-04-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	22.060	221		54.451
2016-04-05	2016-04-01	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	A - Award	D			75.000		75.000
2016-04-05	2016-04-01	4	SBLENDORIO GLENN	OPHT	Stock Option (Right To Buy)	A - Award	D	44,90		150.000		150.000
2016-03-31	2016-03-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-1.185		16.583
2016-03-31	2016-03-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-1.412		1.413
2016-03-31	2016-03-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		43,0700	-6.279	-270		229.595
2016-03-31	2016-03-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		42,0500	-5.118	-215		235.874
2016-03-31	2016-03-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		40,8300	-8.603	-351		240.992
2016-03-31	2016-03-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2160	1.185	16		249.595
2016-03-31	2016-03-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	1.412	2		248.410
2016-03-03	2016-03-01	4	GUYER DAVID R	OPHT	Stock Options (Right to Buy)	M - Exercise	D	10,03		-22.060		146.844
2016-03-03	2016-03-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		46,2100	-2.468	-114		32.391
2016-03-03	2016-03-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		45,5300	-16.592	-755		34.859
2016-03-03	2016-03-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		44,6100	-3.000	-134		51.451
2016-03-03	2016-03-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	22.060	221		54.451
2016-03-02	2016-02-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-3.262		17.768
2016-03-02	2016-02-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-2.825		2.825
2016-03-02	2016-02-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		45,9200	-1.935	-89		246.998
2016-03-02	2016-02-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		45,0400	-18.065	-814		248.933
2016-03-02	2016-02-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2160	3.262	43		266.998
2016-03-02	2016-02-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	2.825	5		263.736
2016-02-02	2016-01-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		54,6900	-100	-5		260.911
2016-02-02	2016-01-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		53,9200	-8.482	-457		261.011
2016-02-02	2016-01-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		53,3300	-11.418	-609		269.493
2016-02-01	2016-01-28	4	GUYER DAVID R	OPHT	Stock Options (Right to Buy)	M - Exercise	D	10,03		-18.598		168.904
2016-02-01	2016-01-28	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		56,2900	-600	-34		32.391
2016-02-01	2016-01-28	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		55,0300	-600	-33		32.991
2016-02-01	2016-01-28	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		54,1000	-3.200	-173		33.591
2016-02-01	2016-01-28	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		53,3500	-14.198	-757		36.791
2016-02-01	2016-01-28	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.598	187		50.989
2016-01-13	2016-01-11	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		65,3300	-499	-33		3.945
2016-01-13	2016-01-11	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		65,4500	-501	-33		4.444
2016-01-13	2016-01-11	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	D		66,3300	-1.001	-66		5.684
2016-01-13	2016-01-11	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	D		65,4500	-999	-65		6.685
2016-01-06	2016-01-04	4	Redlick David E	OPHT	Stock Option (Right to Buy)	A - Award	D	73,22		20.000		20.000
2016-01-06	2016-01-04	4	Bjarke Henric Bjorn	OPHT	Restricted Stock Units	A - Award	D			2.800		2.800
2016-01-06	2016-01-04	4	Bjarke Henric Bjorn	OPHT	Stock Option (Right To Buy)	A - Award	D	73,22		11.300		11.300
2016-01-06	2016-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Restricted Stock Units	A - Award	D			5.300		5.300
2016-01-06	2016-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right to Buy)	A - Award	D	73,22		16.300		16.300
2016-01-06	2016-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Restricted Stock Units	A - Award	D			19.700		19.700
2016-01-06	2016-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right to Buy)	A - Award	D	73,22		78.700		78.700
2016-01-06	2016-01-04	4	GUYER DAVID R	OPHT	Restricted Stock Units	A - Award	D			25.000		25.000
2016-01-06	2016-01-04	4	GUYER DAVID R	OPHT	Stock Option (Right to Buy)	A - Award	D	73,22		95.000		95.000
2016-01-06	2016-01-04	4	WOOD BARBARA A	OPHT	Restricted Stock Units	A - Award	D			4.800		4.800
2016-01-06	2016-01-04	4	WOOD BARBARA A	OPHT	Stock Option (Right to Buy)	A - Award	D	73,22		19.200		19.200
2016-01-06	2016-01-04	4	WOOD BARBARA A	OPHT	Stock Option (Right to Buy)	M - Exercise	D	24,49		-1.000		59.000
2016-01-06	2016-01-04	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		76,3700	-1.000	-76		746
2016-01-06	2016-01-04	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D		24,4900	1.000	24		1.746
2016-01-05	2016-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		74,9600	-85	-6		280.911
2016-01-05	2016-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		74,0500	-454	-34		280.996
2016-01-05	2016-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		72,9300	-881	-64		281.450
2016-01-05	2016-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		71,9300	-472	-34		282.331
2016-01-05	2016-01-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		71,1500	-677	-48		282.803
2016-01-05	2016-01-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Restricted Stock Units	M - Exercise	D			-4.875		14.625
2016-01-05	2016-01-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D			4.875			283.480
2016-01-05	2016-01-04	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		74,9600	-108	-8		32.391
2016-01-05	2016-01-04	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		74,0500	-578	-43		32.499
2016-01-05	2016-01-04	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		72,9300	-1.121	-82		33.077
2016-01-05	2016-01-04	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		71,9300	-600	-43		34.198
2016-01-05	2016-01-04	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		71,1500	-862	-61		34.798
2016-01-05	2016-01-02	4	GUYER DAVID R	OPHT	Restricted Stock Units	M - Exercise	D			-5.750		17.250
2016-01-05	2016-01-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D			5.750			35.660
2016-01-05	2016-01-04	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		74,9600	-21	-2		746
2016-01-05	2016-01-04	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		74,0500	-111	-8		767
2016-01-05	2016-01-04	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		72,9300	-216	-16		878
