HPTX / Hyperion Therapeutics Inc - Depositi SEC, Relazione annuale, dichiarazione di delega

Hyperion Therapeutics Inc
US
QUESTO SIMBOLO NON E' PIU' ATTIVO

Statistiche di base
CIK 1386858
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Hyperion Therapeutics Inc
SEC Filings (Chronological Order)
Questa pagina fornisce un elenco completo e cronologico dei depositi SEC, esclusi i documenti di proprietà che forniamo altrove.
February 11, 2016 SC 13G/A

HPTX / Hyperion Therapeutics Inc / Consonance Capital Management LP - CONSONANCE CAPITAL MANAGEMENT LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 44915N101 (CUSIP Number) December 31, 2015 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designat

May 18, 2015 15-12B

HPTX 15-12B

15-12B UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-35614 HYPERION THERAPEUTICS, INC. (Exact name of registrant as sp

May 15, 2015 SC 13D/A

HPTX / Hyperion Therapeutics Inc / SOFINNOVA VENTURE PARTNERS VII L P - FORM SC 13D/A Activist Investment

SC 13D/A 1 v410450sc13da.htm FORM SC 13D/A CUSIP NO. 44915N101 13D Page 1 of 8 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 6)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (

May 11, 2015 SC 13D/A

HPTX / Hyperion Therapeutics Inc / New Enterprise Associates 12, Limited Partnership - HYPERION THERAPEUTICS, INC. #2 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, $.0001 par value (Title of Class of Securities) 44915N101 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600 Timonium, MD 21093 (410) 842-4000 (Name,

May 7, 2015 S-8 POS

HPTX S-8 POS

S-8 POS As filed with the Securities and Exchange Commission on May 7, 2015 Registration No.

May 7, 2015 RW

HPTX RW

RW Hyperion Therapeutics, Inc. 2000 Sierra Point Parkway, Suite 400 Brisbane, CA 94005 May 7, 2015 VIA EDGAR Daniel F. Duchovny Securities and Exchange Commission Division of Corporation Finance 100 F Street N.E. Washington, D.C. 20549 RE: Hyperion Therapeutics, Inc. Registration Statement on Form S-3 (File No. 333-190624) Filed August 14, 2013 Application for Withdrawal Dear Mr. Duchovny: Pursuan

May 7, 2015 S-8 POS

HPTX S-8 POS

S-8 POS As filed with the Securities and Exchange Commission on May 7, 2015 Registration No.

May 7, 2015 EX-99.A5.IV

Horizon Pharma plc Announces Results of Tender Offer

EX-99.A5.IV Exhibit (a)(5)(iv) Horizon Pharma plc Announces Results of Tender Offer DUBLIN, Ireland – May 7, 2015 – Horizon Pharma plc (“Horizon”) (NASDAQ: HZNP) today announced the results of its tender offer to purchase all of the outstanding shares of common stock of Hyperion Therapeutics, Inc. (“Hyperion”) (NASDAQ: HPTX) for $46.00 per share in cash, net to the seller in cash, without interest

May 7, 2015 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION HORIZON THERAPEUTICS, INC.

EX-3.1 2 d921752dex31.htm EX-3.1 Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF HORIZON THERAPEUTICS, INC. I. The name of this corporation is Horizon Therapeutics, Inc. II. The registered office of the corporation in the State of Delaware shall be 3411 Silverside Road, Rodney Bldg, Suite 104, City of Wilmington, County of New Castle County, 19810 and the name of the registered ag

May 7, 2015 SC 14D9/A

HPTX SC 14D9/A

SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Amendment No. 3) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 HYPERION THERAPEUTICS, INC. (Name of Subject Company) HYPERION THERAPEUTICS, INC. (Name of Person Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securiti

May 7, 2015 EX-3.2

AMENDED AND RESTATED BYLAWS HORIZON THERAPEUTICS, INC. (A DELAWARE CORPORATION) AMENDED AND RESTATED BYLAWS HORIZON THERAPEUTICS, INC. (A DELAWARE CORPORATION) ARTICLE I

EX-3.2 3 d921752dex32.htm EX-3.2 Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF HORIZON THERAPEUTICS, INC. (A DELAWARE CORPORATION) AMENDED AND RESTATED BYLAWS OF HORIZON THERAPEUTICS, INC. (A DELAWARE CORPORATION) ARTICLE I OFFICES Section 1. Registered Office. The registered office of the corporation in the State of Delaware shall be in the City of Wilmington, County of New Castle. Section 2. Other

May 7, 2015 8-K

Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2015 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commis

May 7, 2015 S-8 POS

HPTX S-8 POS

S-8 POS As filed with the Securities and Exchange Commission on May 7, 2015 Registration No.

May 7, 2015 SC TO-T/A

Horizon Pharma SC TO-T/A

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 5) Hyperion Therapeutics, Inc. (Name of Subject Company) Ghrian Acquisition Inc. (Name of Offeror) A Wholly Owned Subsidiary of Horizon Pharma, Inc. (Parent of Offeror) An Indirect Wholly-Owned

May 7, 2015 S-8 POS

HPTX S-8 POS

S-8 POS As filed with the Securities and Exchange Commission on May 7, 2015 Registration No.

May 6, 2015 EX-10.1

COMPLETION OF PHASE III CLINICAL TRIAL, OPTION AND MUTUAL RELEASE AGREEMENT

Exhibit 10.1 *** INDICATES MATERIAL THAT WAS OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT WAS REQUESTED. ALL SUCH OMITTED MATERIAL WAS FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24b-2 PROMULGATED UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. Execution COMPLETION OF PHASE III CLINICAL TRIAL, OPTION AND MUTUAL RELEASE AGREEMENT This COMPLETION OF PHASE III

May 6, 2015 10-Q

HPTX FORM 10-Q (Quarterly Report)

Form 10-Q Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934.

April 30, 2015 EX-99.A5.III

Horizon Pharma plc Announces Waiver of Financing Proceeds Condition

EX-99.A5.III Exhibit (a)(5)(iii) Horizon Pharma plc Announces Waiver of Financing Proceeds Condition (DUBLIN, Ireland and BRISBANE, Calif. ? April 30, 2015) ? Horizon Pharma plc (NASDAQ: HZNP) a specialty biopharmaceutical company focused on improving patients? lives by identifying, developing, acquiring and commercializing differentiated products that address unmet medical needs, today announced

April 30, 2015 EX-99.(A)(11)

Horizon Pharma plc Announces Expiration of HSR Waiting Period for Proposed Hyperion Therapeutics, Inc. Acquisition

EX-99.(A)(11) 2 d919212dex99a11.htm EX-99.(A)(11) Exhibit (a)(11) Horizon Pharma plc Announces Expiration of HSR Waiting Period for Proposed Hyperion Therapeutics, Inc. Acquisition (DUBLIN, Ireland and BRISBANE, Calif. – April 29, 2015) – Horizon Pharma plc (NASDAQ: HZNP) today announced the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (“HSR”) expired e

April 30, 2015 SC TO-T/A

Horizon Pharma SC TO-T/A

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 4) Hyperion Therapeutics, Inc. (Name of Subject Company) Ghrian Acquisition Inc. (Name of Offeror) A Wholly Owned Subsidiary of Horizon Pharma, Inc. (Parent of Offeror) An Indirect Wholly-Owned

April 30, 2015 EX-99.A5.II

Horizon Pharma plc Announces Expiration of HSR Waiting Period for Proposed Hyperion Therapeutics, Inc. Acquisition

Exhibit (a)(5)(ii) Horizon Pharma plc Announces Expiration of HSR Waiting Period for Proposed Hyperion Therapeutics, Inc.

April 30, 2015 SC 14D9/A

HPTX SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Amendment No. 2) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 HYPERION THERAPEUTICS, INC. (Name of Subject Company) HYPERION THERAPEUTICS, INC. (Name of Person Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securities) 44915N

April 29, 2015 10-K/A

HPTX 10-K/A (Annual Report)

10-K/A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 27, 2015 SC TO-T/A

Horizon Pharma SC TO-T/A

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 3) Hyperion Therapeutics, Inc. (Name of Subject Company) Ghrian Acquisition Inc. (Name of Offeror) A Wholly Owned Subsidiary of Horizon Pharma, Inc. (Parent of Offeror) An Indirect Wholly-Owned

April 23, 2015 SC 13D

HPTX / Hyperion Therapeutics Inc / GAMCO INVESTORS, INC. ET AL Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 44915N101 (CUSIP Number) David Goldman GAMCO Investors, Inc. One Corporate Center Rye, New York 10580-1435 (914) 921-5000 (Name, Address and Telephone Number of Person A

April 22, 2015 SC 14D9/A

HPTX SC 14D9/A

SC 14D9/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Amendment No. 1) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 HYPERION THERAPEUTICS, INC. (Name of Subject Company) HYPERION THERAPEUTICS, INC. (Name of Person Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securiti

April 22, 2015 CORRESP

HPTX ESP

CORRESP April 21, 2015 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-3628 Attn: Daniel F. Duchovny, Special Counsel Re: Hyperion Therapeutics, Inc. Schedule 14D-9 filed April 9, 2015 SEC File No. 005-86934 Dear Mr. Duchovny: This letter responds to the letter, dated April 20, 2015 from the staff (the ?Staff?) of the Secu

April 22, 2015 SC TO-T/A

Horizon Pharma SC TO-T/A

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 2) Hyperion Therapeutics, Inc. (Name of Subject Company) Ghrian Acquisition Inc. (Name of Offeror) A Wholly Owned Subsidiary of Horizon Pharma, Inc. (Parent of Offeror) An Indirect Wholly-Owned

April 14, 2015 SC TO-T/A

Horizon Pharma SC TO-T/A

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 1) Hyperion Therapeutics, Inc. (Name of Subject Company) Ghrian Acquisition Inc. (Name of Offeror) A Wholly Owned Subsidiary of Horizon Pharma, Inc. (Parent of Offeror) An Indirect Wholly-Owned

April 9, 2015 EX-99.A.1.VI

Notice of Offer to Purchase for Cash All Outstanding Shares of Common Stock and the Associated Rights to Purchase Capital Stock HYPERION THERAPEUTICS, INC $46.00 Net per Share GHRIAN ACQUISITION INC., a wholly owned subsidiary of Horizon Pharma, Inc.

EX-(a)(1)(vi) Exhibit (a)(1)(vi) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below).

