RLYP / Relypsa, Inc. - Depositi SEC, Relazione annuale, dichiarazione di delega

Relypsa, Inc.
US ˙ NASDAQ
QUESTO SIMBOLO NON E' PIU' ATTIVO

Statistiche di base
CIK 1416792
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Relypsa, Inc.
SEC Filings (Chronological Order)
Questa pagina fornisce un elenco completo e cronologico dei depositi SEC, esclusi i documenti di proprietà che forniamo altrove.
August 13, 2019 CT ORDER

RLYP / Relypsa, Inc. CT ORDER - -

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August 13, 2019 CT ORDER

RLYP / Relypsa, Inc. CT ORDER - -

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September 17, 2018 CT ORDER

RLYP / Relypsa, Inc. CT ORDER

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February 14, 2017 SC 13G/A

RLYP / Relypsa, Inc. / JHL Capital Group LLC - 13G/A Passive Investment

SC 13G/A 1 rlyp123116a1.htm 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Relypsa, Inc. (Name of Issuer) Common Stock, $.001 par value (Title of Class of Securities) 759531106 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to

February 14, 2017 SC 13G/A

RLYP / Relypsa, Inc. / DELPHI VENTURES VII L P - SC 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b) (Amendment No. 2)* Relypsa, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing of this Statemen

October 20, 2016 CT ORDER

Relypsa RDER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION October 20, 2016 ORDER GRANTING CONFIDENTIAL TREATMENT UNDER THE SECURITIES ACT OF 1933 Relypsa, Inc.

October 7, 2016 SC 13G/A

RLYP / Relypsa, Inc. / HIGHLAND CAPITAL MANAGEMENT FUND ADVISORS, L.P. - SC 13G/A Passive Investment

SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A (Rule 13d-102) (Amendment No.

September 19, 2016 CT ORDER

Relypsa RDER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION September 19, 2016 ORDER GRANTING CONFIDENTIAL TREATMENT UNDER THE SECURITIES EXCHANGE ACT OF 1934 Relypsa, Inc.

September 12, 2016 15-12B

Relypsa 15-12B

15-12B UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact name of Registrant as specified in its

September 6, 2016 S-8 POS

Relypsa S-8 POS

S-8 POS As filed with the Securities and Exchange Commission on September 6, 2016 Registration No.

September 6, 2016 S-8 POS

Relypsa S-8 POS

S-8 POS 1 d223345ds8pos.htm S-8 POS As filed with the Securities and Exchange Commission on September 6, 2016 Registration No. 333-192441 Registration No. 333-202678 Registration No. 333-206163 Registration No. 333-209724 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-192441 POST-EFFECTIVE AMENDMENT

September 6, 2016 S-8 POS

Relypsa S-8 POS

S-8 POS As filed with the Securities and Exchange Commission on September 6, 2016 Registration No.

September 6, 2016 S-8 POS

Relypsa S-8 POS

S-8 POS As filed with the Securities and Exchange Commission on September 6, 2016 Registration No.

September 6, 2016 POS AM

Relypsa POS AM

As filed with the Securities and Exchange Commission on September 6, 2016 Registration No.

September 6, 2016 POS AM

Relypsa POS AM

POS AM As filed with the Securities and Exchange Commission on September 6, 2016 Registration No.

September 1, 2016 8-K

Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Termination of a Material Definitive Agreement, Material Modification to Rights of Security Holders, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Triggering Events That Accelerate or Increase a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commissio

September 1, 2016 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION RELYPSA, INC.

EX-3.1 Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF RELYPSA, INC. FIRST: The name of the corporation (the ?Corporation?) is Relypsa, Inc. SECOND: The address of the Corporation?s registered office in the State of Delaware is Corporation Trust Center, 1209 Orange Street, City of Wilmington, County of New Castle, Delaware 19801. The name of the Corporation?s registered agent at s

September 1, 2016 EX-3.2

AMENDED AND RESTATED BYLAWS RELYPSA, INC. ARTICLE I - MEETINGS OF STOCKHOLDERS

EX-3.2 Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF RELYPSA, INC. ARTICLE I - MEETINGS OF STOCKHOLDERS Section 1.1 Annual Meetings. If required by applicable law, an annual meeting of stockholders shall be held for the election of directors at such date, time and place, if any, either within or without the State of Delaware, as may be designated by resolution of the Board of Directors from time to t

September 1, 2016 SC 14D9/A

Relypsa SC 14D9/A

SC 14D9/A 1 d248675dsc14d9a.htm SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Amendment No. 5) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company) RELYPSA, INC. (Name of Person Filing Statement) Common Stock, par value $0.001 per share (Title of Class of Secur

September 1, 2016 SC TO-T/A

Relypsa SC TO-T/A

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 14d-100) TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 5) RELYPSA, INC. (Name of Subject Company (Issuer)) VIFOR PHARMA USA INC. (Offeror) An Indirect Wholly Owned Subsidiary of GALENICA AG (Offeror) (Names of Filing Persons (identify

September 1, 2016 EX-99.(A)(5)(H)

Investor Relations, Galenica Group: Jörg Kneubühler, CFO

EX-99.(A)(5)(H) 2 d222661dex99a5h.htm EX-99.(A)(5)(H) Exhibit (a)(5)(H) PRESS RELEASE Date 1 September 2016 Contact Investor Relations, Galenica Group: Jörg Kneubühler, CFO Media Relations, Galenica Group: Christina Hertig, Head Corporate Communications Media Relations, Vifor Pharma: Beatrix Benz, Head Global Communications & Public Affairs Subject Galenica announces Expiration of Cash Tender Offe

August 25, 2016 SC TO-T/A

Relypsa SC TO-T/A

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 14d-100) TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 4) RELYPSA, INC. (Name of Subject Company (Issuer)) VIFOR PHARMA USA INC. (Offeror) An Indirect Wholly Owned Subsidiary of GALENICA AG (Offeror) (Names of Filing Persons (identify

August 25, 2016 SC 14D9/A

Relypsa SC 14D9/A

SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Amendment No. 4) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company) RELYPSA, INC. (Name of Person Filing Statement) Common Stock, par value $0.001 per share (Title of Class of Securities) 759531106 (CUSIP Number o

August 24, 2016 SC TO-T/A

Relypsa SC TO-T/A

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 14d-100) TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) RELYPSA, INC. (Name of Subject Company (Issuer)) VIFOR PHARMA USA INC. (Offeror) An Indirect Wholly Owned Subsidiary of GALENICA AG (Offeror) (Names of Filing Persons (identify

August 24, 2016 SC 14D9/A

Relypsa SC 14D9/A

SC 14D9/A 1 d246691dsc14d9a.htm SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Amendment No. 3) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company) RELYPSA, INC. (Name of Person Filing Statement) Common Stock, par value $0.001 per share (Title of Class of Secur

August 17, 2016 SC 14D9/A

Relypsa SC 14D9/A

SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Amendment No. 2) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company) RELYPSA, INC. (Name of Person Filing Statement) Common Stock, par value $0.001 per share (Title of Class of Securities) 759531106 (CUSIP Number o

August 17, 2016 CORRESP

250 VESEY STREET • NEW YORK, NEW YORK 10281.1047 TELEPHONE: +1.212.326.3939 • FACSIMILE: +1.212.755.7306

CORRESP 250 VESEY STREET • NEW YORK, NEW YORK 10281.1047 TELEPHONE: +1.212.326.3939 • FACSIMILE: +1.212.755.7306 DIRECT NUMBER: (212) 326-8319 [email protected] JP843204 August 17, 2016 Mr. Nicholas P. Panos Senior Special Counsel Securities and Exchange Commission Office of Mergers and Acquisitions 100 F Street, N.E. Washington, D.C. 20549-3628 Re: Relypsa, Inc. Schedule TO-T Filed August 4,

August 17, 2016 CORRESP

Relypsa ESP

August 17, 2016 VIA EDGAR TRANSMISSION AND FEDERAL EXPRESS Nicholas P. Panos Senior Special Counsel 140 Scott Drive Menlo Park, California 94025 Tel: +1.650.328.4600 Fax: +1.650.463.2600 www.lw.com FIRM / AFFILIATE OFFICES Barcelona Moscow Beijing Munich Boston New Jersey Brussels New York Century City Orange County Chicago Paris Dubai Riyadh Düsseldorf Rome Frankfurt San Diego Hamburg San Francis

August 17, 2016 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 14d-100) TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) RELYPSA, INC. (Name of Subject Compa

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 14d-100) TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) RELYPSA, INC. (Name of Subject Company (Issuer)) VIFOR PHARMA USA INC. (Offeror) An Indirect Wholly Owned Subsidiary of GALENICA AG (Offeror) (Names of Filing Persons (identify

August 15, 2016 LETTER

LETTER

August 12, 2016 Via E-mail Mr. Oliver Kronenberg Group General Counsel Galenica AG Untermattweg 8-P.O. Box CH-3027 Bern, Switzerland Re: Relypsa, Inc. Schedule TO-T Filed August 4, 2016 Amendment No. 1 to Schedule TO-T Filed August 9, 2016 Filed by Vifor Pharma USA Inc. and Galenica AG File No. 005-87732 Dear Mr. Kronenberg: We have limited our review of the filing to those issues we have addresse

August 15, 2016 LETTER

LETTER

August 12, 2016 Via E-mail Mr. John A. Orwin President and Chief Executive Officer Relypsa, Inc. 100 Cardinal Way Redwood City, California 94063 Re: Relypsa, Inc. Schedule 14D-9 Filed August 4, 2016 Amendment No. 1 to Schedule 14D-9 Filed August 9, 2016 File No. 005-87732 Dear Mr. Orwin: We have limited our review of the filing to those issues we have addressed in our comments. In some of our comm

August 10, 2016 EX-24.1

POWER OF ATTORNEY

EX-24.1 2 poamontgomery.htm POWER OF ATTORNEY Know all by these presents, that the undersigned hereby constitutes and appoints each of (i) the Chief Executive Officer of Relypsa, Inc., a Delaware corporation (the "Company"), who is currently John A. Orwin, (ii) the Company's Chief Financial Officer, who is currently Kristine M. Ball, and (iii) the Company's General Counsel, who is currently Ronald

August 10, 2016 EX-24.1

POWER OF ATTORNEY

EX-24.1 2 poamontgomery.htm POWER OF ATTORNEY Know all by these presents, that the undersigned hereby constitutes and appoints each of (i) the Chief Executive Officer of Relypsa, Inc., a Delaware corporation (the "Company"), who is currently John A. Orwin, (ii) the Company's Chief Financial Officer, who is currently Kristine M. Ball, and (iii) the Company's General Counsel, who is currently Ronald

August 9, 2016 SC 14D9/A

Relypsa SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Amendment No. 1) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company) RELYPSA, INC. (Name of Person Filing Statement) Common Stock, par value $0.001 per share (Title of Class of Securities) 759531106 (CUSIP Number of Class of

August 9, 2016 SC TO-T/A

Relypsa SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 14d-100) Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 1) RELYPSA, INC. (Name of Subject Company (issuer)) VIFOR PHARMA USA INC. (Offeror) An Indirect Wholly Owned Subsidiary of GALENICA AG (Parent of Offeror) (Names of Filing Persons (identify

August 8, 2016 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 d208127dex991.htm EX-99.1 EXHIBIT 99-1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto) with respect to the Common stock, par value $0.001 per share e, of Relypsa, Inc., a Delaware corpo

August 8, 2016 SC 13G

RLYP / Relypsa, Inc. / HIGHLAND CAPITAL MANAGEMENT FUND ADVISORS, L.P. - SC 13G Passive Investment

SC 13G SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Relypsa, Inc.