2016-01-05	2016-01-04	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		71,9300	-115	-8		1.094
2016-01-05	2016-01-04	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		71,1500	-166	-12		1.209
2016-01-05	2016-01-02	4	WOOD BARBARA A	OPHT	Restricted Stock Units	M - Exercise	D			-1.375		4.125
2016-01-05	2016-01-02	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D			1.375			1.375
2016-01-05	2016-01-04	4	ATIEH MICHAEL G	OPHT	Common Stock	S - Sale	D		74,9600	-4	-0		295
2016-01-05	2016-01-04	4	ATIEH MICHAEL G	OPHT	Common Stock	S - Sale	D		74,0500	-23	-2		299
2016-01-05	2016-01-04	4	ATIEH MICHAEL G	OPHT	Common Stock	S - Sale	D		72,9300	-45	-3		322
2016-01-05	2016-01-04	4	ATIEH MICHAEL G	OPHT	Common Stock	S - Sale	D		71,9300	-24	-2		367
2016-01-05	2016-01-04	4	ATIEH MICHAEL G	OPHT	Common Stock	S - Sale	D		71,1500	-34	-2		391
2016-01-05	2016-01-02	4	ATIEH MICHAEL G	OPHT	Restricted Stock Units	M - Exercise	D			-425		1.275
2016-01-05	2016-01-02	4	ATIEH MICHAEL G	OPHT	Common Stock	M - Exercise	D			425			425
2016-01-04	2015-12-30	4	SBLENDORIO GLENN	OPHT	Stock Option (right to buy)	M - Exercise	D	13,22		-2.000		11.084
2016-01-04	2015-12-30	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		80,0000	-2.000	-160		0
2016-01-04	2015-12-30	4	SBLENDORIO GLENN	OPHT	Common Stock	M - Exercise	D		13,2160	2.000	26		2.000
2016-01-04	2015-12-30	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-18.582		187.502
2016-01-04	2015-12-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		79,3100	-6.951	-551		29.910
2016-01-04	2015-12-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		78,5300	-11.631	-913		36.861
2016-01-04	2015-12-30	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		48.492
2015-12-31	2015-12-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-1.184		21.030
2015-12-31	2015-12-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		77,9500	-624	-49		278.605
2015-12-31	2015-12-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		77,0000	-560	-43		279.229
2015-12-31	2015-12-29	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2160	1.184	16		279.789
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	31,29		-14.583		72.917
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-5.923		22.214
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-5.530		5.650
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		79,0200	-200	-16		278.605
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		78,2000	-2.100	-164		278.805
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		77,3200	-14.636	-1.132		280.905
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		76,4200	-9.100	-695		295.541
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		31,2900	14.583	456		304.641
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2160	5.923	78		290.058
2015-12-28	2015-12-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	5.530	9		284.135
2015-12-14	2015-12-10	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		64,6300	-733	-47		4.945
2015-12-14	2015-12-10	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		63,9100	-267	-17		5.678
2015-12-14	2015-12-10	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	D		64,6300	-1.467	-95		7.684
2015-12-14	2015-12-10	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	D		63,9000	-533	-34		9.151
2015-12-03	2015-12-01	4	WOOD BARBARA A	OPHT	Stock Option (Right to Buy)	M - Exercise	D	24,49		-2.000		60.000
2015-12-03	2015-12-01	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		63,8300	-100	-6		0
2015-12-03	2015-12-01	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		63,2100	-1.900	-120		100
2015-12-03	2015-12-01	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D		24,4900	2.000	49		2.000
2015-12-02	2015-11-30	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		18.582		206.084
2015-12-02	2015-11-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		63,8000	-2.027	-129		29.910
2015-12-02	2015-11-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		63,2300	-5.049	-319		31.937
2015-12-02	2015-11-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		62,1500	-9.135	-568		36.986
2015-12-02	2015-11-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		61,0800	-2.371	-145		46.121
2015-12-02	2015-11-30	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		48.492
2015-11-25	2015-11-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	31,29		-25.683		87.500
2015-11-25	2015-11-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-1.532		11.180
2015-11-25	2015-11-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		60,6000	-7.844	-475		278.605
2015-11-25	2015-11-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		60,1400	-19.371	-1.165		286.449
2015-11-25	2015-11-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		31,2900	25.683	804		305.820
2015-11-25	2015-11-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	1.532	3		280.137
2015-11-19	2015-11-18	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		60,0000	-500	-30		5.945
2015-11-19	2015-11-18	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	D		60,0000	-1.000	-60		9.684
2015-11-12	2015-11-10	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		58,6900	-500	-29		6.445
2015-11-12	2015-11-10	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	D		58,6900	-1.000	-59		10.684
2015-11-12	2015-11-09	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		60,0000	-500	-30		6.945
2015-11-12	2015-11-09	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	D		60,0000	-1.000	-60		11.684
2015-11-06	2015-11-05	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		54,8000	-3.665	-201		278.605
2015-11-06	2015-11-05	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		53,9500	-4.200	-227		282.270
2015-11-06	2015-11-05	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		53,0600	-12.822	-680		286.470
2015-11-06	2015-11-04	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D			40.000			299.292
2015-11-04	2015-11-02	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		54,0000	-500	-27		7.445
2015-11-04	2015-11-02	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	D		54,0000	-1.000	-54		13.184
2015-11-03	2015-10-30	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		18.582		224.666
2015-11-03	2015-10-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		50,2700	-100	-5		29.910
2015-11-03	2015-10-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		49,8800	-18.482	-922		30.010
2015-11-03	2015-10-30	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		48.492
2015-10-23	2015-10-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-398		28.137
