RNLXY / Renalytix Plc - Depositary Receipt (Common Stock) - Depositi SEC, Relazione annuale, dichiarazione di delega

Renalytix Plc - Depositary Receipt (Common Stock)
US ˙ OTCPK ˙ US75973T1016

Statistiche di base
LEI 213800NTOH3FK3WER551
CIK 1811115
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Renalytix Plc - Depositary Receipt (Common Stock)
SEC Filings (Chronological Order)
Questa pagina fornisce un elenco completo e cronologico dei depositi SEC, esclusi i documenti di proprietà che forniamo altrove.
September 4, 2025 EX-99.(A)(II)

DEPOSIT AGREEMENT by and among Renalytix AI plc CITIBANK, N.A., as Depositary, THE HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES ISSUED HEREUNDER Dated as of July 21, 2020 TABLE OF CONTENTS

Exhibit (a)(ii) DEPOSIT AGREEMENT by and among Renalytix AI plc and CITIBANK, N.A., as Depositary, and THE HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES ISSUED HEREUNDER Dated as of July 21, 2020 TABLE OF CONTENTS Page ARTICLE I DEFINITIONS 1 Section 1.1 “ADS Record Date” 1 Section 1.2 “Affiliate” 1 Section 1.3 “American Depositary Receipt(s)”, “ADR(s)” and “Receipt(s)” 1 Section 1.4

September 4, 2025 F-6 POS

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM F-6 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 FOR AMERICAN DEPOSITARY SHARES EVIDENCED BY AMERICAN DEPOSITARY RECEIPTS Renalytix plc (Exact name

As filed with the Securities and Exchange Commission on September 4, 2025 Registration No.

September 4, 2025 EX-99.(A)(I)

RENALYTIX plc CITIBANK, N.A., As Depositary, ALL HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES ISSUED AND OUTSTANDING UNDER THE TERMS OF THE DEPOSIT AGREEMENT, DATED AS OF JULY 21, 2020 Amendment No. 1 to Deposit Agreement Dated as of [

Exhibit (a)(i) RENALYTIX plc AND CITIBANK, N.A., As Depositary, AND ALL HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES ISSUED AND OUTSTANDING UNDER THE TERMS OF THE DEPOSIT AGREEMENT, DATED AS OF JULY 21, 2020 Amendment No. 1 to Deposit Agreement Dated as of [●], 2025 TABLE OF CONTENTS Page ARTICLE I DEFINITIONS 1 SECTION 1.01 Definitions 1 SECTION 1.02 Effective Date 2 ARTICLE II AME

July 30, 2025 424B3

[FORM OF ADR]

Filed Pursuant to Rule 424(b)(3) Registration Statement on Form F-6 Registration No.

July 30, 2025 15-12G

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-39387 Renalytix plc (Exact name of registrant as specified in its charte

July 29, 2025 POS AM

As filed with the Securities and Exchange Commission on July 29, 2025

As filed with the Securities and Exchange Commission on July 29, 2025 Registration No.

July 29, 2025 POS AM

As filed with the Securities and Exchange Commission on July 29, 2025

As filed with the Securities and Exchange Commission on July 29, 2025 Registration No.

July 29, 2025 POS AM

As filed with the Securities and Exchange Commission on July 29, 2025

As filed with the Securities and Exchange Commission on July 29, 2025 Registration No.

July 29, 2025 POS AM

As filed with the Securities and Exchange Commission on July 29, 2025

As filed with the Securities and Exchange Commission on July 29, 2025 Registration No.

July 29, 2025 POS AM

As filed with the Securities and Exchange Commission on July 29, 2025

As filed with the Securities and Exchange Commission on July 29, 2025 Registration No.

July 25, 2025 S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 Renalytix plc (Exact name of registrant as specified in its charter)

Registration No. 333-274732 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Renalytix plc (Exact name of registrant as specified in its charter) England and Wales Not applicable (State or other jurisdiction of incorporation) (I.R.S. Employer Identification No.) 2 Leman Street

July 25, 2025 S-8 POS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 FORM S-8 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 Renalytix plc (Exact name of registrant as specified in its charter)

Registration No. 333-248741 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Renalytix plc (Exact name of registrant as specified in its charter) England and Wales Not applicable (State or other jurisdiction of incorporation) (I.R.S. Employer Identification No.) 2 Leman Street

January 16, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 16, 2025 Renalytix plc (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 16, 2025 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commis

December 20, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Result of AGM

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Result of AGM LONDON and NEW YORK, 19 December 2024 – Renalytix plc (LSE: RENX) (OTCQB: RNLXY), which is commercialising the only FDA-approved and Medicare reimbursed prognostic test to support early-stage risk assessment for chronic kidney disease, announces that at the Annual General Meeting (“AGM”) held earlier today, all resolutions wer

December 20, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 19, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction (Commission File Number)

November 25, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

November 19, 2024 8-K/A

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of

November 19, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-39387 Renaly

November 14, 2024 SC 13G/A

RNLX / Renalytix Plc - Depositary Receipt (Common Stock) / CVI Investments, Inc. - SC 13G/A Passive Investment

SC 13G/A 1 tm2428264d6sc13ga.htm SC 13G/A CUSIP No: 75973T101 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. 1)* Renalytix plc (Name of Issuer) Ordinary Shares, £0.0025 nominal value per share (Title of Cl

November 14, 2024 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-SAR ☐ Form N-CSR For Period Ended: September 30, 2024 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q ☐ Transition Report

November 12, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

November 7, 2024 SC 13D/A

RNLX / Renalytix Plc - Depositary Receipt (Common Stock) / JEFFERSON RIVER CAPITAL LLC - SCHEDULE 13D/A Activist Investment

SC 13D/A 1 tm2427702d1sc13da.htm SCHEDULE 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* RENALYTIX PLC (Name of Issuer) Ordinary Shares, nominal value £0.0025 per share Underlying American Depositary Shares (Title of Class of Securities) 75973T101 (American Depositary Shares) (CUSIP Number) Pet

November 6, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Result of General Meeting

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Result of General Meeting LONDON and NEW YORK, 31 October 2024 - Renalytix plc (LSE: RENX) (OTCQB: RNLXY), an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved patient outcomes and advance value-based care, announces that, at the General Meeting (“GM”)

November 6, 2024 EX-99.2

Renalytix plc (“Renalytix” or the “Company”) Directorate Change

Exhibit 99.2 Renalytix plc (“Renalytix” or the “Company”) Directorate Change LONDON and NEW YORK, 31 October 2024 – Renalytix plc (LSE: RENX) (OTCQB: RNLXY), an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved patient outcomes and advance value-based care, announces that Dan Levangie, Non-Executive Director

November 6, 2024 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction (Commission File Number)

November 5, 2024 SC 13D/A

RNLX / Renalytix Plc - Depositary Receipt (Common Stock) / ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI - SCHEDULE 13D, AMENDMENT NO. 2 Activist Investment

SC 13D/A 1 sc13da2.htm SCHEDULE 13D, AMENDMENT NO. 2 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.2)* RENALYTIX PLC (Name of Issuer) ORDINARY SHARES (Including Ordinary Shares Underlying American Depository Shares) (Title of Class of Securities) 75973T101 (American Depository Shares) (CUSIP Number) Moun

October 11, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant  ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 1

October 7, 2024 25

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File No. 001-39387 Renalytix plc The Nasdaq

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File No. 001-39387 Renalytix plc The Nasdaq Stock Market LLC (Exact name of registrant as specified in its charter, and name of Exchange where security is listed and/or registered) 2 Leman Stre

October 2, 2024 SC 13D/A

RNLX / Renalytix Plc - Depositary Receipt (Common Stock) / JEFFERSON RIVER CAPITAL LLC - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* RENALYTIX PLC (Name of Issuer) Ordinary Shares, nominal value £0.0025 per share Underlying American Depositary Shares (Title of Class of Securities) 75973T101 (American Depositary Shares) (CUSIP Number) Peter Trapani Chief Financial Officer Jefferson Riv

October 1, 2024 EX-10.2

Form of Subscription Agreement

Exhibit 10.2 FORM OF SUBSCRIPTION LETTER TO: Renalytix PLC (the “Company”) 2 Leman Street, London United Kingdom E1W 9US FAO: FROM:     September 2024 Re: Placing (the “Placing”) of new ordinary shares (the “Shares”) of the Company Please note all definitions used herein shall have the same meaning as defined in the Placing Announcement, unless expressed otherwise. Dear all: We (the “Subscriber” o

October 1, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Update on financial results for the fiscal year ended 30 June 2024

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Update on financial results for the fiscal year ended 30 June 2024 LONDON and NEW YORK, 30 September, 2024 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX), an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved patient outcomes and advance value-based care, w

October 1, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant  ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 1

October 1, 2024 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Comm

October 1, 2024 EX-99.3

Renalytix plc (“Renalytix” or the “Company”) Result of Placing and Subscription Related Party Transaction