August 4, 2016 10-Q

Relypsa 10-Q (Quarterly Report)

rlyp-10q20160630.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2016 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact name of regist

August 4, 2016 EX-99.(D)(4)

RELYPSA, INC. 100 Cardinal Way Redwood City, CA 94063

Exhibit (d)(4) RELYPSA, INC. 100 Cardinal Way Redwood City, CA 94063 May 8, 2016 Galenica Ltd. Untermattweg 8 3027 Bern Switzerland Confidentiality Agreement Ladies and Gentlemen: A. You have indicated your interest in a possible acquisition of Relypsa, Inc. (the ?Company?) by way of a merger, purchase of stock, purchase of assets or otherwise (a ?Potential Transaction?). The Company may from time

August 4, 2016 EX-99.(D)(2)

CONFIDENTIALITY AGREEMENT

Exhibit (d)(2) T094(E) BILATERAL CDA BOTH PARTIES DISCLOSING CONFIDENTIALITY AGREEMENT THIS CONFIDENTIALITY AGREEMENT (hereinafter referred to as the ?Agreement?) shall be effective as of the 6th day of May, 2014 (hereinafter referred to as the ?Effective Date?) and is entered into by and between Vifor Fresenius Medical Care Renal Pharma Ltd.

August 4, 2016 EX-10.2

Amendment No. 1 to Manufacturing and Supply Agreement between Lanxess Corporation and Relypsa, Inc.

Exhibit 10.2 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. Amendment No. 1 to Manufacturing and Supply Agreement between Lanxess Corporation and Relypsa, Inc. This Amendment No. 1 to the Manufacturing and Supply Agreement (“Amendment No. 1”

August 4, 2016 EX-99.(A)(1)(E)

Offer to Purchase for Cash All Outstanding Shares of Common Stock RELYPSA, INC. $32.00 Net Per Share VIFOR PHARMA USA INC., an indirect wholly owned subsidiary GALENICA AG

EX-99.(a)(1)(E) Exhibit (a)(1)(E) Offer to Purchase for Cash All Outstanding Shares of Common Stock of RELYPSA, INC. at $32.00 Net Per Share by VIFOR PHARMA USA INC., an indirect wholly owned subsidiary of GALENICA AG THE OFFER AND WITHDRAWAL RIGHTS EXPIRE AT 12:00 MIDNIGHT, NEW YORK TIME, AT THE END OF THE DAY, WEDNESDAY, AUGUST 31, 2016, UNLESS THE OFFER IS EXTENDED. To Our Clients: Enclosed for

August 4, 2016 EX-99.(A)(1)(D)

Offer to Purchase for Cash All Outstanding Shares of Common Stock RELYPSA, INC. $32.00 Net Per Share VIFOR PHARMA USA INC., an indirect wholly owned subsidiary GALENICA AG

EX-99.(a)(1)(D) Exhibit (a)(1)(D) Offer to Purchase for Cash All Outstanding Shares of Common Stock of RELYPSA, INC. at $32.00 Net Per Share by VIFOR PHARMA USA INC., an indirect wholly owned subsidiary of GALENICA AG THE OFFER AND WITHDRAWAL RIGHTS EXPIRE AT 12:00 MIDNIGHT, NEW YORK TIME, AT THE END OF THE DAY ON WEDNESDAY, AUGUST 31, 2016, UNLESS THE OFFER IS EXTENDED. August 4, 2016 To Brokers,

August 4, 2016 EX-99.(A)(1)(C)

NOTICE OF GUARANTEED DELIVERY To Tender Shares of Common Stock RELYPSA, INC. $32.00 Net Per Share VIFOR PHARMA USA INC., an indirect wholly owned subsidiary GALENICA AG

EX-99.(A)(1)(C) 4 d148903dex99a1c.htm EX-99.(A)(1)(C) Exhibit (a)(1)(C) NOTICE OF GUARANTEED DELIVERY To Tender Shares of Common Stock of RELYPSA, INC. at $32.00 Net Per Share by VIFOR PHARMA USA INC., an indirect wholly owned subsidiary of GALENICA AG This form, or a substantially equivalent form, must be used to accept the Offer (as defined below) if certificates representing tendered Shares (as

August 4, 2016 EX-99.(A)(5)(F)

Notice of Offer to Purchase for Cash All Outstanding Shares of Common Stock Relypsa, Inc. $32.00 Net Per Share Vifor Pharma USA Inc., an indirect wholly owned subsidiary of Galenica AG

EX-99.(a)(5)(F) Exhibit (a)(5)(F) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below), and the provisions herein are subject in their entirety to the provisions of the Offer (as defined below). The Offer is made solely by the Offer to Purchase (as defined below), dated August 4, 2016, and the related Letter of Transmittal (as defined b

August 4, 2016 EX-99.(B)

CHF 1,450,000,000 MULTICURRENCY TERM FACILITY AGREEMENT 20 July 2016 GALENICA AG as Original Guarantor arranged by CREDIT SUISSE AG as Arranger CREDIT SUISSE AG acting as Agent Baker & McKenzie Zurich Holbeinstrasse 30, P.O.Box CH-8034 Zurich, Switze

EX-99.(b) Facility Agreement Execution Copy Exhibit (b) CHF 1,450,000,000 MULTICURRENCY TERM FACILITY AGREEMENT dated 20 July 2016 for GALENICA AG as Original Guarantor arranged by CREDIT SUISSE AG as Arranger with CREDIT SUISSE AG acting as Agent Baker & McKenzie Zurich Holbeinstrasse 30, P.O.Box CH-8034 Zurich, Switzerland Facility Agreement Execution Copy CONTENTS Clause Page 1. Definitions and

August 4, 2016 EX-10.1

CREDIT AGREEMENT Dated as of April 27, 2016 RELYPSA, INC., as the Borrower, CERTAIN DOMESTIC SUBSIDIARIES OF THE BORROWER, as the Guarantors, CANTOR FITZGERALD SECURITIES, as the Administrative Agent THE LENDERS FROM TIME TO TIME PARTY HERETO TABLE O

EX-10.1 2 rlyp-ex101254.htm EX-10.1 Exhibit 10.1 CREDIT AGREEMENT Dated as of April 27, 2016 among RELYPSA, INC., as the Borrower, CERTAIN DOMESTIC SUBSIDIARIES OF THE BORROWER, as the Guarantors, CANTOR FITZGERALD SECURITIES, as the Administrative Agent and THE LENDERS FROM TIME TO TIME PARTY HERETO TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND ACCOUNTING TERMS 1 1.01 Defined Terms1 1.02 Other

August 4, 2016 EX-99.(A)(16)

Relypsa, Inc. 100 Cardinal Way Redwood City, CA 94063

Exhibit (a)(16) Relypsa, Inc. 100 Cardinal Way Redwood City, CA 94063 August 4, 2016 Dear Stockholder: We are pleased to inform you that, on July 20, 2016, Relypsa, Inc. (?Relypsa?) entered into a definitive Agreement and Plan of Merger (the ?Merger Agreement?) with Galenica AG (?Parent?) and Vifor Pharma USA Inc., an indirect wholly owned subsidiary of Parent (?Merger Sub?), pursuant to which Mer

August 4, 2016 EX-99.(A)(1)(A)

Offer to Purchase for Cash All Outstanding Shares of Common Stock Relypsa, Inc. $32.00 Net Per Share Vifor Pharma USA Inc., an indirect wholly owned subsidiary of Galenica AG

EX-99.(A)(1)(A) 2 d148903dex99a1a.htm EX-99.(A)(1)(A) Table of Contents Exhibit (a)(1)(A) August 4, 2016 Offer to Purchase for Cash All Outstanding Shares of Common Stock of Relypsa, Inc. at $32.00 Net Per Share by Vifor Pharma USA Inc., an indirect wholly owned subsidiary of Galenica AG THE OFFER AND WITHDRAWAL RIGHTS WILL EXPIRE AT 12:00 MIDNIGHT, NEW YORK TIME, AT THE END OF THE DAY ON WEDNESDA

August 4, 2016 EX-99.(A)(5)(G)

Investor Relations, Galenica Group: Julien Vignot, Head Investor Relations

EX-99.(A)(5)(G) 8 d148903dex99a5g.htm EX-99.(A)(5)(G) Exhibit (a)(5)(G) PRESS RELEASE Date 4 August 2016 Contact Investor Relations, Galenica Group: Julien Vignot, Head Investor Relations Media Relations, Galenica Group: Christina Hertig, Head Corporate Communications Media Relations, Vifor Pharma: Beatrix Benz, Head Global Communications & Public Affairs Subject Galenica commences Tender Offer fo

August 4, 2016 EX-99.(D)(3)

AMENDMENT NO. 1 TO CONFIDENTIALITY AGREEMENT BETWEEN RELYPSA, INC. AND VIFOR FRESENIUS MEDICAL CARE RENAL PHARMA LTD.