2015-10-23	2015-10-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	31,29		-26.817		113.183
2015-10-23	2015-10-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		45,1900	-100	-5		259.292
2015-10-23	2015-10-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		44,4400	-5.259	-234		259.392
2015-10-23	2015-10-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		43,2700	-13.556	-587		264.651
2015-10-23	2015-10-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		42,5200	-8.300	-353		278.207
2015-10-23	2015-10-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2160	398	5		286.507
2015-10-23	2015-10-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		31,2900	26.817	839		286.109
2015-10-19	2015-10-16	4	WOOD BARBARA A	OPHT	Stock Option (Right to Buy)	M - Exercise	D	24,49		-2.000		62.000
2015-10-19	2015-10-16	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		45,0000	-2.000	-90		0
2015-10-19	2015-10-16	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D		24,4900	2.000	49		2.000
2015-09-30	2015-09-29	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		18.582		243.248
2015-09-30	2015-09-29	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		39,1100	-2.534	-99		29.910
2015-09-30	2015-09-29	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		38,5700	-6.180	-238		32.444
2015-09-30	2015-09-29	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		37,4000	-3.953	-148		38.624
2015-09-30	2015-09-29	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		36,3700	-5.915	-215		42.577
2015-09-30	2015-09-29	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		48.492
2015-09-23	2015-09-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-13.991		42.867
2015-09-23	2015-09-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-13.224		0
2015-09-23	2015-09-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		49,2400	-500	-25		259.292
2015-09-23	2015-09-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		47,4500	-10.814	-513		259.792
2015-09-23	2015-09-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		46,1400	-4.300	-198		270.606
2015-09-23	2015-09-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		45,2600	-11.601	-525		274.906
2015-09-23	2015-09-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2160	13.991	185		286.507
2015-09-23	2015-09-21	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	13.224	22		272.516
2015-09-02		3	Bjarke Henric Bjorn By wife	OPHT	Common Stock		I						1.600
2015-09-02		3	Bjarke Henric Bjorn	OPHT	Common Stock		D						2.300
2015-09-02		3	Bjarke Henric Bjorn	OPHT	Common Stock		D						2.300
2015-09-02		3	Bjarke Henric Bjorn By wife	OPHT	Common Stock		I						1.600
2015-09-02	2015-08-31	4	Bjarke Henric Bjorn	OPHT	Stock Option (Right To Buy)	A - Award	D	44,03		120.000		120.000
2015-09-02	2015-08-31	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		18.582		261.830
2015-09-02	2015-08-31	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		45,3000	-8.498	-385		29.910
2015-09-02	2015-08-31	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		44,5350	-10.084	-449		38.408
2015-09-02	2015-08-31	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		48.492
2015-08-24	2015-08-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-1.820		13.224
2015-08-24	2015-08-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-25.395		12.712
2015-08-24	2015-08-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		49,6300	-7.942	-394		259.292
2015-08-24	2015-08-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		48,9600	-9.643	-472		267.234
2015-08-24	2015-08-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		47,8000	-9.630	-460		276.877
2015-08-24	2015-08-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	1.820	3		286.507
2015-08-24	2015-08-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	25.395	42		284.687
2015-08-11	2015-08-07	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-29.910		280.412
2015-08-11	2015-08-07	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	29.910	300		29.910
2015-08-03	2015-07-30	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-18.582		310.322
2015-08-03	2015-07-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		67,1500	-1.794	-120		0
2015-08-03	2015-07-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		66,4400	-11.488	-763		1.794
2015-08-03	2015-07-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		65,7900	-5.300	-349		13.282
2015-08-03	2015-07-30	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		18.582
2015-07-22	2015-07-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-27.215		38.107
2015-07-22	2015-07-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		70,1900	-300	-21		259.292
2015-07-22	2015-07-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		68,8000	-4.954	-341		259.592
2015-07-22	2015-07-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		67,9500	-11.663	-793		264.546
2015-07-22	2015-07-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		67,2600	-10.298	-693		276.209
2015-07-22	2015-07-20	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	27.215	45		286.507
2015-07-20	2015-07-17	4	SBLENDORIO GLENN	OPHT	Stock Option (right to buy)	M - Exercise	D	13,22		-2.000		13.084
2015-07-20	2015-07-17	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		70,0000	-2.000	-140		0
2015-07-20	2015-07-17	4	SBLENDORIO GLENN	OPHT	Common Stock	M - Exercise	D		13,2160	2.000	26		2.000
2015-07-20	2015-07-16	4	SBLENDORIO GLENN	OPHT	Common Stock	S - Sale	D		62,0000	-1.000	-62		0
2015-07-20	2013-09-30	4	SBLENDORIO GLENN	OPHT	Common Stock	P - Purchase	D		22,0000	1.000	22		1.000
2015-07-02	2015-07-01	4	WOOD BARBARA A	OPHT	Stock Option (Right to Buy)	M - Exercise	D	24,49		-2.000		64.000
2015-07-02	2015-07-01	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		51,9400	-2.000	-104		0
2015-07-02	2015-07-01	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D		24,4900	2.000	49		2.000
2015-07-01	2015-06-29	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-18.582		328.904
2015-07-01	2015-06-29	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		51,5100	-8.001	-412		0
2015-07-01	2015-06-29	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		50,7100	-10.581	-537		8.001
2015-07-01	2015-06-29	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		18.582
2015-06-29	2015-06-12	4	GALAKATOS NICHOLAS	OPHT	Common Stock	G - Gift	D			-1.020			14.184
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-14.331		14.382
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-3		0
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-42.583		0
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-37.377		0