Exhibit 99.3 THIS ANNOUNCEMENT AND THE INFORMATION CONTAINED HEREIN (TOGETHER THIS “ANNOUNCEMENT”) IS RESTRICTED AND IS NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM THE UNITED STATES OF AMERICA, AUSTRALIA, NEW ZEALAND, CANADA, THE REPUBLIC OF SOUTH AFRICA, JAPAN OR ANY OTHER JURISDICTION WHERE, OR TO ANY OTHER P

October 1, 2024 EX-10.1

Placing Agreement dated October 1, 2024

Exhibit 10.1 Dated 1 October 2024 RENALYTIX PLC as the Company AND OBERON CAPITAL (A TRADING NAME OF OBERON INVESTMENTS LIMITED) as Broker PLACING AGREEMENT in respect of a Placing of Ordinary Shares to raise gross proceeds of approximately £10 million in two tranches TABLE OF CONTENTS Page 1. DEFINITIONS AND INTERPRETATION 4 2. CONDITIONS 12 3. DELIVERY OF DOCUMENTS 15 4. APPLICATIONS FOR ADMISSI

October 1, 2024 EX-99.2

Renalytix Plc (“Renalytix” or the “Company”) Placing and Subscription Proposed conversion of existing debt into equity Transfer from Nasdaq to OTCQX of American Depositary Shares Board Appointment

Exhibit 99.2 THIS ANNOUNCEMENT, INCLUDING THE APPENDICES TO THIS ANNOUNCEMENT, AND THE INFORMATION CONTAINED HEREIN, IS RESTRICTED AND IS NOT FOR PUBLICATION, DISTRIBUTION OR RELEASE DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES, AUSTRALIA, CANADA, JAPAN, NEW ZEALAND OR THE REPUBLIC OF SOUTH AFRICA OR IN OR INTO ANY OTHER JURISDICTION IN WHICH IT WOULD BE UNLAWFUL TO DO

September 30, 2024 EX-21.1

Subsidiaries of the registrant

EX-21.1 2 rnlx-ex211.htm EX-21.1 EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction Renalytix AI, Inc. United States Renalytix AI Limited Ireland

September 30, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-39387 Renalytix plc (Exac

August 27, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Nasdaq Grants Listing Extension Renalytix’s American Depositary Shares (“ADSs”) will Continue Trading on The Nasdaq Capital Market Effective at the Open of Trading on August 27, 2024

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Nasdaq Grants Listing Extension Renalytix’s American Depositary Shares (“ADSs”) will Continue Trading on The Nasdaq Capital Market Effective at the Open of Trading on August 27, 2024 LONDON and NEW YORK, 27 August 2024 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX), an artificial intelligence-enabled in vitro diagnostics company, focused on opt

August 27, 2024 8-K

Regulation FD Disclosure, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 23, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commiss

July 15, 2024 8-K

Regulation FD Disclosure, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 15, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissio

July 15, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Issue of Shares and Rule 2.9 Announcement

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Issue of Shares and Rule 2.9 Announcement LONDON and NEW YORK – July 15, 2024 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX), announces the repayment of $1.06 million of the principal amount of the Company’s convertible bond and the interest for the period, further details of which were announced on 31 March 2022. The repayment is being made th

June 28, 2024 424B3

Ordinary Shares

Table of Contents Filed pursuant to Rule 424(b)(3) File No. 333-279966 PROSPECTUS 26,815,841 Ordinary Shares This prospectus relates to the resale by the selling securityholders identified in this prospectus, or the selling securityholders, of up to 26,815,841 ordinary shares of Renalytix plc, or the Company. We are not selling any securities and will not receive any proceeds from the sale of the

June 26, 2024 S-3/A

As filed with the Securities and Exchange Commission on June 25, 2024

S-3/A Table of Contents As filed with the Securities and Exchange Commission on June 25, 2024 Registration No.

June 26, 2024 CORRESP

2 Leman Street London E1W 9US United Kingdom

2 Leman Street London E1W 9US United Kingdom June 26, 2024 Via Edgar U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Jane Park Re: Renalytix plc Registration Statement on Form S-3 File No. 333-279966 Acceleration Request Requested Date: June 28, 2024 Requested Time: 4:00 p.m. Eastern Time Ladies and Gentlemen: Pursuant to R

June 25, 2024 EX-16.1

Letter from Ernst & Young addressed to the United States Securities and Exchange Commission, dated June 24, 2024

Exhibit 16.1 June 24, 2024 Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Commissioners: We have read Item 4.01 of Form 8-K dated June 18, 2024, of Renalytix plc and are in agreement with the statements contained in the first, second, third and fourth paragraphs under the heading (b) Previous Independent Registered Public Accounting Firm on page 3 therein. We have no ba

June 25, 2024 8-K/A

Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incor

June 24, 2024 8-K

Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissio

June 24, 2024 EX-16.1

Letter from Ernst & Young addressed to the United States Securities and Exchange Commission, dated June 24, 2024

Exhibit 16.1 June 24, 2024 Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Commissioners: We have read Item 4.01 of Form 8-K dated June 19, 2024, of Renalytix plc and are in agreement with the statements contained in the first, second, third and fourth paragraphs under the heading (b) Previous Independent Registered Public Accounting Firm on page 3 therein. We have no ba

June 24, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 21, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissio

June 17, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 14, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissio

June 17, 2024 EX-99.1

This announcement contains inside information for the purposes of Article 7 of the UK version of Regulation (EU) No 596/2014 which is part of UK law by virtue of the European Union (Withdrawal) Act 2018, as amended ("MAR"). Upon the publication of th

Exhibit 99.1 This announcement contains inside information for the purposes of Article 7 of the UK version of Regulation (EU) No 596/2014 which is part of UK law by virtue of the European Union (Withdrawal) Act 2018, as amended ("MAR"). Upon the publication of this announcement via a Regulatory Information Service, this inside information is now considered to be in the public domain. Renalytix plc

June 14, 2024 S-3/A

As filed with the Securities and Exchange Commission on June 14, 2024

Table of Contents As filed with the Securities and Exchange Commission on June 14, 2024 Registration No.

June 12, 2024 EX-10.1

Consulting Agreement, dated as of June 7, 2024, between Renalytix AI, Inc. and Joel R. Jung

Exhibit 10.1 Consulting Services Agreement This Consulting Services Agreement (“Agreement”) is made and entered into as of June 7th, 2024 by and between Renalytix AI, Inc. (the “Company”), and the undersigned individual (“Consultant”). The Company desires to retain Consultant as an independent contractor to perform consulting services for the Company and Consultant is willing to perform such servi

June 12, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commission

June 5, 2024 EX-FILING FEES

Filing Fee Table.

EX-FILING FEES Exhibit 107 Calculation of Filing Fee Table Form S-3 (Form Type) Renalytix plc (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1)(2) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee(3) Equity American Depositary Shares (ADSs) 457(c) 13,407,921 $0.

June 5, 2024 S-3

As filed with the Securities and Exchange Commission on June 5, 2024

S-3 Table of Contents As filed with the Securities and Exchange Commission on June 5, 2024 Registration No.

May 28, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Management Change

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Management Change LONDON and SALT LAKE CITY – 28 May 2024 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX) announces that O. James Sterling will step down from his role as Chief Financial Officer of the Company as of 24 May 2024 and will remain at the Company until 10 June 2024. The Board has appointed Joel R. Jung as Interim Chief Financial Offi

May 28, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 24, 2024 Renalytix plc (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 24, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commission

May 15, 2024 EX-1.1

At The Market Offering Agreement by and between Renalytix plc and H.C. Wainwright & Co. LLC

Exhibit 1.1 AT THE MARKET OFFERING AGREEMENT May 15, 2024 H.C. Wainwright & Co., LLC 430 Park Avenue New York, NY 10022 Ladies and Gentlemen: Renalytix plc, a public limited company incorporated under the laws of England and Wales (the “Company”), confirms its agreement (this “Agreement”) with H.C. Wainwright & Co., LLC (the “Manager”) as follows: 1. Definitions. The terms that follow, when used i

May 15, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commission

May 15, 2024 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commission

May 15, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Financial Results for Third Quarter of Fiscal Year 2024

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Financial Results for Third Quarter of Fiscal Year 2024 LONDON and NEW YORK, May 15, 2024 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX), an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved patient outcomes and advance value-based care,

May 15, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-39387 Renalytix

May 15, 2024 424B5

Up to $15,000,000 American Depositary Shares Representing Ordinary Shares

Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-274733 PROSPECTUS SUPPLEMENT To Prospectus, dated October 6, 2023 Up to $15,000,000 American Depositary Shares Representing Ordinary Shares We have entered into an At The Market Offering Agreement, or the Sales Agreement, with H.C. Wainwright & Co., LLC, or Wainwright, relating to the offer and sale of our American Depositary

May 8, 2024 424B3

Ordinary Shares

Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-278765 PROSPECTUS 19,986,031 Ordinary Shares This prospectus relates to the resale by the selling securityholders identified in this prospectus, or the selling securityholders, of up to 19,986,031 ordinary shares of Renalytix plc, or the Company. We are not selling any securities and will not receive any proceeds from the sale