April 9, 2015 EX-99.D.3

Hyperion Therapeutics, Inc. 2000 Sierra Point Parkway, Suite 400 Brisbane, CA 94005

EX-(d)(3) Exhibit (d)(3) Execution Copy Hyperion Therapeutics, Inc. 2000 Sierra Point Parkway, Suite 400 Brisbane, CA 94005 March 8, 2015 Horizon Pharma plc Connaught House, 1st Floor Dublin 4, Ireland Attention: Timothy Walbert Confidentiality Agreement Ladies and Gentlemen: We are in receipt of the letter from Timothy P. Walbert, Chairman, President and Chief Executive Officer of Horizon Pharma

April 9, 2015 8-K

Results of Operations and Financial Condition

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 9, 2015 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation)

April 9, 2015 SC TO-T

Horizon Pharma SC TO-T

SC TO-T UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Hyperion Therapeutics, Inc. (Name of Subject Company) Ghrian Acquisition Inc. (Name of Offeror) A Wholly Owned Subsidiary of Horizon Pharma, Inc. (Parent of Offeror) An Indirect Wholly-Owned Subsidiary of Horizo

April 9, 2015 EX-99.A.1.II

LETTER OF TRANSMITTAL To Tender Shares of Common Stock and the Associated Rights to Purchase Capital Stock HYPERION THERAPEUTICS, INC. $46.00 Net per Share Pursuant to the Offer to Purchase dated April 9, 2015 GHRIAN ACQUISITION INC., a wholly owned

EX-99.A.1.II 3 d903951dex99a1ii.htm EX-(A)(1)(II) Exhibit (a)(1)(ii) LETTER OF TRANSMITTAL To Tender Shares of Common Stock and the Associated Rights to Purchase Capital Stock of HYPERION THERAPEUTICS, INC. at $46.00 Net per Share Pursuant to the Offer to Purchase dated April 9, 2015 by GHRIAN ACQUISITION INC., a wholly owned subsidiary of HORIZON PHARMA, INC., a wholly owned subsidiary of HORIZON

April 9, 2015 SC TO-C

Horizon Pharma FORM 8-K/A

Form 8-K/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A Amendment No. 1 CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 29, 2015 Horizon Pharma Public Limited Company (Exact name of registrant as specified in its charter) Ireland 001-35238 Not Applicable (State or oth

April 9, 2015 8-K/A

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 9, 2015 (March 29, 2015) HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 001-35614 61-1512713 (State or Oth

April 9, 2015 EX-99.A.1.I

Offer to Purchase for Cash All Outstanding Shares of Common Stock Hyperion Therapeutics, Inc., $46.00 NET PER SHARE Ghrian Acquisition Inc. a wholly owned subsidiary of Horizon Pharma, Inc.

EX-99.A.1.I 2 d903951dex99a1i.htm EX-(A)(1)(I) Table of Contents Exhibit (a)(1)(i) Offer to Purchase for Cash All Outstanding Shares of Common Stock of Hyperion Therapeutics, Inc., at $46.00 NET PER SHARE by Ghrian Acquisition Inc. a wholly owned subsidiary of Horizon Pharma, Inc. THE OFFER AND WITHDRAWAL RIGHTS EXPIRE AT 12.01 AM (NEW YORK CITY TIME) ON MAY 7, 2015, UNLESS THE OFFER IS EXTENDED.

April 9, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER

EX-2.1 2 d907599dex21.htm EX-2.1 Exhibit 2.1 EXECUTION AGREEMENT AND PLAN OF MERGER among: HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER 1.1 The Offer 6 1.2 Company Actions 9 ARTICLE II. THE MERGER 2.1 Merger of Purchaser int

April 9, 2015 EX-99.A.1.III

NOTICE OF GUARANTEED DELIVERY For Tender of All Outstanding Shares of Common Stock and the Associated Rights to Purchase Capital Stock HYPERION THERAPEUTICS, INC. $46.00 Net per Share Pursuant to the Offer to Purchase dated April 9, 2015 GHRIAN ACQUI

EX-(a)(1)(iii) Exhibit (a)(1)(iii) NOTICE OF GUARANTEED DELIVERY For Tender of All Outstanding Shares of Common Stock and the Associated Rights to Purchase Capital Stock of HYPERION THERAPEUTICS, INC.

April 9, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER

EX-2.1 Exhibit 2.1 EXECUTION AGREEMENT AND PLAN OF MERGER among: HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER 1.1 The Offer 6 1.2 Company Actions 9 ARTICLE II. THE MERGER 2.1 Merger of Purchaser into the Company 10 2.2 Effec

April 9, 2015 SC TO-C

HPTX 8-K/A

8-K/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 9, 2015 (March 29, 2015) HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 001-35614 61-1512713 (State or Oth

April 9, 2015 EX-99.A.1.V

Offer To Purchase For Cash All Outstanding Shares of Common Stock and the Associated Rights to Purchase Capital Stock HYPERION THERAPEUTICS, INC. $46.00 Net per Share Pursuant to the Offer to Purchase dated April 9, 2015 GHRIAN ACQUISITION INC., a wh

EX-(a)(1)(v) Exhibit (a)(1)(v) Offer To Purchase For Cash All Outstanding Shares of Common Stock and the Associated Rights to Purchase Capital Stock of HYPERION THERAPEUTICS, INC.

April 9, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER

EX-2.1 Exhibit 2.1 EXECUTION AGREEMENT AND PLAN OF MERGER among: HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER 1.1 The Offer 6 1.2 Company Actions 9 ARTICLE II. THE MERGER 2.1 Merger of Purchaser into the Company 10 2.2 Effec

April 9, 2015 EX-99.A.1.IV

Offer To Purchase For Cash All Outstanding Shares of Common Stock and the Associated Rights to Purchase Capital Stock HYPERION THERAPEUTICS, INC. $46.00 Net per Share Pursuant to the Offer to Purchase dated April 9, 2015 GHRIAN ACQUISITION INC., a wh

EX-(a)(1)(iv) Exhibit (a)(1)(iv) Offer To Purchase For Cash All Outstanding Shares of Common Stock and the Associated Rights to Purchase Capital Stock of HYPERION THERAPEUTICS, INC.

April 9, 2015 SC 14D9

HPTX SC 14D9

SC 14D9 Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 7, 2015 SC 13D/A

HPTX / Hyperion Therapeutics Inc / New Enterprise Associates 12, Limited Partnership - HYPERION THERAPEUTICS, INC. Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, $.0001 par value (Title of Class of Securities) 44915N101 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600 Timonium, MD 21093 (410) 842-4000 (Name,

April 3, 2015 SC 13D/A

HPTX / Hyperion Therapeutics Inc / SOFINNOVA VENTURE PARTNERS VII L P - SC 13D/A Activist Investment

CUSIP NO. 44915N101 13D Page 1 of 10 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 5)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 44915N101 (C

March 31, 2015 EX-2.2

TENDER AND SUPPORT AGREEMENT

Exhibit 2.2 TENDER AND SUPPORT AGREEMENT THIS TENDER AND SUPPORT AGREEMENT (this “Agreement”) is entered into as of March 29, 2015, by and among Horizon Pharma, Inc., a Delaware corporation (“Parent”), Ghrian Acquisition Inc., a Delaware corporation and wholly owned subsidiary of Parent (“Purchaser”), and (“Stockholder”). RECITALS A. Stockholder is a holder of record and the “beneficial owner” (wi

March 31, 2015 SC TO-C

Horizon Pharma FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 29, 2015 Horizon Pharma Public Limited Company (Exact name of registrant as specified in its charter) Ireland 001-35238 Not Applicable (State or other jurisdiction of incorporat

March 31, 2015 EX-99.1

CITIGROUP GLOBAL MARKETS INC. 390 Greenwich Street New York, New York 10013

EX-99.1 Exhibit 99.1 Execution Version CITIGROUP GLOBAL MARKETS INC. 390 Greenwich Street New York, New York 10013 JEFFERIES FINANCE LLC 520 Madison Avenue New York, New York 10022 March 29, 2015 Horizon Pharma, Inc. c/o Horizon Pharma Public Limited Company Connaught House, 1 Floor 1 Burlington Road, Dublin 4, Ireland Attention: Paul W. Hoelscher, Executive Vice President and Chief Financial Offi

March 31, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER

EX-2.1 2 d899083dex21.htm EX-2.1 Exhibit 2.1 EXECUTION AGREEMENT AND PLAN OF MERGER among: HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER 1.1 The Offer 6 1.2 Company Actions 9 ARTICLE II. THE MERGER 2.1 Merger of Purchaser int

March 30, 2015 EX-99.2

Horizon Pharma plc

EX-99.2 Exhibit 99.2 Horizon Pharma plc Acquisition of Hyperion Therapeutics March 30, 2015 Non-Confidential Information ? Horizon Pharma plc Forward-Looking Statements This presentation contains forward-looking statements, including, but not limited to, statements related to Horizon?s anticipated acquisition of Hyperion Therapeutics, Inc. and the timing and benefits thereof, estimated future fina

March 30, 2015 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 30, 2015 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in its Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation)

March 30, 2015 SC 14D9

HPTX SC 14D9

SC 14D9 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (Rule 14d-101) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 HYPERION THERAPEUTICS, INC. (Name of Subject Company) HYPERION THERAPEUTICS, INC. (Name of Person Filing Statement) Common Stock, par value $0.0001 per share (Title of Class of Securities) 4

March 30, 2015 EX-99.1

Horizon Pharma plc to Acquire Hyperion Therapeutics, Inc. for $46.00 per share or $1.1 Billion in Cash — Addition of RAVICTI® (glycerol phenylbutyrate) Oral Liquid and BUPHENYL® (sodium phenylbutyrate) Tablets and Powder Significantly Expands Horizon

EX-99.1 4 d899299dex991.htm EX-99.1 Exhibit 99.1 Horizon Pharma plc to Acquire Hyperion Therapeutics, Inc. for $46.00 per share or $1.1 Billion in Cash — Addition of RAVICTI® (glycerol phenylbutyrate) Oral Liquid and BUPHENYL® (sodium phenylbutyrate) Tablets and Powder Significantly Expands Horizon’s Orphan Business – — Transaction is Expected to be Immediately Accretive to Adjusted Earnings Per S