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-7.937		0
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-68.157		0
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-88.904		0
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2200	14.331	189		259.292
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6500	3	0		244.961
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6500	42.583	70		244.958
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5900	37.377	59		202.375
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5900	7.937	13		164.998
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5900	68.157	108		157.061
2015-06-23	2015-06-19	4/A	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5900	88.904	141		88.904
2015-06-22	2015-06-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-2.471		65.322
2015-06-22	2015-06-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-9.529		0
2015-06-22	2015-06-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		50,1400	-3.900	-196		0
2015-06-22	2015-06-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		49,6000	-8.100	-402		3.900
2015-06-22	2015-06-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6520	2.471	4		2.471
2015-06-22	2015-06-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5930	9.529	15		9.529
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	13,22		-14.331		14.382
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-3		0
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-42.583		0
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-37.377		0
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-7.937		0
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-68.157		0
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-88.904		0
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		13,2200	14.331	189		14.331
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6500	3	0		3
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,6500	42.583	70		42.583
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5900	37.377	59		37.377
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5900	7.937	13		7.937
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5900	68.157	108		68.157
2015-06-22	2015-06-19	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5900	88.904	141		88.904
2015-06-08	2015-06-04	4	GALAKATOS NICHOLAS	OPHT	Restricted Stock Units	A - Award	D			1.750		1.750
2015-06-08	2015-06-04	4	GALAKATOS NICHOLAS	OPHT	Stock Option (Right To Buy)	A - Award	D	48,30		7.000		7.000
2015-06-08	2015-06-04	4	SBLENDORIO GLENN	OPHT	Restricted Stock Units	A - Award	D			1.750		1.750
2015-06-08	2015-06-04	4	SBLENDORIO GLENN	OPHT	Stock Option (Right To Buy)	A - Award	D	48,30		7.000		7.000
2015-06-08	2015-06-04	4	ROSS MICHAEL JAY	OPHT	Restricted Stock Units	A - Award	D			1.750		1.750
2015-06-08	2015-06-04	4	ROSS MICHAEL JAY	OPHT	Stock Option (right to buy)	A - Award	D	48,30		7.000		7.000
2015-06-01	2015-05-28	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-18.582		347.486
2015-06-01	2015-05-28	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		49,0900	-5.918	-291		0
2015-06-01	2015-05-28	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		48,6400	-10.264	-499		5.918
2015-06-01	2015-05-28	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		47,4000	-2.400	-114		16.182
2015-06-01	2015-05-28	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		18.582
2015-05-28	2015-05-26	4	GALAKATOS NICHOLAS	OPHT	Common Stock	J - Other	I			3.137			7.945
2015-05-28	2015-05-26	4	GALAKATOS NICHOLAS	OPHT	Common Stock	J - Other	D			7.319			15.204
2015-05-28	2015-05-26	4	GALAKATOS NICHOLAS	OPHT	Common Stock	J - Other	I			-1.554.744			0
2015-05-28	2015-05-26	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	J - Other	D			-1.554.744			0
2015-05-20	2015-05-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-12.000		5.802
2015-05-20	2015-05-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		52,1900	-1.300	-68		0
2015-05-20	2015-05-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		51,9300	-10.700	-556		1.300
2015-05-20	2015-05-18	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5930	12.000	19		12.000
2015-05-05	2015-05-01	4	WOOD BARBARA A	OPHT	Stock Option (Right to Buy)	M - Exercise	D	24,49		-2.000		66.000
2015-05-05	2015-05-01	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		45,8800	-2.000	-92		0
2015-05-05	2015-05-01	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D		24,4900	2.000	49		2.000
2015-04-30	2015-04-29	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-18.582		366.068
2015-04-30	2015-04-29	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		49,8500	-340	-17		0
2015-04-30	2015-04-29	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		49,0900	-5.582	-274		340
2015-04-30	2015-04-29	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		48,1300	-12.660	-609		5.922
2015-04-30	2015-04-29	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		18.582
2015-04-21	2015-04-17	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,59		-12.000		459
2015-04-21	2015-04-17	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		51,0900	-700	-36		0
2015-04-21	2015-04-17	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		50,4300	-11.300	-570		700
2015-04-21	2015-04-17	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	M - Exercise	D		1,5930	12.000	19		12.000
2015-04-01	2015-03-30	4	Bolte Axel	OPHT	Common Stock	P - Purchase	D		48,2700	500	24		2.500
2015-03-31	2015-03-30	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-18.582		384.650
2015-03-31	2015-03-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		48,9400	-1.800	-88		0
2015-03-31	2015-03-30	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		48,1900	-16.782	-809		1.800
2015-03-31	2015-03-30	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		18.582
2015-03-26	2015-03-25	4	Novo A/S	OPHT	SERIES A PREFERRED STOCK WARRANT (RIGHT TO BUY)	X - Other	D	0,06		-13.668		0
2015-03-26	2015-03-25	4	Novo A/S	OPHT	COMMON STOCK	X - Other	D		0,0590	13.668	1		4.910.487
2015-03-09	2015-03-05	4	Novo A/S	OPHT	COMMON STOCK	S - Sale	D		51,7500	-1.005.000	-52.009		4.896.819
2015-03-03	2015-03-02	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-18.582		403.232
2015-03-03	2015-03-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		53,8200	-4.171	-224		0
2015-03-03	2015-03-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		53,0500	-14.411	-765		4.171
2015-03-03	2015-03-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	18.582	186		18.582
2015-03-02	2015-03-02	4	WOOD BARBARA A	OPHT	Stock Option (Right to Buy)	M - Exercise	D	24,49		-2.000		68.000