EX-99.(D)(3) 11 d148903dex99d3.htm EX-99.(D)(3) Exhibit (d)(3) AMENDMENT NO. 1 TO CONFIDENTIALITY AGREEMENT BETWEEN RELYPSA, INC. AND VIFOR FRESENIUS MEDICAL CARE RENAL PHARMA LTD. THIS AMENDMENT NO. 1 TO THE CONFIDENTIALITY AGREEMENT (“Amendment No. 1”) is made and entered into effective as of May 6, 2015 (the “Amendment No. 1 Effective Date”) by and between RELYPSA, INC., a Delaware corporation,

August 4, 2016 EX-99.(D)(5)

AMENDMENT NO. 1 TO CONFIDENTIALITY AGREEMENT BETWEEN RELYPSA, INC. AND GALENICA LTD.

EX-99.(D)(5) 13 d148903dex99d5.htm EX-99.(D)(5) Exhibit (d)(5) AMENDMENT NO. 1 TO CONFIDENTIALITY AGREEMENT BETWEEN RELYPSA, INC. AND GALENICA LTD. THIS AMENDMENT NO. 1 TO THE CONFIDENTIALITY AGREEMENT (“Amendment No. 1”) is made and entered into effective as of May 11, 2016 (the “Amendment No. 1 Effective Date”) by and between RELYPSA, INC., a Delaware corporation, located at 100 Cardinal Way, Re

August 4, 2016 SC TO-T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 14d-100) TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RELYPSA, INC. (Name of Subject Company (Issuer)) VIFOR

SC TO-T 1 d148903dsctot.htm SC TO-T UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 14d-100) TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RELYPSA, INC. (Name of Subject Company (Issuer)) VIFOR PHARMA USA INC. (Offeror) An Indirect Wholly Owned Subsidiary of GALENICA AG (Parent of Offeror) (Names of Filing

August 4, 2016 EX-10.3

SETTLEMENT AGREEMENT AND MUTUAL GENERAL RELEASE

Exhibit 10.3 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. SETTLEMENT AGREEMENT AND MUTUAL GENERAL RELEASE This Settlement Agreement and Mutual General Release (this "Agreement") is made and entered into as of June 21, 2016 (the “Effective

August 4, 2016 SC 14D9

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company) RELYPSA,

SC 14D9 1 d343483dsc14d9.htm SC 14D9 Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company) RELYPSA, INC. (Name of Person Filing Statement) Common Stock, par value $0.001 per share (Title of Clas

August 4, 2016 EX-99.(A)(1)(B)

Letter of Transmittal to Offer to Purchase for Cash All Outstanding Shares of Common Stock Relypsa, Inc. $32.00 Net Per Share Vifor Pharma USA Inc., an indirect wholly owned subsidiary of Galenica AG

EX-99.(A)(1)(B) 3 d148903dex99a1b.htm EX-99.(A)(1)(B) Exhibit (a)(1)(B) Letter of Transmittal to Offer to Purchase for Cash All Outstanding Shares of Common Stock of Relypsa, Inc. at $32.00 Net Per Share by Vifor Pharma USA Inc., an indirect wholly owned subsidiary of Galenica AG The undersigned represents that I (we) have full authority to surrender without restriction the certificate(s) listed b

July 28, 2016 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 ss4640ex9901.htm JOINT FILING AGREEMENT EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13D, dated July 28, 2016 (the “Schedule 13D”), with respect to the Common Stock of Relypsa, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended,

July 28, 2016 SC 13D/A

RLYP / Relypsa, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 9 Activist Investment

SC 13D/A 1 ss4640sc13da.htm AMENDMENT NO. 9 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 9)* RELYPSA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 759531106 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP IV LLC Samuel D. Isaly 601 Lexington Avenue, 54th Floor New York, NY 1

July 26, 2016 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 ss4294ex9901.htm JOINT FILING AGREEMENT EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13D, dated July 26, 2016 (the “Schedule 13D”), with respect to the Common Stock of Relypsa, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended,

July 26, 2016 SC 13D/A

RLYP / Relypsa, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 8 Activist Investment

SC 13D/A 1 ss4294sc13da.htm AMENDMENT NO. 8 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 8)* RELYPSA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 759531106 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP IV LLC Samuel D. Isaly 601 Lexington Avenue, 54th Floor New York, NY 1

July 25, 2016 SC TO-C

Relypsa SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RELYPSA, INC. (Name of Subject Company (Issuer)) VIFOR PHARMA USA INC. (Offeror) A Wholly-Owned Subsidiary of GALENICA AG (Ultimate Parent Entity of Offeror) (Names of Filing Persons (identifying status as offeror, issu

July 25, 2016 EX-99.1

1

EX-99.1 Exhibit 99.1 EDITED TRANSCRIPT GALNA.S ? Galenica AG To Acquire Relypsa To Strengthen Its Business Unit Vifor Pharma M&A Call EVENT DATE/TIME: JULY 21, 2016 / 12:00PM GMT 1 JULY 21, 2016 / 12:00PM GMT, GALNA.S ? Galenica AG To Acquire Relypsa To Strengthen Its Business Unit Vifor Pharma M&A Call CORPORATE PARTICIPANTS Jorg Kneubuhler Galenica Group - CFO, Galenica Group & CEO, Galenica San

July 21, 2016 SC14D9C

Relypsa SC14D9C

SC14D9C UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company) RELYPSA, INC. (Name of Person Filing Statement) Common Stock, par value $0.001 per share (Title of Class of Securities) 759531106 (CUSIP Number of Class of Securitie

July 21, 2016 EX-99.4

Trust in excellence

EX-99.4 Exhibit 99.4 EXHIBIT 99.4 Trust in excellence Colin Bond CFO Vifor Pharma Vifor Pharma, a company of the Galenica Group Vifor Pharma aims to become a successful, stand-alone, global speciality pharma company 21/07/2016? ? Vifor Pharma 2 VIFOR PHARMA GALENICA CURRENTLY PART OF THE GALENLCA GROUP SWITZERLAND HEADQUARTERS IN ZURICH, SWITZERLAND REASERACH & DEVELOPMENT FACILITIES IN ST. Gallen

July 21, 2016 EX-99.3

Galenica to acquire Relypsa

EX-99.3 Exhibit 99.3 GALENICA Galenica to acquire Relypsa Vifor Pharma & relypsa Conference Call, July 21, 2016, 2 p.m. CET The Galenica Group - Excellence in the healthcare market GALENICA Agenda and speakers Etienne Jornod Executive Chairman Galenica Group J?rg Kneub?hler CFO Galenica Group & CEO Galenica Sant? Gianni Zampieri Vice-CEO Vifor Pharma Christoph Springer Head BD & Licensing & Deputy

July 21, 2016 EX-99.2

Galenica and Relypsa Announce Agreement for Galenica to Acquire Relypsa – Acquisition Strengthens Galenica’s Business Unit, Vifor Pharma

EX-99.2 3 d219698dex992.htm EX-99.2 Exhibit 99.2 NEWS RELEASE Relypsa Contact Charlotte Arnold, Vice President, Corporate Communications and Investor Relations Tel.: +1 650 421 9352 E-mail: [email protected] Galenica Contacts Galenica Media Relations: Galenica Investor Relations: Christina Hertig, Head Corporate Communications Tel.: +41 58 852 85 17 E-mail: [email protected] Jörg Kneubühler, Chief F

July 21, 2016 EX-99.1

Galenica and Relypsa announce agreement for Galenica to acquire Relypsa.

EX-99.1 Exhibit 99.1 PRESS RELEASE Date 21 July 2016 Contact Investor Relations, Galenica Group: J?rg Kneub?hler, CFO Media Relations, Galenica Group: Christina Hertig, Head Corporate Communications Media Relations, Vifor Pharma: Beatrix Benz, Head Global Communications & Public Affairs Media & Investor Relations, Relypsa: Charlotte Arnold, Vice President, Corporate Communications & Investor Relat

July 21, 2016 SC TO-C

Relypsa SC TO-C

SC TO-C UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company (issuer)) VIFOR PHARMA USA INC. (Offeror) A Wholly-Owned Subsidiary of GALENICA AG (Ultimate Parent Entity of Offeror) (Names of Filing Persons (identifying status as offer

July 21, 2016 SC14D9C

Relypsa SC14D9C

SC14D9C UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 RELYPSA, INC. (Name of Subject Company) RELYPSA, INC. (Name of Person Filing Statement) Common Stock, par value $0.001 per share (Title of Class of Securities) 759531106 (CUSIP Number of Class of Securitie

July 21, 2016 EX-99.1

Galenica and Relypsa Announce Agreement for Galenica to Acquire Relypsa – Acquisition Strengthens Galenica’s Business Unit, Vifor Pharma

EX-99.1 Exhibit 99.1 NEWS RELEASE Relypsa Contact Charlotte Arnold, Vice President, Corporate Communications and Investor Relations Tel.: +1 650 421 9352 E-mail: [email protected] Galenica Contacts Galenica Media Relations: Galenica Investor Relations: Christina Hertig, Head Corporate Communications Tel.: +41 58 852 85 17 E-mail: [email protected] J?rg Kneub?hler, Chief Financial Officer Tel.: +41 5

July 21, 2016 EX-2.1

AGREEMENT AND PLAN OF MERGER by and among GALENICA AG, VIFOR PHARMA USA INC. RELYPSA, INC. Dated as of July 20, 2016 TABLE OF CONTENTS Page Article I THE OFFER 2 1.1 The Offer 2 1.2 Company Actions 4 Article II THE MERGER 6 2.1 The Merger 6 2.2 The E

EX-2.1 Exhibit 2.1 EXECUTION VERSION AGREEMENT AND PLAN OF MERGER by and among GALENICA AG, VIFOR PHARMA USA INC. and RELYPSA, INC. Dated as of July 20, 2016 TABLE OF CONTENTS Page Article I THE OFFER 2 1.1 The Offer 2 1.2 Company Actions 4 Article II THE MERGER 6 2.1 The Merger 6 2.2 The Effective Time 6 2.3 The Closing 6 2.4 Effect of the Merger 6 2.5 Certificate of Incorporation and Bylaws 6 2.

July 21, 2016 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 20, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File Nu

July 11, 2016 8-K

Other Events

8-K 1 d224165d8k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 11, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorpor

June 27, 2016 8-K

Submission of Matters to a Vote of Security Holders

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 21, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission Fi

June 15, 2016 CT ORDER

Relypsa RDER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION 15 June 2016 ORDER GRANTING CONFIDENTIAL TREATMENT UNDER THE SECURITIES EXCHANGE ACT OF 1934 Relypsa, Inc.