March 30, 2015 EX-99.1

Horizon Pharma plc to Acquire Hyperion Therapeutics, Inc. for $46.00 per share or $1.1 Billion in Cash — Addition of RAVICTI® (glycerol phenylbutyrate) Oral Liquid and BUPHENYL® (sodium phenylbutyrate) Tablets and Powder Significantly Expands Horizon

EX-99.1 Exhibit 99.1 Horizon Pharma plc to Acquire Hyperion Therapeutics, Inc. for $46.00 per share or $1.1 Billion in Cash ? Addition of RAVICTI? (glycerol phenylbutyrate) Oral Liquid and BUPHENYL? (sodium phenylbutyrate) Tablets and Powder Significantly Expands Horizon?s Orphan Business ? ? Transaction is Expected to be Immediately Accretive to Adjusted Earnings Per Share and Contribute Approxim

March 30, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER

EX-2.1 Exhibit 2.1 EXECUTION AGREEMENT AND PLAN OF MERGER among: HORIZON PHARMA, INC. a Delaware corporation, GHRIAN ACQUISITION INC., a Delaware corporation, and HYPERION THERAPEUTICS, INC., a Delaware corporation Dated as of March 29, 2015 TABLE OF CONTENTS Page ARTICLE I. THE OFFER 1.1 The Offer 6 1.2 Company Actions 9 ARTICLE II. THE MERGER 2.1 Merger of Purchaser into the Company 10 2.2 Effec

March 30, 2015 SC TO-C

Horizon Pharma FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 29, 2015 Horizon Pharma Public Limited Company (Exact name of registrant as specified in its charter) Ireland 001-35238 Not Applicable (State or other jurisdiction of i

March 30, 2015 EX-2.2

TENDER AND SUPPORT AGREEMENT

EX-2.2 Exhibit 2.2 TENDER AND SUPPORT AGREEMENT THIS TENDER AND SUPPORT AGREEMENT (this ?Agreement?) is entered into as of March 29, 2015, by and among Horizon Pharma, Inc., a Delaware corporation (?Parent?), Ghrian Acquisition Inc., a Delaware corporation and wholly owned subsidiary of Parent (?Purchaser?), and (?Stockholder?). RECITALS A. Stockholder is a holder of record and the ?beneficial own

March 12, 2015 SC 13D/A

HPTX / Hyperion Therapeutics Inc / BAY CITY CAPITAL LLC - AMENDMENT NO. 2 TO SCHEDULE 13D Activist Investment

Amendment no. 2 to Schedule 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 44915N 101 (CUSIP Number) Judy Koh Chief Financial Officer Bay City Capital LLC 750 Battery Street, Suite 400 San Francisco, CA 94111

February 26, 2015 EX-99

Hyperion Therapeutics Announces Fourth Quarter and Full Year 2014 Financial Results

EXHIBIT 99.1 Hyperion Therapeutics Announces Fourth Quarter and Full Year 2014 Financial Results UCD Product Portfolio Generates $113.6 Million for Fiscal Year 2014 and $30.8 Million in Net Sales During the Fourth Quarter of 2014 - Company Generates $31 Million in Operating Cash Flows in 2014 - Company to Host Conference Call Today at 4:30 p.m. ET (1:30 p.m. PT) BRISBANE, Calif., Feb. 26, 2015 (GL

February 26, 2015 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event Reported): February 26, 2015 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commissi

February 17, 2015 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 16, 2015 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation)

February 17, 2015 SC 13G

HPTX / Hyperion Therapeutics Inc / Consonance Capital Management LP - CONSONANCE CAPITAL MANAGEMENT LP Passive Investment

SC 13G 1 hptx21315.htm CONSONANCE CAPITAL MANAGEMENT LP UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 44915N101 (CUSIP Number) December 31, 2014 (Date of Event which Requires Filing o

February 17, 2015 EX-99.1

Hyperion Therapeutics Enters Into Completion of Phase III Clinical Trial, Option and Mutual Release Agreement with Clal Biotechnology Industries and Yeda Research and Development Company

EX-99.1 Exhibit 99.1 Hyperion Therapeutics Enters Into Completion of Phase III Clinical Trial, Option and Mutual Release Agreement with Clal Biotechnology Industries and Yeda Research and Development Company BRISBANE, Calif, Feb 16, 2015 — Hyperion Therapeutics, Inc. (Nasdaq:HPTX) (“Hyperion”) today announced that it has amicably resolved its disputes, and entered into a completion of phase III cl

February 13, 2015 SC 13G/A

HPTX / Hyperion Therapeutics Inc / Highland Management Partners VII, LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 44915N 101 (CUSIP Number) December 31, 2014 Date of Event Which Requires Filing of the Statement Check the appropriate box to designate the rule p

February 12, 2015 SC 13G/A

HPTX / Hyperion Therapeutics Inc / Wellington Management Group LLP - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3 )* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 44915N101 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

February 10, 2015 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 9, 2015 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (

January 21, 2015 S-8

HPTX / Hyperion Therapeutics Inc S-8 - - S-8

S-8 As filed with the Securities and Exchange Commission on January 21, 2015 Registration No.

December 10, 2014 SC 13G/A

HPTX / Hyperion Therapeutics Inc / Wellington Management Group LLP - DISCLOSURE DOCUMENT Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 44915N101 (CUSIP Number) November 28, 2014 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

November 6, 2014 EX-99

Hyperion Therapeutics Announces Third Quarter 2014 Financial Results

EXHIBIT 99.1 Hyperion Therapeutics Announces Third Quarter 2014 Financial Results - UCD Product Portfolio Generates $26.2 Million in Net Sales During the Quarter - - Company Delivers Fifth Consecutive Quarter of Adjusted Net Income - - Company to Host Conference Call Today at 4:05 p.m. ET (1:05 p.m. PT) - BRISBANE, Calif., Nov. 6, 2014 (GLOBE NEWSWIRE) - Hyperion Therapeutics, Inc. (Nasdaq:HPTX) t

November 6, 2014 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event Reported): November 6, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commissio

September 8, 2014 8-K

Financial Statements and Exhibits, Material Impairments, Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 7, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation)

September 8, 2014 EX-99.1

Hyperion Therapeutics Terminates DiaPep277® Program Company Discovers Serious Misconduct by Andromeda Biotech Ltd. Company to Host Conference Call Today at 9:00 a.m. ET (6:00 a.m. PT)

EX-99.1 Exhibit 99.1 CONTACT: Myesha Edwards Corporate Communications and Investor Relations (650) 745-7829 Carolyn Wang WCG (415) 225-5050 Hyperion Therapeutics Terminates DiaPep277® Program Company Discovers Serious Misconduct by Andromeda Biotech Ltd. Company to Host Conference Call Today at 9:00 a.m. ET (6:00 a.m. PT) Brisbane, Calif. – September 8, 2014 – Hyperion Therapeutics, Inc. (NASDAQ:

August 18, 2014 144

HPTX / Hyperion Therapeutics Inc 144 - -

144 1 hyperion144.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933 ATTENTION: Transmit for filing 3 copies of this form concurrently with either placing an order with a broker to execute sale or executing a sale directly with a market maker. 1 (a) NAME OF ISSUER (Please t

August 12, 2014 EX-99

Hyperion Therapeutics Appoints Theodore Schroeder to Board of Directors

EXHIBIT 99.1 Hyperion Therapeutics Appoints Theodore Schroeder to Board of Directors BRISBANE, Calif., Aug. 12, 2014 (GLOBE NEWSWIRE) - Hyperion Therapeutics, Inc. (Nasdaq:HPTX) today announced the appointment of Theodore "Ted" Schroeder to its board of directors effective August 11, 2014. Mr. Schroeder has over two decades of experience in the life sciences industry. Most recently, he was the fou

August 12, 2014 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event Reported): August 12, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commission

August 7, 2014 EX-99

Hyperion Therapeutics Announces Second Quarter 2014 Financial Results

EXHIBIT 99.1 Hyperion Therapeutics Announces Second Quarter 2014 Financial Results UCD Product Portfolio Generates $37.1 Million in Net Sales During the Quarter -$31.6 million of RAVICTI® recognized in the quarter including $11.7 million of previously deferred revenue -Adjusted net income of $21.1 million earned in quarter Company to Host Conference Call Today at 4:30 p.m. ET (1:30 p.m. PT) BRISBA

August 7, 2014 EX-99.2

Hyperion Therapeutics, Inc. Unaudited Pro Forma Condensed Combined Financial Statements

EX-99.2 Exhibit 99.2 Hyperion Therapeutics, Inc. Unaudited Pro Forma Condensed Combined Financial Statements On June 12, 2014, Hyperion Therapeutics, Inc. a Delaware corporation (“Hyperion” or the “Company”), and Hyperion Therapeutics Israel Holding Corp, Ltd., a wholly-owned subsidiary of the Company, completed the purchase of all of the outstanding ordinary shares of Andromeda Biotech Ltd (“Andr

August 7, 2014 EX-99.1

Andromeda Biotech Ltd. (A Development Stage Company) Financial Statements As of December 31, 2013

EX-99.1 3 d767400dex991.htm EX-99.1 Exhibit 99.1 Andromeda Biotech Ltd. (A Development Stage Company) Financial Statements As of December 31, 2013 Andromeda Biotech Ltd. (A Development Stage Company) Financial Statements as at December 31, 2013 Contents Page Independent Auditor’s Report 2-3 Balance Sheets 4 Statements of Operations 5 Statements of Comprehensive Loss 6 Statements of Changes in Shar

August 7, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event Reported): August 7, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commission

August 7, 2014 8-K/A

Financial Statements and Exhibits

8-K/A 1 d767400d8ka.htm FORM 8-K/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdi

July 21, 2014 EX-10.1

LOAN AND SECURITY AGREEMENT

EX-10.1 Exhibit 10.1 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (this “Agreement”) dated as of July 18, 2014 (the “Effective Date”) between SILICON VALLEY BANK, a California corporation (“Bank”), and HYPERION THERAPEUTICS, INC., a Delaware corporation (“Borrower”) provides the terms on which Bank shall lend to Borrower and Borrower shall repay Bank. The parties agree as follows:

July 21, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 18, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commissi

July 8, 2014 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 8, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Comm

June 13, 2014 8-K

Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 12, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Com

June 13, 2014 EX-99.1

Hyperion Therapeutics Completes Acquisition of Andromeda Biotech, Ltd. - Hyperion’s Orphan Drug Pipeline Now Includes DiaPep277®, A First-in-Class Immunotherapy for New Onset Type 1 Diabetes, with Phase 3 Data Expected in the First Quarter of 2015 -