April 26, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Allotment and issue of the Second Tranche Placing Shares Rule 2.9 Announcement

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Allotment and issue of the Second Tranche Placing Shares Rule 2.9 Announcement LONDON and SALT LAKE CITY – 25 April 2024 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX) confirms that the Second Tranche Placing Shares of 26,815,841 ordinary shares of £0.0025 each (the “Ordinary Shares”) were issued yesterday, on the 24 April 2024. An application

April 26, 2024 SC 13D/A

RNLX / Renalytix Plc - Depositary Receipt (Common Stock) / ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI - SCHEDULE 13D/A - AMENDMENT NO. 1 Activist Investment

SC 13D/A 1 sc13da-1.htm SCHEDULE 13D/A - AMENDMENT NO. 1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1 )* RENALYTIX PLC (Name of Issuer) ORDINARY SHARES (Including Ordinary Shares Underlying American Depository Shares) (Title of Class of Securities) 75973T101 (American Depository Shares) (CUSIP Number

April 26, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2024 Renalytix plc (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissi

April 25, 2024 CORRESP

2 Leman Street London E1W 9US United Kingdom

2 Leman Street London E1W 9US United Kingdom April 25, 2024 Via Edgar U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Jessica Ansart Re: Renalytix plc Registration Statement on Form S-3 Filed on April 17, 2024 File No. 333-278765 Acceleration Request Requested Date: April 29, 2024 Requested Time: 4:00 p.m. Eastern Time Ladi

April 23, 2024 EX-10.2

Separation Agreement, dated April 17, 2024, by and between the Company and Tom McLain

Exhibit 10.2 April 17, 2024 Thomas McLain Dear Tom: As we have discussed, your employment with Renalytix AI, Inc. (the “Company”) is coming to an end, effective as of April 30, 2024 (the “Separation Date”). The purpose of this letter agreement (this “Agreement”) is to confirm the terms concerning your transition from employment. Capitalized terms not defined in this Agreement will have the respect

April 23, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 17, 2024 Renalytix plc (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 17, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissi

April 23, 2024 EX-10.1

Letter Agreement, dated April 19, 2024, by and between the Company and DB Capital Partners Healthcare, L.P.

Exhibit 10.1 19 April 2024 DB Capital Partners Healthcare, L.P. c/o Robert T. Dhamer DBC I, LLC 1165 Cypress Drive Brownsville, TX 78520 (the “Purchaser”) Re: Securities Purchase Agreement Dear Sirs and Madams: Reference is made to the securities purchase agreement between Renalytix plc (the “Company”) and the Purchaser dated 5 April 2024 (the “Securities Purchase Agreement”). The Purchaser has no

April 17, 2024 S-3

As filed with the Securities and Exchange Commission on April 17, 2024

Table of Contents As filed with the Securities and Exchange Commission on April 17, 2024 Registration No.

April 17, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Table Form S-3 (Form Type) Renalytix plc (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation  Rule Amount Registered(1)(2)  Proposed Maximum  Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee(3) Equity American Depositary  Shares (ADSs) 457(c) 9,993,016 $0.

April 10, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 10, 2024 Renalytix plc (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 10, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissi

April 10, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Issue of Shares

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Issue of Shares LONDON and SALT LAKE CITY – 10 April 2024 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX), announces the repayment of $1.06 million of principal and interest amount due under the Company’s convertible bonds for the period from 8 January 2024 to 7 April 2024, further details of the convertible bonds were announced on 31 March 2022

April 9, 2024 424B5

Ordinary Shares

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-274733 PROSPECTUS SUPPLEMENT (To Prospectus Dated October 6, 2023) 2,666,667 Ordinary Shares We are offering 2,666,667 ordinary shares directly to an investor in this offering at a price per ordinary share of $0.375. This offering is being made without an underwriter or placement agent and we are not paying underwriting discou

April 9, 2024 EX-10.1

Form of Securities Purchase Agreement, dated April 5, 2024 by and among Renalytix plc and each of the purchasers party thereto

Exhibit 10.1 EXECUTION VERSION SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of April 5, 2024 between Renalytix plc, a public limited company incorporated under the laws of England and Wales (the “Company”), and each of the purchasers identified on Schedule A attached hereto (including such purchasers successors and assigns, each a “Purchaser” and,

April 9, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 5, 2024 Renalytix plc (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 5, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissio

April 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 8, 2024 Renalytix plc (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 8, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissio

April 8, 2024 EX-99.1

Renalytix Announces Financing with Expected Size of up to $4 Million

Exhibit 99.1 NOT FOR PUBLICATION, DISTRIBUTION OR RELEASE DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES, CANADA, AUSTRALIA, JAPAN OR THE REPUBLIC OF SOUTH AFRICA OR IN OR INTO ANY OTHER JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. THIS ANNOUNCEMENT IS NOT AN OFFER TO SELL OR A SOLICITATION TO BUY SECU

April 4, 2024 SC 13G

RNLX / Renalytix Plc - Depositary Receipt (Common Stock) / CVI Investments, Inc. - SC 13G Passive Investment

SC 13G 1 tm2411010d1sc13g.htm SC 13G CUSIP No: 75973T101 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. )* Renalytix plc (Name of Issuer) Ordinary Shares, £0.0025 nominal value per share (Title of Class of

March 29, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant  ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 1

March 29, 2024 EX-10.1

Bond Amendment Agreement, dated March 28, 2024, by and between Renalytix plc and CVI Investments, Inc.

Exhibit 10.1 EXECUTION VERSION Dated 28 March 2024 Second Amendment and Restatement Agreement in respect of the Original Bond Agreement by Renalytix plc with CVI Investments, Inc. as Initial Bondholder White & Case llp 5 Old Broad Street London EC2N 1DW EMEA 149041286 Exhibit 10.1 White & Case llp 5 Old Broad Street London EC2N 1DW EMEA 149041286 Table of Contents 1. Definitions and Interpretation

March 29, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 28, 2024 Renalytix plc (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 28, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissi

March 21, 2024 SC 13D/A

RNLX / Renalytix Plc - Depositary Receipt (Common Stock) / JEFFERSON RIVER CAPITAL LLC - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* RENALYTIX PLC (Name of Issuer) Ordinary Shares, nominal value £0.0025 per share Underlying American Depositary Shares (Title of Class of Securities) 75973T101 (American Depositary Shares) (CUSIP Number) Peter Trapani Chief Financial Officer Jefferson Riv

March 19, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant  ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defi

March 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2024 Renalytix plc (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissi

March 14, 2024 EX-99.1

KidneyIntelX™ included in Final KDIGO 2024 Clinical Guideline for Chronic Kidney Disease (CKD) Guidelines highlight the importance of risk prediction and personalized treatment to reduce risk

Exhibit 99.1 KidneyIntelX™ included in Final KDIGO 2024 Clinical Guideline for Chronic Kidney Disease (CKD) Guidelines highlight the importance of risk prediction and personalized treatment to reduce risk LONDON and SALT LAKE CITY, March 14, 2024 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX) (Renalytix) announces that the KidneyIntelX In-Vitro Diagnostic test has been included in the final KDIGO (Kid

March 13, 2024 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 12, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissi

March 13, 2024 EX-99.1

Renalytix plc ("Renalytix" or the "Company") Renalytix announces the launch of an equity placing of Ordinary Shares of approximately US$10 million

Exhibit 99.1 March 12, 2024 NOT FOR PUBLICATION, DISTRIBUTION OR RELEASE DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES, AUSTRALIA, CANADA, JAPAN, NEW ZEALAND OR THE REPUBLIC OF SOUTH AFRICA OR IN OR INTO ANY OTHER JURISDICTION IN WHICH OFFERS OR SALES WOULD BE PROHIBITED BY APPLICABLE LAW. THIS ANNOUNCEMENT IS NOT AN OFFER TO SELL OR A SOLICITATION TO BUY SECURITIES IN

March 13, 2024 EX-10.1

Placing Agreement dated March 12, 2024, by and between Renalytix plc and Stifel Nicolaus Europe Limited

Exhibit 10.1 Dated 12 March 2024 RENALYTIX PLC as the Company and STIFEL NICOLAUS EUROPE LIMITED as Bookrunner PLACING AGREEMENT in respect of a Placing to raise gross proceeds of approximately £7.8 million TABLE OF CONTENTS Page 1. Definitions and Interpretation 3 2. Conditions 10 3. Delivery of Documents 13 4. Applications for Admission 13 5. The Placing 14 6. Settlement 15 7. Undertakings 18 8.