June 15, 2016 8-K

Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission Fi

June 3, 2016 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13D, dated June 3, 2016 (the “Schedule 13D”), with respect to the Common Stock of Relypsa, Inc.

June 3, 2016 SC 13D/A

RLYP / Relypsa, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 7 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 7)* RELYPSA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 75931106 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP IV LLC Samuel D. Isaly 601 Lexington Avenue, 54th Floor New York, NY 10022 Telephone: (212) 739-6400 (Name, Address

May 27, 2016 SC 13G

RLYP / Relypsa, Inc. / Flynn James E Passive Investment

SC 13G 1 e615097sc13g-relypsa.htm SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. ) * Relypsa, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) May 17, 2016 (Date of

May 16, 2016 8-K

Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission Fil

May 4, 2016 10-Q

Relypsa 10-Q (Quarterly Report)

rlyp-10q20160331.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2016 or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact name of regis

May 4, 2016 8-K

Relypsa FORM 8-K (Current Report/Significant Event)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File

May 4, 2016 EX-99.1

Relypsa Reports First Quarter 2016 Financial Results Relypsa Management to Host Conference Call/Webcast this Afternoon at 5:00 p.m. ET/2:00 p.m. PT

Exhibit 99.1 Contact: Charlotte Arnold Vice President, Corporate Communications and Investor Relations 650-421-9352 [email protected] Relypsa Reports First Quarter 2016 Financial Results Relypsa Management to Host Conference Call/Webcast this Afternoon at 5:00 p.m. ET/2:00 p.m. PT REDWOOD CITY, Calif., May 4, 2016 — Relypsa, Inc. (NASDAQ: RLYP), a biopharmaceutical company, today reported financial r

May 4, 2016 EX-10.2

Amendment No. 1 to Manufacturing and Supply Agreement

EX-10.2 3 rlyp-ex102421.htm EX-10.2 Exhibit 10.2 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. Amendment No. 1 to Manufacturing and Supply Agreement This Amendment No. 1 to the Manufacturing and Supply Agreement (“Amendment No. 1”) is made

May 4, 2016 EX-10.1

ADDENDUM 1 Additional MFA Services

Exhibit 10.1 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. ADDENDUM 1 Additional MFA Services This Addendum 1 dated February 11th, 2015 ("Addendum 1 Effective Date") describes certain services to be managed by DPx Fine Chemicals Austria Gmb

May 3, 2016 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

8-K 1 d190908d8k.htm FROM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 27, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorpo

May 3, 2016 EX-4.1

RELYPSA, INC. COMMON STOCK PURCHASE WARRANT Date of Issuance: April 27, 2016 Certificate No. 2016-[___]

EX-4.1 Exhibit 4.1 THIS COMMON STOCK PURCHASE WARRANT AND THE SHARES THAT MAY BE PURCHASED HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR UNDER THE SECURITIES LAWS OF ANY STATE. THIS COMMON STOCK PURCHASE WARRANT HAS BEEN ACQUIRED FOR INVESTMENT PURPOSES AND NOT WITH A VIEW TO DISTRIBUTION, AND THIS COMMON STOCK PURCHASE WARRANT AND THE SHARES THAT MAY BE PURCHASED HEREUNDE

April 28, 2016 DEFA14A

Relypsa DEFINITIVE ADDITIONAL MATERIALS

Definitive Additional Materials UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 28, 2016 DEF 14A

Relypsa DEFINITIVE PROXY STATEMENT

Definitive Proxy Statement Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 15, 2016 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File Numbe

April 11, 2016 SC 13G/A

RLYP / Relypsa, Inc. / JANUS CAPITAL MANAGEMENT LLC - RLYP SC13GA Passive Investment

SC 13G/A 1 rlyp4102016.txt RLYP SC13GA UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment No.: 2* Name of Issuer: RELYPSA, INC. Title of Class of Securities: Common Stock CUSIP Number: 759531106 Date of Event Which Requires Filing of this Statement: 3/31/2016 Check the appropriate box to designate the rule pursua

March 15, 2016 8-K

Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 15, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File N

March 11, 2016 8-K

Entry into a Material Definitive Agreement

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission Fi

February 25, 2016 S-8

Relypsa S-8

S-8 1 d116696ds8.htm S-8 As filed with the Securities and Exchange Commission on February 25, 2016 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Relypsa, Inc. (Exact name of registrant as specified in its charter) Delaware 26-0893742 (State or other jurisdiction of incorporation or orga

February 25, 2016 10-K

Relypsa 10-K (Annual Report)

10-K 1 rlyp-10k20151231.htm 10-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2015 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact name o

February 25, 2016 EX-12.1

STATEMENT REGARDING THE COMPUTATION OF RATIOS

Exhibit 12.1 STATEMENT REGARDING THE COMPUTATION OF RATIOS Our earnings are inadequate to cover combined fixed charges and preference dividends. The following table sets forth the dollar amount of the coverage deficiency (in thousands) for the periods indicated. Year Ended December 31, 2015 2014 2013(1) 2012(2) 2011 EARNINGS: Net loss $ (178,716 ) $ (79,888 ) $ (73,845 ) $ (43,725 ) $ (25,823 ) Pl

February 25, 2016 EX-10.4(F)

FIFTH AMENDMENT LOAN AND SECURITY AGREEMENT

Exhibit 10.4(f) FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT This FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into as of December 17, 2015, by and between Silicon Valley Bank (“Bank”) and Relypsa, Inc., a Delaware corporation (“Borrower”), whose address is 100 Cardinal Way, Redwood City, California 94063. Recitals A. Bank and Borrower have entered into that certa

February 25, 2016 EX-10.15(A)

RELYPSA, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN (as amended by the Board on December 10, 2015) ARTICLE 1.

Exhibit 10.15(a) RELYPSA, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN (as amended by the Board on December 10, 2015) ARTICLE 1. PURPOSE The purpose of the Relypsa, Inc. 2014 Employment Commencement Incentive Plan (as it may be amended from time to time, the “Plan”) is to promote the success and enhance the value of Relypsa, Inc. (the “Company”) by linking the individual interests of the Eligi

February 24, 2016 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 24, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commissio

February 24, 2016 EX-99.1

Relypsa Reports Fourth Quarter and Full Year 2015 Financial Results and Announces Other Corporate Updates

EX-99.1 Exhibit 99.1 Contact: Charlotte Arnold Vice President, Corporate Communications 650-421-9352 [email protected] Relypsa Reports Fourth Quarter and Full Year 2015 Financial Results and Announces Other Corporate Updates ? Relypsa reports encouraging initial demand for Veltassa ? Veltassa added to CMS 2016 Formulary Reference File and agreements signed with Express Scripts and CVS Caremark, the t

February 16, 2016 SC 13G/A

RLYP / Relypsa, Inc. / JANUS CAPITAL MANAGEMENT LLC - RLYP SC13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment No.: 1* Name of Issuer: RELYPSA, INC. Title of Class of Securities: Common Stock CUSIP Number: 759531106 Date of Event Which Requires Filing of this Statement: 12/31/2015 Check the appropriate box to designate the rule pursuant to which this Schedule is filed. [X

February 5, 2016 CORRESP

Relypsa Form CORRESP

Acceleration Request Relypsa, Inc. 100 Cardinal Way Redwood City, CA 94063 January 5, 2016 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Irene Paik Suzanne Hayes Re: Relypsa, Inc. Registration Statement on Form S-3 (Registration No. 333-207806) Ladies and Gentlemen: In accordance with Rule 461 of Regulation C of the

January 28, 2016 SC 13G

RLYP / Relypsa, Inc. / BlackRock Inc. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No: ) RELYPSA INC - (Name of Issuer) Common Stock - (Title of Class of Securities) 759531106 - (CUSIP Number) December 31, 2015 - (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

January 25, 2016 8-K

Relypsa Form 8-K (Current Report/Significant Event)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 25, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission

January 25, 2016 8-K

Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 25, 2016 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission

January 6, 2016 CT ORDER

Relypsa RDER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION January 6, 2016 ORDER GRANTING CONFIDENTIAL TREATMENT UNDER THE SECURITIES EXCHANGE ACT OF 1934 Relypsa, Inc.

January 5, 2016 CORRESP

Relypsa ESP

Acceleration Request Relypsa, Inc. 100 Cardinal Way Redwood City, CA 94063 January 5, 2016 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Irene Paik Suzanne Hayes Re: Relypsa, Inc. Registration Statement on Form S-3 (Registration No. 333-207806) Ladies and Gentlemen: In accordance with Rule 461 of Regulation C of the

January 5, 2016 10-Q/A

Relypsa Form 10-Q/A (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q/A (Amendment No. 1) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2015 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36

January 5, 2016 EX-10.2

DETAILING AGREEMENT sanofi-aventis US LLC Relypsa, Inc. Dated as of August 10, 2015

EX-10.2 Exhibit 10.2 EXECUTION VERSION [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. DETAILING AGREEMENT between sanofi-aventis US LLC and Relypsa, Inc. Dated as of August 10, 2015 EXECUTION VERSION Table of Contents 1. DEFINITIONS 1 2. GOV

January 5, 2016 10-Q/A

RLYP / Relypsa, Inc. 10-Q/A - Quarterly Report - FORM 10-Q/A

Form 10-Q/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q/A (Amendment No. 1) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2015 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Nu

December 24, 2015 SC 13D/A

RLYP / Relypsa, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 6 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.6)* RELYPSA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 759531106 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP IV LLC Samuel D. Isaly 601 Lexington Avenue, 54th Floor New York, NY 10022 Telephone: (212) 739-6400 (Name, Address

December 24, 2015 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13D, dated December 24, 2015 (the “Schedule 13D”), with respect to the Common Stock of Relypsa, Inc.