EX-99.1 Exhibit 99.1 CONTACT: Myesha Edwards Corporate Communications and Investor Relations (650) 745-7829 Hyperion Therapeutics Completes Acquisition of Andromeda Biotech, Ltd. - Hyperion’s Orphan Drug Pipeline Now Includes DiaPep277®, A First-in-Class Immunotherapy for New Onset Type 1 Diabetes, with Phase 3 Data Expected in the First Quarter of 2015 - Brisbane, Calif. – June 12, 2014 – Hyperio

June 9, 2014 SC 13D/A

HPTX / Hyperion Therapeutics Inc / SOFINNOVA VENTURE PARTNERS VII L P - SC 13D/A Activist Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 4)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 44915N101 (CUSIP Number) Nathalie Auber Sofinnova

June 6, 2014 8-K

Regulation FD Disclosure - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 4, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Comm

May 28, 2014 8-K

Submission of Matters to a Vote of Security Holders

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 27, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Comm

May 6, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event Reported): May 6, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 6, 2014 EX-99

Hyperion Therapeutics Announces First Quarter 2014 Financial Results

EXHIBIT 99.1 Hyperion Therapeutics Announces First Quarter 2014 Financial Results - Company signs definitive agreement to expand its pipeline - - Company to Host Conference Call Today at 4:30 p.m. ET (1:30 p.m. PT) - BRISBANE, Calif., May 6, 2014 (GLOBE NEWSWIRE) - Hyperion Therapeutics, Inc. (Nasdaq:HPTX) today reported net revenue of $19.5 million for the first quarter of 2014 from the sales of

April 24, 2014 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events - FORM 8-K FILING DOCUMENT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event Reported): April 23, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commission

April 24, 2014 EX-99

Hyperion Therapeutics to Broaden Orphan Disease Pipeline With Acquisition of Andromeda Biotech Ltd.

EXHIBIT 99.1 Hyperion Therapeutics to Broaden Orphan Disease Pipeline With Acquisition of Andromeda Biotech Ltd. -DiaPep277®, a First-in-Class Immune Intervention Therapy in Phase 3 Testing for New Onset Type 1 Diabetes- -Hyperion to Host Analyst/Investor Teleconference Today at 8:45 a.m. EDT (5:45 a.m. PDT)- BRISBANE, Calif., April 24, 2014 (GLOBE NEWSWIRE) - Hyperion Therapeutics (Nasdaq:HPTX) a

April 21, 2014 DEF 14A

- DEF 14A

DEF 14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 18, 2014 8-K

Other Events - FORM 8-K

Prepared by R.R. Donnelley Financial - Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 17, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or O

March 11, 2014 8-K

Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Co

March 7, 2014 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 5, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Com

March 7, 2014 10-K

HPTX FORM 10-K (Annual Report)

Form 10-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2013 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-35614 HYPERION THERAPEUTICS, INC.

March 6, 2014 SC 13D/A

HPTX / Hyperion Therapeutics Inc / SOFINNOVA VENTURE PARTNERS VII L P - SC 13D/A Activist Investment

CUSIP NO. 44915N101 13D Page 1 of 9 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 3)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 44915N101 (CU

February 27, 2014 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K FILING DOCUMENT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event Reported): February 27, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commissi

February 27, 2014 EX-99

Hyperion Therapeutics Announces Fourth Quarter and Full Year 2013 Financial Results

EXHIBIT 99.1 Hyperion Therapeutics Announces Fourth Quarter and Full Year 2013 Financial Results Total 2013 Net Revenue of $42.2 Million; Fourth Quarter Net Sales of $18.6 Million, Including 46 Percent Growth in RAVICTI Sales BRISBANE, Calif., Feb. 27, 2014 (GLOBE NEWSWIRE) - Hyperion Therapeutics, Inc. (Nasdaq:HPTX) today reported net revenue of $18.6 million and $42.2 million for the fourth quar

February 25, 2014 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 21, 2014 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation)

February 14, 2014 SC 13G/A

HPTX / Hyperion Therapeutics Inc / Highland Management Partners VII, LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 44915N 101 (CUSIP Number) December 31, 2013 Date of Event Which Requires Filing of the Statement Check the appropriate box to designate the rule p

February 14, 2014 SC 13G/A

HPTX / Hyperion Therapeutics Inc / Wellington Management Group LLP - DISCLOSURE DOCUMENT Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 44915N101 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

February 14, 2014 SC 13G/A

HPTX / Hyperion Therapeutics Inc / RA Capital Management, LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 44915N101 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule

January 31, 2014 S-8

- FORM S-8

Form S-8 As filed with the Securities and Exchange Commission on January 31, 2014 Registration No.

January 30, 2014 SC 13D/A

HPTX / Hyperion Therapeutics Inc / SOFINNOVA VENTURE PARTNERS VII L P - SC 13D/A Activist Investment

CUSIP NO. 44915N101 13D Page 1 of 11 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 2)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 44915N101 (C

December 24, 2013 SC 13D/A

HPTX / Hyperion Therapeutics Inc / SOFINNOVA VENTURE PARTNERS VII L P - SC 13D/A Activist Investment

CUSIP NO. 44915N101 13D Page 1 of 9 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. 1)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 44915N101 (CU

November 12, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event Reported): November 12, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commissi

November 12, 2013 EX-99

Hyperion Therapeutics Announces Third Quarter 2013 Financial Results

EXHIBIT 99.1 Hyperion Therapeutics Announces Third Quarter 2013 Financial Results UCD Product Portfolio Generates $15.5 Million in Net Sales During the Quarter Including 58 Percent Growth in RAVICTI Sales SOUTH SAN FRANCISCO, Calif., Nov. 12, 2013 (GLOBE NEWSWIRE) - Hyperion Therapeutics, Inc. (Nasdaq:HPTX) today reported net revenue of $15.5 million during the third quarter of 2013 which includes

October 16, 2013 EX-10.1

OFFICE LEASE by and between 2000 SIERRA POINT PARKWAY LLC, a Delaware limited liability company, as Landlord HYPERION THERAPEUTICS, INC., a Delaware corporation as Tenant 2000 Sierra Point Parkway Brisbane, California 94065 October 14, 2013 OFFICE LE

EX-10.1 Exhibit 10.1 OFFICE LEASE by and between 2000 SIERRA POINT PARKWAY LLC, a Delaware limited liability company, as Landlord and HYPERION THERAPEUTICS, INC., a Delaware corporation as Tenant 2000 Sierra Point Parkway Brisbane, California 94065 October 14, 2013 OFFICE LEASE THIS LEASE is entered into as of October 14, 2013 (the “Effective Date”), by and between 2000 SIERRA POINT PARKWAY LLC, a

October 16, 2013 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 14, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (

September 10, 2013 SC 13G

HPTX / Hyperion Therapeutics Inc / WELLINGTON MANAGEMENT GROUP LLP - DISCLOSURE DOCUMENT Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 44915N101 (CUSIP Number) August 31, 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which thi

August 14, 2013 EX-1.1

HYPERION THERAPEUTICS, INC. Up to $50,000,000 of Shares of Common Stock (par value $0.0001 per share) Controlled Equity OfferingSM Sales Agreement

EX-1.1 Exhibit 1.1 EXECUTION VERSION HYPERION THERAPEUTICS, INC. Up to $50,000,000 of Shares of Common Stock (par value $0.0001 per share) Controlled Equity OfferingSM Sales Agreement August 14, 2013 Cantor Fitzgerald & Co. 499 Park Avenue New York, NY 10022 Ladies and Gentlemen: Hyperion Therapeutics, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Can

August 14, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K FILING DOCUMENT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event Reported): August 14, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commission

August 14, 2013 EX-4.7

HYPERION THERAPEUTICS, INC. as Issuer, as Trustee Dated as of , 201 Senior Debt Securities Reconciliation and tie between Trust Indenture Act of 1939 and Indenture, dated as of December 7, 2007 Trust Indenture Act Section Indenture Section § 310(a)(1

EX-4.7 Exhibit 4.7 HYPERION THERAPEUTICS, INC. as Issuer, and , as Trustee INDENTURE Dated as of , 201 Senior Debt Securities Reconciliation and tie between Trust Indenture Act of 1939 and Indenture, dated as of December 7, 2007 Trust Indenture Act Section Indenture Section § 310(a)(1) 6.9 (a)(2) 6.9 (a)(3) Not Applicable (a)(4) Not Applicable (a)(5) 6.9 (b) 6.8, 6.10 § 311(a) 6.13(a) (b) 6.13(b)

August 14, 2013 EX-99

Hyperion Therapeutics Announces Second Quarter 2013 Financial Results

EXHIBIT 99.1 Hyperion Therapeutics Announces Second Quarter 2013 Financial Results Strong Early Launch Progress With Company's First Product, RAVICTI(R); Completed Integration of Acquired Product, BUPHENYL(R) SOUTH SAN FRANCISCO, Calif., Aug. 14, 2013 (GLOBE NEWSWIRE) - Hyperion Therapeutics, Inc. (Nasdaq:HPTX) today reported net revenue of $7.3 million following the first full quarter of sales of

August 14, 2013 EX-12.1

STATEMENT REGARDING COMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES (in thousands, except ratios)

EX-12.1 Exhibit 12.1 STATEMENT REGARDING COMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES (in thousands, except ratios) The following table sets forth our ratio of earnings to fixed charges for the six months ended June 30, 2013, and for the years ended December 31, 2012, 2011, 2010, 2009 and 2008. As the ratios of earnings to fixed charges indicate less than one-to-one coverage in each of the ye

August 14, 2013 S-3

- FORM S-3

Form S-3 Table of Contents As filed with the Securities and Exchange Commission on August 14, 2013 Registration No.