March 13, 2024 EX-99.2

Renalytix plc ("Renalytix" or the "Company") Successful completion of upsized $12 million equity placing

Exhibit 99.2 NOT FOR PUBLICATION, DISTRIBUTION OR RELEASE DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES, CANADA, AUSTRALIA, JAPAN, THE REPUBLIC OF SOUTH AFRICA, NEW ZEALAND OR IN OR INTO ANY OTHER JURISDICTION IN WHICH OFFERS OR SALES WOULD BE PROHIBITED BY APPLICABLE LAW. THIS ANNOUNCEMENT IS NOT AN OFFER TO SELL OR A SOLICITATION TO BUY SECURITIES IN ANY JURISDICTION,

March 4, 2024 EX-99.1

Renalytix plc (“Renalytix plc” or the “Company”) Unsolicited Approach from Possible Strategic Acquiror, Launch of Formal Sale Process, and Update on Financing

Exhibit 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF THAT JURISDICTION. THIS IS AN ANNOUNCEMENT UNDER RULE 2.4 OF THE CITY CODE ON TAKEOVERS AND MERGERS (THE “TAKEOVER CODE”) AND DOES NOT CONSTITUTE AN ANNOUNCEMENT OF A FIRM INTENTION

March 4, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 4, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissio

February 29, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 29, 2024 Renalytix plc (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 29, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commi

February 15, 2024 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Financial Results for Second Quarter of Fiscal Year 2024

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Financial Results for Second Quarter of Fiscal Year 2024 LONDON and SALT LAKE CITY, February 15, 2024 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX) (the “Company”), an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease, today reported financial results for

February 15, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 15, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commi

February 14, 2024 EX-3.1

Reference is made to Exhibit 3.1

Exhibit 3.1 RENALYTIX PLC ARTICLES OF ASSOCIATION ADOPTED ON 15 DECEMBER 2023 Contents Clause 1. Exclusion of model articles (and any other prescribed regulations) 1 2. Interpretation 1 3. Form of resolution 3 4. Limited liability 4 5. Change of name 4 6. Shareholder rights 4 7. Power to attach rights to shares 5 8. Allotment of shares and pre-emption 5 9. Redeemable shares 6 10. Pari passu issues

February 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-39387 Renalyt

February 9, 2024 EX-99.1

Renalytix plc ("Renalytix" or the "Company") Centers for Medicare & Medicaid Services Publishes Draft Local Coverage Determination for KidneyIntelX and kidneyintelX.dkd

Exhibit 99.1 Renalytix plc ("Renalytix" or the "Company") Centers for Medicare & Medicaid Services Publishes Draft Local Coverage Determination for KidneyIntelX and kidneyintelX.dkd LONDON and SALT LAKE CITY, February 9, 2024 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX) announces that on February 8, 2024 the Centers for Medicare and Medicaid Services (“CMS”) published a draft Local Coverage Determin

February 9, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 9, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commis

January 17, 2024 EX-99.1

Renalytix plc ("Renalytix" or the "Company") Update on kidneyIntelX.dkd Local Coverage Determination Consideration Local Coverage Determination would result in contracted coverage for an estimated additional five million Medicare patients with Type 2

Exhibit 99.1 Renalytix plc ("Renalytix" or the "Company") Update on kidneyIntelX.dkd Local Coverage Determination Consideration Local Coverage Determination would result in contracted coverage for an estimated additional five million Medicare patients with Type 2 diabetes and early-stage chronic kidney disease LONDON and SALT LAKE CITY, January 17, 2024 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX) a

January 17, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 17, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commis

January 10, 2024 EX-99.1

New published data demonstrates KidneyIntelX™ has broad implications for winning war on chronic kidney disease Electronic health record deployment of KidneyIntelX was associated with clinical actions that slowed progression of chronic kidney disease

Exhibit 99.1 New published data demonstrates KidneyIntelX™ has broad implications for winning war on chronic kidney disease Electronic health record deployment of KidneyIntelX was associated with clinical actions that slowed progression of chronic kidney disease and improved Type 2 diabetes control in just 12 months Results demonstrated a 61% increase in preventative drug prescriptions among patie

January 10, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 10, 2024 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commis

December 29, 2023 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commi

December 18, 2023 8-K

Regulation FD Disclosure, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 15, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commi

December 18, 2023 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Issue of Shares

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Issue of Shares LONDON and SALT LAKE CITY – December 18, 2023 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX), announces the repayment of $1.06 million of the Company’s convertible bond and the interest for the period, further details of which were announced on 31 March 2022. The repayment is being made through the issue of 2,500,000 Ordinary Sh

December 18, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 15, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commi

December 8, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

December 8, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 5, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commis

November 14, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commi

November 14, 2023 EX-10.2

Employment Agreement, dated as of August 22, 2023, among Howard Doran, Renalytix AI, Inc. and Renalytix plc

Exhibit 10.2 August 22, 2023 Howard Doran Dear Howard: Renalytix AI, Inc. ("Renalytix" or the "Company") is pleased to offer you the position of Chief Business Officer, reporting to James McCullough, Chief Executive Officer, with a dotted line to Tom Mclain, President. We feel strongly that your intellect, energy and experience are an ideal fit with our Company culture and objectives, and that you

November 14, 2023 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Financial Results for First Quarter of Fiscal Year 2024

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Financial Results for First Quarter of Fiscal Year 2024 LONDON and SALT LAKE CITY, November 14, 2023 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX), an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved patient outcomes and advance value-b

November 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-39387 Renaly

November 13, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14

November 13, 2023 DEFR14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 1

November 3, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.     )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.     ) Filed by the Registrant  ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Ru

October 31, 2023 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Announcement of AGM and Publication of Annual Report 2023

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Announcement of AGM and Publication of Annual Report 2023 LONDON and SALT LAKE CITY, UT October 30, 2023 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX) announces that its Annual General Meeting (“AGM”) will be held in-person on 15 December 2023 at 15.30 p.m. (GMT) at 6 Stratton Street Mayfair, London W1J 8LD. In addition, the Company’s Annual R

October 31, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commis

October 24, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commis

October 17, 2023 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Issue of Shares

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Issue of Shares LONDON and SALT LAKE CITY – October 17, 2023 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX), announces the repayment of $1.06 million of the Company’s convertible bond, further details of which were announced on 31 March 2022. The repayment is being made through the issue of 150,000 Ordinary Shares and 1,092,694 American Deposit

October 17, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 17, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commis

October 6, 2023 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1 (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30, 2023 OR c☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-39387

October 5, 2023 CORRESP

5-7 Cranwood Street London EC1V 9EE United Kingdom

Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom October 5, 2023 VIA EDGAR U.

October 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 3, 2023 Renalytix plc (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 3, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commiss

October 3, 2023 RW WD

October 3, 2023

October 3, 2023 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Renalytix plc Registration Statement on Form S-3 (File No. 333-274733) Dear Sir or Madam: Pursuant to Rule 477 under the Securities Act of 1933, as amended, Renalytix plc (the “Company”) hereby requests withdrawal, effective immediately, of its Withdrawal Re

October 2, 2023 RW

October 2, 2023

October 2, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

October 2, 2023 CORRESP

October 2, 2023

October 2, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

September 29, 2023 CORRESP

September 29, 2023

September 29, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

September 28, 2023 POS AM

As filed with the Securities and Exchange Commission on September 28, 2023

Table of Contents As filed with the Securities and Exchange Commission on September 28, 2023 Registration No.

September 28, 2023 EX-4.6

Form of Debt Securities Warrant Agreement and Warrant Certificate

EX-4.6 Exhibit 4.6 RENALYTIX PLC and        , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OF       RENALYTIX PLC FORM OF DEBT SECURITIES WARRANT AGREEMENT THIS DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of [•], between RENALYTIX PLC, a public limited company incorporated under the laws of England and Wales under company number 11257655 and having its reg

September 28, 2023 EX-10.8

Employment Agreement, dated June 1, 2019, by and among Thomas McLain, Renalytix AI, Inc. and Renalytix plc

EXHIBIT 10.8 EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into effective June 1, 2019 (the “Effective Date”), by and among Thomas McLain (the “Employee”) and Renalytix AI, Inc. (“Renalytix DE” or the “Company”), a Delaware corporation, and Renalytix AI plc (“Parent” and collectively with Renalytix DE, the “Group”). The Company desires to continue to employ the Employ

September 28, 2023 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Full Year Fiscal 2023 Results

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Full Year Fiscal 2023 Results LONDON and SALT LAKE CITY, September 28, 2023 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX), an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved patient outcomes and advance value-based care, reports its fi

September 28, 2023 EX-4.5

Form of Ordinary Share Warrant Agreement and Warrant Certificate.