December 22, 2015 EX-10.1

FIFTH AMENDMENT AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

EX-10.1 FIFTH AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT This FIFTH AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (this ?Amendment?) is entered into as of December , 2015, by and among OXFORD FINANCE LLC (?Oxford?) as collateral agent (in such capacity, ?Collateral Agent?), the Lenders listed on Schedule 1.1 of the Loan Agreement or otherwise a party thereto from

December 22, 2015 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K 1 d107047d8k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 17, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of inco

December 22, 2015 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 17, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commissio

December 21, 2015 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 21, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File Nu

December 21, 2015 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 21, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File Nu

December 14, 2015 SC 13G

RLYP / Relypsa, Inc. / JHL Capital Group LLC - SCHEDULE 13G HOLDINGS REPORT Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

November 16, 2015 LETTER

LETTER

Mail Stop 4720 November 16, 2015 Via E-mail John A. Orwin President and Chief Executive Officer Relypsa, Inc. 100 Cardinal Way Redwood City, CA 94063 Re: Relypsa, Inc. Registration Statement on Form S-3 Filed November 4, 2015 File No. 333-207806 Dear Mr. Orwin: We have limited our review of your registration statement to consideration of your pending request for confidential treatment. Please be a

November 4, 2015 EX-25.1

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE

EX-25.1 Exhibit 25.1 File No. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE ? CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO SECTION 305(b)(2) WILMINGTON TRUST, NATIONAL ASSOCIATION (Exact name of trustee as specified in its charter) 16-148645

November 4, 2015 EX-10.2

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. DETAILING AGREEMENT sanofi-aventis US LLC Re

EX-10.2 3 rlyp-ex102513.htm EX-10.2 Exhibit 10.2 EXECUTION VERSION [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. DETAILING AGREEMENT between sanofi-aventis US LLC and Relypsa, Inc. Dated as of August 10, 2015 EXECUTION VERSION Table of Cont

November 4, 2015 EX-4.4

Relypsa, Inc. Dated as of , 20 Wilmington Trust, National Association TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions. 1 Section 1.2. Other Definitions. 4 Section 1.3. Incorporation by Reference

EX-4.4 Exhibit 4.4 Relypsa, Inc. INDENTURE Dated as of , 20 Wilmington Trust, National Association Trustee TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions. 1 Section 1.2. Other Definitions. 4 Section 1.3. Incorporation by Reference of Trust Indenture Act. 5 Section 1.4. Rules of Construction. 5 ARTICLE II. THE SECURITIES 5 Section 2.1. Issuab

November 4, 2015 EX-10.3

FOURTH AMENDMENT AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

EX-10.3 4 rlyp-ex103512.htm EX-10.3 Exhibit 10.3 FOURTH AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT This FOURTH AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into this 1st day of October, 2015, by and among OXFORD FINANCE LLC (“Oxford”) as collateral agent (in such capacity, “Collateral Agent”), the Lenders listed on Schedule 1.1 of t

November 4, 2015 S-3

Relypsa S-3

Table of Contents As filed with the Securities and Exchange Commission on November 4, 2015 Registration No.

November 4, 2015 EX-1.2

RELYPSA, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement

EX-1.2 Exhibit 1.2 RELYPSA, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement November 4, 2015 Cantor Fitzgerald & Co. 499 Park Avenue New York, NY 10022 Ladies and Gentlemen: Relypsa, Inc., a Delaware corporation (the ?Company?), confirms its agreement (this ?Agreement?) with Cantor Fitzgerald & Co. (the ?Agent?), as follows: 1. Issuance and Sal

November 4, 2015 S-3

Relypsa Form S-3

Table of Contents As filed with the Securities and Exchange Commission on November 4, 2015 Registration No.

November 4, 2015 EX-10.4

FOURTH AMENDMENT LOAN AND SECURITY AGREEMENT

EX-10.4 5 rlyp-ex104514.htm EX-10.4 Exhibit 10.4 FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT This FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into this 1st day of October, 2015, by and between Silicon Valley Bank (“Bank”) and Relypsa, Inc., a Delaware corporation (“Borrower”), whose address is 100 Cardinal Way, Redwood City, California 94063. Recitals A. Bank

November 4, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

10-Q 1 rlyp-10q20150930.htm 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2015 or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exa

November 4, 2015 EX-99.1

Relypsa Announces Third Quarter 2015 Financial Results

EX-99.1 Exhibit 99.1 Contact: Charlotte Arnold Vice President, Corporate Communications 650-421-9352 [email protected] Relypsa Announces Third Quarter 2015 Financial Results REDWOOD CITY, Calif., November 4, 2015 ? Relypsa, Inc. (NASDAQ: RLYP), a biopharmaceutical company, today reported financial results for the quarter ended September 30, 2015 and recent business highlights. ?We are very excited th

November 4, 2015 EX-12.1

STATEMENT REGARDING THE COMPUTATION OF RATIOS

EX-12.1 Exhibit 12.1 STATEMENT REGARDING THE COMPUTATION OF RATIOS Our earnings are inadequate to cover combined fixed charges and preference dividends. The following table sets forth the dollar amount of the coverage deficiency (in thousands) for the periods indicated. Year Ended December 31, Nine Months Ended September 30, 2015 2014 2013(1) 2012(2) 2011 EARNINGS: Net loss $ (79,888 ) $ (73,845 )

November 4, 2015 EX-10.1

LICENSE AGREEMENT

EX-10.1 2 rlyp-ex101543.htm EX-10.1 Exhibit 10.1 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. Confidential Execution Copy LICENSE AGREEMENT This License Agreement (the “Agreement”) is effective as of August 10, 2015 (the “Effective Date”)

November 4, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 4, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File

November 4, 2015 8-K

Relypsa Form 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 4, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File

October 30, 2015 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13D, dated October 30, 2015 (the “Schedule 13D”), with respect to the Common Stock of Relypsa, Inc.

October 30, 2015 SC 13D/A

RLYP / Relypsa, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO.5 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 5)* RELYPSA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 759531106 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP IV LLC Samuel D. Isaly 601 Lexington Avenue, 54th Floor New York, NY 10022 Telephone: (212) 739-6400 (Name, Addres

October 22, 2015 8-K

Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 21, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission

August 12, 2015 8-K

Entry into a Material Definitive Agreement

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission

August 12, 2015 8-K

Entry into a Material Definitive Agreement

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission

August 6, 2015 S-8

Relypsa FORM S-8

Form S-8 As filed with the Securities and Exchange Commission on August 6, 2015 Registration No.

August 6, 2015 EX-99.1

RELYPSA ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS

EX-99.1 Exhibit 99.1 Contact: Charlotte Arnold Vice President, Corporate Communications 650-421-9352 [email protected] RELYPSA ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS REDWOOD CITY, Calif., August 6, 2015 ? Relypsa, Inc. (NASDAQ: RLYP), a biopharmaceutical company, today reported financial results for the quarter ended June 30, 2015. Net loss for the second quarter 2015 was $39.3 million, or $

August 6, 2015 EX-10.1

FIRST AMENDMENT TO LEASE

EX-10.1 2 rlyp-ex101420.htm EX-10.1 Exhibit 10.1 FIRST AMENDMENT TO LEASE This FIRST AMENDMENT TO LEASE (“First Amendment”) is made and entered into as of the 10th day of July, 2015, by and between HCP LS REDWOOD CITY, LLC, a Delaware limited liability company (“Landlord”), and RELYPSA, INC., a Delaware corporation (“Tenant”). r e c i t a l s : A.Landlord and Tenant entered into that certain Lease

August 6, 2015 EX-10.2(A)

RELYPSA, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN (as amended by the Board on July 8, 2015) ARTICLE 1. PURPOSE

EX-10.2(A) 3 rlyp-ex102a421.htm EX-10.2(A) Exhibit 10.2(a) RELYPSA, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN (as amended by the Board on July 8, 2015) ARTICLE 1. PURPOSE The purpose of the Relypsa, Inc. 2014 Employment Commencement Incentive Plan (as it may be amended from time to time, the “Plan”) is to promote the success and enhance the value of Relypsa, Inc. (the “Company”) by linking

August 6, 2015 EX-10.2(B)

RELYPSA, inc. 2014 Employment commencement incentive PLAN RESTRICTED STOCK UNIT AWARD GRANT NOTICE

EX-10.2(B) 4 rlyp-ex102b422.htm EX-10.2(B) Exhibit 10.2(b) RELYPSA, inc. 2014 Employment commencement incentive PLAN RESTRICTED STOCK UNIT AWARD GRANT NOTICE Relypsa, Inc., a Delaware corporation, (the “Company”), pursuant to its 2014 Employment Commencement Incentive Plan, as amended from time to time (the “Plan”), hereby grants to the holder listed below (the “Participant”), an award of restrict

August 6, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

10-Q 1 rlyp-10q20150630.htm 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2015 or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact na

August 6, 2015 8-K

Relypsa FORM 8-K (Current Report/Significant Event)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 6, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission F

July 27, 2015 SC 13D/A

RLYP / Relypsa, Inc. / 5AM VENTURES III, L.P. - 5AM VENTURES III - RELYPSA - 13DA 7-24-15 Activist Investment

CUSIP NO. 759531106 13D Page 1 of 14 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 5)* Relypsa, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) Paul Stone 5AM Ventures III, L

June 9, 2015 EX-3.1

AMENDED AND RESTATED BYLAWS OF RELYPSA, INC. (a Delaware corporation) (As amended on June 4, 2015) TABLE OF CONTENTS Page ARTICLE I - CORPORATE OFFICES 1 1.1 REGISTERED OFFICE 1 1.2 OTHER OFFICES 1 ARTICLE II - MEETINGS OF STOCKHOLDERS 1 2.1 PLACE OF

EX-3.1 Exhibit 3.1 AMENDED AND RESTATED BYLAWS OF RELYPSA, INC. (a Delaware corporation) (As amended on June 4, 2015) TABLE OF CONTENTS Page ARTICLE I - CORPORATE OFFICES 1 1.1 REGISTERED OFFICE 1 1.2 OTHER OFFICES 1 ARTICLE II - MEETINGS OF STOCKHOLDERS 1 2.1 PLACE OF MEETINGS 1 2.2 ANNUAL MEETING 1 2.3 SPECIAL MEETING 1 2.4 ADVANCE NOTICE PROCEDURES FOR BUSINESS BROUGHT BEFORE A MEETING 2 2.5 AD

June 9, 2015 8-K

Relypsa FORM 8-K (Current Report/Significant Event)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 4, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission Fil

May 27, 2015 SC 13G

RLYP / Relypsa, Inc. / CITADEL ADVISORS LLC - SCHEDULE 13G Passive Investment

SC 13G 1 v411592sc13g.htm SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) Information Statement Pursuant to Rules 13d-1 and 13d-2 Under the Securities Exchange Act of 1934 (Amendment No. )* Relypsa, Inc. (Name of Issuer) Common stock, par value $0.001 per share (Title of Class of Securities) 759531106 (CUSIP Number) May 18, 2015 Date

May 27, 2015 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the common stock of Relypsa, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(c) under the Securities Exchange Act of 1934, as amended, on behalf of each of the undersigned

May 20, 2015 SC 13D/A

RLYP / Relypsa, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 4 Activist Investment

SC 13D/A 1 ss430957sc13da.htm AMENDMENT NO. 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.4)* RELYPSA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 759531106 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP IV LLC Samuel D. Isaly 601 Lexington Avenue, 54th Floor New York, NY

May 20, 2015 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13D, dated May 20, 2015 (the “Schedule 13D”), with respect to the Common Stock of Relypsa, Inc.