2015-03-02	2015-03-02	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		53,7500	-100	-5		0
2015-03-02	2015-03-02	4	WOOD BARBARA A	OPHT	Common Stock	S - Sale	D		53,2300	-1.900	-101		100
2015-03-02	2015-03-02	4	WOOD BARBARA A	OPHT	Common Stock	M - Exercise	D		24,4900	2.000	49		2.000
2015-02-04	2015-02-02	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-15.018		421.814
2015-02-04	2015-02-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		55,4000	-1.300	-72		0
2015-02-04	2015-02-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		54,3100	-3.600	-196		1.300
2015-02-04	2015-02-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		53,5300	-4.400	-236		4.900
2015-02-04	2015-02-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		52,4300	-1.000	-52		9.300
2015-02-04	2015-02-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		51,5900	-4.718	-243		10.300
2015-02-04	2015-02-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	15.018	151		15.018
2015-01-06	2015-01-02	4	WOOD BARBARA A	OPHT	Restricted Stock Units	A - Award	D			5.500		22.500
2015-01-06	2015-01-02	4	WOOD BARBARA A	OPHT	Stock Option (Right to Buy)	A - Award	D	45,60		22.500		22.500
2015-01-06	2015-01-02	4	SMITH TODD N	OPHT	Restricted Stock Units	A - Award	D			1.400		1.400
2015-01-06	2015-01-02	4	SMITH TODD N	OPHT	Stock Option (Right to Buy)	A - Award	D	45,60		5.500		5.500
2015-01-06	2015-01-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Restricted Stock Units	A - Award	D			19.500		19.500
2015-01-06	2015-01-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right to Buy)	A - Award	D	45,60		78.000		78.000
2015-01-06	2015-01-02	4	ATIEH MICHAEL G	OPHT	Restricted Stock Units	A - Award	D			1.700		1.700
2015-01-06	2015-01-02	4	ATIEH MICHAEL G	OPHT	Stock Option (Right to Buy)	A - Award	D	45,60		6.500		6.500
2015-01-06	2015-01-02	4	GUYER DAVID R	OPHT	Restricted Stock Units	A - Award	D			23.000		23.000
2015-01-06	2015-01-02	4	GUYER DAVID R	OPHT	Option (Right to Buy)	A - Award	D	45,60		91.500		91.500
2015-01-06	2015-01-02	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-15.034		436.832
2015-01-06	2015-01-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		45,6800	-8.466	-387		0
2015-01-06	2015-01-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		44,9100	-6.568	-295		8.466
2015-01-06	2015-01-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	15.034	151		15.034
2014-12-03	2014-12-01	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-15.034		451.866
2014-12-03	2014-12-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		42,8000	-500	-21		0
2014-12-03	2014-12-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		41,9700	-4.300	-180		500
2014-12-03	2014-12-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		41,3500	-10.234	-423		4.800
2014-12-03	2014-12-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	15.034	151		15.034
2014-11-17	2014-11-13	4	Novo A/S	OPHT	COMMON STOCK	S - Sale	D		40,2000	-995.000	-39.999		5.901.819
2014-11-04	2014-11-03	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-15.034		19.486
2014-11-04	2014-11-03	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		41,3900	-800	-33		0
2014-11-04	2014-11-03	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		40,3000	-1.400	-56		800
2014-11-04	2014-11-03	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		39,5400	-12.834	-507		2.200
2014-11-04	2014-11-03	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	15.034	151		15.034
2014-10-07	2014-10-03	4	SMITH TODD N	OPHT	Stock Option (Right To Buy)	A - Award	D	38,41		150.000		150.000
2014-10-03	2014-09-30	4	ATIEH MICHAEL G	OPHT	Stock Option (Right To Buy)	A - Award	D	38,93		200.000		200.000
2014-10-03	2014-10-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		38,6600	-600	-23		1.965
2014-10-03	2014-10-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		37,5800	-3.647	-137		2.565
2014-10-03	2014-10-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		37,1400	-13.429	-499		6.212
2014-10-03	2014-10-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		38,0400	-1.965	-75		0
2014-10-03	2014-10-02	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-2.807		34.520
2014-10-03	2014-10-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		38,5200	-2.807	-108		0
2014-10-03	2014-10-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	2.807	28		2.807
2014-10-03	2014-10-01	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-12.227		37.327
2014-10-03	2014-10-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		38,6500	-300	-12		0
2014-10-03	2014-10-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		37,6100	-3.572	-134		300
2014-10-03	2014-10-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		37,1200	-8.355	-310		3.872
2014-10-03	2014-10-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	12.277	123		12.277
2014-09-08	2014-09-04	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-1.107		49.554
2014-09-08	2014-09-04	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		38,5800	-1.107	-43		0
2014-09-08	2014-09-04	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	1.107	11		1.107
2014-09-04	2014-09-02	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-12.727		50.661
2014-09-04	2014-09-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		38,3400	-1.718	-66		0
2014-09-04	2014-09-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		37,5800	-11.009	-414		1.718
2014-09-04	2014-09-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	12.727	128		12.727
2014-09-04	2014-09-02	4	PEACOCK BRUCE	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-6.191		21.834
2014-09-04	2014-09-02	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		38,2500	-900	-34		0
2014-09-04	2014-09-02	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		37,6500	-5.291	-199		900
2014-09-04	2014-09-02	4	PEACOCK BRUCE	OPHT	Common Stock	M - Exercise	D		1,6520	6.191	10		6.191
2014-09-04	2014-09-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		38,3500	-2.140	-82		19.641
2014-09-04	2014-09-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		37,6000	-16.846	-633		21.781
2014-08-04	2014-08-01	4	PEACOCK BRUCE	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-6.191		28.025
2014-08-04	2014-08-01	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		38,5500	-100	-4		0
2014-08-04	2014-08-01	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		37,7700	-6.091	-230		100
2014-08-04	2014-08-01	4	PEACOCK BRUCE	OPHT	Common Stock	M - Exercise	D		1,6520	6.191	10		6.191
2014-08-04	2014-08-01	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-13.136		63.388