Exhibit 4.5 RENALYTIX PLC AND , AS WARRANT AGENT FORM OF ORDINARY SHARES WARRANT AGREEMENT DATED AS OF RENALYTIX PLC FORM OF ORDINARY SHARES WARRANT AGREEMENT THIS ORDINARY SHARES WARRANT AGREEMENT (this “Agreement”), dated as of [•], between RENALYTIX PLC, a public limited company incorporated under the laws of England and Wales under company number 11257655 and having its registered office at Fi

September 28, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30, 2023 OR c☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-39387 Renalytix plc (Exa

September 28, 2023 EX-10.9

Employment Agreement, dated as of November 2, 2018, by and among Fergus Fleming, Renalytix AI, Inc. and Renalytix plc

EXHIBIT 10.9 Dated 2 NOVEMBER 2018 (1) RENALYTIX AI PLC (2) FERGUS FLEMING DIRECTORS SERVICE AGREEMENT Berry Smith Haywood House Dumfries Place Cardiff CF10 3GA THIS AGREEMENT is made the 2 day of November 2018 BETWEEN: (1) RENALYTIX AI PLC Registered Number 11257655 whose registered office is at Avon House, 19 Stanwell Road, Penarth, Cardiff CF64 2EZ (“the Company”); and (2) FERGUS FLEMING of 12

September 28, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Renalytix plc (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Ordinary shares, nominal value £0.

September 28, 2023 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 28, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Comm

September 28, 2023 EX-21.1

Subsidiaries of the registrant

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction Renalytix AI, Inc. United States Renalytix AI Limited Ireland

September 28, 2023 EX-10.16

Relationship Agreement, by and among Renalytix plc, the Icahn School of Medicine at Mount Sinai and NPLUS1 Singer Advisory LLP, dated as of October 30, 2018

EXHIBIT 10.16 EXECUTION VERSION DATED 30 OCTOBER 2018 RENALYTIX AI PLC and ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI and NPLUS1 SINGER ADVISORY LLP RELATIONSHIP AGREEMENT Cooley (UK) LLP DASHWOOD, 69 OLD BROAD STREET, LONDON EC2N 1QS, UK T: +44 (0) 20 7583 4055 f: +44 (0) 20 7785 9355 WWW.COOLEY.COM THIS AGREEMENT is made on 30 October 2018 BETWEEN: (1) RENALYTIX AI PLC, incorporated and registered

September 28, 2023 EX-10.10

Employment Agreement, dated December 12, 2020, by and among Michael Donovan, Renalytix AI, Inc. and Renalytix plc

EXHIBIT 10.10 December 12, 2020 Michael J. Donovan PhD MD 601 NE 27th St., Apt. 1707 Miami, FL 33137 Dear Michael: Renalytix AI, Inc. (the “Company”) is pleased to offer you the position of Chief Medical Officer, reporting directly to CEO James McCullough. We feel strongly that your intellect, energy and experience are an ideal fit with our company culture and objectives, and that you would make a

September 28, 2023 S-8

As filed with the Securities and Exchange Commission on September 28, 2023

As filed with the Securities and Exchange Commission on September 28, 2023 Registration No.

September 28, 2023 EX-10.6

Employment Agreement, dated as of October 22, 2018, by and among James McCullough, Renalytix AI, Inc. and Renalytix plc

EXHIBIT 10.6 EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement’) is entered into on October 22, 2018 and shall become effective on the date of admission of the entire issued share capital of Renalytix AI plc (“Parent”) to trading on AIM, the market operated by London Stock Exchange plc (the “Effective Date”), by and among James McCullough (the “Employee”) and Renalytix AI, Inc. (“Rena

September 28, 2023 S-3

As filed with the Securities and Exchange Commission on September 28, 2023

Table of Contents As filed with the Securities and Exchange Commission on September 28, 2023 Registration No.

September 28, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) RENALYTIX PLC (Exact name of Registrant as specified in its charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial effective date Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to Be Paid Equity Ordinary shares, nominal value $0.

September 28, 2023 EX-10.7

Employment Agreement, dated as of October 12, 2018, by and among O. James Sterling, Renalytix AI, Inc. and Renalytix plc

EXHIBIT 10.7 EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is entered into on October 12, 2018 and shall become effective on the date of admission of the entire issued share capital of Renalytix AI plc (“Parent”) to trading on AIM, the market operated by London Stock Exchange plc (the “Effective Date”), by and among Oliver James Sterling (the “Employee”) and Renalytix AI, Inc. (

September 28, 2023 EX-4.3

Form of Indenture.

EX-4.3 Exhibit 4.3 Renalytix plc, Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [•], 20  Debt Securities TABLE OF CONTENTS ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee’s Certificate 8 Section 2.

September 28, 2023 POS AM

As filed with the Securities and Exchange Commission on September 28, 2023

Table of Contents As filed with the Securities and Exchange Commission on September 28, 2023 Registration No.

September 22, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 22, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Comm

September 8, 2023 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commi

September 8, 2023 EX-99.1

Renalytix Appoints Senior Executive Howard Doran as Chief Business Officer Doran Brings Significant Diagnostics Sector Experience to Lead the KidneyIntelX Global Sales Effort

Exhibit 99.1 Renalytix Appoints Senior Executive Howard Doran as Chief Business Officer Doran Brings Significant Diagnostics Sector Experience to Lead the KidneyIntelX Global Sales Effort LONDON and SALT LAKE CITY – September 07, 2023 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX), the first company to commercialize an FDA approved artificial intelligence (AI) enabled prognostic blood test for individ

August 21, 2023 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 21, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commiss

July 17, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 17, 2023 Renalytix plc (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 17, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commissio

July 17, 2023 EX-99.1

The following amendment has been made to the ‘Issue of Shares’ announcement released on 17 July 2023 at 07:00 under RNS No 1495G The correct figure for the principal remaining under the convertible bond after the settlement of the repayment is $15.90

Exhibit 99.1 The following amendment has been made to the ‘Issue of Shares’ announcement released on 17 July 2023 at 07:00 under RNS No 1495G The correct figure for the principal remaining under the convertible bond after the settlement of the repayment is $15.90 million. All other details remain unchanged. The full amended text is shown below. Renalytix plc (“Renalytix” or the “Company”) Issue of

July 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 3, 2023 Renalytix plc (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 3, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commission

July 3, 2023 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Directorate Change Renalytix Appoints Financial Executive Catherine Coste to its Board of Directors

Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Directorate Change Renalytix Appoints Financial Executive Catherine Coste to its Board of Directors LONDON and SALT LAKE CITY – July 3, 2023 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX), the first company to commercialize an FDA approved artificial intelligence (AI) enabled prognostic blood test for individuals with Type 2 diabetes and chroni

July 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 1, 2023 Renalytix plc (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 1, 2023 Renalytix plc (Exact name of registrant as specified in its Charter) England and Wales 001-39387 Not Applicable (State or other jurisdiction of incorporation) (Commission

June 30, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 30, 2023 Commission File Number: 001-39

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 30, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal ex

June 30, 2023 EX-99.1

FDA Grants De Novo Marketing Authorization for KidneyIntelX.dkd to Assess Risk of Progressive Kidney Function Decline in Adults with Diabetes and Early-Stage Kidney Disease Simple Blood Test Aids Risk Assessment for Approximately 14 Million Eligible

Exhibit 99.1 FDA Grants De Novo Marketing Authorization for KidneyIntelX.dkd to Assess Risk of Progressive Kidney Function Decline in Adults with Diabetes and Early-Stage Kidney Disease Simple Blood Test Aids Risk Assessment for Approximately 14 Million Eligible Patients in the United States Diabetic Kidney Disease is the Leading Cause of End Stage Kidney Disease in the United States LONDON and SA

June 9, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 9, 2023 Commission File Number: 001-393

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 9, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal exe

June 9, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 9, 2023 Commission File Number: 001-393

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 9, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal exe

May 22, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: May 22, 2023 Commission File Number: 001-393

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: May 22, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal exe

May 11, 2023 EX-99.1

Finsgate, 5-7 Cranwood Street, London, EC1V 9EE

Exhibit 99.1 11 May 2023 Dear Shareholder, Renalytix plc – Notice of General Meeting Please accept this letter as notification that a notice of general meeting (the “Notice of General Meeting”) has now been published on the Company’s website at https://investors.renalytix.com/news-and-events/documents-and-presentations and is enclosed for shareholders who elected for a hard copy of the Notice of G

May 11, 2023 EX-99.2

RENALYTIX PLC (incorporated and registered in England and Wales under the Companies Act 2006 with company number 11257655) Notice of General Meeting

Exhibit 99.2 THIS DOCUMENT IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION. If you are in any doubt about the contents of this document or the action you should take, you should immediately consult your stockbroker, bank manager, solicitor, accountant, or other independent financial adviser duly authorised under the Financial Services and Markets Act 2000, if you are resident in the United King

May 11, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: May 11, 2023 Commission File Number: 001-393

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: May 11, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal exe

May 11, 2023 EX-99

Renalytix plc ("Renalytix" or the "Company") Notice of General Meeting and Posting of Circular

Renalytix plc ("Renalytix" or the "Company") Notice of General Meeting and Posting of Circular LONDON and SALT LAKE CITY, May 11, 2023 - Renalytix (NASDAQ: RNLX) (LSE: RENX) announces that a circular containing a notice convening a General Meeting to be held at the offices of Harwood Capital LLP, 6 Stratton Street Mayfair, London W1J 8LD at 3 p.