May 7, 2015 8-K

Relypsa 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File Numb

May 7, 2015 EX-99.1

RELYPSA ANNOUNCES FIRST QUARTER 2015 FINANCIAL RESULTS

EX-99.1 2 d924958dex991.htm EX-99.1 Exhibit 99.1 Contact: Alex Dobbin Associate Director, Investor Relations 650-421-9687 [email protected] RELYPSA ANNOUNCES FIRST QUARTER 2015 FINANCIAL RESULTS REDWOOD CITY, Calif., May 7, 2015 — Relypsa, Inc. (Nasdaq: RLYP), a biopharmaceutical company, today reported financial results for the quarter ended March 31, 2015. Net loss for the first quarter 2015 was $2

May 7, 2015 EX-10.1

CONSENT, RELEASE AND THIRD AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

Exhibit 10.1 CONSENT, RELEASE AND THIRD AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT This CONSENT, RELEASE AND THIRD AMENDMENT to Amended and Restated Loan and Security Agreement (this “Consent”) is entered into this 30th day of January, 2015, by and among OXFORD FINANCE LLC (“Oxford”) as collateral agent (in such capacity, “Collateral Agent”), the Lenders listed on Schedule 1.1 o

May 7, 2015 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

10-Q 1 rlyp-10q20150331.htm 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2015 or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact n

May 7, 2015 EX-10.2

CONSENT, RELEASE AND THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT

Exhibit 10.2 CONSENT, RELEASE AND THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT This CONSENT, RELEASE AND THIRD AMENDMENT to Loan and Security Agreement (this ?Consent?) is entered into this 30th day of January, 2015, by and between Silicon Valley Bank (?Bank?) and Relypsa, Inc., a Delaware corporation (?Borrower?) whose address is 700 Saginaw Drive, Redwood City, CA 94063. Recitals A. Bank and B

May 7, 2015 EX-4.4

WARRANT TO PURCHASE STOCK

Exhibit 4.4 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTAN

May 7, 2015 EX-10.3

RELYPSA, INC. NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM

Exhibit 10.3 RELYPSA, INC. NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM Non-employee members of the board of directors (the ?Board?) of Relypsa, Inc. (the ?Company?) shall be eligible to receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this ?Program?), which was adopted pursuant to the Board?s resolutions on June 6, 2013, and amended pursuant to t

April 22, 2015 DEF 14A

Relypsa DEFINITIVE PROXY STATEMENT

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14

April 22, 2015 DEFA14A

Relypsa DEFINITIVE ADDITIONAL MATERIALS

Definitive Additional Materials UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 27, 2015 SC 13D/A

RLYP / Relypsa, Inc. / 5AM VENTURES III, L.P. - SC 13D/A Activist Investment

CUSIP NO. 759531106 13D Page 1 of 12 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 4)* Relypsa, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) Paul Stone 5AM Ventures III, L

March 12, 2015 EX-10.23

RELYPSA, INC. EMPLOYMENT AGREEMENT

Exhibit 10.23 RELYPSA, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?) is made and entered into by and between Stephen D. Harrison, M.A., Ph.D. (?Executive?) and Relypsa, Inc. (the ?Company?) (together referred to herein as the ?Parties?), effective as of December 15, 2014 (the ?Effective Date?). This Agreement supersedes in its entirety that certain employment letter agreeme

March 12, 2015 EX-10.22

RELYPSA, INC. EMPLOYMENT AGREEMENT

Exhibit 10.22 RELYPSA, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?) is made and entered into by and between Scott Garland (?Executive?) and Relypsa, Inc. (the ?Company?) (together referred to herein as the ?Parties?), effective as of October 31, 2014 (the ?Effective Date?). This Agreement supersedes in its entirety that certain employment letter agreement dated as of Septe

March 12, 2015 S-8

Relypsa FORM S-8

S-8 1 d888692ds8.htm FORM S-8 As filed with the Securities and Exchange Commission on March 11, 2015 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Relypsa, Inc. (Exact name of registrant as specified in its charter) Delaware 26-0893742 (State or other jurisdiction of incorporation or or

March 12, 2015 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2014 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact name of registrant as specified in its

March 11, 2015 EX-99.1

RELYPSA ANNOUNCES FOURTH QUARTER AND FULL YEAR 2014 FINANCIAL RESULTS

EX-99.1 Exhibit 99.1 Contact: Alex Dobbin Associate Director, Investor Relations 650-421-6879 [email protected] RELYPSA ANNOUNCES FOURTH QUARTER AND FULL YEAR 2014 FINANCIAL RESULTS REDWOOD CITY, Calif., March 11, 2014 ? Relypsa, Inc. (Nasdaq: RLYP), a biopharmaceutical company, today reported financial results for the fourth quarter and year ended December 31, 2014. Cash, cash equivalents and short-

March 11, 2015 8-K

Relypsa 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 11, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File N

March 6, 2015 EX-99.2

FORM OF LOCK-UP LETTER

EXHIBIT 2 FORM OF LOCK-UP LETTER RELYPSA, INC. LOCK-UP AGREEMENT , 2015 Merrill Lynch, Pierce, Fenner & Smith Incorporated Cowen and Company, LLC As Representatives of the several Underwriters listed in Schedule I to the Underwriting Agreement c/o Merrill Lynch, Pierce, Fenner & Smith Incorporated 1 Bryant Park New York, NY 10036 c/o Cowen and Company, LLC 599 Lexington Avenue, 27th Floor New York

March 6, 2015 SC 13D/A

RLYP / Relypsa, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 3 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* RELYPSA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 759531106 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP IV LLC Samuel D. Isaly 601 Lexington Avenue, 54th Floor New York, NY 10022 Telephone: (212) 739-6400 (Name, Addres

March 6, 2015 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13D, dated March 6, 2015 (the “Schedule 13D”), with respect to the Common Stock of Relypsa, Inc.

March 6, 2015 CT ORDER

Relypsa RDER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION March 4, 2015 ORDER GRANTING CONFIDENTIAL TREATMENT UNDER THE SECURITIES EXCHANGE ACT OF 1934 Relypsa, Inc.

March 3, 2015 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q/A (Amendment No. 1) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2014 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36

March 3, 2015 8-K

Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 25, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission Fil

March 3, 2015 EX-10.1

SUPPLY AGREEMENT

Exhibit 10.1 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. SUPPLY AGREEMENT THIS SUPPLY AGREEMENT (?Agreement?) is made effective as of August 15, 2014 by and among Relypsa Inc., having its principal place of business at 700 Saginaw Drive,

March 3, 2015 EX-1.1

3,900,000 Shares RELYPSA, INC. COMMON STOCK, $0.001 PAR VALUE PER SHARE UNDERWRITING AGREEMENT

EX-1.1 Exhibit 1.1 Execution Version 3,900,000 Shares RELYPSA, INC. COMMON STOCK, $0.001 PAR VALUE PER SHARE UNDERWRITING AGREEMENT February 25, 2015 February 25, 2015 Merrill Lynch, Pierce, Fenner & Smith Incorporated Cowen and Company, LLC As Representatives of the several Underwriters listed in Schedule I to the Underwriting Agreement c/o Merrill Lynch, Pierce, Fenner & Smith Incorporated 1 Bry

February 26, 2015 424B5

3,900,000 Shares Common Stock

Prospectus Supplement Table of Contents Filed pursuant to Rule 424(b)(5) Registration Statement No.

February 24, 2015 424B5

Subject to completion, dated February 24, 2015.

Preliminary Prospectus Supplement Table of Contents Filed pursuant to Rule 424(b)(5) Registration Statement No.

February 18, 2015 SC 13G

RLYP / Relypsa, Inc. / JANUS CAPITAL MANAGEMENT LLC - RLYP 12.31.14 Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment No.: * Name of Issuer: RELYPSA, INC. Title of Class of Securities: Common Stock CUSIP Number: 759531106 Date of Event Which Requires Filing of this Statement: 12/31/2014 Check the appropriate box to designate the rule pursuant to which this Schedule is filed. [X]

February 17, 2015 SC 13G/A

RLYP / Relypsa, Inc. / New Leaf Ventures I, L.p. - SC 13G/A Passive Investment

SC 13G/A 1 d871787dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 (Amendment No. 1)* Relypsa, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 759531106 (CUSIP Number) Dece

February 11, 2015 SC 13G/A

RLYP / Relypsa, Inc. / DELPHI VENTURES VII L P - SC 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b) (Amendment No. 1)* Relypsa, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing of this Statemen

February 6, 2015 EX-99.1

In accordance with Securities and Exchange Commission Release No. 34-39538 (January 12, 1998), this Statement is being filed by Credit Suisse AG (the "Bank"), a Swiss bank, on behalf of its subsidiaries to the extent that they constitute the Investme

In accordance with Securities and Exchange Commission Release No. 34-39538 (January 12, 1998), this Statement is being filed by Credit Suisse AG (the "Bank"), a Swiss bank, on behalf of its subsidiaries to the extent that they constitute the Investment Banking Division (the "Investment Banking Division") and the Alternative Investments business (the "AI Business") and U.S. private client services

February 6, 2015 SC 13G/A

RLYP / Relypsa, Inc. / CREDIT SUISSE AG/ - NONE Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Relypsa Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) Calendar Year 2014 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which t

January 28, 2015 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 22, 2015 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File

December 15, 2014 8-K

Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 15, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commissio

December 12, 2014 SC 13D/A

RLYP / Relypsa, Inc. / 5AM VENTURES III, L.P. - SC 13D/A Activist Investment

CUSIP NO. 759531106 13D Page 1 of 13 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 3)* Sc 13d/a Relypsa, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) Paul Stone 5AM Ventur

December 4, 2014 EX-25.1

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE

EX-25.1 Exhibit 25.1 File No. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE x CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO SECTION 305(b)(2) WILMINGTON TRUST, NATIONAL ASSOCIATION (Exact name of trustee as specified in its charter) 16-148645

December 4, 2014 S-3

RLYP / Relypsa, Inc. S-3 - - S-3

S-3 Table of Contents As filed with the Securities and Exchange Commission on December 4, 2014 Registration No.