August 12, 2013 EX-99

Hyperion Therapeutics, Inc. and BUPHENYL Product Line Unaudited Pro Forma Condensed Combined Financial Statements

Exhibit 99.2 Hyperion Therapeutics, Inc. and BUPHENYL Product Line Unaudited Pro Forma Condensed Combined Financial Statements On May 31, 2013, Hyperion Therapeutics, Inc. (“Hyperion”) completed its acquisition of BUPHENYL® (sodium phenylbutyrate) Tablets and Powder, an FDA-approved therapy for treatment of the most prevalent urea cycle disorders (“UCD”), from Ucyclyd Pharma, Inc. (“Ucyclyd”), a w

August 12, 2013 EX-99

BUPHENYL® Product Line (a component of Ucyclyd Pharma Inc.) Financial Statements For the Period From December 11, 2012 Through December 31, 2012, the Period From January 1, 2012 Through December 10, 2012, the Year Ended December 31, 2011, the Three M

Exhibit 99.1 FINANCIAL STATEMENTS BUPHENYL® Product Line (a component of Ucyclyd Pharma Inc.) For the Period From December 11, 2012 Through December 31, 2012, the Period From January 1, 2012 Through December 10, 2012, the Year Ended December 31, 2011, the Three Months Ended March 31, 2013 (unaudited), and the Three Months Ended March 31, 2012 (unaudited) With Reports of Independent Auditors BUPHEN

August 12, 2013 8-K/A

Financial Statements and Exhibits - 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commission

July 22, 2013 SC 13D/A

HPTX / Hyperion Therapeutics Inc / BAY CITY CAPITAL LLC - AMENDMENT NO. 1 TO SCHEDULE 13D Activist Investment

SC 13D/A 1 d571323dsc13da.htm AMENDMENT NO. 1 TO SCHEDULE 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 44915N 101 (CUSIP Number) Judy Koh Chief Financial Officer Bay City Capital LLC 750 Battery Street, Sui

June 3, 2013 EX-99.1

HYPERION THERAPEUTICS ACQUIRES WORLDWIDE RIGHTS TO BUPHENYL

EX-99.1 Exhibit 99.1 CONTACT: Sylvia Wheeler Vice President, Investor Relations (650) 745-7834 [email protected] HYPERION THERAPEUTICS ACQUIRES WORLDWIDE RIGHTS TO BUPHENYL SOUTH SAN FRANCISCO, Calif., June 3, 2013 — Hyperion Therapeutics, Inc. (NasdaqGM: HPTX) today announced the completion of its acquisition of BUPHENYL® (sodium phenylbutyrate) Tablets and Powder, an FDA-approved the

June 3, 2013 8-K

Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets, Submission of Matters to a Vote of Security Holders - 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commissio

May 17, 2013 8-K

Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 17, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Comm

May 16, 2013 EX-99.1

Hyperion Therapeutics Added to Nasdaq Biotechnology Index (NBI)

EX-99.1 Exhibit 99.1 Contact: Jeffrey Farrow CFO Hyperion Therapeutics (650) 745-7816 Hyperion Therapeutics Added to Nasdaq Biotechnology Index (NBI) SOUTH SAN FRANCISCO, Calif., May16, 2013 — Hyperion Therapeutics, Inc. (NasdaqGM: HPTX) today announced that it has been selected for addition to the Nasdaq Biotechnology Index® (Nasdaq:NBI). The semi-annual re-ranking of the NASDAQ Biotechnology Ind

May 16, 2013 8-K

Financial Statements and Exhibits, Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Comm

May 9, 2013 EX-99.1

Hyperion Therapeutics Announces First Quarter 2013 Operating Results First Net Sales of RAVICTI Post-approval Reported at $0.8 Million Strong Cash Position of $102.7 million

EX-99.1 Exhibit 99.1 CONTACTS: Jeffrey Farrow, CFO Kristie Kuhl, Media Relations (650) 745-7816 (203) 556-7417 [email protected] [email protected] Hyperion Therapeutics Announces First Quarter 2013 Operating Results First Net Sales of RAVICTI Post-approval Reported at $0.8 Million Strong Cash Position of $102.7 million South San Francisco, CA – May 9, 2013 – Hyperion Therapeutics, Inc. (

May 9, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commi

April 30, 2013 8-K

Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 29, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Co

April 23, 2013 S-8

- FORM S-8

Form S-8 As filed with the Securities and Exchange Commission on April 23, 2013 Registration No.

April 22, 2013 DEF 14A

- DEFINITIVE PROXY STATEMENT

Definitive Proxy Statement Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 11, 2013 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 8, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Com

March 8, 2013 424B4

2,875,000 Shares Common Stock

Prospectus Supplement Filed Pursuant to Rule 424(b)(4) Table of Contents Filed Pursuant to Rule 424(b)(4) Registration No.

March 7, 2013 S-1MEF

- S-1MEF

S-1MEF As filed with the Securities and Exchange Commission on March 7, 2013 Registration Statement File No.

March 5, 2013 CORRESP

-

Acceleration Request by the Underwriters March 5, 2013 VIA EDGAR AND FACSIMILE United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

March 5, 2013 EX-1.1

HYPERION THERAPEUTICS, INC. (a Delaware corporation) [ ] Shares of Common Stock UNDERWRITING AGREEMENT

EX-1.1 Exhibit 1.1 HYPERION THERAPEUTICS, INC. (a Delaware corporation) [ ] Shares of Common Stock UNDERWRITING AGREEMENT Dated: [ ], 2013 Hyperion Therapeutics, Inc. (a Delaware corporation) [ ] Shares of Common Stock ($0.0001 Par Value Per Share) UNDERWRITING AGREEMENT [ ], 2013 Leerink Swann LLC Cowen and Company, LLC As Representatives of the Several Underwriters c/o Leerink Swann LLC One Fede

March 5, 2013 CORRESP

-

Acceleration Request by the Company HYPERION THERAPEUTICS, INC. 601 Gateway Boulevard, Suite 200 South San Francisco, CA 94080 March 5, 2013 VIA EDGAR Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Attn: Jeffrey Riedler Re: Hyperion Therapeutics, Inc. Registration Statement on Form S-1 (File No. 333-186880) Request for Acceleration of Effective Date Dear Mr. Riedler:

March 5, 2013 S-1/A

- AMENDMENT NO. 1 TO FORM S-1

Amendment No. 1 to Form S-1 Table of Contents As filed with the Securities and Exchange Commission on March 5, 2013 Registration Statement File No. 333-186880 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to Form S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HYPERION THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) De

March 4, 2013 SC 13G

HPTX / Hyperion Therapeutics Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13G Passive Investment

SC 13G 1 v336979sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.)* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 44915N101 (CUSIP Number) February 28, 2013 (Date of Event Which Requires Filing of this Statement) Check the approp

February 26, 2013 S-1

Registration Statement - FORM S-1

Form S-1 Table of Contents As filed with the Securities and Exchange Commission on February 26, 2013 Registration Statement File No.

February 25, 2013 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 25, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commissi

February 25, 2013 EX-99.1

Hyperion Therapeutics Announces Fourth Quarter and Full Year 2012 Operating Results

EX-99.1 Exhibit 99.1 Contact: Shari Annes, Investor Relations 650-888-0902 [email protected] Hyperion Therapeutics Announces Fourth Quarter and Full Year 2012 Operating Results South San Francisco, CA – February 25, 2013 – Hyperion Therapeutics, Inc. (Nasdaq GM: HPTX) today reported financial operating results for the fourth quarter and the year ended December 31, 2012. According to Chief

February 25, 2013 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 19, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation)

February 20, 2013 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 14, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commissi

February 20, 2013 EX-10.1

DISTRIBUTION SERVICES AGREEMENT

EX-10.1 Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24(B)(2) OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. DISTRIBUTION SERVICES AGREEMENT This Distribution Services Agreement (this “Agreement”) dated as of February 14, 2013 (the “Effective Date

February 1, 2013 8-K

Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 1, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (

February 1, 2013 EX-99.2

RISK FACTORS

Risk Factors Exhibit 99.2 RISK FACTORS An investment in our common stock involves a high degree of risk. We operate in a dynamic and rapidly changing industry that involves numerous risks and uncertainties. The risks and uncertainties described below are not the only ones we face. Other risks and uncertainties, including those that we do not currently consider material, may impair our business. If

February 1, 2013 EX-99.1

Hyperion Therapeutics’ RAVICTI™ (glycerol phenylbutyrate) Liquid Receives FDA Approval for Treatment of Urea Cycle Disorders

Press Release Exhibit 99.1 CONTACTS: Myesha Edwards, Investor Relations (650) 745-7829 [email protected] Kristie Kuhl, Media Relations (203) 556-7417 [email protected] Hyperion Therapeutics’ RAVICTI™ (glycerol phenylbutyrate) Liquid Receives FDA Approval for Treatment of Urea Cycle Disorders • Anticipated market launch by end of April 2013 • Patent allowance extends coverage to 2032 S

January 22, 2013 8-K

Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 22, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (

January 16, 2013 EX-99.1

Hyperion Notified that FDA Will Not Meet the PDUFA Action Date for Ravicti™

Press Release Exhibit 99.1 Hyperion Notified that FDA Will Not Meet the PDUFA Action Date for Ravicti™ South San Francisco, CA – January 16, 2013 – Hyperion Therapeutics, Inc. (Nasdaq GM:HPTX) said that the U.S. Food and Drug Administration (FDA) has advised the Company not to expect a final action by the Prescription Drug User Fee Act (PDUFA) action date of January 23, 2013. The agency explained

January 16, 2013 8-K

Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 15, 2013 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (

December 4, 2012 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 30, 2012 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation)

December 4, 2012 EX-10.1

601 GATEWAY BOULEVARD SECOND AMENDMENT TO OFFICE LEASE

Second Amendment to Office Lease by and between the Company and Gateway Center Exhibit 10.

November 8, 2012 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 d434876d8k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2012 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdictio

November 8, 2012 EX-99.1

Hyperion Therapeutics Announces Third Quarter 2012 Operating Results

Press Release Exhibit 99.1 Hyperion Therapeutics Announces Third Quarter 2012 Operating Results South San Francisco, CA – November 7, 2012 – Hyperion Therapeutics, Inc. (NasdaqGM: HPTX) today reported consolidated financial results for the third quarter of 2012. According to Chief Executive Officer, Donald J. Santel, “The past several months have been an exciting time for Hyperion. As we move clos

October 18, 2012 S-8

- FORM S-8

Form S-8 As filed with the Securities and Exchange Commission on October 18, 2012 Registration No.