May 11, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: May 11, 2023 Commission File Number: 001-393

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: May 11, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal exe

May 10, 2023 424B3

18,402,287 Ordinary Shares 3,379,237 Ordinary Shares 7,511,525 American Depositary Shares Representing 15,023,050 Ordinary Shares

424B3 Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-271579 PROSPECTUS 18,402,287 Ordinary Shares 3,379,237 Ordinary Shares 7,511,525 American Depositary Shares Representing 15,023,050 Ordinary Shares This prospectus relates to the resale by the selling securityholders identified in this prospectus, or the selling securityholders, of up to (i) 3,379,237 ordinary shares and

May 8, 2023 CORRESP

5-7 Cranwood Street London EC1V 9EE United Kingdom

Acceleration Request Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom May 8, 2023 VIA EDGAR U.

May 2, 2023 F-3

Power of Attorney (included on signature page to registration statement)

F-3 Table of Contents As filed with the Securities and Exchange Commission on May 2, 2023 Registration No.

May 2, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form F-3 (Form Type) Renalytix plc (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1)(2) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee(3) Equity American Depositary Shares (ADSs) 457(c) 9,201,144 $2.

March 30, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 30, 2023 Commission File Number: 001-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 30, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal e

March 27, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 27, 2023 Commission File Number: 001-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 27, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal e

March 21, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 21, 2023 Commission File Number: 001-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 21, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal e

March 10, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 10, 2023 Commission File Number: 001-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 10, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal e

February 17, 2023 SC 13D

US75973T1016 / RENALYTIX AI PLC-ADR DEPOSITARY RECEIPT / JEFFERSON RIVER CAPITAL LLC - SC 13D Activist Investment

SC 13D 1 tm237208d1sc13d.htm SC 13D    UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* RENALYTIX PLC (Name of Issuer) Ordinary Shares, nominal value £0.0025 per share Underlying American Depositary Shares (Title of Class of Securities) 75973T101 (American Depositary Shares) (CUSIP Number) Peter Trapani

February 17, 2023 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 tm237208d1ex99-1.htm EXHIBIT 99.1 EXHIBIT 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a statement on this Schedule 13D dated February 17, 2023 (including amendments thereto) with respect to the ordinary shares of Renalytix plc. Thi

February 17, 2023 EX-99.4

RENALYTIX PLC Lock-Up Agreement February 7, 2023

EX-99.4 3 tm237208d1ex99-4.htm EXHIBIT 99.4 Exhibit 99.4 RENALYTIX PLC Lock-Up Agreement February 7, 2023 Renalytix plc Finsgate 5-7 Cranwood Street London EC1V 9EE Re: Renalytix plc - Lock-Up Agreement Ladies and Gentlemen: The undersigned understands that Renalytix plc, a public limited company incorporated under the laws of England and Wales (the “Company”), is proposing to engage in a private

February 14, 2023 SC 13G/A

US75973T1016 / RENALYTIX AI PLC-ADR DEPOSITARY RECEIPT / GILDER GAGNON HOWE & CO LLC - SC 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (RULE 13d - 102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (Amendment No. 2)* Renalytix plc (Name of Issuer) Ordinary Shares, £0.0025 par value per share (Title of Class of Securities) 75973T101 (CUSIP Number) December 31, 2022 (Date of Event

February 10, 2023 EX-99.3

DATED 30 OCTOBER 2018 RENALYTIX AI PLC ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI NPLUS1 SINGER ADVISORY LLP

EX-99.3 2 ex993.htm EXHIBIT 3 - RELATIONSHIP AGREEMENT EXECUTION VERSION DATED 30 OCTOBER 2018 RENALYTIX AI PLC and ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI and NPLUS1 SINGER ADVISORY LLP RELATIONSHIP AGREEMENT COOLEY (UK) LLP, DASHWOOD, 69 OLD BROAD STREET, LONDON EC2M 1QS, UK T: +44 (0) 20 7583 4055 F: +44 (0) 20 7785 9355 WWW.COOLEY.COM THIS AGREEMENT is dated 30 October 2018 BETWEEN: (1) RENALY

February 10, 2023 SC 13D

US75973T1016 / RENALYTIX AI PLC-ADR DEPOSITARY RECEIPT / ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI - SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* RENALYTIX PLC (Name of Issuer) ORDINARY SHARES (Including Ordinary Shares Underlying American Depository Shares) (Title of Class of Securities) 75973T101 (American Depository Shares) (CUSIP Number) Mount Sinai Health System, Inc. 150 East 42nd Street Suit

February 8, 2023 EX-99.4

REGISTRATION RIGHTS AGREEMENT by and between The Hamilton E. James 2003 Childrens Trust Renalytix plc Dated as of February 6, 2023 Table of Contents

Execution Version Exhibit 99.4 REGISTRATION RIGHTS AGREEMENT by and between The Hamilton E. James 2003 Childrens Trust and Renalytix plc Dated as of February 6, 2023 Table of Contents Page 1. Certain Definitions. 1 2. Shelf Registration Statement. 3 3. Piggyback Registrations. 4 4. Other Registrations 5 5. Selection of Underwriters. 5 6. Procedures. 5 7. Registration Expenses. 9 8. Board Appointme

February 8, 2023 EX-99.2

SECURITIES PURCHASE AGREEMENT (Ordinary Shares)

Exhibit 99.2 Exhibit 99.2 SECURITIES PURCHASE AGREEMENT (Ordinary Shares) This Securities Purchase Agreement (this “Agreement”) is dated as of February 7, 2023 (the “Effective Date”), by and among Renalytix plc, a public limited company incorporated under the laws of England and Wales (the “Company”), and each purchaser identified on the signature pages hereto (each a “Purchaser” and collectively

February 8, 2023 EX-99.1

Renalytix plc ("Renalytix" or the "Company") Renalytix announces a c.$20.3 million private placement

Exhibit 99.1 NOT FOR PUBLICATION, DISTRIBUTION OR RELEASE DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES, CANADA, AUSTRALIA, JAPAN OR THE REPUBLIC OF SOUTH AFRICA OR IN OR INTO ANY OTHER JURISDICTION IN WHICH OFFERS OR SALES WOULD BE PROHIBITED BY APPLICABLE LAW. THIS ANNOUNCEMENT IS NOT AN OFFER TO SELL OR A SOLICITATION TO BUY SECURITIES IN ANY JURISDICTION, INCLUDING

February 8, 2023 EX-99.3

SECURITIES PURCHASE AGREEMENT (American Depositary Shares)

Exhibit 99.3 Exhibit 99.3 SECURITIES PURCHASE AGREEMENT (American Depositary Shares) This Securities Purchase Agreement (this “Agreement”) is dated as of February 7, 2023 (the “Effective Date”), by and among Renalytix plc, a public limited company incorporated under the laws of England and Wales (the “Company”), and each purchaser identified on the signature pages hereto (each a “Purchaser” and co

February 8, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: February 8, 2023 Commission File Number: 001

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: February 8, 2023 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal

December 20, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: December 20, 2022 Commission File Number: 00

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: December 20, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant?s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principa

November 30, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: November 30, 2022 Commission File Number: 00

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: November 30, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant?s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principa

November 29, 2022 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Published Real World Evidence Demonstrates KidneyIntelX™ Improved Clinical Decisions and Outcomes in High-Risk Patients with Early-Stage Diabetic Kidney Disease Risk scoring by KidneyIntelX resulted in a 4

EX-99.1 2 rnlx-ex991.htm EX-99.1 Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Published Real World Evidence Demonstrates KidneyIntelX™ Improved Clinical Decisions and Outcomes in High-Risk Patients with Early-Stage Diabetic Kidney Disease Risk scoring by KidneyIntelX resulted in a 4.5-fold increase in new drug prescriptions (for SGLT2 inhibitors) for high risk compared to low risk pat

November 29, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: November 29, 2022 Commission File Number: 00

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: November 29, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principa

November 22, 2022 EX-99.3

RENALYTIX PLC (incorporated and registered in England and Wales under the Companies Act 2006 with company number 11257655) Notice of Annual General Meeting to be held at 6 Stratton Street Mayfair, London W1J 8LD on 19 December 2022

Exhibit 99.3 THIS DOCUMENT IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION. If you are in any doubt about the contents of this document or the action you should take, you should immediately consult your stockbroker, bank manager, solicitor, accountant, or other independent financial adviser duly authorised under the Financial Services and Markets Act 2000, if you are resident in the United King

November 22, 2022 EX-99.2

Finsgate, 5-7 Cranwood Street, London, EC1V 9EE

Exhibit 99.2 10 November 2022 Dear Shareholder, Renalytix plc ? Annual Report 2022 and Notice of 2022 Annual General Meeting Please accept this letter as notification that Renalytix plc?s (the ?Company?) Annual Report for the year ended 30 June 2022 and the Notice of the 2022 Annual General Meeting have now been published on the Company?s website at https://investors.renalytix.com/news-and-events/