2014-08-04	2014-08-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		38,6200	-800	-31		0
2014-08-04	2014-08-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		37,8000	-12.336	-466		800
2014-08-04	2014-08-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	13.136	132		13.136
2014-08-04	2014-08-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		38,6600	-400	-15		38.627
2014-08-04	2014-08-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		37,7800	-18.586	-702		39.027
2014-07-03	2014-07-01	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	M - Exercise	D	10,03		-15.034		76.524
2014-07-03	2014-07-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		41,6000	-3.482	-145		0
2014-07-03	2014-07-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		40,9200	-11.552	-473		3.482
2014-07-03	2014-07-01	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	15.034	151		15.034
2014-07-03	2014-07-01	4	PEACOCK BRUCE	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-7.739		34.216
2014-07-03	2014-07-01	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		41,6100	-2.002	-83		0
2014-07-03	2014-07-01	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		40,8800	-5.737	-235		2.002
2014-07-03	2014-07-01	4	PEACOCK BRUCE	OPHT	Common Stock	M - Exercise	D		1,6520	7.739	13		7.739
2014-07-03	2014-07-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		41,6100	-4.892	-204		57.613
2014-07-03	2014-07-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		40,8900	-14.094	-576		62.505
2014-06-18	2014-06-16	4	GALAKATOS NICHOLAS	OPHT	Common Stock	J - Other	I		44,2390	2.308	102		4.808
2014-06-18	2014-06-16	4	GALAKATOS NICHOLAS	OPHT	Common Stock	J - Other	D		44,2390	5.385	238		7.885
2014-06-18	2014-06-16	4	GALAKATOS NICHOLAS	OPHT	Common Stock	J - Other	I		44,2390	-1.143.844	-50.603		1.554.744
2014-06-16	2014-06-16	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		44,0000	-15.482	-681		2.698.588
2014-06-16	2014-06-13	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		44,0126	-82.277	-3.621		2.714.070
2014-06-16	2014-06-12	4	GALAKATOS NICHOLAS	OPHT	Common Stock	S - Sale	I		44,5106	-47.217	-2.102		2.796.347
2014-06-11	2014-06-11	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	S - Sale	I		44,3200	-500	-22		4.500
2014-06-11	2014-06-11	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	S - Sale	D		44,5314	-29.217	-1.301		2.843.564
2014-06-11	2014-06-10	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	S - Sale	D		46,8000	-200	-9		2.872.781
2014-06-11	2014-06-10	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	S - Sale	D		45,8956	-36.880	-1.693		2.872.981
2014-06-11	2014-06-10	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	S - Sale	D		44,6606	-79.824	-3.565		2.909.861
2014-06-11	2014-06-09	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	S - Sale	D		46,7837	-39.362	-1.841		2.989.685
2014-06-11	2014-06-09	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	S - Sale	D		46,0156	-25.697	-1.182		3.029.047
2014-06-06	2014-06-04	4	PATEL SAMIR CHANDRAKANT See footnote.	OPHT	Common Stock	J - Other	I			-384.984			0
2014-06-05	2014-06-04	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		42,5400	-18.100	-770		84.325
2014-06-05	2014-06-04	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		42,5400	-637.545	-27.121		2.970.133
2014-06-05	2014-06-04	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		42,5400	-655.645	-27.891		3.054.458
2014-06-05	2014-06-04	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		42,5400	-655.645	-27.891		3.054.458
2014-06-04	2014-06-02	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	D - Sale to Issuer	D	10,03		-13.526		91.558
2014-06-04	2014-06-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		40,8500	-950	-39		0
2014-06-04	2014-06-02	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		39,8800	-24.467	-976		950
2014-06-04	2014-06-02	4	GUYER DAVID R	OPHT	Common Stock	M - Exercise	D		10,0300	13.526	136		25.417
2014-06-04	2014-06-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		40,7500	-900	-37		76.599
2014-06-04	2014-06-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		39,8800	-26.973	-1.076		77.499
2014-06-04	2014-06-03	4	PEACOCK BRUCE	OPHT	Stock Option (Right To Buy)	D - Sale to Issuer	D	1,65		-5.094		41.955
2014-06-04	2014-06-03	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		40,4100	-5.094	-206		0
2014-06-04	2014-06-03	4	PEACOCK BRUCE	OPHT	Common Stock	M - Exercise	D		1,6520	5.094	8		5.094
2014-06-04	2014-06-02	4	PEACOCK BRUCE	OPHT	Stock Option (Right To Buy)	D - Sale to Issuer	D	1,65		-8.837		47.049
2014-06-04	2014-06-02	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		40,8000	-700	-29		0
2014-06-04	2014-06-02	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		39,8800	-8.137	-325		700
2014-06-04	2014-06-02	4	PEACOCK BRUCE	OPHT	Common Stock	M - Exercise	D		1,6520	8.837	15		8.837
2014-06-04	2014-06-03	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		40,8100	-14.022	-572		102.425
2014-06-04	2014-06-03	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		40,8100	-493.901	-20.156		3.607.678
2014-06-04	2014-06-03	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		40,8100	-507.923	-20.728		3.710.103
2014-06-04	2014-06-03	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		40,8100	-507.923	-20.728		3.710.103
2014-06-04	2014-06-02	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		39,9100	-3.146	-126		116.447
2014-06-04	2014-06-02	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		39,9100	-110.804	-4.422		4.101.579
2014-06-04	2014-06-02	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		39,9100	-113.950	-4.548		4.218.026
2014-06-04	2014-06-02	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		39,9100	-113.950	-4.548		4.218.026
2014-06-02	2014-05-30	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		41,0100	-1.983	-81		119.593
2014-06-02	2014-05-30	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		41,0100	-69.853	-2.865		4.212.383
2014-06-02	2014-05-30	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		41,0100	-71.836	-2.946		4.331.976
2014-06-02	2014-05-30	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		41,0100	-71.836	-2.946		4.331.976
2014-06-02	2014-05-29	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		40,9900	-6.592	-270		121.576
2014-06-02	2014-05-29	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		40,9900	-232.195	-9.518		4.282.236
2014-06-02	2014-05-29	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		40,9900	-238.787	-9.788		4.403.812
2014-06-02	2014-05-29	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		40,9900	-238.787	-9.788		4.403.812