September 28, 2012 8-K

Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2012 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation)

September 6, 2012 8-K

Financial Statements and Exhibits, Other Events - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 5, 2012 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation)

September 6, 2012 EX-99.1

Hyperion Therapeutics Announces Second Quarter 2012 Operating Results

Press Release Exhibit 99.1 Hyperion Therapeutics Announces Second Quarter 2012 Operating Results South San Francisco, CA – September 6, 2012 – Hyperion Therapeutics, Inc. (NasdaqGM: HPTX) today reported consolidated financial results for the second quarter of 2012. The company reported cash and cash equivalents of $7.3 million as of June 30, 2012. Subsequent to the end of the quarter, on July 31,

September 6, 2012 EX-99.1

Hyperion Therapeutics Announces Extension of Action Date for Ravicti™ NDA to January 23, 2013

EX-99.1 2 d407379dex991.htm PRESS RELEASE Exhibit 99.1 Hyperion Therapeutics Announces Extension of Action Date for Ravicti™ NDA to January 23, 2013 — Extension to enable FDA to review additional solicited analyses of existing clinical information provided by the company — South San Francisco, CA –Sept 5, 2012— Hyperion Therapeutics, Inc. (NasdaqGM:HPTX) announced today that it has received a comm

September 6, 2012 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 6, 2012 HYPERION THERAPEUTICS, INC. (Exact Name of Registrant as Specified in Charter) Delaware 001-35614 61-1512713 (State or Other Jurisdiction of Incorporation) (Commissi

August 28, 2012 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 23, 2012 HYPERION THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35614 61-1512713 (state or other jurisdiction of incorporation

August 10, 2012 SC 13G

HPTX / Hyperion Therapeutics Inc / Highland Management Partners VII, LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) Information Statement Pursuant to Rules 13d-1 and 13d-2 Under the Securities Exchange Act of 1934 (Amendment No. )* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 44915N 101 (CUSIP Number) July 31, 2012 Date of Event Which Requires Filing

August 7, 2012 SC 13D

HPTX / Hyperion Therapeutics Inc / New Enterprise Associates 12, Limited Partnership - HYPERION THERAPEUTICS Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, $.0001 par value (Title of Class of Securities) 44915N101 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600 Timonium, MD 21093 (410) 842-4000 (Name,

August 6, 2012 SC 13D

HPTX / Hyperion Therapeutics Inc / SOFINNOVA VENTURE PARTNERS VII L P - FORM SC 13D Activist Investment

CUSIP NO. 44915N101 13D Page 1 of 14 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) (Amendment No. )* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 44915N101 (CU

August 2, 2012 SC 13D

HPTX / Hyperion Therapeutics Inc / BAY CITY CAPITAL LLC - SCHEDULE 13D Activist Investment

SC 13D 1 d390939dsc13d.htm SCHEDULE 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Hyperion Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 44915N 101 (CUSIP Number) Judy Koh Chief Financial Officer Bay City Capital LLC 750 Battery Street, Suite 400 San Francisco, C

August 2, 2012 EX-99.7.1

JOINT FILING AGREEMENT

EX-99.7.1 2 d390939dex9971.htm JOINT FILING AGREEMENT Exhibit 7.1 JOINT FILING AGREEMENT Each of Bay City Capital LLC, Bay City Capital Management V LLC, Bay City Capital Fund V, L.P. and Bay City Capital Fund V Co-Investment Fund, L.P. hereby express its agreement that the attached Schedule 13D (and any amendments thereto) relating to the common stock of Hyperion Therapeutics, Inc. is filed on be

July 31, 2012 EX-3.1

HYPERION THERAPEUTICS, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

Amended and Restated Certificate of Incorporation Exhibit 3.1 HYPERION THERAPEUTICS, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION Hyperion Therapeutics, Inc., a Delaware Corporation, (the “Corporation”) hereby certifies as follows. 1. The name of the Corporation is Hyperion Therapeutics, Inc. The Certificate of Incorporation was originally filed with the Secretary of State on November 1,

July 31, 2012 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2012 HYPERION THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35614 61-1512713 (state or other jurisdiction of incorporation)

July 27, 2012 424B4

5,000,000 Shares Common Stock

424B4 1 d178027d424b4.htm PROSPECTUS FILED PURSUANT TO RULE 424(B)(4) Table of Contents Filed Pursuant to Rule 424(b)(4) Registration Nos. 333-180694 and 333-182850 PROSPECTUS 5,000,000 Shares Common Stock Hyperion Therapeutics, Inc. is offering 5,000,000 shares of common stock. This is our initial public offering, and no public market currently exists for our common stock. The initial public offe

July 25, 2012 S-1MEF

- FILED PURSUANT TO RULE 462(B)

Filed Pursuant to Rule 462(b) As filed with the Securities and Exchange Commission on July 25, 2012 Registration Statement File No.

July 25, 2012 8-A12B

- FORM 8-A12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 HYPERION THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 61-1512713 (State of Incorporation or Organization) (I.R.S. Employer Identification No.) 601 Gateway Bo

July 24, 2012 CORRESP

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Acceleration Request HYPERION THERAPEUTICS, INC. 601 Gateway Boulevard, Suite 200 South San Francisco, CA 94080 July 24, 2012 VIA EDGAR AND FACSIMILE Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Attn: Jeffrey Riedler Re: Hyperion Therapeutics, Inc. Registration Statement on Form S-1 (File No. 333-180694) Request for Acceleration of Effective Date Dear Mr. Riedler: P

July 24, 2012 CORRESP

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Acceleration Request July 24, 2012 VIA EDGAR AND FACSIMILE United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

July 13, 2012 EX-4.2

AMENDED AND RESTATED WARRANT TO PURCHASE STOCK Corporation: HYPERION THERAPEUTICS, INC., a Delaware corporation Number of Shares: 1,671 Class of Securities: Common Stock Initial Exercise Price: $314.13 per share Original Issue Date: October 2, 2007 D

Amended and Restated Warrant issued pursuant to the Loan and Security Agreement Exhibit 4.

July 13, 2012 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION HYPERION THERAPEUTICS, INC.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF HYPERION THERAPEUTICS, INC. Hyperion Therapeutics, Inc., a corporation organized and existing under and by virtue of the Delaware General Corporation Law, hereby certifies as follows: 1. The name of this corporation is Hyperion Therapeutics, Inc. and the date of filing of the original Certificate of Incorporation of this corporation

July 13, 2012 S-1/A

- AMENDMENT NO. 4 TO FORM S-1

Amendment No. 4 to Form S-1 Table of Contents As filed with the Securities and Exchange Commission on July 13, 2012 Registration Statement File No. 333-180694 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 4 to Form S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HYPERION THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) De

July 12, 2012 CORRESP

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SEC Correspondence Hogan Lovells US LLP Columbia Square 555 Thirteenth Street, NW Washington, DC 20004 T +1 202 637 5600 F +1 202 637 5910 www.

July 11, 2012 CORRESP

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SEC Correspondence Hogan Lovells US LLP Columbia Square 555 Thirteenth Street, NW Washington, DC 20004 T +1 202 637 5600 F +1 202 637 5910 www.

July 10, 2012 CORRESP

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Correspondence with the SEC Hogan Lovells US LLP Columbia Square 555 Thirteenth Street, NW Washington, DC 20004 T +1 202 637 5600 F +1 202 637 5910 www.

July 10, 2012 CORRESP

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Correspondence with the SEC Hogan Lovells US LLP Columbia Square 555 Thirteenth Street, NW Washington, DC 20004 T +1 202 637 5600 F +1 202 637 5910 www.

July 9, 2012 CORRESP

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Correspondence with the SEC Hogan Lovells US LLP Columbia Square 555 Thirteenth Street, NW Washington, DC 20004 T +1 202 637 5600 F +1 202 637 5910 www.

July 5, 2012 EX-4.1

Additional abbreviations may also be used though not in the above list. For Value Received, hereby sell, assign and transfer unto PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE (PLEASE PRINT OR TYPE NAME AND ADDRESS, INCLUDING

Specimen Common Stock Certificate of the Company Exhibit 4.1 The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according to applicable laws or regulations: TEN COM - as tenants in common UNIF GIFT MIN ACT - ................. Custodian ................. TEN ENT - as tenants by the entireties (Cust) (

July 5, 2012 CORRESP

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Response Letter to the SEC Hogan Lovells US LLP 525 University Avenue 4th Floor Palo Alto, CA 94301 T +1 650 463 4000 F +1 650 463 4199 www.

July 5, 2012 S-1/A

- AMENDMENT NO. 3 TO FORM S-1

Amendment No. 3 to Form S-1 Table of Contents As filed with the Securities and Exchange Commission on July 5, 2012 Registration Statement File No. 333-180694 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 3 to Form S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HYPERION THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Del

July 3, 2012 CORRESP

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Hogan Lovells US LLP Columbia Square 555 Thirteenth Street, NW Washington, DC 20004 T +1 202 637 5600 F +1 202 637 5910 www.

June 18, 2012 S-1/A

- AMENDMENT NO. 2 TO FORM S-1

Amendment No. 2 to Form S-1 Table of Contents As filed with the Securities and Exchange Commission on June 18, 2012 Registration Statement File No. 333-180694 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 2 to Form S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HYPERION THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) De

June 18, 2012 CORRESP

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Response Letter to the SEC Hogan Lovells US LLP Columbia Square 555 Thirteenth Street, NW Washington, DC 20004 T +1 202 637 5600 F +1 202 637 5910 www.

June 18, 2012 EX-1.1

HYPERION THERAPEUTICS, INC. (a Delaware corporation) [ ] Shares of Common Stock UNDERWRITING AGREEMENT

Underwriting Agreement Exhibit 1.1 HYPERION THERAPEUTICS, INC. (a Delaware corporation) [ ] Shares of Common Stock UNDERWRITING AGREEMENT Dated: , 2012 Hyperion Therapeutics, Inc. (a Delaware corporation) [ ] Shares of Common Stock ($0.0001 Par Value Per Share) UNDERWRITING AGREEMENT , 2012 Leerink Swann LLC Cowen and Company, LLC As Representatives of the Several Underwriters c/o Leerink Swann LL

May 24, 2012 EX-10.17

HYPERION THERAPEUTICS, INC. 2012 OMNIBUS INCENTIVE PLAN NON-QUALIFIED OPTION AGREEMENT

Form of Nonstatutory Option Agreement Exhibit 10.17 HYPERION THERAPEUTICS, INC. 2012 OMNIBUS INCENTIVE PLAN NON-QUALIFIED OPTION AGREEMENT Hyperion Therapeutics, Inc., a Delaware corporation (the “Company”), hereby grants an option to purchase shares of its common stock, par value $ per share (the “Option”), to the optionee named below, subject to the vesting and other conditions set forth below.