December 4, 2014 EX-1.2

RELYPSA, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement

EX-1.2 Exhibit 1.2 Execution Version RELYPSA, INC. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement December 4, 2014 Cantor Fitzgerald & Co. 499 Park Avenue New York, NY 10022 Ladies and Gentlemen: Relypsa, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Cantor Fitzgerald & Co. (the “Agent”), as follows: 1

December 4, 2014 EX-4.4

Relypsa, Inc. Dated as of , 20 Wilmington Trust, National Association TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions 1 Section 1.2. Other Definitions 4 Section 1.3. Incorporation by Reference o

EX-4.4 Exhibit 4.4 Relypsa, Inc. INDENTURE Dated as of , 20 Wilmington Trust, National Association Trustee TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions 1 Section 1.2. Other Definitions 4 Section 1.3. Incorporation by Reference of Trust Indenture Act 5 Section 1.4. Rules of Construction 5 ARTICLE II. THE SECURITIES 5 Section 2.1. Issuable i

December 4, 2014 EX-12.1

STATEMENT REGARDING THE COMPUTATION OF RATIOS

EX-12.1 Exhibit 12.1 STATEMENT REGARDING THE COMPUTATION OF RATIOS Our earnings are inadequate to cover combined fixed charges and preference dividends. The following table sets forth the dollar amount of the coverage deficiency (in thousands) for the periods indicated. Year Ended December 31, Nine Months Ended September 30, 2013(1) 2012(2) 2011 2014 EARNINGS: Net loss $ (73,845 ) $ (43,725 ) $ (2

November 10, 2014 EX-10.4

October 27, 2014

Exhibit 10.4 October 28, 2014 Relypsa, Inc. 5301 Patrick Henry Drive Santa Clara, CA 95054 Dear Sir or Madam: Reference is made to the Amended and Restated Intellectual Property License and Assignment Agreement dated November 23, 2009 between Ilypsa, Inc. and Relypsa, Inc. (the ?Agreement?). Capitalized terms used but not defined herein shall have the same meanings as assigned to such terms in the

November 10, 2014 EX-10.2

CONSENT AND SECOND AMENDMENT AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

Exhibit 10.2 CONSENT AND SECOND AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT THIS CONSENT AND SECOND AMENDMENT to Amended and Restated Loan and Security Agreement (this “Amendment”) is entered into as of October 24, 2014, by and among OXFORD FINANCE LLC (“Oxford”) as collateral agent (in such capacity, “Collateral Agent”), the Lenders listed on Schedule 1.1 of the Loan Agreement o

November 10, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commissio

November 10, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2014 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact name of registrant as specifie

November 10, 2014 EX-10.1

SUPPLY AGREEMENT

Exhibit 10.1 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. SUPPLY AGREEMENT THIS SUPPLY AGREEMENT (?Agreement?) is made effective as of August 15, 2014 by and among Relypsa Inc., having its principal place of business at 700 Saginaw Drive,

November 10, 2014 EX-99.1

RELYPSA ANNOUNCES THIRD QUARTER 2014 FINANCIAL RESULTS

EX-99.1 Exhibit 99.1 Contact: Sylvia Wheeler VP, Investor Relations & Corporate Affairs 650-421-9504 [email protected] RELYPSA ANNOUNCES THIRD QUARTER 2014 FINANCIAL RESULTS REDWOOD CITY, Calif., November 10, 2014 — Relypsa, Inc. (Nasdaq: RLYP), a biopharmaceutical company, today reported financial results for the third quarter ended September 30, 2014. Net loss for the third quarter 2014 was $19.4 m

November 10, 2014 EX-10.3

CONSENT AND SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT

Exhibit 10.3 CONSENT AND SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT This CONSENT AND SECOND AMENDMENT to Loan and Security Agreement (this ?Consent?) is entered into as of October 24, 2014, by and between Silicon Valley Bank (?Bank?) and Relypsa, Inc., a Delaware corporation (?Borrower?) whose address is 700 Saginaw Drive, Redwood City, California 94063. RECITALS A. Bank and Borrower have ent

October 22, 2014 8-K

Other Events

8-K 1 d809335d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 22, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporat

October 14, 2014 CT ORDER

RLYP / Relypsa, Inc. CT ORDER - -

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September 25, 2014 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K 1 d794636d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 22, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorpor

September 17, 2014 SC 13D/A

RLYP / Relypsa, Inc. / 5AM VENTURES III, L.P. - SC 13D/A Activist Investment

SC 13D/A 1 v389381sc13d-a.htm SC 13D/A CUSIP NO. 759531106 13D Page 1 of 12 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 2)* Relypsa, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP

September 9, 2014 8-K

Entry into a Material Definitive Agreement

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 5, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commissio

September 3, 2014 SC 13D/A

RLYP / Relypsa, Inc. / 5AM VENTURES III, L.P. - SC 13D/A Activist Investment

CUSIP NO. 759531106 13D Page 1 of 13 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 1)* Relypsa, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) Paul Stone 5AM Ventures III, L

August 19, 2014 SC 13D/A

RLYP / Relypsa, Inc. / ORBIMED ADVISORS LLC - UNDER THE SECURITIES EXCHANGE ACT OF 1934 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No.2)* RELYPSA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 759531106 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP IV LLC Samuel D. Isaly 601 Lexington Avenue, 54th Floor New York, NY 10022 Telephone: (212) 739-6400 (Name, Address

August 19, 2014 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13D, dated August 19, 2014 (the “Schedule 13D”), with respect to the Common Stock of Relypsa, Inc.

August 11, 2014 EX-10.2

MANUFACTURING AND SUPPLY AGREEMENT

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission.

August 11, 2014 EX-10

RELYPSA, INC. FIRST AMENDMENT TO OFFER LETTER AGREEMENT JOHN A. ORWIN

EX-10 5 rlyp-ex1020140630372.htm EX-10.8 Exhibit 10.8 RELYPSA, INC. FIRST AMENDMENT TO OFFER LETTER AGREEMENT JOHN A. ORWIN This FIRST AMENDMENT TO OFFER LETTER AGREEMENT (this “Amendment”) is entered into effective as of August 8, 2014, by and between RELYPSA, INC. (the “Company”) and JOHN A. ORWIN (“Executive”) (collectively, the “Parties”). RECITAL: WHEREAS, the Parties entered into that certai

August 11, 2014 EX-99.1

Relypsa Announces Second Quarter 2014 Financial Results — Company Updates Plans for NDA Submission to Early Q4 2014; Continues to Expect Approval 2H 2015 —

EX-99.1 2 d770319dex991.htm EX-99.1 Exhibit 99.1 NEWS RELEASE Contact: Sylvia Wheeler VP, Investor Relations & Corporate Affairs 650-421-9504 [email protected] Relypsa Announces Second Quarter 2014 Financial Results — Company Updates Plans for NDA Submission to Early Q4 2014; Continues to Expect Approval 2H 2015 — REDWOOD CITY, Calif., August 11, 2014 — Relypsa, Inc. (Nasdaq: RLYP), a biopharmaceutic

August 11, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File

August 11, 2014 EX-10

RELYPSA, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN ARTICLE 1.

Exhibit 10.6 RELYPSA, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN ARTICLE 1. PURPOSE The purpose of the Relypsa, Inc. 2014 Employment Commencement Incentive Plan (as it may be amended from time to time, the ?Plan?) is to promote the success and enhance the value of Relypsa, Inc. (the ?Company?) by linking the individual interests of the Eligible Participants to those of the Company?s stockhol

August 11, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2014 or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact name of registrant as specified in

August 11, 2014 EX-10

RELYPSA, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN STOCK OPTION GRANT NOTICE

EX-10 4 rlyp-ex1020140630373.htm EX-10.7 Exhibit 10.7 RELYPSA, INC. 2014 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN STOCK OPTION GRANT NOTICE Relypsa, Inc., a Delaware corporation, (the “Company”), pursuant to its 2014 Employment Commencement Incentive Plan, as may be amended from time to time (the “Plan”), hereby grants to the holder listed below (“Participant”), an option to purchase the number of s

July 31, 2014 SC 13D

RLYP / Relypsa, Inc. / 5AM VENTURES III, L.P. - SC 13D Activist Investment

CUSIP NO. 759531106 13D Page 1 of 20 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. )* Relypsa, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) Paul Stone 5AM Ventures III, L.

July 1, 2014 EX-10.1

BRITANNIA SEAPORT CENTRE

EX-10.1 Exhibit 10.1 BRITANNIA SEAPORT CENTRE LEASE This Lease (the “Lease”), dated as of the date set forth in Section 1 of the Summary of Basic Lease Information (the “Summary”), below, is made by and between HCP LS REDWOOD CITY, LLC, a Delaware limited liability company (“Landlord”), and RELYPSA, INC., a Delaware corporation (“Tenant”). SUMMARY OF BASIC LEASE INFORMATION TERMSOF LEASE DESCRIPTI

July 1, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 26, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission Fi

July 1, 2014 EX-10.2

CONSENT AND FIRST AMENDMENT AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

EX-10.2 Exhibit 10.2 CONSENT AND FIRST AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT THIS CONSENT AND FIRST AMENDMENT to Amended and Restated Loan and Security Agreement (this “Amendment”) is entered into as of June 26, 2014, by and among OXFORD FINANCE LLC (“Oxford”) as collateral agent (in such capacity, “Collateral Agent”), the Lenders listed on Schedule 1.1 of the Loan Agreemen

June 24, 2014 8-K

Submission of Matters to a Vote of Security Holders - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 19, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File Nu

June 2, 2014 EX-10.1

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

EX-10.1 Exhibit 10.1 AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (as the same may from time to time be amended, modified, supplemented or restated, this “Agreement”) dated as of May 30, 2014 (the “Effective Date”) among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 133 North Fairfax Street, Alexandria,

June 2, 2014 EX-4.1

WARRANT TO PURCHASE STOCK Company: RELYPSA, INC. Number of Shares: [$ /Warrant Price] (the “Original Shares”), plus all Additional Shares which Holder is entitled to purchase pursuant to Section 1.7. Type/Series of Stock: Common Stock, $0.001 par val

EX-4.1 Exhibit 4.1 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND

June 2, 2014 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 30, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File Num

May 20, 2014 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File Number)

May 12, 2014 8-K

Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission Fil

May 7, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File

May 7, 2014 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2014 or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-36184 RELYPSA, INC. (Exact name of registrant as specified in

May 7, 2014 EX-99.1

Relypsa Announces First Quarter 2014 Financial Results

EX-99.1 Exhibit 99.1 NEWS RELEASE Contact: Sylvia Wheeler VP, Investor Relations & Corporate Affairs 650-421-9504 [email protected] Relypsa Announces First Quarter 2014 Financial Results REDWOOD CITY, Calif., May 7, 2014 – Relypsa, Inc. (Nasdaq: RLYP), a biopharmaceutical company, today reported financial results for the first quarter ended March 31, 2014. Net loss for the first quarter 2014 was $16.