2014-05-29	2014-05-28	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		40,3300	-6.321	-255		128.168
2014-05-29	2014-05-28	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		40,3300	-222.651	-8.980		4.514.431
2014-05-29	2014-05-28	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		40,3300	-228.972	-9.234		4.642.599
2014-05-29	2014-05-28	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		40,3300	-228.972	-9.234		4.642.599
2014-05-29	2014-05-27	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		39,8700	-2.698	-108		134.489
2014-05-29	2014-05-27	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		39,8700	-95.039	-3.789		4.737.082
2014-05-29	2014-05-27	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		39,8700	-97.737	-3.897		4.871.571
2014-05-29	2014-05-27	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		39,8700	-97.737	-3.897		4.871.571
2014-05-27	2014-05-23	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		38,3400	-2.102	-81		137.187
2014-05-27	2014-05-23	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		38,3400	-74.048	-2.839		4.832.121
2014-05-27	2014-05-23	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		38,3400	-76.150	-2.920		4.969.308
2014-05-27	2014-05-23	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		38,3400	-76.150	-2.920		4.969.308
2014-05-27	2014-05-22	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		37,5700	-939	-35		139.289
2014-05-27	2014-05-22	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		37,5700	-33.061	-1.242		4.906.169
2014-05-27	2014-05-22	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		37,5700	-34.000	-1.277		5.045.458
2014-05-27	2014-05-22	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		37,5700	-34.000	-1.277		5.045.458
2014-05-23	2014-05-21	4	GALAKATOS NICHOLAS	OPHT	Director Stock Options (Right to Buy)	A - Award	D	37,00		15.000		15.000
2014-05-23	2014-05-21	4	SBLENDORIO GLENN	OPHT	Stock Option (Right To Buy)	A - Award	D	37,00		15.000		15.000
2014-05-23	2014-05-21	4	ROSS MICHAEL JAY	OPHT	Employee Stock Option (right to buy)	A - Award	D	37,00		15.000		15.000
2014-05-15	2014-05-13	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Common Stock	S - Sale	D		29,7500	-500.000	-14.875		3.139.902
2014-05-05	2014-05-01	4	PEACOCK BRUCE	OPHT	Stock Option (Right To Buy)	D - Sale to Issuer	D	1,65		-4.643		55.916
2014-05-05	2014-05-01	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		32,7100	-2.642	-86		0
2014-05-05	2014-05-01	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		32,0600	-2.001	-64		2.642
2014-05-05	2014-05-01	4	PEACOCK BRUCE	OPHT	Common Stock	M - Exercise	D		1,6520	4.643	8		4.643
2014-05-05	2014-05-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		33,7700	-100	-3		104.472
2014-05-05	2014-05-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		32,8100	-4.396	-144		104.572
2014-05-05	2014-05-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		32,2700	-9.823	-317		108.968
2014-05-05	2014-05-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		34,7400	-6.638	-231		11.891
2014-05-05	2014-05-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		32,0100	-4.027	-129		18.529
2014-04-03	2014-04-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		34,7900	-4.181	-145		22.556
2014-04-03	2014-04-01	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		34,0000	-7.846	-267		26.737
2014-04-03	2014-04-01	4	PEACOCK BRUCE	OPHT	Stock Option (Right To Buy)	D - Sale to Issuer	D	1,65		-6.191		60.559
2014-04-03	2014-04-01	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		34,7600	-2.267	-79		0
2014-04-03	2014-04-01	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		33,9700	-3.924	-133		2.267
2014-04-03	2014-04-01	4	PEACOCK BRUCE	OPHT	Common Stock	M - Exercise	D		1,6520	6.191	10		6.191
2014-04-03	2014-04-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		35,7000	-100	-4		118.791
2014-04-03	2014-04-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		34,7600	-6.100	-212		118.891
2014-04-03	2014-04-01	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		33,9800	-10.676	-363		124.991
2014-03-26	2014-03-24	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		34,9200	-3.693	-129		34.583
2014-03-26	2014-03-24	4	GUYER DAVID R	OPHT	Common Stock	S - Sale	D		34,3600	-8.334	-286		38.276
2014-03-26	2014-03-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		35,4600	-200	-7		135.667
2014-03-26	2014-03-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		34,9300	-4.092	-143		135.867
2014-03-26	2014-03-24	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	S - Sale	D		34,4000	-12.584	-433		139.959
2014-03-26	2014-03-24	4	PEACOCK BRUCE	OPHT	Stock Option (Right To Buy)	M - Exercise	D	1,65		-6.191		66.750
2014-03-26	2014-03-24	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		35,0300	-1.106	-39		0
2014-03-26	2014-03-24	4	PEACOCK BRUCE	OPHT	Common Stock	S - Sale	D		34,7100	-5.031	-175		1.106
2014-03-26	2014-03-24	4	PEACOCK BRUCE	OPHT	Common Stock	M - Exercise	D		1,6520	6.191	10		6.191
2014-02-19	2014-02-18	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		29,6100	-19.429	-575		140.228
2014-02-19	2014-02-18	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	D		29,6100	-684.359	-20.264		4.939.230
2014-02-19	2014-02-18	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		29,6100	-703.788	-20.839		5.079.458
2014-02-19	2014-02-18	4	SVLSF IV, LLC	OPHT	Common Stock	S - Sale	I		29,6100	-703.788	-20.839		5.079.458
2014-01-06	2014-01-02	4	GUYER DAVID R	OPHT	Stock Option (Right To Buy)	A - Award	D	31,29		175.000		175.000
2014-01-06	2014-01-02	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (Right To Buy)	A - Award	D	31,29		140.000		140.000
2014-01-06	2014-01-02	4	PEACOCK BRUCE	OPHT	Stock Option (Right To Buy)	A - Award	D	31,29		100.000		100.000
2013-11-20	2013-09-30	4	GALAKATOS NICHOLAS	OPHT	Common Stock	P - Purchase	D		22,0000	2.500	55		2.500
2013-11-20	2013-09-30	4	GALAKATOS NICHOLAS	OPHT	Common Stock	P - Purchase	I		22,0000	2.500	55		2.500
2013-10-25	2013-10-23	4	GALAKATOS NICHOLAS	OPHT	Stock Option (Right to Buy)	A - Award	D	33,27		22.033		22.033
2013-10-25	2013-10-23	4	ROSS MICHAEL JAY	OPHT	Employee Stock Option (right to buy)	A - Award	D	33,27		22.033		22.033
2013-10-25	2013-10-23	4	SBLENDORIO GLENN	OPHT	Stock Option (Right To Buy)	A - Award	D	33,27		6.949		22.033
2013-10-25	2013-10-23	4	Dyrberg Thomas	OPHT	STOCK OPTION (RIGHT TO BUY)	A - Award	D	33,27		22.033		22.033
2013-10-07	2013-09-25	4	Bolte Axel	OPHT	Common Stock	P - Purchase	D		22,0000	-2.000	-44		2.000