May 24, 2012 EX-4.9

FORM OF WARRANT TO PURCHASE STOCK

Exhibit 4.9 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR IN FORM AND SUBSTANCE SATISFACTORY TO THE COMPANY, S

May 24, 2012 EX-10.3

HYPERION THERAPEUTICS, INC. RESTATED OMNIBUS AMENDMENT TO CONVERTIBLE NOTE AND WARRANT PURCHASE AGREEMENT DATED APRIL 1, 2011, CONVERTIBLE UNSECURED PROMISSORY NOTES DATED APRIL 1, 2011, MAY 2, 2011, MAY 4, 2011 AND MAY 10, 2011 WARRANTS TO PURCHASE

Restated Omnibus Amendment to Convertible Note and Warrant Purchase Agreement Exhibit 10.

May 24, 2012 EX-10.15

HYPERION THERAPEUTICS, INC. 2012 OMNIBUS INCENTIVE PLAN TABLE OF CONTENTS

2012 Omnibus Incentive Plan Exhibit 10.15 HYPERION THERAPEUTICS, INC. 2012 OMNIBUS INCENTIVE PLAN TABLE OF CONTENTS Page 1. PURPOSE 1 2. DEFINITIONS 1 3. ADMINISTRATION OF THE PLAN 7 3.1. Board 7 . 3.2 Committee 8 3.3. Terms of Awards 8 3.4. Forfeiture; Recoupment 9 3.5. Repricing 10 3.6. Deferral Arrangement 10 3.7. No Liability 10 3.8. Stock Issuance/Book-Entry 10 4. STOCK SUBJECT TO THE PLAN 11

May 24, 2012 S-1/A

- AMENDMENT #1 TO FORM S-1

Amendment #1 to Form S-1 Table of Contents As filed with the Securities and Exchange Commission on May 24, 2012 Registration Statement File No.

May 24, 2012 EX-10.23

AGREEMENT

Agreement by and between Dr. Marshall L. Summar and Medicis Exhibit 10.23 *** INDICATES MATERIAL THAT WAS OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT WAS REQUESTED. ALL SUCH OMITTED MATERIAL WAS FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. AGREEMENT This Agreement (the “Agreement”) is entered into by an

May 24, 2012 CORRESP

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Hogan Lovells US LLP Columbia Square 555 Thirteenth Street, NW Washington, DC 20004 T +1 202 637 5600 F +1 202 637 5910 www.

May 24, 2012 EX-10.24

LOAN AND SECURITY AGREEMENT

Exhibit 10.24 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (this “Agreement”) dated as of April 19, 2012 (the “Effective Date”) between SILICON VALLEY BANK (“Bank”), as collateral agent and Administrative Agent (in such capacity referred to herein as “Agent” or “Collateral Agent”), and the Lenders listed on Schedule 1.1 hereof and party hereto (each, a “Lender” and collectively, th

May 24, 2012 EX-4.8

FORM OF SECURED PROMISSORY NOTE $5,000,000 Dated: April 19, 2012

Form of Secured Promissory Note Exhibit 4.8 FORM OF SECURED PROMISSORY NOTE $5,000,000 Dated: April 19, 2012 FOR VALUE RECEIVED, the undersigned, HYPERION THERAPEUTICS, INC., a Delaware corporation (“Borrower”), HEREBY PROMISES TO PAY to (“Lender”) the principal amount of Five Million Dollars ($5,000,000) or such lesser amount as shall equal the outstanding principal balance of the Term Loan made

May 24, 2012 EX-3.4

HYPERION THERAPEUTICS, INC. a Delaware Corporation AMENDED AND RESTATED BYLAWS As Adopted April 6, 2012 HYPERION THERAPEUTICS, INC. a Delaware Corporation AMENDED AND RESTATED BYLAWS TABLE OF CONTENTS Page ARTICLE I – OFFICES 1 Section 1.1. Registere

Amended and Restated Bylaws of the Company Exhibit 3.4 HYPERION THERAPEUTICS, INC. a Delaware Corporation AMENDED AND RESTATED BYLAWS As Adopted April 6, 2012 HYPERION THERAPEUTICS, INC. a Delaware Corporation AMENDED AND RESTATED BYLAWS TABLE OF CONTENTS Page ARTICLE I – OFFICES 1 Section 1.1. Registered Office 1 Section 1.2. Other Offices 1 ARTICLE II - STOCKHOLDERS 1 Section 2.1. Place of Meeti

May 24, 2012 EX-10.21

LICENSE AGREEMENT

License Agreement Exhibit 10.21 *** INDICATES MATERIAL THAT WAS OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT WAS REQUESTED. ALL SUCH OMITTED MATERIAL WAS FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. EXECUTION COPY LICENSE AGREEMENT THIS LICENSE AGREEMENT (the “Agreement”) is made and entered into as of A

May 24, 2012 EX-10.20

AMENDED AND RESTATED COLLABORATION AGREEMENT by and between UCYCLYD PHARMA, INC. HYPERION THERAPEUTICS, INC. March 22, 2012 TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS 1 ARTICLE 2 AMENDMENT AND RESTATEMENT; PRE-CLOSING PERIOD 9 ARTICLE 3 RIGHTS TO P

Amended and Restated Collaboration Agreement Exhibit 10.20 *** INDICATES MATERIAL THAT WAS OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT WAS REQUESTED. ALL SUCH OMITTED MATERIAL WAS FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. EXECUTION COPY AMENDED AND RESTATED COLLABORATION AGREEMENT by and between UCYC

May 24, 2012 EX-3.2

HYPERION THERAPEUTICS, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

Amended and Restated Certificate of Incorporation of the Company Exhibit 3.2 HYPERION THERAPEUTICS, INC. AMENDED AND RESTATED CERTIFICATE OF INCORPORATION Hyperion Therapeutics, Inc., a Delaware Corporation, (the “Corporation”) hereby certifies as follows. 1. The name of the Corporation is Hyperion Therapeutics, Inc. The Certificate of Incorporation was originally filed with the Secretary of State

May 24, 2012 EX-2.1

Asset Purchase Agreement, dated March 22, 2012, by and between Hyperion Therapeutics, Inc. and Bausch Health Companies Inc. (formerly Ucyclyd Pharma, Inc.) (incorporated by reference to Exhibit 2.1 to Hyperion Therapeutics, Inc.’s Amendment No. 1 to the Registration Statement on Form S-1, filed on May 24, 2012).

Exhibit 2.1 *** INDICATES MATERIAL THAT WAS OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT WAS REQUESTED. ALL SUCH OMITTED MATERIAL WAS FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. EXECUTION COPY ASSET PURCHASE AGREEMENT between UCYCLYD PHARMA, INC., and HYPERION THERAPEUTICS, INC. dated as of March 22, 20

May 24, 2012 EX-10.22

Settlement Agreement and First Amendment to License Agreement, dated August 21, 2007, by and among Saul Brusilow, M.D., Brusilow Enterprises, Inc., Medicis Pharmaceutical Corporation and Bausch Health Companies Inc. (formerly Ucyclyd Pharma, Inc.) (incorporated by reference to Exhibit 10.22 to Hyperion Therapeutics, Inc.’s Amendment No. 1 to the Registration Statement on Form S-1, filed on May 24, 2012).

Exhibit 10.22 *** INDICATES MATERIAL THAT WAS OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT WAS REQUESTED. ALL SUCH OMITTED MATERIAL WAS FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. EXECUTION COPY SETTLEMENT AGREEMENT AND FIRST AMENDMENT TO LICENSE AGREEMENT This Settlement Agreement and First Amendment t

May 24, 2012 EX-10.16

HYPERION THERAPEUTICS, INC. 2012 OMNIBUS INCENTIVE PLAN INCENTIVE STOCK OPTION AGREEMENT

Form of Incentive Stock Option Agreement Exhibit 10.16 HYPERION THERAPEUTICS, INC. 2012 OMNIBUS INCENTIVE PLAN INCENTIVE STOCK OPTION AGREEMENT Hyperion Therapeutics, Inc., a Delaware corporation (the “Company”), hereby grants an option to purchase shares of its common stock, par value $ per share (the “Option”), to the optionee named below, subject to the vesting and other conditions set forth be

April 13, 2012 EX-10.11

HYPERION THERAPEUTICS, INC. EXECUTIVE CHANGE OF CONTROL AND SEVERANCE AGREEMENT

Form of Executive Change of Control and Severance Agreement Exhibit 10.11 HYPERION THERAPEUTICS, INC. EXECUTIVE CHANGE OF CONTROL AND SEVERANCE AGREEMENT This Change of Control and Severance Agreement (the “Agreement”) is made and entered into by and between (the “Executive”) and Hyperion Therapeutics, Inc. (the “Company”), effective as of the latest date set forth by the signatures of the parties

April 13, 2012 EX-10.4

HYPERION THERAPEUTICS, INC. CONVERTIBLE NOTE AND WARRANT PURCHASE AGREEMENT

The October 2011 Purchase Agreement Exhibit 10.4 HYPERION THERAPEUTICS, INC. CONVERTIBLE NOTE AND WARRANT PURCHASE AGREEMENT This Convertible Note and Warrant Purchase Agreement (this “Agreement”) is made as of October 26, 2011 (the “Effective Date”) by and between Hyperion Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the purchasers listed on Exhibit A attached to this A

April 13, 2012 EX-10.12

HYPERION THERAPEUTICS, INC. 2006 EQUITY INCENTIVE PLAN ADOPTED BY BOARD ON: DECEMBER 20, 2006 APPROVED BY STOCKHOLDERS: DECEMBER 20, 2006 TERMINATION DATE: DECEMBER 19, 2016 (AS AMENDED ON JUNE 25, 2009 AND JUNE 30, 2010)

2006 Equity Incentive Plan, as amended Exhibit 10.12 HYPERION THERAPEUTICS, INC. 2006 EQUITY INCENTIVE PLAN ADOPTED BY BOARD ON: DECEMBER 20, 2006 APPROVED BY STOCKHOLDERS: DECEMBER 20, 2006 TERMINATION DATE: DECEMBER 19, 2016 (AS AMENDED ON JUNE 25, 2009 AND JUNE 30, 2010) 1. GENERAL. (a) Eligible Stock Award Recipients. The persons eligible to receive Stock Awards are Employees, Directors and Co