November 22, 2022 EX-99.1

On 30 June 2022 Ordinary Shares of 0.25p each

Exhibit 99.1 Renalytix plc Annual Report and Financial Statements FOR THE YEAR ENDED 30 JUNE 2022 | Renalytix plc Annual Report and Financial Statements 1 Index STRATEGIC REPORT 3-21 Chairman & CEO?s Joint Statement 3 Company Overview 8 Operational and Financial Highlights 9 Product Overview and Strategy 11 Financial Review 13 Risk Management Approach 15 Section 172 Statement 19 Corporate Social R

November 22, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: November 22, 2022 Commission File Number: 00

6-K 1 rnlx-6-k-agmnotice.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: November 22, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE Un

November 22, 2022 EX-99.4

Annual General Meeting The Voting Instructions must be signed, completed and received at the indicated address prior to 10:00 A.M. (New York City time) on December 13, 2022 for action to be taken. 2022 VOTING INSTRUCTIONS AMERICAN DEPOSITARY SHARES R

EX-99.4 5 rnlx-ex994.htm EX-99.4 Exhibit 99.4 Annual General Meeting The Voting Instructions must be signed, completed and received at the indicated address prior to 10:00 A.M. (New York City time) on December 13, 2022 for action to be taken. 2022 VOTING INSTRUCTIONS AMERICAN DEPOSITARY SHARES Renalytix plc (the “Company”) CUSIP No.: 75973T101. ADS Record Date: November 14, 2022. Meeting Specifics

October 31, 2022 EX-13.1

Certification by the Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

EXHIBIT 13.1 CERTIFICATION BY THE PRINCIPAL EXECUTIVE OFFICER AND PRINCIPAL FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 Pursuant to the requirement set forth in Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?) and Section 1350 of Chapter 63 of Title 18 of the United States Code (18

October 31, 2022 EX-10.11

Amended and Restated Bond Agreement between registrant and CVI Investments, dated as of April 5, 2022

EXHIBIT 10.11 Dated 5 April 2022 Amendment and Restatement Agreement in respect of the Original Bond Agreement by Renalytix plc with CVI Investments, Inc. as Initial Bondholder White & Case LLP 5 Old Broad Street London EC2N 1DW CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT

October 31, 2022 EX-15.2

Consent of Deloitte & Touche LLP, independent registered public accounting firm (PCAOB ID No. 34)

Exhibit 15.2 Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement No. 333-265280 on Form F-3 and Registration Statement No. 333-248741 on Form S-8 of our report dated October 27, 2020, relating to the financial statements of Renalytix plc (formerly Renalytix AI plc) appearing in this Form 20-F for the year ended June 30, 20

October 31, 2022 EX-15.1

Consent of Ernst & Young LLP, independent registered public accounting firm (PCAOB ID No. 42)

Exhibit 15.1 Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in the Post-Effective Amendment No.1 to the Registration Statement on Form F-3 (No. 333-265280) and to the Registration Statement on Form S-8 (No. 333-248741) pertaining to the Share Option Plan for Employees with Non-Employee Sub-Plan and U.S. Sub-Plan, 2020 Employee Share Purchase P

October 31, 2022 EX-12.1

Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

EXHIBIT 12.1 CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, James McCullough, certify that: 1. I have reviewed this annual report on Form 20-F of Renalytix plc; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a m

October 31, 2022 EX-12.2

Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

EXHIBIT 12.2 CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, O. James Sterling, certify that: 1. I have reviewed this annual report on Form 20-F of Renalytix plc; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a

October 31, 2022 EX-21.1

Subsidiaries of the registrant

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction Renalytix AI, Inc. United States Renalytix AI Limited Ireland

October 31, 2022 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 13(d) OF THE SECURITIES EXCHANG

October 25, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: October 25, 2022 Commission File Number: 001

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: October 25, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal

October 25, 2022 EX-99.1

Renalytix plc ("Renalytix" or the "Company") KidneyIntelX Medicare Update

Exhibit 99.1 Renalytix plc ("Renalytix" or the "Company") KidneyIntelX Medicare Update NEW YORK and SALT LAKE CITY, October 25, 2022 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX) today announced that, building on recently established private payer and Medicaid insurance coverage contracts for KidneyIntelX, the Federal Medicare Administrative Contractor (MAC) National Government Services (NGS) has ini

September 21, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: September 21, 2022 Commission File Number: 0

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: September 21, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant?s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of princip

September 21, 2022 EX-99.1

Renalytix plc ("Renalytix" or the "Company") Renalytix Announces Change to Board of Directors

Exhibit 99.1 Renalytix plc ("Renalytix" or the "Company") Renalytix Announces Change to Board of Directors LONDON and SALT LAKE CITY, 20 September 2022 ? Renalytix plc (NASDAQ: RNLX) (LSE: RENX) announces that Ann Berman, non-executive director and chair of the audit and nomination committees, has resigned as a director of the Company for personal reasons effective immediately. Ms. Berman commente

August 17, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: August 17, 2022 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: August 17, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant?s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal

August 1, 2022 EX-13.1

Certification by the Principal Executive Officer and Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

EX-13.1 EXHIBIT 13.1 CERTIFICATION BY THE PRINCIPAL EXECUTIVE OFFICER AND PRINCIPAL FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 Pursuant to the requirement set forth in Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) and Section 1350 of Chapter 63 of Title 18 of the United States C

August 1, 2022 EX-12.2

Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

EX-12.2 EXHIBIT 12.2 CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, O. James Sterling, certify that: 1. I have reviewed this annual report on Form 20-F of Renalytix plc; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to

August 1, 2022 EX-15.1

Consent of Ernst & Young LLP, independent registered public accounting firm

EX-15.1 5 d381344dex151.htm EX-15.1 EXHIBIT 15.1 Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in the Registration Statement (Form S-8 No. 333-248741) pertaining to the Share Option Plan for Employees with Non-Employee Sub-Plan and U.S. Sub-Plan, 2020 Employee Share Purchase Plan, and 2020 Equity Incentive Plan of Renalytix plc of our report

August 1, 2022 EX-15.2

Consent of Deloitte & Touche LLP, independent registered public accounting firm

EX-15.2 EXHIBIT 15.2 Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement No. 333-248741 on Form S-8 of our report dated October 27, 2020, relating to the financial statements of Renalytix plc (formerly Renalytix AI plc) appearing in this Annual Report on Amendment No. 2 to Form 20-F/A for the years ended June 30, 2020 and

August 1, 2022 EX-12.1

Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

EX-12.1 EXHIBIT 12.1 CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, James McCullough, certify that: 1. I have reviewed this annual report on Form 20-F of Renalytix plc; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to s

August 1, 2022 POS AM

As filed with the Securities and Exchange Commission on August 1, 2022

Table of Contents As filed with the Securities and Exchange Commission on August 1, 2022 Registration No.

August 1, 2022 20-F/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F/A (Amendment No. 2) (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 1

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F/A (Amendment No. 2) (Mark One) ? REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION

June 30, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 30, 2022 Commission File Number: 001-39

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 30, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant?s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Address of principal ex

June 27, 2022 EX-99.1

Renalytix to Report Financial Results for Third Quarter Fiscal 2022 on June 30

Exhibit 99.1 Renalytix to Report Financial Results for Third Quarter Fiscal 2022 on June 30 NEW YORK and SALT LAKE CITY, June 23, 2022 - Renalytix plc (NASDAQ: RNLX) (LSE: RENX) today announced the Company will report its third quarter fiscal 2022 financial results on Thursday, June 30, 2022, before market open. The Company will host a corresponding conference call and live webcast to discuss the

June 27, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 27, 2022 Commission File Number: 001-39

6-K 1 rnlx-6-k-q3earningsannou.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: June 27, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE

June 6, 2022 424B3

11,075,220 Ordinary Shares 1,052,197 American Depositary Shares Representing 13,179,614 Ordinary Shares

424B3 1 d338565d424b3.htm 424B3 Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-265280 PROSPECTUS 11,075,220 Ordinary Shares 1,052,197 American Depositary Shares Representing 13,179,614 Ordinary Shares This prospectus relates to the resale by the selling securityholders identified in this prospectus, or the selling securityholders, of (i) up to 11,075,220 ordinary shares an

June 2, 2022 CORRESP

5-7 Cranwood Street London EC1V 9EE United Kingdom

CORRESP 1 filename1.htm Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom June 2, 2022 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Dorrie Yale Re: Renalytix plc Registration Statement on Form F-3 Filed May 27, 2022 File No. 333-265280 Acceleration Request Requested Date: June 6, 2022 Requested Time:

May 27, 2022 EX-4.4

Securities Purchase Agreement, by and among the registrant and the purchasers named therein, dated as of March 31, 2022

Exhibit 4.4 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of March 31, 2022 (the ?Effective Date?), by and among Renalytix plc, a public limited company incorporated under the laws of England and Wales (the ?Company?), and each purchaser identified on the signature pages hereto (each a ?Purchaser? and collectively the ?Purchasers?). WHEREAS, the Co

May 27, 2022 F-3

As filed with the Securities and Exchange Commission on May 27, 2022

Table of Contents As filed with the Securities and Exchange Commission on May 27, 2022 Registration No.