2013-10-03	2013-09-30	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Common Stock Warrant	C - Conversion	D	0,06		13.670		13.670
2013-10-03	2013-09-30	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Series A Preferred Stock Warrant	C - Conversion	D			-13.670		0
2013-10-03	2013-09-30	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Series C Preferred Stock	C - Conversion	D			-206.756		0
2013-10-03	2013-09-30	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Series B Preferred Stock	C - Conversion	D			-398.208		0
2013-10-03	2013-09-30	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Series A Preferred Stock	C - Conversion	D			-2.806.937		0
2013-10-03	2013-09-30	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Common Stock	P - Purchase	D		22,0000	228.000	5.016		3.639.902
2013-10-03	2013-09-30	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Common Stock	C - Conversion	D			206.756			3.411.902
2013-10-03	2013-09-30	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Common Stock	C - Conversion	D			398.208			3.205.145
2013-10-03	2013-09-30	4	HBM Healthcare Investments (Cayman) Ltd.	OPHT	Common Stock	C - Conversion	D			2.806.937			2.806.937
2013-10-02	2013-09-30	4	PATEL SAMIR CHANDRAKANT	OPHT	Series C Preferred Stock	C - Conversion	I			-23.081		0
2013-10-02	2013-09-30	4	PATEL SAMIR CHANDRAKANT	OPHT	Series B Preferred Stock	C - Conversion	I			-70.621		0
2013-10-02	2013-09-30	4	PATEL SAMIR CHANDRAKANT	OPHT	Series A Preferred Stock	C - Conversion	I			-244.821		0
2013-10-02	2013-09-30	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	C - Conversion	I			23.282			537.527
2013-10-02	2013-09-30	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	C - Conversion	I			79.638			514.242
2013-10-02	2013-09-30	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	C - Conversion	I			282.061			434.604
2013-10-02	2013-09-23	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	G - Gift	D			-5.084			152.543
2013-10-02	2013-09-23	4	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock	G - Gift	D			-5.084			152.543
2013-10-02	2013-08-07	4	PATEL SAMIR CHANDRAKANT	OPHT	Series C Preferred Stock	P - Purchase	I			15.388		23.081
2013-10-02	2013-05-28	4	PATEL SAMIR CHANDRAKANT	OPHT	Stock Option (right to buy)	A - Award	D	13,22		56.858		418.185
2013-10-02	2013-05-23	4	PATEL SAMIR CHANDRAKANT	OPHT	Series C Preferred Stock	P - Purchase	I			7.693		7.693
2013-10-02	2013-09-30	4	Dyrberg Thomas	OPHT	COMMON STOCK	P - Purchase	D		22,0000	700	15		700
2013-10-02	2013-09-30	4	Novo A/S	OPHT	SERIES C PREFERRED STOCK	C - Conversion	D			-15.438.009		0
2013-10-02	2013-09-30	4	Novo A/S	OPHT	SERIES B PREFERRED STOCK	C - Conversion	D			-5.208.334		0
2013-10-02	2013-09-30	4	Novo A/S	OPHT	SERIES A PREFERRED STOCK	C - Conversion	D			-14.374.443		0
2013-10-02	2013-09-30	4	Novo A/S	OPHT	COMMON STOCK	P - Purchase	D		22,0000	455.000	10.010		6.896.819
2013-10-02	2013-09-30	4	Novo A/S	OPHT	COMMON STOCK	C - Conversion	D			6.441.819			6.441.819
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series C Preferred Stock	C - Conversion	I			-346.733		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series C Preferred Stock	C - Conversion	I			-346.733		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series B Preferred Stock	C - Conversion	I			-1.066.383		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series B Preferred Stock	C - Conversion	I			-1.066.383		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Warrant to Purchase Shares (Series A Preferred Stock)	C - Conversion	I	0,06		-11.863		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Warrant to Purchase Shares (Series A Preferred Stock)	C - Conversion	I	0,06		-11.863		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series A Preferred Stock	C - Conversion	I			-3.660.452		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series A Preferred Stock	C - Conversion	I			-3.660.452		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series C Preferred Stock	C - Conversion	D			-9.572		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series B Preferred Stock	C - Conversion	D			-29.439		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Warrant to Purchase Shares (Series A Preferred Stock)	C - Conversion	D	0,06		-327		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series A Preferred Stock	C - Conversion	D			-101.054		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series C Preferred Stock	C - Conversion	D			-337.161		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series B Preferred Stock	C - Conversion	D			-1.036.944		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Warrant to Purchase Shares (Series A Preferred Stock)	C - Conversion	D	0,06		-11.536		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Series A Preferred Stock	C - Conversion	D			-3.559.398		0
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Common Stock	C - Conversion	D			159.657			159.657
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Common Stock	C - Conversion	D			5.623.587			5.623.587
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Common Stock	C - Conversion	I			5.783.244			5.783.244
2013-10-02	2013-09-30	4	SVLSF IV, LLC	OPHT	Common Stock	C - Conversion	I			5.783.244			5.783.244
2013-10-02	2013-09-30	4	Clarus Lifesciences II, L.P.	OPHT	Series C Preferred Stock	C - Conversion	D			-186.027		0
2013-10-02	2013-09-30	4	Clarus Lifesciences II, L.P.	OPHT	Series B Preferred Stock	C - Conversion	D			-2.542.373		0
2013-10-02	2013-09-30	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	C - Conversion	D			186.027			2.728.390
2013-10-02	2013-09-30	4	Clarus Lifesciences II, L.P.	OPHT	Common Stock	C - Conversion	D			2.542.373			2.542.373
2013-09-24		3	PATEL SAMIR CHANDRAKANT	OPHT	Common Stock		D						152.543
2013-09-24		3	GUYER DAVID R	OPHT	Common Stock		D						46.610

Acquisto sul mercato aperto o privato di un titolo non derivato o derivato

Vendita sul mercato aperto o privato di un titolo non derivato o derivato

Concessione, assegnazione o altra acquisizione di titoli dall'azienda (ad esempio un'opzione)

Conversione di un derivato

Vendita o trasferimento di titoli alla società

Pagamento del prezzo di esercizio o del debito fiscale con la quota di titoli ricevuta dalla società

Regalo di titoli da parte o a favore dell'insider

Equity swap e operazioni di copertura analoghe

Esercizio o conversione di un titolo derivato ricevuto dall'azienda (ad esempio un'opzione)

Una transazione dichiarata volontariamente sul modulo 4

Altro (accompagnato da una nota a piè di pagina che descriva l'operazione)

ISEE / IVERIC bio Inc - Insider Trading and Ownership Report - SEC Form 3, 4, 5