April 13, 2012 EX-10.5

FORM OF INDEMNIFICATION AGREEMENT

Form of Indemnification Agreement Exhibit 10.5 FORM OF INDEMNIFICATION AGREEMENT THIS AGREEMENT (the “Agreement”) is made and entered into as of , 2012 between Hyperion Therapeutics, Inc., a Delaware corporation (the “Company”), and (“Indemnitee”). This Agreement will become effective only upon the effectiveness of the Company’s registration statement on Form S-1 in connection with the Company’s i

April 13, 2012 EX-4.4

WARRANT TO PURCHASE SHARES OF COMMON STOCK

Form of Warrant to Purchase Common Stock Exhibit 4.4 WARRANT TO PURCHASE SHARES OF COMMON STOCK THIS WARRANT AND THE SECURITIES ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT

April 13, 2012 EX-4.7

CONVERTIBLE UNSECURED PROMISSORY NOTE $«Principal_Dollar_Amount» October [ ], 2011 South San Francisco, California

Form of Convertible Unsecured Promissory Note Exhibit 4.7 THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE SECURITIES LAWS AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT OR QUA

April 13, 2012 EX-10.13

HYPERION THERAPEUTICS, INC. 2006 EQUITY INCENTIVE PLAN AMENDMENT April 15, 2011

Exhibit 10.13 HYPERION THERAPEUTICS, INC. 2006 EQUITY INCENTIVE PLAN AMENDMENT April 15, 2011 The 2006 Equity Incentive Plan (the “Plan”), adopted as of December 20, 2006, of Hyperion Therapeutics, Inc., a Delaware corporation (the “Company”), is hereby amended pursuant to Section 2(b)(vi) thereof to increase the number of shares of Common Stock that may be issued thereunder. 1. DEFINITIONS Capita

April 13, 2012 EX-10.6

HYPERION THERAPEUTICS, INC. Executive Employment Agreement

Employment Agreement - Donald J. Santel Exhibit 10.6 HYPERION THERAPEUTICS, INC. Executive Employment Agreement This employment agreement (“Agreement”) dated and effective as of April 9, 2012 (the “Effective Date”) is between Hyperion Therapeutics, Inc., a Delaware corporation (the “Company”) and Donald J. Santel, a resident of San Francisco, California (“Executive”). WHEREAS, Executive began his

April 13, 2012 EX-10.8

* * * * *

Offer Letter Agreement - Bruce F. Scharschmidt, M.D. Exhibit 10.8 March 14, 2008 Bruce F. Scharschmidt, M.D. [Address] Dear Bruce: Hyperion Therapeutics, Inc. (the “Company”) is pleased to extend an offer to join the Company as a full-time employee. Your offer shall be on the following terms: 1. Position. Upon approval by the Board of Directors, you will be appointed Senior Vice President, Chief M

April 13, 2012 EX-10.9

* * * * *

Offer Letter Agreement - Klara A. Dickinson Exhibit 10.9 September 7, 2007 Klara A. Dickinson [Address] Dear Klara: Hyperion Therapeutics, Inc. (the “Company”) is pleased to an offer to join the Company as a full-time employee. This letter amends and restates in its entirety the previous conditional offer letter (“Conditional Offer Letter”). Your offer shall be on the following terms: 1. Position.

April 13, 2012 EX-4.5

WARRANT TO PURCHASE SHARES OF PREFERRED STOCK THIS WARRANT AND THE SECURITIES ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED OR OT

Form of Warrant to Purchase Preferred Stock Exhibit 4.5 WARRANT TO PURCHASE SHARES OF PREFERRED STOCK THIS WARRANT AND THE SECURITIES ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIE

April 13, 2012 EX-10.10

* * * * *

Offer Letter Agreement - Christine A. Nash Exhibit 10.10 September 7, 2007 Christine Nash [Address] Dear Christine: Hyperion Therapeutics, Inc. (the “Company”) is pleased to an offer to join the Company as a full-time employee. This letter amends and restates in its entirety the previous conditional offer letter (“Conditional Offer Letter”). Your offer shall be on the following terms: 1. Position.

April 13, 2012 S-1

Registration Statement - FORM S-1

Form S-1 Table of Contents As filed with the Securities and Exchange Commission on April 13, 2012 Registration Statement File No.

April 13, 2012 EX-10.1

HYPERION THERAPEUTICS, INC. SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT HYPERION THERAPEUTICS, INC. SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

Second Amended and Restated Investor Rights Agreement Exhibit 10.1 HYPERION THERAPEUTICS, INC. SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT HYPERION THERAPEUTICS, INC. SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT THIS SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the “Agreement”) is entered into as of the 29th day of June, 2009, by and among Hyperion Therapeutics, Inc.,

April 13, 2012 EX-10.18

OFFICE LEASE 601 GATEWAY BOULEVARD GATEWAY CENTER, LLC, a Delaware limited liability company, as Landlord, HYPERION THERAPEUTICS, INC. a Delaware corporation, as Tenant. TABLE OF CONTENTS Page ARTICLE 1 PREMISES, BUILDING, PROJECT, AND COMMON AREAS 4

Office Lease Exhibit 10.18 OFFICE LEASE 601 GATEWAY BOULEVARD GATEWAY CENTER, LLC, a Delaware limited liability company, as Landlord, and HYPERION THERAPEUTICS, INC. a Delaware corporation, as Tenant. TABLE OF CONTENTS Page ARTICLE 1 PREMISES, BUILDING, PROJECT, AND COMMON AREAS 4 ARTICLE 2 LEASE TERM 6 ARTICLE 3 BASE RENT 10 ARTICLE 4 ADDITIONAL RENT 10 ARTICLE 5 USE OF PREMISES 18 ARTICLE 6 SERV

April 13, 2012 EX-10.7

Page 1 of 4

Offer Letter Agreement - Jeffrey Farrow Exhibit 10.7 November 12, 2009 Jeffrey Farrow [Address] Dear Jeff: Hyperion Therapeutics, Inc. (the “Company”) is pleased to extend an offer to join the Company as a full-time employee based on the following terms: 1. Position. The Company proposes to offer you the position of Vice President, Finance reporting to the Chief Executive Officer. By signing this

April 13, 2012 EX-10.19

601 GATEWAY BOULEVARD FIRST AMENDMENT TO OFFICE LEASE

First Amendment to Office Lease Exhibit 10.19 601 GATEWAY BOULEVARD FIRST AMENDMENT TO OFFICE LEASE This FIRST AMENDMENT TO OFFICE LEASE (this “First Amendment”) is made and entered into as of October 31, 2011 by and between GATEWAY CENTER, LLC, a Delaware limited liability company (“Landlord”), and HYPERION THERAPEUTICS, INC., a Delaware corporation (“Tenant”). RECITALS A. Landlord and Tenant ent

April 13, 2012 EX-3.3

AMENDED AND RESTATED BYLAWS HYPERION THERAPEUTICS, INC. (A DELAWARE CORPORATION) TABLE OF CONTENTS PAGE ARTICLE I OFFICES 1 Section 1. Registered Office 1 Section 2. Other Offices 1 ARTICLE II CORPORATE SEAL 1 Section 3. Corporate Seal 1 ARTICLE III

Amended and Restated Bylaws of the Company Exhibit 3.3 AMENDED AND RESTATED BYLAWS OF HYPERION THERAPEUTICS, INC. (A DELAWARE CORPORATION) TABLE OF CONTENTS PAGE ARTICLE I OFFICES 1 Section 1. Registered Office 1 Section 2. Other Offices 1 ARTICLE II CORPORATE SEAL 1 Section 3. Corporate Seal 1 ARTICLE III STOCKHOLDERS’ MEETINGS 1 Section 4. Place of Meetings 1 Section 5. Annual Meeting 1 Section

April 13, 2012 EX-4.6

Form of Convertible Unsecured Promissory Note

Form of Convertible Unsecured Promissory Note Exhibit 4.6 Form of Convertible Unsecured Promissory Note THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE SECURITIES LAWS AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITH

April 13, 2012 EX-21.1

List of Subsidiaries Name Jurisdiction of Incorporation Hyperion Therapeutics Limited United Kingdom

Subsidiaries of the Company Exhibit 21.1 List of Subsidiaries Name Jurisdiction of Incorporation Hyperion Therapeutics Limited United Kingdom

April 13, 2012 EX-4.3

HYPERION THERAPEUTICS, INC. WARRANT TO PURCHASE COMMON STOCK No. CSW-1 December 14, 2007 VOID AFTER DECEMBER 13, 2012

Warrant to Purchase Common Stock issued to Keelin Reeds Exhibit 4.3 THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”). THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO SUCH SECURITIES UNDER THE ACT OR AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY

April 13, 2012 EX-10.2

HYPERION THERAPEUTICS, INC. CONVERTIBLE NOTE AND WARRANT PURCHASE AGREEMENT

The April 2011 Purchase Agreement Exhibit 10.2 HYPERION THERAPEUTICS, INC. CONVERTIBLE NOTE AND WARRANT PURCHASE AGREEMENT This Convertible Note and Warrant Purchase Agreement (this “Agreement”) is made as of April 1, 2011 (the “Effective Date”) by and between Hyperion Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the purchasers listed on Exhibit A attached to this Agreem

April 13, 2012 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION HYPERION THERAPEUTICS, INC.

Amended and Restated Certificate of Incorporation of the Company Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF HYPERION THERAPEUTICS, INC. Hyperion Therapeutics, Inc., a corporation organized and existing under and by virtue of the Delaware General Corporation Law, hereby certifies as follows: 1. The name of this corporation is Hyperion Therapeutics, Inc. and the date of filing

April 13, 2012 EX-10.14

HYPERION THERAPEUTICS, INC. 2006 EQUITY INCENTIVE PLAN OPTION AGREEMENT (INCENTIVE STOCK OPTION OR NONSTATUTORY STOCK OPTION)

Form of Option Agreement under 2006 Equity Incentive Plan Exhibit 10.14 HYPERION THERAPEUTICS, INC. 2006 EQUITY INCENTIVE PLAN OPTION AGREEMENT (INCENTIVE STOCK OPTION OR NONSTATUTORY STOCK OPTION) Pursuant to your Stock Option Grant Notice (“Grant Notice”) and this Option Agreement, Hyperion Therapeutics, Inc. (the “Company”) has granted you an option under its 2006 Equity Incentive Plan (the “Pl

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