April 30, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission File N

April 30, 2014 EX-10.1

FIRST AMENDMENT TO LEASE

EX-10.1 Exhibit 10.1 FIRST AMENDMENT TO LEASE This FIRST AMENDMENT TO LEASE (“Amendment”) is made and entered into as of April 24, 2014, by and between HCP LS REDWOOD CITY, LLC, a Delaware limited liability company (“Landlord”), and RELYPSA, INC., a Delaware corporation (“Tenant”). R E C I T A L S : A. Landlord and Tenant are parties to that certain Lease dated September 7, 2012, (the “Lease”), pu

April 28, 2014 DEFA14A

- DEFA14A

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

April 28, 2014 DEF 14A

- DEFINITIVE NOTICE AND PROXY STATEMENT

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14

April 17, 2014 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13D, dated April 17, 2014 (the “Schedule 13D”), with respect to the Common Stock of Relypsa, Inc.

April 17, 2014 SC 13D/A

RLYP / Relypsa, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 1 TO SCHEDULE 13D Activist Investment

SC 13D/A 1 ss210340sc13da.htm AMENDMENT NO. 1 TO SCHEDULE 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* RELYPSA, INC. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 759531106 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP IV LLC Samuel D. Isaly 601 Lexington Avenue, 54th Fl

April 16, 2014 8-K

Financial Statements and Exhibits, Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 16, 2014 RELYPSA, INC. (Exact name of registrant as specified in its charter) Delaware 001-36184 26-0893742 (State or other jurisdiction of incorporation) (Commission F

April 16, 2014 EX-99.1

Relypsa, Inc. Announces Closing of Public Offering of Common Stock

EX-99.1 Exhibit 99.1 NEWS RELEASE Contact: Sylvia Wheeler V.P. Investor Relations and Corporate Affairs 650-421-9504 [email protected] Relypsa, Inc. Announces Closing of Public Offering of Common Stock REDWOOD CITY, Calif., April 16, 2014 (GLOBE NEWSWIRE) — Relypsa, Inc. (Nasdaq:RLYP), a biopharmaceutical company, today announced the closing of its public offering of 4,130,611 shares of its common st

April 11, 2014 424B4

3,591,836 Shares Common Stock

424B4 1 d692360d424b4.htm 424B4 Table of Contents Filed Pursuant to Rule 424(b)(4) Registration No. 333-194673 Registration No. 333-195198 3,591,836 Shares Common Stock We are offering 3,591,836 shares of our common stock in this offering. Our common stock is listed on The NASDAQ Global Select Market under the symbol “RLYP.” On April 10, 2014, the last reported sale price of our common stock was $

April 10, 2014 S-1MEF

- FORM S-1MEF

Form S-1MEF As filed with the Securities and Exchange Commission on April 10, 2014 Registration No.

April 8, 2014 CORRESP

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CORRESP 1 filename1.htm April 8, 2014 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-6010 Attention: Jeffrey Riedler, Assistant Director Amy Reischauer Re: Relypsa, Inc. Registration Statement on Form S-1 (Registration No. 333-194673) Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933, as

April 8, 2014 S-1/A

- AMENDMENT NO. 1 TO FORM S-1

Table of Contents As filed with the Securities and Exchange Commission on April 8, 2014 Registration No.

April 8, 2014 EX-1.1

[ ] Shares RELYPSA, INC. COMMON STOCK, $0.001 PAR VALUE PER SHARE UNDERWRITING AGREEMENT

EX-1.1 Exhibit 1.1 [ ] Shares RELYPSA, INC. COMMON STOCK, $0.001 PAR VALUE PER SHARE UNDERWRITING AGREEMENT [ ], 2014 [ ], 2014 Morgan Stanley & Co. LLC Merrill Lynch, Pierce, Fenner & Smith Incorporated Cowen and Company, LLC As Representatives of the several Underwriters listed in Schedule I to the Underwriting Agreement c/o Morgan Stanley & Co. LLC 1585 Broadway New York, NY 10036 c/o Merrill L

April 8, 2014 CORRESP

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CORRESP Relypsa, Inc. 700 Saginaw Drive Redwood City, CA 94063 April 8, 2014 VIA EDGAR AND E-MAIL United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-6010 Attention: Jeffrey Riedler, Assistant Director Amy Reischauer Re: Relypsa, Inc. Registration Statement on Form S-1 (Registration No. 333-194673) Ladies and Gentlemen: In acco

April 1, 2014 CT ORDER

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begin 644 filename1.pdf M)5!$1BTQ+C4-)>+CS],-"C$P(#`@;V)J#3P\+TQI;F5A7!E+UA2968O5ULQ(#(@,5T^/G-T#0IE;F1S M=')E86T-96YD;V)J#7-T87)T>')E9@T*,`T*)25%3T8-"B`@("`@("`@#0HR M,B`P(&]B:@T\/"]&:6QT97(O1FQA=&5$96-O9&4O22`X-"],(#8X+TQE;F=T M:"`V,2]3(#,X/CYS=')E86T-"FC>8F!@8&9@8.)G``(.1@94`.*S,'`T((LQ M0S$#0R,#-P/[/L&J$J1'JB.-K`N!A5^")]1`B#``)\*!'H-"F5N9'-T7!E+T-A=&%L;V<^/@UE;F1O8FH-,3(@ M,"!O8FH-/#PO0V]N=&5N

March 26, 2014 LETTER

LETTER

March 26, 2014 Via E-Mail Ronald A. Krasnow General Counsel and Senior Vice President Relypsa, Inc. 700 Saginaw Drive Redwood City, CA 94063 Re: Relypsa, Inc. Registration Statement on Form S-1 Filed March 19, 2014 File No. 333-194673 Dear Mr. Krasnow: We have limited our review of your registration statement to resolution of your pending confidential treatment request. We urge all persons who are

March 19, 2014 EX-10.6

CONFIDENTIAL Manufacturing and Supply Agreement LANXESS CORPORATION RELYPSA, INC. EFFECTIVE AS OF NOVEMBER 27, 2012

EX-10.6 Exhibit 10.6 [***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. Execution copy CONFIDENTIAL Manufacturing and Supply Agreement BETWEEN LANXESS CORPORATION AND RELYPSA, INC. EFFECTIVE AS OF NOVEMBER 27, 2012 Execution copy CONFIDENTIAL TA

March 19, 2014 EX-10.10

RELYPSA, INC. 2013 EMPLOYEE STOCK PURCHASE PLAN ARTICLE I. PURPOSE, SCOPE AND ADMINISTRATION OF THE PLAN

EX-10.10 Exhibit 10.10 RELYPSA, INC. 2013 EMPLOYEE STOCK PURCHASE PLAN ARTICLE I. PURPOSE, SCOPE AND ADMINISTRATION OF THE PLAN 1.1 Purpose and Scope. The purpose of the Relypsa, Inc. 2013 Employee Stock Purchase Plan, as it may be amended from time to time, (the “Plan”) is to assist employees of Relypsa, Inc., a Delaware corporation, (the “Company”) and its Designated Subsidiaries in acquiring a

March 19, 2014 EX-10.21

RELYPSA, INC. EMPLOYMENT AGREEMENT

Exhibit 10.21 RELYPSA, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?) is made and entered into by and between Mary Corbett (?Executive?) and Relypsa, Inc. (the ?Company?) (together referred to herein as the ?Parties?) as of the date of the last signature hereto. This Agreement supersedes in its entirety any agreement to which the Company is a party with respect to Executive?

March 19, 2014 S-1

Registration Statement - FORM S-1

Form S-1 Table of Contents As filed with the Securities and Exchange Commission on March 19, 2014 Registration No.

March 19, 2014 EX-99.1

In accordance with Securities and Exchange Commission Release No. 34-39538 (January 12, 1998), this Statement is being filed by Credit Suisse AG (the "Bank"), a Swiss bank, on behalf of its subsidiaries to the extent that they constitute the Investme

In accordance with Securities and Exchange Commission Release No. 34-39538 (January 12, 1998), this Statement is being filed by Credit Suisse AG (the "Bank"), a Swiss bank, on behalf of its subsidiaries to the extent that they constitute the Investment Banking Division (the "Investment Banking Division") and the Alternative Investments business (the "AI Business") and U.S. private client services

March 19, 2014 SC 13G

RLYP / Relypsa, Inc. / CREDIT SUISSE AG/ - NONE Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. n/a )* Relypsa Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 759531106 (CUSIP Number) Calendar Year 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to whic

March 19, 2014 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

10-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 19, 2014 EX-10.9(A)

RELYPSA, INC. 2013 EQUITY INCENTIVE AWARD PLAN ARTICLE 1.

EX-10.9(a) Exhibit 10.9(a) RELYPSA, INC. 2013 EQUITY INCENTIVE AWARD PLAN ARTICLE 1. PURPOSE The purpose of the Relypsa, Inc. 2013 Equity Incentive Award Plan (as it may be amended from time to time, the “Plan”) is to promote the success and enhance the value of Relypsa, Inc. (the “Company”) by linking the individual interests of the members of the Board, Employees, and Consultants to those of the

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