May 27, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form F-3 (Form Type) Renalytix plc (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1)(2) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee(6) Equity American Depositary Shares (ADSs) 457(c) 6,589,807 $3.

May 27, 2022 SC 13G/A

US75973T1016 / RENALYTIX AI PLC-ADR DEPOSITARY RECEIPT / ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Act of 1934 (Amendment No. 1)* RENALYTIX AI plc (Name of Issuer) ORDINARY SHARES (Including Ordinary Shares Underlying American Depository Shares) (Title of Class of Securities) 75973T101 (American Depository Shares) (CUSIP Number) March 31, 2022 (Date of Event Which Requires Filing of this St

May 27, 2022 SC 13G

US75973T1016 / RENALYTIX AI PLC-ADR DEPOSITARY RECEIPT / ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Act of 1934 (Amendment No. )* RENALYTIX AI plc (Name of Issuer) ORDINARY SHARES (Including Ordinary Shares Underlying American Depository Shares) (Title of Class of Securities) 75973T101 (American Depository Shares) (CUSIP Number) JULY 21, 2020 (Date of Event Which Requires Filing of this Stat

April 29, 2022 6-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K/A Amendment No. 1 REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: April 29, 2022 Commission

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K/A Amendment No. 1 REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: April 29, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kingdom (Addr

April 1, 2022 EX-99.1

Renalytix plc ("Renalytix" or the "Company") Renalytix announces a $30.0 million financing package

EX-99.1 2 rnlx-ex991.htm EX-99.1 Exhibit 99.1 NOT FOR PUBLICATION, DISTRIBUTION OR RELEASE DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES, CANADA, AUSTRALIA, JAPAN, THE REPUBLIC OF SOUTH AFRICA, NEW ZEALAND OR IN OR INTO ANY OTHER JURISDICTION IN WHICH OFFERS OR SALES WOULD BE PROHIBITED BY APPLICABLE LAW. THIS ANNOUNCEMENT IS NOT AN OFFER TO SELL OR A SOLICITATION TO BU

April 1, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: April 1, 2022 Commission File Number: 001-39

6-K 1 rnlx-6-k-financing.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: April 1, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United

March 31, 2022 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Financial Results for Second Quarter of Fiscal Year 2022

Exhibit 99.1 Renalytix plc (?Renalytix? or the ?Company?) Renalytix Reports Financial Results for Second Quarter of Fiscal Year 2022 LONDON and SALT LAKE CITY, March 31, 2022 ? Renalytix plc (NASDAQ: RNLX) (LSE: RENX), an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved patient outcomes and advance value-bas

March 31, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 31, 2022 Commission File Number: 001-3

6-K 1 rnlx-6-k-q3er.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: March 31, 2022 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kin

February 14, 2022 SC 13G/A

US75973T1016 / RENALYTIX AI PLC-ADR DEPOSITARY RECEIPT / GILDER GAGNON HOWE & CO LLC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (RULE 13d - 102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (Amendment No. 1)* Renalytix plc (Name of Issuer) Ordinary Shares, ?0.0025 par value per share (Title of Class of Securities) 75973T101 (CUSIP Number) December 31, 2021 (Date of Event

February 11, 2022 SC 13G

US75973T1016 / RENALYTIX AI PLC-ADR DEPOSITARY RECEIPT / GILDER GAGNON HOWE & CO LLC - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (RULE 13d - 102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 Renalytix plc (Name of Issuer) Ordinary Shares, £0.0025 par value per share (Title of Class of Securities) 75973T101 (CUSIP Number) December 31, 2020 (Date of Event which Requires Fili

January 27, 2022 EX-12.1

Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

EX-12.1 EXHIBIT 12.1 CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, James McCullough, certify that: 1. I have reviewed this annual report on Form 20-F of Renalytix plc; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to s

January 27, 2022 20-F/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F/A (Amendment No. 1) (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F/A (Amendment No. 1) (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 13(d) OF TH

January 27, 2022 CORRESP

* * *

CORRESP 1 filename1.htm Marc Recht +1 617 937 2316 [email protected] VIA EDGAR January 27, 2022 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Mary Mast Daniel Gordon Re: Renalytix plc Form 20-F for the fiscal year ended June 30, 2021 Filed October 21, 2021 File number 001-39387 Ladies and Gentlemen: This letter is submitted

January 27, 2022 EX-12.2

Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

EXHIBIT 12.2 CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, O. James Sterling, certify that: 1. I have reviewed this annual report on Form 20-F of Renalytix plc; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a

December 20, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: December 20, 2021 Commission File Number: 00

6-K 1 d226133d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: December 20, 2021 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United Kin

December 7, 2021 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Financial Results for First Quarter of Fiscal Year 2022

EX-99.1 2 d259607dex991.htm EX-99.1 Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Financial Results for First Quarter of Fiscal Year 2022 LONDON and SALT LAKE CITY, December 7, 2021 – Renalytix plc (NASDAQ: RNLX) (LSE: RENX), an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved p

December 7, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: December 7, 2021 Commission File Number: 001

6-K 1 d259607d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: December 7, 2021 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Finsgate 5-7 Cranwood Street London EC1V 9EE United King

November 30, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: November 30, 2021 Commission File Number: 00

6-K 1 d218032d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Date of report: November 30, 2021 Commission File Number: 001-39387 Renalytix plc (Translation of registrant’s name into English) Avon House 19 Stanwell Road Penarth, Cardiff CF64 2EZ U

November 30, 2021 EX-99.3

RENALYTIX PLC (incorporated and registered in England and Wales under the Companies Act 2006 with company number 11257655) Notice of Annual General Meeting to be held at 6 Stratton Street Mayfair, London W1J 8LD on 17 December 2021

EX-99.3 4 d218032dex993.htm EX-99.3 Exhibit 3 THIS DOCUMENT IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION. If you are in any doubt about the contents of this document or the action you should take, you should immediately consult your stockbroker, bank manager, solicitor, accountant, or other independent financial adviser duly authorised under the Financial Services and Markets Act 2000, if yo

November 30, 2021 EX-99.4

Annual General Meeting The Voting Instructions must be signed, completed and received at the indicated address prior to 10:00 A.M. (New York City time) on December 13, 2021 for action to be taken. 2021 VOTING INSTRUCTIONS AMERICAN DEPOSITARY SHARES R

EX-99.4 5 d218032dex994.htm EX-99.4 Exhibit 4 Annual General Meeting The Voting Instructions must be signed, completed and received at the indicated address prior to 10:00 A.M. (New York City time) on December 13, 2021 for action to be taken. 2021 VOTING INSTRUCTIONS AMERICAN DEPOSITARY SHARES Renalytix plc (the “Company”) CUSIP No.: 75973T101. ADS Record Date: November 22, 2021. Meeting Specifics

November 30, 2021 EX-99.2

Finsgate, 5-7 Cranwood Street, London, EC1V 9EE

Exhibit 2 19 November 2021 Dear Shareholder, Renalytix plc ? Annual Report 2021 and Notice of 2021 Annual General Meeting Please accept this letter as notification that Renalytix plc?s (the ?Company?) Annual Report for the year ended 30 June 2021 and the Notice of the 2021 Annual General Meeting have now been published on the Company?s website at https://investors.

November 30, 2021 EX-99.1

REMUNERATION COMMITTEE REPORT DR. ERIK LIUM CHAIR OF THE REMUNERATION

EX-99.1 2 d218032dex991.htm EX-99.1 Exhibit 1 Renalytix plc Annual Report and Financial Statements FOR THE YEAR ENDED 30 JUNE 2021 | Renalytix plc Annual Report and Financial Statements 2 Index STRATEGIC REPORT 4-23 Chairman & CEO’s Joint Statement 4 Company Overview 9 Operational and Financial Highlights 10 Product Overview and Strategy 12 Financial Review 15 Risk Management Approach 17 Section 1

October 21, 2021 EX-99.1

Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Full Year Fiscal 2021 Results

EX-99.1 2 d164692dex991.htm EX-99.1 Exhibit 99.1 Renalytix plc (“Renalytix” or the “Company”) Renalytix Reports Full Year Fiscal 2021 Results LONDON and SALT LAKE CITY, October 21, 2021 – Renalytix plc (NASDAQ: RNLX), (LSE: RENX) an artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management of kidney disease to drive improved patient outcomes and advanc

October 21, 2021 EX-12.1

Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

EX-12.1 EXHIBIT 12.1 CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, James McCullough, certify that: 1. I have reviewed this annual report on Form 20-F of Renalytix plc; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to s

October 21, 2021 EX-13.1

Certification by the Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

EXHIBIT 13.1 CERTIFICATION BY THE PRINCIPAL EXECUTIVE OFFICER AND PRINCIPAL FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 Pursuant to the requirement set forth in Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?) and Section 1350 of Chapter 63 of Title 18 of the United States Code (18

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